JP2019523761A5 - - Google Patents

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Publication number
JP2019523761A5
JP2019523761A5 JP2018562186A JP2018562186A JP2019523761A5 JP 2019523761 A5 JP2019523761 A5 JP 2019523761A5 JP 2018562186 A JP2018562186 A JP 2018562186A JP 2018562186 A JP2018562186 A JP 2018562186A JP 2019523761 A5 JP2019523761 A5 JP 2019523761A5
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JP
Japan
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pab
adc
ala
formula
group
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JP2018562186A
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English (en)
Japanese (ja)
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JP7103953B2 (ja
JP2019523761A (ja
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Priority claimed from PCT/US2017/035206 external-priority patent/WO2017210288A1/en
Publication of JP2019523761A publication Critical patent/JP2019523761A/ja
Publication of JP2019523761A5 publication Critical patent/JP2019523761A5/ja
Priority to JP2021143103A priority Critical patent/JP7403507B2/ja
Application granted granted Critical
Publication of JP7103953B2 publication Critical patent/JP7103953B2/ja
Expired - Fee Related legal-status Critical Current
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JP2018562186A 2016-05-31 2017-05-31 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート Expired - Fee Related JP7103953B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021143103A JP7403507B2 (ja) 2016-05-31 2021-09-02 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662343825P 2016-05-31 2016-05-31
US62/343,825 2016-05-31
PCT/US2017/035206 WO2017210288A1 (en) 2016-05-31 2017-05-31 Antibody drug conjugates having derivatives of amatoxin as the drug

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021143103A Division JP7403507B2 (ja) 2016-05-31 2021-09-02 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート

Publications (3)

Publication Number Publication Date
JP2019523761A JP2019523761A (ja) 2019-08-29
JP2019523761A5 true JP2019523761A5 (https=) 2020-07-09
JP7103953B2 JP7103953B2 (ja) 2022-07-20

Family

ID=60421192

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018562186A Expired - Fee Related JP7103953B2 (ja) 2016-05-31 2017-05-31 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート
JP2021143103A Active JP7403507B2 (ja) 2016-05-31 2021-09-02 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021143103A Active JP7403507B2 (ja) 2016-05-31 2021-09-02 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート

Country Status (6)

Country Link
US (2) US11013816B2 (https=)
EP (1) EP3471771A4 (https=)
JP (2) JP7103953B2 (https=)
CN (2) CN115645544A (https=)
CA (1) CA3025931A1 (https=)
WO (1) WO2017210288A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3471771A4 (en) * 2016-05-31 2020-04-15 Sorrento Therapeutics, Inc. ANTIBODY-MEDICINE CONJUGATES WITH DERIVATIVES OF AMATOXIN AS A MEDICINAL PRODUCT
CN109641051A (zh) 2016-06-17 2019-04-16 美真达治疗公司 用于耗尽细胞的组合物和方法
MX395639B (es) 2017-01-20 2025-03-25 Heidelberg Pharma Res Gmbh Composiciones y métodos para el agotamiento de células cd137+.
JP2021521202A (ja) * 2018-04-13 2021-08-26 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング 固形腫瘍の治療のための標的化されたアマトキシン複合体
KR20250100803A (ko) * 2019-01-31 2025-07-03 항저우 디에이씨 바이오테크 씨오, 엘티디 분지형 링커를 갖는 아마니타 독소의 접합체
SG11202110287QA (en) * 2019-04-24 2021-10-28 Heidelberg Pharma Res Gmbh Amatoxin antibody-drug conjugates and uses thereof
MX2021015887A (es) * 2019-06-24 2022-03-22 Hangzhou Dac Biotech Co Ltd Un conjugado de un agente citotóxico y una molécula de unión a células con enlazadores ramificados.
BR112022019042A2 (pt) * 2020-03-25 2022-11-01 Jiangsu Hengrui Pharmaceuticals Co Ltd Método de preparação para conjugado anticorpo-fármaco
US20240181073A1 (en) 2021-03-03 2024-06-06 Sorrento Therapeutics, Inc. Antibody-Drug Conjugates Comprising an Anti-BCMA Antibody
CN117241832A (zh) 2021-03-19 2023-12-15 海德堡医药研究有限责任公司 B淋巴细胞特异性的鹅膏毒素抗体缀合物
CN113980909B (zh) * 2021-11-16 2022-06-14 江南大学 一种α-鹅膏蕈碱人工抗原、单克隆抗体、杂交瘤细胞株及应用
EP4489790A1 (en) 2022-03-10 2025-01-15 Vivasor, Inc. Antibody-drug conjugates and uses thereof
EP4687997A2 (en) 2023-04-05 2026-02-11 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
EP4687995A1 (en) 2023-04-05 2026-02-11 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
EP4687996A1 (en) 2023-04-05 2026-02-11 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
WO2024243706A1 (en) * 2023-06-02 2024-12-05 The University Of British Columbia Amatoxin analogs and uses thereof
CN117683079B (zh) * 2023-12-12 2025-04-04 九洲药业(杭州)有限公司 一种抗体偶联药物连接子的固相合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4806680B2 (ja) * 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
US9233173B2 (en) * 2009-04-08 2016-01-12 Deutsches Krebsforschungszentrum Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
FR2947320B1 (fr) * 2009-06-30 2011-07-22 Valeo Systemes Thermiques Vanne de commande pour un circuit de refroidissement d'un moteur de vehicule automobile
ES2402254T3 (es) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
US9981046B2 (en) * 2012-05-15 2018-05-29 Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. Drug-conjugates, conjugation methods, and uses thereof
US20150218220A1 (en) * 2012-09-12 2015-08-06 Brian Alan MENDELSOHN Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
JP6506262B2 (ja) * 2013-05-31 2019-04-24 ジェネンテック， インコーポレイテッド 抗細胞壁タイコ酸抗体及びコンジュゲート
WO2015057876A1 (en) * 2013-10-15 2015-04-23 Sorrento Therapeutics Inc. Drug-conjugates with a targeting molecule and two different drugs
US9239324B2 (en) 2013-12-06 2016-01-19 Gang Chen Antibody-binding protein-drug conjugate and methods of use
KR20170042495A (ko) * 2013-12-16 2017-04-19 제넨테크, 인크. 펩티드모방체 화합물 및 그의 항체-약물 접합체
EP3160513B1 (en) * 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
WO2016004043A1 (en) * 2014-06-30 2016-01-07 Blend Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
EP3471771A4 (en) * 2016-05-31 2020-04-15 Sorrento Therapeutics, Inc. ANTIBODY-MEDICINE CONJUGATES WITH DERIVATIVES OF AMATOXIN AS A MEDICINAL PRODUCT

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