JP2019523761A5 - - Google Patents
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- JP2019523761A5 JP2019523761A5 JP2018562186A JP2018562186A JP2019523761A5 JP 2019523761 A5 JP2019523761 A5 JP 2019523761A5 JP 2018562186 A JP2018562186 A JP 2018562186A JP 2018562186 A JP2018562186 A JP 2018562186A JP 2019523761 A5 JP2019523761 A5 JP 2019523761A5
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- JP
- Japan
- Prior art keywords
- pab
- adc
- ala
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021143103A JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343825P | 2016-05-31 | 2016-05-31 | |
| US62/343,825 | 2016-05-31 | ||
| PCT/US2017/035206 WO2017210288A1 (en) | 2016-05-31 | 2017-05-31 | Antibody drug conjugates having derivatives of amatoxin as the drug |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143103A Division JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523761A JP2019523761A (ja) | 2019-08-29 |
| JP2019523761A5 true JP2019523761A5 (https=) | 2020-07-09 |
| JP7103953B2 JP7103953B2 (ja) | 2022-07-20 |
Family
ID=60421192
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562186A Expired - Fee Related JP7103953B2 (ja) | 2016-05-31 | 2017-05-31 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
| JP2021143103A Active JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143103A Active JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11013816B2 (https=) |
| EP (1) | EP3471771A4 (https=) |
| JP (2) | JP7103953B2 (https=) |
| CN (2) | CN109195631B (https=) |
| CA (1) | CA3025931A1 (https=) |
| WO (1) | WO2017210288A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017210288A1 (en) * | 2016-05-31 | 2017-12-07 | Sorrento Therapeutics, Inc. | Antibody drug conjugates having derivatives of amatoxin as the drug |
| CN109641051A (zh) | 2016-06-17 | 2019-04-16 | 美真达治疗公司 | 用于耗尽细胞的组合物和方法 |
| EP3571230A4 (en) | 2017-01-20 | 2020-12-16 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DELETION OF CD137 + CELLS |
| JP2021521202A (ja) * | 2018-04-13 | 2021-08-26 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 固形腫瘍の治療のための標的化されたアマトキシン複合体 |
| CA3128264A1 (en) * | 2019-01-31 | 2020-08-06 | Hangzhou Dac Biotech Co., Ltd | A conjugate of an amanita toxin with branched linkers |
| NZ781538A (en) | 2019-04-24 | 2025-12-19 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| PH12021500050A1 (en) * | 2019-06-24 | 2022-05-02 | Hangzhou Dac Biotech Co Ltd | A conjugate of a cytotoxic agent to a cell binding molecule with branched linkers |
| CN115103858B (zh) * | 2020-03-25 | 2025-07-15 | 江苏恒瑞医药股份有限公司 | 一种抗体药物偶联物的制备方法 |
| US20240181073A1 (en) | 2021-03-03 | 2024-06-06 | Sorrento Therapeutics, Inc. | Antibody-Drug Conjugates Comprising an Anti-BCMA Antibody |
| CN117241832A (zh) | 2021-03-19 | 2023-12-15 | 海德堡医药研究有限责任公司 | B淋巴细胞特异性的鹅膏毒素抗体缀合物 |
| CN113980909B (zh) * | 2021-11-16 | 2022-06-14 | 江南大学 | 一种α-鹅膏蕈碱人工抗原、单克隆抗体、杂交瘤细胞株及应用 |
| EP4489790A1 (en) | 2022-03-10 | 2025-01-15 | Vivasor, Inc. | Antibody-drug conjugates and uses thereof |
| CN121969398A (zh) | 2023-04-05 | 2026-05-01 | 维硕公司 | 抗体偶联药物及其用途 |
| CN121969397A (zh) | 2023-04-05 | 2026-05-01 | 维硕公司 | 抗体偶联药物及其用途 |
| WO2024211235A1 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024243706A1 (en) * | 2023-06-02 | 2024-12-05 | The University Of British Columbia | Amatoxin analogs and uses thereof |
| CN117683079B (zh) * | 2023-12-12 | 2025-04-04 | 九洲药业(杭州)有限公司 | 一种抗体偶联药物连接子的固相合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4806680B2 (ja) * | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
| ES2784829T3 (es) | 2009-04-08 | 2020-10-01 | Faulstich Heinz Dr | Componentes de unión a la superficie de células terapéuticas provistos de amatoxina diseñados para terapia de tumores |
| FR2947320B1 (fr) * | 2009-06-30 | 2011-07-22 | Valeo Systemes Thermiques | Vanne de commande pour un circuit de refroidissement d'un moteur de vehicule automobile |
| ES2402254T3 (es) | 2010-09-30 | 2013-04-30 | Heidelberg Pharma Ag | Conjugados de amatoxinas con ligadores mejorados |
| CN104640572B (zh) * | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| US20150218220A1 (en) * | 2012-09-12 | 2015-08-06 | Brian Alan MENDELSOHN | Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase |
| RU2687044C2 (ru) * | 2013-05-31 | 2019-05-06 | Дженентек, Инк. | Антитела против стеночной тейхоевой кислоты и их конъюгаты |
| AU2014337317A1 (en) | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| US9239324B2 (en) * | 2013-12-06 | 2016-01-19 | Gang Chen | Antibody-binding protein-drug conjugate and methods of use |
| WO2015095227A2 (en) * | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| WO2016004043A1 (en) | 2014-06-30 | 2016-01-07 | Blend Therapeutics, Inc. | Targeted conjugates and particles and formulations thereof |
| EP3160513B1 (en) * | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| WO2017210288A1 (en) * | 2016-05-31 | 2017-12-07 | Sorrento Therapeutics, Inc. | Antibody drug conjugates having derivatives of amatoxin as the drug |
-
2017
- 2017-05-31 WO PCT/US2017/035206 patent/WO2017210288A1/en not_active Ceased
- 2017-05-31 EP EP17807392.0A patent/EP3471771A4/en not_active Withdrawn
- 2017-05-31 CN CN201780033085.5A patent/CN109195631B/zh active Active
- 2017-05-31 JP JP2018562186A patent/JP7103953B2/ja not_active Expired - Fee Related
- 2017-05-31 CA CA3025931A patent/CA3025931A1/en active Pending
- 2017-05-31 CN CN202211405532.4A patent/CN115645544A/zh active Pending
- 2017-05-31 US US15/609,858 patent/US11013816B2/en not_active Expired - Fee Related
-
2021
- 2021-04-26 US US17/240,700 patent/US20210260211A1/en not_active Abandoned
- 2021-09-02 JP JP2021143103A patent/JP7403507B2/ja active Active
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