JP2017512752A5 - - Google Patents
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- Publication number
- JP2017512752A5 JP2017512752A5 JP2016552268A JP2016552268A JP2017512752A5 JP 2017512752 A5 JP2017512752 A5 JP 2017512752A5 JP 2016552268 A JP2016552268 A JP 2016552268A JP 2016552268 A JP2016552268 A JP 2016552268A JP 2017512752 A5 JP2017512752 A5 JP 2017512752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- solvate
- pharmaceutically acceptable
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CNC(*)C(NCC(*)NC([C@](CCC(O)=O)N[S+])=O)=O Chemical compound CNC(*)C(NCC(*)NC([C@](CCC(O)=O)N[S+])=O)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461940759P | 2014-02-17 | 2014-02-17 | |
| US61/940,759 | 2014-02-17 | ||
| US201461947368P | 2014-03-03 | 2014-03-03 | |
| US61/947,368 | 2014-03-03 | ||
| PCT/US2015/016185 WO2015123679A1 (en) | 2014-02-17 | 2015-02-17 | Hydrophilic antibody-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024690A Division JP2020073607A (ja) | 2014-02-17 | 2020-02-17 | 親水性抗体−薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512752A JP2017512752A (ja) | 2017-05-25 |
| JP2017512752A5 true JP2017512752A5 (https=) | 2018-01-25 |
| JP6716461B2 JP6716461B2 (ja) | 2020-07-01 |
Family
ID=53800705
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552268A Expired - Fee Related JP6716461B2 (ja) | 2014-02-17 | 2015-02-17 | 親水性抗体−薬物コンジュゲート |
| JP2020024690A Withdrawn JP2020073607A (ja) | 2014-02-17 | 2020-02-17 | 親水性抗体−薬物コンジュゲート |
| JP2022078761A Active JP7447183B2 (ja) | 2014-02-17 | 2022-05-12 | 親水性抗体－薬物コンジュゲート |
| JP2022194229A Pending JP2023018157A (ja) | 2014-02-17 | 2022-12-05 | 親水性抗体－薬物コンジュゲート |
| JP2024075020A Pending JP2024096335A (ja) | 2014-02-17 | 2024-05-06 | 親水性抗体－薬物コンジュゲート |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024690A Withdrawn JP2020073607A (ja) | 2014-02-17 | 2020-02-17 | 親水性抗体−薬物コンジュゲート |
| JP2022078761A Active JP7447183B2 (ja) | 2014-02-17 | 2022-05-12 | 親水性抗体－薬物コンジュゲート |
| JP2022194229A Pending JP2023018157A (ja) | 2014-02-17 | 2022-12-05 | 親水性抗体－薬物コンジュゲート |
| JP2024075020A Pending JP2024096335A (ja) | 2014-02-17 | 2024-05-06 | 親水性抗体－薬物コンジュゲート |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10933112B2 (https=) |
| EP (2) | EP3912641B1 (https=) |
| JP (5) | JP6716461B2 (https=) |
| KR (3) | KR20160120777A (https=) |
| CN (1) | CN106029083B (https=) |
| AU (3) | AU2015218202B2 (https=) |
| CA (1) | CA2937753A1 (https=) |
| EA (1) | EA201691650A1 (https=) |
| ES (2) | ES2994375T3 (https=) |
| IL (4) | IL309933A (https=) |
| MX (2) | MX385823B (https=) |
| SG (2) | SG10202001468UA (https=) |
| WO (1) | WO2015123679A1 (https=) |
| ZA (1) | ZA201605111B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10202001468UA (en) | 2014-02-17 | 2020-04-29 | Seattle Genetics Inc | Hydrophilic antibody-drug conjugates |
| JP6486316B2 (ja) | 2015-11-03 | 2019-03-20 | 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 抗体−薬物複合体（ａｄｃ）およびそれを形成するための方法 |
| MX2019001302A (es) | 2016-08-09 | 2019-06-12 | Seattle Genetics Inc | Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas. |
| KR102574659B1 (ko) | 2016-10-11 | 2023-09-04 | 비온디스 비.브이. | 비선형 자가 희생 링커 및 이의 접합체 |
| KR20240000650A (ko) | 2016-10-19 | 2024-01-02 | 인벤라 인코포레이티드 | 항체 구조물 |
| EP3559039A1 (en) | 2016-12-22 | 2019-10-30 | Università Degli Studi Magna Graecia Catanzaro | A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43 |
| CN110177569A (zh) | 2017-03-30 | 2019-08-27 | 江苏恒瑞医药股份有限公司 | 抗体药物偶联物的制备方法 |
| US12605458B2 (en) * | 2017-06-19 | 2026-04-21 | Systimmune, Inc. | Antibody-drug conjugate having acidic self-stabilization junction |
| CN109106951A (zh) * | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| CN108853514B (zh) * | 2017-08-18 | 2022-07-22 | 四川百利药业有限责任公司 | 具有两种不同药物的抗体药物偶联物 |
| CA3082271A1 (en) | 2017-11-14 | 2019-05-23 | Debiopharm Research & Manufacturing S.A. | Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b |
| CN111989339A (zh) | 2018-02-20 | 2020-11-24 | 西雅图基因公司 | 疏水性奥瑞他汀f化合物及其缀合物 |
| WO2019234136A1 (en) | 2018-06-05 | 2019-12-12 | King's College London | Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system |
| AR120079A1 (es) * | 2019-09-19 | 2022-02-02 | Seattle Genetics Inc | Liberación selectiva de fármacos de conjugados internalizados de compuestos biológicamente activos |
| JP7787083B2 (ja) | 2020-03-12 | 2025-12-16 | テフニーシェ ウニヴェルジテート ミュンヘン | アルファ－ｖ－ベータ－６－インテグリンをインビボでアドレッシングするための環状ペプチド及びそれらのコンジュゲート |
| AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| JP7717832B2 (ja) | 2021-04-10 | 2025-08-04 | ジェンマブ エー／エス | Ｆｏｌｒ１結合剤、そのコンジュゲートおよびこれを使用する方法 |
| WO2022226317A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| MX2024002571A (es) | 2021-09-03 | 2024-03-20 | Toray Industries | Composicion farmaceutica para tratamiento y/o prevencion de cancer. |
| EP4434548A1 (en) | 2021-11-15 | 2024-09-25 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
| WO2023092099A1 (en) | 2021-11-19 | 2023-05-25 | Ardeagen Corporation | Gpc3 binding agents, conjugates thereof and methods of using the same |
| CN116212044A (zh) * | 2021-12-03 | 2023-06-06 | 成都百利多特生物药业有限责任公司 | 抗人Trop2抗体-喜树碱类药物偶联物及其医药用途 |
| CN119317646A (zh) * | 2022-06-16 | 2025-01-14 | 山东博安生物技术股份有限公司 | 抗liv-1抗体及其药物偶联物 |
| KR20250031149A (ko) | 2022-06-30 | 2025-03-06 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| AU2024339683A1 (en) | 2023-09-13 | 2026-03-26 | Toray Industries, Inc. | Pharmaceutical composition for treating, preventing and/or diagnosing cancer |
| AU2024353316A1 (en) | 2023-09-26 | 2026-03-26 | Genmab A/S | Ptk7 binding agents, conjugates thereof and methods of using the same |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
| WO2025149661A1 (en) | 2024-01-10 | 2025-07-17 | Genmab A/S | Slitrk6 binding agents, conjugates thereof and methods of using the same |
| WO2025181219A1 (en) | 2024-02-29 | 2025-09-04 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| WO2026007511A1 (en) * | 2024-07-05 | 2026-01-08 | Beijing Innocare Pharma Tech Co., Ltd. | Drug conjugates, their preparation methods and uses |
| WO2026027771A1 (en) | 2024-08-02 | 2026-02-05 | Trimt Gmbh | Alpha v beta 6-integrin binding cyclopeptides with non-natural amino acids, and conjugates thereof |
| WO2026039642A1 (en) | 2024-08-16 | 2026-02-19 | Ardeagen Corporation | Anti-mesothelin antibody conjugates and methods of use thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3628624A (en) | 1967-04-26 | 1971-12-21 | Buero Patent Ag | Guidance system for self-propelled trackless carriages |
| GB2036891B (en) | 1978-12-05 | 1983-05-05 | Windsor Smith C | Change speed gear |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| JP2001505194A (ja) | 1996-11-05 | 2001-04-17 | ブリストル―マイヤーズ・スクイブ・カンパニー | 分枝ペプチド・リンカー |
| SI1545613T1 (sl) * | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| US7498298B2 (en) * | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| CN101203241B (zh) | 2005-04-19 | 2012-02-22 | 西雅图基因公司 | 人源化抗-cd70结合物和其应用 |
| JP5171621B2 (ja) * | 2005-07-07 | 2013-03-27 | シアトル ジェネティックス， インコーポレイテッド | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
| WO2007086083A1 (en) | 2006-01-24 | 2007-08-02 | Tecnoimage Srl | Supporting frame for covering elements |
| US8257706B2 (en) | 2006-08-25 | 2012-09-04 | Seattle Genetics, Inc. | CD30 binding agents and uses thereof |
| CA2678514A1 (en) | 2007-02-21 | 2008-08-28 | Medarex, Inc. | Chemical linkers with single amino acids and conjugates thereof |
| RU2476441C2 (ru) | 2007-10-19 | 2013-02-27 | Сиэтл Дженетикс, Инк. | Cd19-связывающие средства и их применение |
| EP2265283B1 (en) | 2008-03-18 | 2014-09-03 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| JP6105481B2 (ja) | 2010-12-06 | 2017-03-29 | シアトル ジェネティクス，インコーポレーテッド | Ｌｉｖ−１に対するヒト化抗体および癌治療のためのその使用 |
| CN104220094A (zh) | 2012-02-17 | 2014-12-17 | 西雅图基因公司 | 针对整联蛋白αvβ6的抗体和使用该抗体治疗癌症 |
| JP6280031B2 (ja) | 2012-03-29 | 2018-02-14 | 中外製薬株式会社 | 抗ｌａｍｐ５抗体およびその利用 |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| SG10202001468UA (en) | 2014-02-17 | 2020-04-29 | Seattle Genetics Inc | Hydrophilic antibody-drug conjugates |
| AR120079A1 (es) | 2019-09-19 | 2022-02-02 | Seattle Genetics Inc | Liberación selectiva de fármacos de conjugados internalizados de compuestos biológicamente activos |
| AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| MX2023010819A (es) | 2021-03-18 | 2023-09-28 | Seagen Inc | Liberacion selectiva de farmacos a partir de conjugados internalizados de compuestos biologicamente activos. |
-
2015
- 2015-02-17 SG SG10202001468UA patent/SG10202001468UA/en unknown
- 2015-02-17 ES ES21168364T patent/ES2994375T3/es active Active
- 2015-02-17 SG SG11201605886RA patent/SG11201605886RA/en unknown
- 2015-02-17 IL IL309933A patent/IL309933A/en unknown
- 2015-02-17 AU AU2015218202A patent/AU2015218202B2/en not_active Ceased
- 2015-02-17 ES ES15748980T patent/ES2885686T3/es active Active
- 2015-02-17 KR KR1020167025612A patent/KR20160120777A/ko not_active Ceased
- 2015-02-17 EA EA201691650A patent/EA201691650A1/ru unknown
- 2015-02-17 CA CA2937753A patent/CA2937753A1/en active Pending
- 2015-02-17 MX MX2016009862A patent/MX385823B/es unknown
- 2015-02-17 EP EP21168364.4A patent/EP3912641B1/en active Active
- 2015-02-17 KR KR1020247007857A patent/KR20240036143A/ko not_active Withdrawn
- 2015-02-17 JP JP2016552268A patent/JP6716461B2/ja not_active Expired - Fee Related
- 2015-02-17 US US15/118,031 patent/US10933112B2/en active Active
- 2015-02-17 EP EP15748980.8A patent/EP3107557B1/en active Active
- 2015-02-17 CN CN201580008876.3A patent/CN106029083B/zh not_active Expired - Fee Related
- 2015-02-17 WO PCT/US2015/016185 patent/WO2015123679A1/en not_active Ceased
- 2015-02-17 KR KR1020237014278A patent/KR102647074B1/ko active Active
- 2015-02-17 IL IL290116A patent/IL290116B2/en unknown
-
2016
- 2016-07-19 IL IL246829A patent/IL246829B/en active IP Right Grant
- 2016-07-21 ZA ZA2016/05111A patent/ZA201605111B/en unknown
- 2016-07-28 MX MX2021010550A patent/MX2021010550A/es unknown
-
2020
- 2020-02-17 JP JP2020024690A patent/JP2020073607A/ja not_active Withdrawn
- 2020-09-24 AU AU2020239744A patent/AU2020239744B2/en not_active Ceased
-
2021
- 2021-01-27 US US17/160,225 patent/US11510959B2/en active Active
- 2021-04-19 IL IL282434A patent/IL282434B/en unknown
-
2022
- 2022-05-12 JP JP2022078761A patent/JP7447183B2/ja active Active
- 2022-10-11 US US17/963,939 patent/US20230132738A1/en not_active Abandoned
- 2022-12-05 JP JP2022194229A patent/JP2023018157A/ja active Pending
-
2023
- 2023-03-06 AU AU2023201373A patent/AU2023201373A1/en not_active Abandoned
- 2023-07-28 US US18/361,558 patent/US12257281B2/en active Active
-
2024
- 2024-05-06 JP JP2024075020A patent/JP2024096335A/ja active Pending
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