JP2019522050A5 - - Google Patents

Download PDF

Info

Publication number
JP2019522050A5
JP2019522050A5 JP2019518185A JP2019518185A JP2019522050A5 JP 2019522050 A5 JP2019522050 A5 JP 2019522050A5 JP 2019518185 A JP2019518185 A JP 2019518185A JP 2019518185 A JP2019518185 A JP 2019518185A JP 2019522050 A5 JP2019522050 A5 JP 2019522050A5
Authority
JP
Japan
Prior art keywords
optionally substituted
antibody
antigen
binding fragment
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019518185A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019522050A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/038151 external-priority patent/WO2017219025A1/en
Publication of JP2019522050A publication Critical patent/JP2019522050A/ja
Publication of JP2019522050A5 publication Critical patent/JP2019522050A5/ja
Priority to JP2022116511A priority Critical patent/JP2022163075A/ja
Priority to JP2023208327A priority patent/JP2024037832A/ja
Pending legal-status Critical Current

Links

JP2019518185A 2016-06-17 2017-06-19 細胞の枯渇のための組成物および方法 Pending JP2019522050A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022116511A JP2022163075A (ja) 2016-06-17 2022-07-21 細胞の枯渇のための組成物および方法
JP2023208327A JP2024037832A (ja) 2016-06-17 2023-12-11 細胞の枯渇のための組成物および方法

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201662351778P 2016-06-17 2016-06-17
US201662351725P 2016-06-17 2016-06-17
US62/351,725 2016-06-17
US62/351,778 2016-06-17
US201662437729P 2016-12-22 2016-12-22
US201662437756P 2016-12-22 2016-12-22
US62/437,729 2016-12-22
US62/437,756 2016-12-22
US201762448782P 2017-01-20 2017-01-20
US201762448768P 2017-01-20 2017-01-20
US62/448,768 2017-01-20
US62/448,782 2017-01-20
PCT/US2017/038151 WO2017219025A1 (en) 2016-06-17 2017-06-19 Compositions and methods for the depletion of cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022116511A Division JP2022163075A (ja) 2016-06-17 2022-07-21 細胞の枯渇のための組成物および方法

Publications (2)

Publication Number Publication Date
JP2019522050A JP2019522050A (ja) 2019-08-08
JP2019522050A5 true JP2019522050A5 (https=) 2020-07-30

Family

ID=60664586

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019518185A Pending JP2019522050A (ja) 2016-06-17 2017-06-19 細胞の枯渇のための組成物および方法
JP2022116511A Pending JP2022163075A (ja) 2016-06-17 2022-07-21 細胞の枯渇のための組成物および方法
JP2023208327A Pending JP2024037832A (ja) 2016-06-17 2023-12-11 細胞の枯渇のための組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022116511A Pending JP2022163075A (ja) 2016-06-17 2022-07-21 細胞の枯渇のための組成物および方法
JP2023208327A Pending JP2024037832A (ja) 2016-06-17 2023-12-11 細胞の枯渇のための組成物および方法

Country Status (13)

Country Link
US (5) US20190328901A1 (https=)
EP (1) EP3471772A4 (https=)
JP (3) JP2019522050A (https=)
KR (2) KR20230082055A (https=)
CN (1) CN109641051A (https=)
AU (3) AU2017204139B2 (https=)
BR (1) BR112018076263A2 (https=)
CA (1) CA3028145A1 (https=)
IL (1) IL263743A (https=)
MA (1) MA45407A (https=)
MX (1) MX2018015683A (https=)
SG (1) SG11201811292RA (https=)
WO (1) WO2017219025A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017176760A2 (en) 2016-04-04 2017-10-12 Vladislav Sandler Method of eliminating hematopoietic stem cells/hematopoietic progenitors (hsc/hp) in a patient using bi-specific antibodies
WO2019018383A1 (en) 2017-07-18 2019-01-24 Calimmune, Inc. COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES
WO2019108863A1 (en) 2017-11-29 2019-06-06 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cd5+ cells
CN121555430A (zh) 2018-05-11 2026-02-24 比姆医疗股份有限公司 使用可编程碱基编辑器系统取代病原性氨基酸的方法
CA3098103A1 (en) * 2018-05-23 2019-11-28 Adc Therapeutics Sa Molecular adjuvant
CA3107383A1 (en) * 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy
CA3107378A1 (en) * 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of an anti-cd2 antibody drug conjugate (adc) in allogeneic cell therapy
JP2022512781A (ja) * 2018-10-30 2022-02-07 マジェンタ セラピューティクス インコーポレイテッド 同種造血幹細胞移植の方法
CA3117367A1 (en) * 2018-10-30 2020-05-07 Magenta Therapeutics, Inc. Anti-cd45 antibodies and conjugates thereof
JP2022514955A (ja) 2018-12-23 2022-02-16 シーエスエル・ベーリング・エルエルシー ウィスコット・アルドリッチ症候群の造血幹細胞遺伝子治療
CA3125751A1 (en) * 2019-01-07 2020-07-16 Magenta Therapeutics, Inc. Use of an anti-cd45 antibody drug conjugate (adc) in cell therapy
CN113993550A (zh) * 2019-04-24 2022-01-28 美真达治疗公司 用于基因疗法的调理方法
WO2020219959A1 (en) * 2019-04-24 2020-10-29 Magenta Therapeutics, Inc. Anti-cd45 antibody drug conjugates and uses thereof
US20220211885A1 (en) * 2019-04-25 2022-07-07 Actinium Pharmaceuticals, Inc. Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
JP2022535527A (ja) * 2019-06-04 2022-08-09 マジェンタ セラピューティクス インコーポレイテッド 自己免疫疾患を治療するための方法および組成物
CR20210687A (es) * 2019-06-25 2022-03-03 Gilead Sciences Inc PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO
TWI877179B (zh) * 2019-06-27 2025-03-21 德商百靈佳殷格翰國際股份有限公司 抗-angpt2抗體
WO2021007266A1 (en) * 2019-07-09 2021-01-14 Hemogenyx Llc Method of eliminating hematopoietic stem cells/hematopoietic progenitors (hsc/hp) in a patient using bi-specific antibodies
JP2022543779A (ja) * 2019-07-30 2022-10-14 デンドロサイト バイオテック ピーティーワイ リミテッド イムノコンジュゲート
EP4051711A4 (en) * 2019-11-01 2024-02-21 Magenta Therapeutics, Inc. ANTI-CD45 ANTIBODIES AND THEIR CONJUGATES
CA3168039A1 (en) * 2020-02-18 2021-08-26 Geoffrey O. GILLARD Compositions and methods for allogeneic transplantation
US20230158104A1 (en) * 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
US12496303B2 (en) 2020-10-19 2025-12-16 Washington University Conditioning agents for use in allogeneic hematopoietic stem cell transplantation
WO2023118608A1 (en) 2021-12-23 2023-06-29 Universität Basel Discernible cell surface protein variants of cd45 for use in cell therapy
WO2025213182A1 (en) * 2024-04-05 2025-10-09 The Board Of Trustees Of The Leland Stanford Junior University Combinatorial approaches for targeting hematopoietic cells

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074650A (en) 1985-06-24 2000-06-13 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
AU5186090A (en) 1989-02-23 1990-09-26 Colorado State University Research Foundation Gnrh analogs for destroying gonadotrophs
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US6106834A (en) 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
US6024957A (en) 1993-06-02 2000-02-15 Research Corporation Technologies, Inc. Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same
GB9323199D0 (en) 1993-11-10 1994-01-05 Falkenberg J H F Leukaemia treatment
US6759509B1 (en) 1996-11-05 2004-07-06 Bristol-Myers Squibb Company Branched peptide linkers
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
AU2002351204B2 (en) * 2001-12-03 2008-07-10 Abgenix, Inc. Anti-CD45RB antibodies for use in treating autoimmune disease and transplant rejection
HRP20100334T1 (hr) * 2003-09-18 2010-07-31 Novartis Ag Terapeutska humanizirana antitijela protiv cd45-izoforma
EP1718667B1 (en) 2004-02-23 2013-01-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
EP1661584A1 (en) 2004-11-26 2006-05-31 Heinz Dr. Faulstich Use of conjugates of amatoxins and phallotoxins with macromolecules for cancer and inflammation therapy
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
WO2007087453A2 (en) 2006-01-27 2007-08-02 Cellerant Therapeutics, Inc. Compositions and methods for treating haematological proliferative disorders
JP2009529522A (ja) 2006-03-10 2009-08-20 ディアト 酵素で切断可能なリンカーを介して抗体に複合された抗癌剤
ES2371085T3 (es) 2006-05-27 2011-12-27 Faulstich, Heinz, Dr. Utilización de conjugados de amatoxinas o falotoxinas con macromoléculas para la terapia tumoral y de la inflamación.
ES2567402T3 (es) 2006-05-30 2016-04-22 Genentech, Inc. Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos
CA2683137A1 (en) * 2006-10-10 2008-04-17 Squicor Compositions and methods for treating and diagnosing cancers
ES2882360T3 (es) * 2006-11-03 2021-12-01 Univ Leland Stanford Junior Inmunoempobrecimiento selectivo de un nicho de células madre endógenas para injerto
WO2008070593A2 (en) 2006-12-01 2008-06-12 Seattle Genetics, Inc. Variant target binding agents and uses thereof
MX2011010265A (es) * 2009-04-01 2011-10-11 Genentech Inc Anticuerpos anti-fcrh5 e inmunoconjugados y metodos de uso.
JP2012523383A (ja) * 2009-04-08 2012-10-04 ファウルシュティヒ,ハインツ がんの治療のためのアマトキシンと複合体形成した標的結合部分
US9233173B2 (en) 2009-04-08 2016-01-12 Deutsches Krebsforschungszentrum Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
MX391454B (es) 2010-04-15 2025-03-05 Seagen Inc Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
ES2402254T3 (es) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (en) 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
HUE045348T2 (hu) 2011-05-08 2019-12-30 Legochem Biosciences Inc Fehérje-hatóanyag konjugátumok és eljárás elõállításukra
WO2013055993A1 (en) 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CN103998449A (zh) 2011-10-14 2014-08-20 斯皮罗根有限公司 吡咯并苯并二氮杂卓
JP2015502397A (ja) 2011-12-23 2015-01-22 ファイザー・インク 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
US9504756B2 (en) 2012-05-15 2016-11-29 Seattle Genetics, Inc. Self-stabilizing linker conjugates
EP2684865A1 (en) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
US20150218220A1 (en) 2012-09-12 2015-08-06 Brian Alan MENDELSOHN Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
US9324898B2 (en) * 2012-09-25 2016-04-26 Alliance For Sustainable Energy, Llc Varying cadmium telluride growth temperature during deposition to increase solar cell reliability
ES2732574T3 (es) 2012-11-30 2019-11-25 Novartis Ag Métodos para preparar conjugados a partir de proteínas que contienen disulfuro
JP2016516672A (ja) 2013-02-28 2016-06-09 プレジデント アンド フェローズ オブ ハーバード カレッジ 幹細胞を動員するための方法および組成物
EP2774624A1 (en) 2013-03-04 2014-09-10 Heidelberg Pharma GmbH Amatoxin derivatives
EP2968591A1 (en) * 2013-03-15 2016-01-20 Novartis AG Cell proliferation inhibitors and conjugates thereof
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
US9803002B2 (en) 2013-05-31 2017-10-31 Genentench, Inc. Anti-wall teichoic antibodies and conjugates
US11229711B2 (en) 2013-06-06 2022-01-25 Magenta Therapeutics, Inc. Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
AU2014299561B2 (en) 2013-06-24 2017-06-08 Ablbio Antibody-drug conjugate having improved stability and use thereof
FR3008408B1 (fr) 2013-07-11 2018-03-09 Mc Saf Nouveaux conjugues anticorps-medicament et leur utilisation en therapie
CN105377304B (zh) * 2014-03-10 2018-05-15 海德堡医药有限责任公司 鹅膏毒肽衍生物
CA2950155C (en) 2014-06-02 2021-11-23 Regeneron Pharmaceuticals, Inc. Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses
EP3174902B1 (en) * 2014-08-01 2019-04-17 Institut National de la Sante et de la Recherche Medicale (INSERM) An anti-cd45rc antibody for use as drug
JP6863888B2 (ja) 2014-10-01 2021-04-21 メディミューン,エルエルシー ポリペプチドをコンジュゲートさせる方法
EP3209334A2 (en) 2014-10-20 2017-08-30 Igenica Biotherapeutics, Inc. Novel antibody-drug conjugates and related compounds, compositions, and methods of use
EP3215519A1 (en) * 2014-11-06 2017-09-13 Novartis AG Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
EP3026060A1 (en) * 2014-11-26 2016-06-01 Miltenyi Biotec GmbH Humanized antibody or fragment thereof specific for CD45R0
US9729129B2 (en) * 2014-12-05 2017-08-08 Bhaskar Gopalan System and method for reducing metastability in CMOS flip-flops
US20160220687A1 (en) 2015-02-02 2016-08-04 National Guard Health Affairs Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
JP6863900B2 (ja) 2015-03-09 2021-04-21 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規アマトキシン−抗体コンジュゲート
HK1249534A1 (zh) * 2015-04-06 2018-11-02 哈佛大学校长及研究员协会 用於非清髓性预处理的组合物和方法
EP3297684B1 (en) 2015-05-21 2020-12-23 Actinium Pharmaceuticals, Inc. Infusion administration of conjugated monoclonal antibodies
WO2017051249A1 (en) 2015-09-25 2017-03-30 Legochem Biosciences, Inc. Compositions and methods related to anti-cd19 antibody drug conjugates
EP3362100B1 (en) 2015-10-16 2022-06-22 Genentech, Inc. Hindered disulfide drug conjugates
US10723766B2 (en) 2015-11-27 2020-07-28 Heidelberg Pharma Research Gmbh Derivatives of gamma-amanitin
EP3222292A1 (en) 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Amanitin conjugates
HUE071169T2 (hu) 2016-03-07 2025-08-28 Actinium Pharmaceuticals Inc Stabilizált, radioaktívan jelölt anti-CD45 immunglobulin-készítmények
CA3016172C (en) 2016-04-20 2024-03-12 Hangzhou Dac Biotech Co., Ltd Derivatives of amanita toxins and their conjugation to a cell binding molecule
US10464969B2 (en) 2016-05-05 2019-11-05 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
EP3464363A1 (en) 2016-05-27 2019-04-10 Actinium Pharmaceuticals, Inc. Low dose antibody-based methods for treating hematologic malignancies
EP3471771A4 (en) 2016-05-31 2020-04-15 Sorrento Therapeutics, Inc. ANTIBODY-MEDICINE CONJUGATES WITH DERIVATIVES OF AMATOXIN AS A MEDICINAL PRODUCT
BR112018076306A2 (pt) 2016-06-17 2019-03-26 Magenta Therapeutics, Inc. composições e métodos para a supressão de células cd117+
EP3500663A1 (en) 2016-08-29 2019-06-26 PDI Pharm Development International AG Provision of a therapeutically active cell product
US10112266B2 (en) * 2016-09-09 2018-10-30 Baltic Innovation Holding PRO, AS Pressed thermite rod for a self-contained portable cutting device
EP3526260A4 (en) * 2016-10-13 2020-11-18 President and Fellows of Harvard College NON-MYELOABLATIVE PACKAGING COMPOSITIONS AND METHODS
US11446388B2 (en) 2016-12-23 2022-09-20 Heidelberg Pharma Research Gmbh Amanitin antibody conjugates
MX395639B (es) 2017-01-20 2025-03-25 Heidelberg Pharma Res Gmbh Composiciones y métodos para el agotamiento de células cd137+.
JP7321934B2 (ja) 2017-01-30 2023-08-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 幹細胞移植のための非遺伝毒性移植前処置レジメン
WO2019030171A1 (en) 2017-08-07 2019-02-14 Heidelberg Pharma Gmbh NOVEL METHOD FOR SYNTHESIZING AMANITINES

Similar Documents

Publication Publication Date Title
JP2019522050A5 (https=)
WO2019108863A4 (en) Compositions and methods for the depletion of cd5+ cells
JP2021500391A5 (https=)
WO2019084064A4 (en) Compositions and methods for the depletion of cd117+ cells
JP2019522680A5 (https=)
US11384148B2 (en) Anti-FcRn antibodies
CN110461876B (zh) 用于耗尽cd137+细胞的组合物和方法
WO2019108860A4 (en) Compositions and methods for the depletion of cd2+ cells
KR102236259B1 (ko) 항-lag-3 항체 및 그것의 사용
ES2649155T3 (es) Anticuerpos anti-OX40 y procedimientos de uso de los mismos
JP2020513791A5 (https=)
JP6998857B2 (ja) Cd79に結合する抗体分子
JP2021519295A (ja) 抗cd38抗体の皮下投薬
JP2021504414A5 (https=)
KR20180119653A (ko) Tigit에 대한 항체
RU2008149918A (ru) Антитела к nkg2a и их применения
RU2012142311A (ru) Интерлейкин-13-связывающие белки
JP2025183307A5 (https=)
WO2013072523A4 (en) Bi-specific antibodies for medical use
TW201902925A (zh) 抗cd40抗體、其抗原結合片段及其醫藥用途
CN110343180B (zh) 抗ctla-4抗体及其应用
EP3959242A1 (en) Anthracycline antibody-drug conjugates and uses thereof
JPWO2021163389A5 (https=)
AU2021391779A1 (en) Modulating the immune response using anti-cd30 antibody-drug conjugates
CN114206358A (zh) T细胞消耗疗法