JP2019520063A5 - - Google Patents
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- JP2019520063A5 JP2019520063A5 JP2018562201A JP2018562201A JP2019520063A5 JP 2019520063 A5 JP2019520063 A5 JP 2019520063A5 JP 2018562201 A JP2018562201 A JP 2018562201A JP 2018562201 A JP2018562201 A JP 2018562201A JP 2019520063 A5 JP2019520063 A5 JP 2019520063A5
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- Prior art keywords
- antibody
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021184049A JP2022010244A (ja) | 2016-05-26 | 2021-11-11 | 抗体の混合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662342167P | 2016-05-26 | 2016-05-26 | |
| US62/342,167 | 2016-05-26 | ||
| PCT/US2017/030676 WO2017205014A1 (en) | 2016-05-26 | 2017-05-02 | Mixtures of antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021184049A Division JP2022010244A (ja) | 2016-05-26 | 2021-11-11 | 抗体の混合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520063A JP2019520063A (ja) | 2019-07-18 |
| JP2019520063A5 true JP2019520063A5 (https=) | 2020-06-18 |
| JP7301540B2 JP7301540B2 (ja) | 2023-07-03 |
Family
ID=58709577
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562201A Active JP7301540B2 (ja) | 2016-05-26 | 2017-05-02 | 抗体の混合物 |
| JP2021184049A Withdrawn JP2022010244A (ja) | 2016-05-26 | 2021-11-11 | 抗体の混合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021184049A Withdrawn JP2022010244A (ja) | 2016-05-26 | 2021-11-11 | 抗体の混合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11130808B2 (https=) |
| EP (1) | EP3463451A1 (https=) |
| JP (2) | JP7301540B2 (https=) |
| CN (1) | CN109475627B (https=) |
| AU (1) | AU2017269115B2 (https=) |
| CA (1) | CA3025162A1 (https=) |
| WO (1) | WO2017205014A1 (https=) |
Families Citing this family (46)
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|---|---|---|---|---|
| TWI452136B (zh) | 2010-11-17 | 2014-09-11 | 中外製藥股份有限公司 | A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation |
| PT3434767T (pt) | 2010-11-30 | 2026-01-23 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de citotoxicidade |
| CN109134658B (zh) | 2011-10-31 | 2022-10-14 | 中外制药株式会社 | 控制了重链与轻链的缔合的抗原结合分子 |
| WO2017110980A1 (ja) | 2015-12-25 | 2017-06-29 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| CR20180554A (es) | 2016-04-28 | 2019-01-10 | Chugai Pharmaceutical Co Ltd | Preparaciones que contienen anticuerpos |
| US20190185578A1 (en) | 2016-07-29 | 2019-06-20 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity |
| JP7066696B2 (ja) | 2016-10-11 | 2022-05-13 | アジェナス インコーポレイテッド | 抗ｌａｇ－３抗体及びその使用方法 |
| TW201834688A (zh) * | 2017-02-24 | 2018-10-01 | 日商中外製藥股份有限公司 | 藥學組成物、抗原結合分子、治療方法以及篩選方法 |
| ES2863412T3 (es) | 2017-03-29 | 2021-10-11 | Shionogi & Co | Composición farmacéutica para el tratamiento del cáncer |
| CN110461358A (zh) | 2017-03-31 | 2019-11-15 | 公立大学法人奈良县立医科大学 | 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物 |
| PE20210005A1 (es) | 2017-09-29 | 2021-01-05 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno multiespecifica que tiene actividad de sustitucion de la funcion de cofactor del factor viii de coagulacion de sangre (fviii) y formulacion farmaceutica que contiene tal molecula como ingrediente activo |
| CN119161488A (zh) | 2017-11-01 | 2024-12-20 | 中外制药株式会社 | 具有降低的生物活性的抗体变体和同种型 |
| TWI880235B (zh) | 2017-11-28 | 2025-04-11 | 日商中外製藥股份有限公司 | 可調整配體結合活性的配體結合分子 |
| JP2019151621A (ja) * | 2018-02-28 | 2019-09-12 | 学校法人藤田学園 | Ｋａｔ阻害活性を有する化合物を含有するがん治療用組成物 |
| CN110357960A (zh) * | 2018-04-10 | 2019-10-22 | 广州爱思迈生物医药科技有限公司 | 抗体及抗体改造方法 |
| BR112021005585A2 (pt) | 2018-09-27 | 2021-06-29 | Celgene Corporation | proteínas de ligação a sirpa e métodos de uso das mesmas |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| WO2020180811A1 (en) | 2019-03-04 | 2020-09-10 | Qilu Puget Sound Biotherapeutics Corporation | Anti-sirp-alpha antibodies |
| CN110551221B (zh) * | 2019-07-02 | 2021-03-05 | 广州爱思迈生物医药科技有限公司 | 一种双特异性抗体及其制备方法与应用 |
| WO2021041678A1 (en) | 2019-08-30 | 2021-03-04 | Qilu Puget Sound Biotherapeutics Corporation | Anti-cd20 antibodies, anti-cd37 antibodies, and mixtures thereof |
| CN120383671A (zh) * | 2019-09-30 | 2025-07-29 | 阿迪马布有限责任公司 | 被工程化用于优先轻链配对的ch1结构域变体和包括所述ch1结构域变体的多特异性抗体 |
| CA3160436A1 (en) * | 2019-12-17 | 2021-06-24 | Jack Chongyang LI | Bispecific antibodies with alternatively matched interchain cysteines and uses thereof |
| EP4093875A4 (en) * | 2020-01-20 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding fusion proteins |
| WO2022023559A1 (en) * | 2020-07-31 | 2022-02-03 | Curevac Ag | Nucleic acid encoded antibody mixtures |
| US20230322955A1 (en) * | 2020-08-20 | 2023-10-12 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in fab region |
| EP4186926A4 (en) * | 2020-08-28 | 2024-06-05 | Harbour Biomed US, Inc. | ANTI-CCR8 ANTIBODIES AND CORRESPONDING APPLICATION |
| CN114437226A (zh) * | 2020-11-05 | 2022-05-06 | 杭州菁因康生物科技有限公司 | 制备双特异性抗体的方法 |
| WO2022178319A1 (en) * | 2021-02-18 | 2022-08-25 | Qilu Puget Sound Biotherapeutics Corporation | Combinations of anti-pd1 and anti-ctla4 antibodies |
| CN112961245B (zh) * | 2021-02-24 | 2023-07-25 | 重庆精准生物技术有限公司 | 一种靶向cd96的双特异性抗体及其制备方法和用途 |
| MX2023012324A (es) * | 2021-04-20 | 2023-10-30 | Amgen Inc | Distribucion de carga equilibrada en una direccion electrostatica del emparejamiento de cadenas en el conjunto de moleculas de igg multiespecificas y monovalentes. |
| CA3217487A1 (en) * | 2021-04-23 | 2022-10-27 | Chimagen Biosciences, Ltd | Heterodimeric antibodies and antigen-binding fragment thereof |
| EP4370545A1 (en) * | 2021-07-12 | 2024-05-22 | Genentech, Inc. | Structures for reducing antibody-lipase binding |
| US12240910B2 (en) | 2021-07-14 | 2025-03-04 | Genentech, Inc. | Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use |
| CN117957258A (zh) * | 2021-07-19 | 2024-04-30 | 中外制药株式会社 | 利用融合多肽的蛋白酶介导的靶向特异性细胞因子递送 |
| US12441816B2 (en) * | 2021-09-21 | 2025-10-14 | Qilu Puget Sound Biotherapeutics Corporation | Heterodimeric Fc for making fusion proteins and bispecific antibodies |
| CN118660720A (zh) * | 2022-02-22 | 2024-09-17 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| TW202346594A (zh) * | 2022-03-11 | 2023-12-01 | 中國大陸商科望（上海）生物醫藥科技有限公司 | 經修飾之抗體及其用途 |
| WO2023198089A1 (zh) * | 2022-04-13 | 2023-10-19 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| US20250376525A1 (en) * | 2022-06-28 | 2025-12-11 | Qilu Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising mixed antibody of anti-ctla4 and anti-pd1 and therapeutic use thereof |
| EP4548930A4 (en) * | 2022-06-30 | 2025-10-22 | Qilu Pharmaceutical Co Ltd | PHARMACEUTICAL COMPOSITION COMPRISING A MIXTURE OF ANTI-CTLA4 AND ANTI-PD1 ANTIBODIES AND ITS THERAPEUTIC USE |
| JP2025524024A (ja) | 2022-07-22 | 2025-07-25 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | 多重特異性抗体の重鎖及び軽鎖の相同対合を促進する変異体 |
| JPWO2024143442A1 (https=) | 2022-12-27 | 2024-07-04 | ||
| EP4655595A1 (en) * | 2023-01-25 | 2025-12-03 | Regeneron Pharmaceuticals, Inc. | Mass spectrometry-based characterization of antibodies co-expressed in vivo |
| AU2024341660A1 (en) * | 2023-09-11 | 2026-03-12 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting b7-h4 and cd3 and methods of use thereof |
| WO2025117485A1 (en) * | 2023-11-29 | 2025-06-05 | Qilu Puget Sound Biotherapeutics Corporation | Anti-il33 and anti-tslp antibodies, and mixtures |
| WO2025228542A1 (en) | 2024-05-03 | 2025-11-06 | Genmab B.V. | Method for co-expression of a plurality of antibodies |
Family Cites Families (30)
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|---|---|---|---|---|
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| SI1583830T1 (sl) * | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| GB0514779D0 (en) | 2005-07-19 | 2005-08-24 | Celltech R&D Ltd | Biological products |
| JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| BRPI0808551B1 (pt) * | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| JP6071165B2 (ja) | 2007-05-31 | 2017-02-01 | ゲンマブ エー／エス | 安定なＩｇＧ４抗体 |
| JP6157046B2 (ja) | 2008-01-07 | 2017-07-05 | アムジェン インコーポレイテッド | 静電的ステアリング（ｅｌｅｃｔｒｏｓｔａｔｉｃｓｔｅｅｒｉｎｇ）効果を用いた抗体Ｆｃヘテロ二量体分子を作製するための方法 |
| AU2009324092A1 (en) | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| CN104262483A (zh) | 2009-01-26 | 2015-01-07 | 根马布股份公司 | 用于生成抗体混合物的方法 |
| WO2011109726A2 (en) * | 2010-03-05 | 2011-09-09 | Bioatla Llc | Homologous multi-specific antibodies |
| JP2013537416A (ja) | 2010-08-13 | 2013-10-03 | メディミューン リミテッド | 変異型Ｆｃ領域を含むモノマーポリペプチド及び使用方法 |
| WO2012125495A2 (en) | 2011-03-11 | 2012-09-20 | Amgen Inc. | Method of correlated mutational analysis to improve therapeutic antibodies |
| EP2686345B1 (en) | 2011-03-16 | 2018-04-25 | Amgen Inc. | Fc variants |
| IN2013MN01438A (https=) | 2011-03-17 | 2015-06-12 | Univ Ramot | |
| SG11201401422VA (en) | 2011-10-27 | 2014-09-26 | Genmab As | Production of heterodimeric proteins |
| RS60499B1 (sr) * | 2011-12-20 | 2020-08-31 | Medimmune Llc | Modifikovani polipeptidi za bispecifične skelete antitela |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| AU2013258834B2 (en) | 2012-05-10 | 2017-09-07 | Zymeworks Bc Inc. | Heteromultimer constructs of immunoglobulin heavy chains with mutations in the Fc domain |
| CN102851338A (zh) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| CN110669136A (zh) * | 2012-11-05 | 2020-01-10 | 全药工业株式会社 | 抗体或抗体组合物的制备方法 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| JP6385357B2 (ja) | 2012-11-27 | 2018-09-05 | アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションＡｊｏｕ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎｄｕｓｔｒｙ−Ａｃａｄｅｍｉｃ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ | 抗体重鎖不変部位の異種二量体、高効率の形成を誘導するｃｈ３ドメイン変異体対、その作製方法および用途 |
| CN105026430B (zh) | 2012-11-28 | 2025-03-25 | 酵活英属哥伦比亚有限公司 | 工程化免疫球蛋白重链-轻链对及其用途 |
| US10118971B2 (en) | 2013-03-13 | 2018-11-06 | Ibentrus, Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
| ES2821753T3 (es) | 2013-03-15 | 2021-04-27 | Lilly Co Eli | Procedimientos de producción de Fab y de anticuerpos biespecíficos |
| CA2919076C (en) | 2013-07-31 | 2024-01-30 | Amgen Inc. | Stabilization of fc-containing polypeptides |
| EP3080158A4 (en) | 2013-12-09 | 2018-03-21 | Adimab, LLC | Polyclonal mixtures of antibodies, and methods of making and using them |
| ES2936810T3 (es) * | 2014-05-16 | 2023-03-22 | Pfizer | Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería |
| JP2019534044A (ja) * | 2016-11-08 | 2019-11-28 | クイル ピュージェット サウンド バイオセラピューティクス コーポレーション | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
-
2017
- 2017-05-02 CN CN201780043870.9A patent/CN109475627B/zh active Active
- 2017-05-02 WO PCT/US2017/030676 patent/WO2017205014A1/en not_active Ceased
- 2017-05-02 CA CA3025162A patent/CA3025162A1/en active Pending
- 2017-05-02 AU AU2017269115A patent/AU2017269115B2/en not_active Expired - Fee Related
- 2017-05-02 JP JP2018562201A patent/JP7301540B2/ja active Active
- 2017-05-02 EP EP17723832.6A patent/EP3463451A1/en active Pending
- 2017-05-05 US US16/303,611 patent/US11130808B2/en active Active
-
2021
- 2021-09-23 US US17/483,630 patent/US20220073615A1/en active Pending
- 2021-11-11 JP JP2021184049A patent/JP2022010244A/ja not_active Withdrawn
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