JP2019519546A5 - - Google Patents
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- JP2019519546A5 JP2019519546A5 JP2018565674A JP2018565674A JP2019519546A5 JP 2019519546 A5 JP2019519546 A5 JP 2019519546A5 JP 2018565674 A JP2018565674 A JP 2018565674A JP 2018565674 A JP2018565674 A JP 2018565674A JP 2019519546 A5 JP2019519546 A5 JP 2019519546A5
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- Prior art keywords
- patient
- pharmaceutical composition
- sequence
- bmp6
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 122
- 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 claims description 118
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims description 106
- 239000005557 antagonist Substances 0.000 claims description 102
- 102000008857 Ferritin Human genes 0.000 claims description 74
- 108050000784 Ferritin Proteins 0.000 claims description 74
- 238000008416 Ferritin Methods 0.000 claims description 72
- 239000012472 biological sample Substances 0.000 claims description 56
- 239000000427 antigen Substances 0.000 claims description 54
- 102000036639 antigens Human genes 0.000 claims description 54
- 108091007433 antigens Proteins 0.000 claims description 54
- 239000012634 fragment Substances 0.000 claims description 51
- 208000007502 anemia Diseases 0.000 claims description 50
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 20
- 102000003951 Erythropoietin Human genes 0.000 claims description 12
- 108090000394 Erythropoietin Proteins 0.000 claims description 12
- 102000001554 Hemoglobins Human genes 0.000 claims description 12
- 108010054147 Hemoglobins Proteins 0.000 claims description 12
- 229940105423 erythropoietin Drugs 0.000 claims description 12
- 102000046095 human BMP6 Human genes 0.000 claims description 12
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 12
- 229910052742 iron Inorganic materials 0.000 claims description 10
- 210000002966 serum Anatomy 0.000 claims description 10
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims description 8
- 102000046107 human BMP7 Human genes 0.000 claims description 8
- 210000001995 reticulocyte Anatomy 0.000 claims description 8
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims description 6
- 102000045896 human BMP2 Human genes 0.000 claims description 6
- 102000004338 Transferrin Human genes 0.000 claims description 5
- 108090000901 Transferrin Proteins 0.000 claims description 5
- 239000012581 transferrin Substances 0.000 claims description 5
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims description 4
- 208000017667 Chronic Disease Diseases 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 4
- 101000899388 Homo sapiens Bone morphogenetic protein 5 Proteins 0.000 claims description 4
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 238000004820 blood count Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 210000003743 erythrocyte Anatomy 0.000 claims description 4
- 238000005534 hematocrit Methods 0.000 claims description 4
- 102000018511 hepcidin Human genes 0.000 claims description 4
- 108060003558 hepcidin Proteins 0.000 claims description 4
- 229940066919 hepcidin Drugs 0.000 claims description 4
- 102000046096 human BMP5 Human genes 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 230000004043 responsiveness Effects 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000020832 chronic kidney disease Diseases 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 230000010437 erythropoiesis Effects 0.000 claims description 2
- 210000003608 fece Anatomy 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000001631 haemodialysis Methods 0.000 claims description 2
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- 238000004128 high performance liquid chromatography Methods 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 229940127121 immunoconjugate Drugs 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
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- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
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- 230000035772 mutation Effects 0.000 claims description 2
- 201000008383 nephritis Diseases 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
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- 210000001179 synovial fluid Anatomy 0.000 claims description 2
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- 238000001262 western blot Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 76
- 230000004044 response Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 14
- 108060003951 Immunoglobulin Proteins 0.000 description 13
- 102000018358 immunoglobulin Human genes 0.000 description 13
- 102000016359 Fibronectins Human genes 0.000 description 9
- 108010067306 Fibronectins Proteins 0.000 description 9
- 102000009027 Albumins Human genes 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 102000008102 Ankyrins Human genes 0.000 description 4
- 108010049777 Ankyrins Proteins 0.000 description 4
- 102100040892 Growth/differentiation factor 2 Human genes 0.000 description 4
- 101000893585 Homo sapiens Growth/differentiation factor 2 Proteins 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
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- 102000044159 Ubiquitin Human genes 0.000 description 3
- 108090000848 Ubiquitin Proteins 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 102000013069 gamma-Crystallins Human genes 0.000 description 3
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- 229940072221 immunoglobulins Drugs 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
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- 235000002198 Annona diversifolia Nutrition 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
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- 241000282836 Camelus dromedarius Species 0.000 description 1
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 description 1
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- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 description 1
- -1 Fabs Proteins 0.000 description 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
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- 241000282842 Lama glama Species 0.000 description 1
- 102000019298 Lipocalin Human genes 0.000 description 1
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- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000255972 Pieris <butterfly> Species 0.000 description 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 101710204410 Scaffold protein Proteins 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009824 affinity maturation Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
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- 238000010367 cloning Methods 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 239000002539 nanocarrier Substances 0.000 description 1
- NGHTXZCKLWZPGK-UHFFFAOYSA-N nefiracetam Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1C(=O)CCC1 NGHTXZCKLWZPGK-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662350257P | 2016-06-15 | 2016-06-15 | |
| US62/350,257 | 2016-06-15 | ||
| PCT/IB2017/053507 WO2017216724A1 (en) | 2016-06-15 | 2017-06-13 | Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519546A JP2019519546A (ja) | 2019-07-11 |
| JP2019519546A5 true JP2019519546A5 (enExample) | 2020-07-27 |
| JP7231411B2 JP7231411B2 (ja) | 2023-03-01 |
Family
ID=59239934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565674A Active JP7231411B2 (ja) | 2016-06-15 | 2017-06-13 | 骨形成タンパク質６（ｂｍｐ６）の阻害剤を使用して疾患を処置する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11434269B2 (enExample) |
| EP (1) | EP3471759A1 (enExample) |
| JP (1) | JP7231411B2 (enExample) |
| KR (1) | KR102492057B1 (enExample) |
| CN (1) | CN110381988A (enExample) |
| AU (1) | AU2017283787B2 (enExample) |
| CA (1) | CA3027651A1 (enExample) |
| IL (1) | IL263664A (enExample) |
| WO (1) | WO2017216724A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2550114A (en) | 2016-05-03 | 2017-11-15 | Kymab Ltd | Methods, regimens, combinations & antagonists |
| WO2019173283A1 (en) | 2018-03-05 | 2019-09-12 | Marquette University | Method and apparatus for non-invasive hemoglobin level prediction |
| WO2019234680A1 (en) * | 2018-06-08 | 2019-12-12 | Pfizer Inc. | Methods of treating iron metabolic disease with a neutralizing antibody binding erhythroferrone |
| GB201815629D0 (en) * | 2018-09-25 | 2018-11-07 | Kymab Ltd | Antagonists |
| WO2020257587A1 (en) * | 2019-06-19 | 2020-12-24 | Cornell University | Methods of promoting erythropoiesis and overcoming erythropoitein resistance in patients |
| KR20220088699A (ko) | 2019-09-27 | 2022-06-28 | 디스크 메디슨, 인크. | 골수섬유증 및 관련 상태의 치료 방법 |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| CN114075287B (zh) * | 2020-08-18 | 2023-07-21 | 湖南远泰生物技术有限公司 | 人源化bcma抗体和bcma-car-t细胞 |
| KR20240062222A (ko) | 2022-10-28 | 2024-05-09 | 안재남 | IoT 동작 기기 제어용 디지털 통신 시스템 및 그 구동방법 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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-
2017
- 2017-06-13 CN CN201780049356.6A patent/CN110381988A/zh active Pending
- 2017-06-13 CA CA3027651A patent/CA3027651A1/en active Pending
- 2017-06-13 KR KR1020197001175A patent/KR102492057B1/ko active Active
- 2017-06-13 EP EP17733900.9A patent/EP3471759A1/en not_active Withdrawn
- 2017-06-13 JP JP2018565674A patent/JP7231411B2/ja active Active
- 2017-06-13 US US16/464,113 patent/US11434269B2/en active Active
- 2017-06-13 WO PCT/IB2017/053507 patent/WO2017216724A1/en not_active Ceased
- 2017-06-13 AU AU2017283787A patent/AU2017283787B2/en not_active Ceased
-
2018
- 2018-12-12 IL IL263664A patent/IL263664A/en unknown
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