KR102492057B1 - 골 형태형성 단백질 6(ｂｍｐ6)의 억제제를 사용한 질병의 치료 방법 - Google Patents

골 형태형성 단백질 6(ｂｍｐ6)의 억제제를 사용한 질병의 치료 방법 Download PDF

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KR102492057B1
KR102492057B1 KR1020197001175A KR20197001175A KR102492057B1 KR 102492057 B1 KR102492057 B1 KR 102492057B1 KR 1020197001175 A KR1020197001175 A KR 1020197001175A KR 20197001175 A KR20197001175 A KR 20197001175A KR 102492057 B1 KR102492057 B1 KR 102492057B1
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seq
bmp6
nos
antibody
sequences
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KR20190018690A (ko
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펭 콩
윌리엄 디트리히
나탈리 조지
동 리우
아셔 스캐치터
아디티 소니
징 조우
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노파르티스 아게
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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KR1020197001175A 2016-06-15 2017-06-13 골 형태형성 단백질 6(ｂｍｐ6)의 억제제를 사용한 질병의 치료 방법 Active KR102492057B1 (ko)

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Application Number Priority Date Filing Date Title
US201662350257P 2016-06-15 2016-06-15
US62/350,257 2016-06-15
PCT/IB2017/053507 WO2017216724A1 (en) 2016-06-15 2017-06-13 Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)

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KR20190018690A KR20190018690A (ko) 2019-02-25
KR102492057B1 true KR102492057B1 (ko) 2023-01-26

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US (1) US11434269B2 (enExample)
EP (1) EP3471759A1 (enExample)
JP (1) JP7231411B2 (enExample)
KR (1) KR102492057B1 (enExample)
CN (1) CN110381988A (enExample)
AU (1) AU2017283787B2 (enExample)
CA (1) CA3027651A1 (enExample)
IL (1) IL263664A (enExample)
WO (1) WO2017216724A1 (enExample)

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EP3802594A1 (en) * 2018-06-08 2021-04-14 Pfizer Inc. Methods of treating iron metabolic disease with a neutralizing antibody binding erhythroferrone
GB201815629D0 (en) * 2018-09-25 2018-11-07 Kymab Ltd Antagonists
WO2020257587A1 (en) * 2019-06-19 2020-12-24 Cornell University Methods of promoting erythropoiesis and overcoming erythropoitein resistance in patients
JP2022549506A (ja) 2019-09-27 2022-11-25 ディスク・メディシン・インコーポレイテッド 骨髄線維症および関連状態を処置するための方法
EP4149548A4 (en) 2020-05-13 2024-05-08 Disc Medicine, Inc. ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
CN114075287B (zh) * 2020-08-18 2023-07-21 湖南远泰生物技术有限公司 人源化bcma抗体和bcma-car-t细胞
KR20240062222A (ko) 2022-10-28 2024-05-09 안재남 IoT 동작 기기 제어용 디지털 통신 시스템 및 그 구동방법
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