JP2019517808A5 - - Google Patents

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JP2019517808A5
JP2019517808A5 JP2018565659A JP2018565659A JP2019517808A5 JP 2019517808 A5 JP2019517808 A5 JP 2019517808A5 JP 2018565659 A JP2018565659 A JP 2018565659A JP 2018565659 A JP2018565659 A JP 2018565659A JP 2019517808 A5 JP2019517808 A5 JP 2019517808A5
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Japan
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microfluidic
gel
cell
microfluidic channel
capillary pressure
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JP2018565659A
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Japanese (ja)
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JP2019517808A (ja
JP6967535B2 (ja
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Priority claimed from NL2016965A external-priority patent/NL2016965B1/en
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Priority claimed from PCT/EP2017/064302 external-priority patent/WO2017216113A2/en
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Publication of JP2019517808A5 publication Critical patent/JP2019517808A5/ja
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JP2018565659A 2016-06-15 2017-06-12 細胞培養装置及び方法 Active JP6967535B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL2016965 2016-06-15
NL2016965A NL2016965B1 (en) 2016-06-15 2016-06-15 Cell culture device.
NL2018033 2016-12-21
NL2018033 2016-12-21
PCT/EP2017/064302 WO2017216113A2 (en) 2016-06-15 2017-06-12 Cell culture device and methods

Publications (3)

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JP2019517808A JP2019517808A (ja) 2019-06-27
JP2019517808A5 true JP2019517808A5 (https=) 2020-07-27
JP6967535B2 JP6967535B2 (ja) 2021-11-17

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JP2018565659A Active JP6967535B2 (ja) 2016-06-15 2017-06-12 細胞培養装置及び方法

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US (1) US11629319B2 (https=)
EP (1) EP3472301B1 (https=)
JP (1) JP6967535B2 (https=)
CN (1) CN109804057B (https=)
AU (1) AU2017286096B2 (https=)
BR (1) BR112018075920A2 (https=)
CA (1) CA3027616A1 (https=)
RU (1) RU2741806C2 (https=)
WO (1) WO2017216113A2 (https=)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11760965B2 (en) 2017-10-19 2023-09-19 Georgia Tech Research Corporation Mesofluidic device for culture of cell aggregates
NL2020518B1 (en) 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
CN108486035B (zh) * 2018-03-26 2021-11-26 西北大学 一种三维类器官的液滴培养方法
NL2022085B1 (en) * 2018-11-28 2020-06-25 Mimetas B V Device for assessing mechanical strain induced in or by cells
KR102209346B1 (ko) * 2019-03-13 2021-01-29 재단법인대구경북과학기술원 미세관통막 기반의 수화젤 마이크로웰 어레이 및 이를 이용한 3차원 단일세포 분리 및 배양방법
US12024696B2 (en) * 2019-05-08 2024-07-02 Molecular Devices (Austria) GmbH System and method for organoid culture
US20220238042A1 (en) * 2019-05-10 2022-07-28 Oregon Health & Science University Engineered bone marrow model
JP2022534778A (ja) * 2019-05-28 2022-08-03 シリン・シェン 患者由来ミクロオルガノスフェアのための方法及び装置
KR102233992B1 (ko) * 2019-06-28 2021-03-29 건양대학교 산학협력단 면역화학진단 세포 칩 구조체
WO2021040874A1 (en) * 2019-08-28 2021-03-04 Massachusetts Institute Of Technology In vitro tissue plate
CN110564674B (zh) * 2019-09-29 2021-05-11 广东工业大学 一种干细胞铺底工作液及其应用
EP4047082A4 (en) * 2019-10-17 2023-08-16 Public University Corporation Yokohama City University METHOD OF EVALUATION OF TOXICITY OF DRUG
NL2024202B1 (en) * 2019-11-08 2021-07-20 Mimetas B V Microfluidic cell culture system
US20230029554A1 (en) * 2019-12-12 2023-02-02 The Walter And Eliza Hall Institute Of Medecal Research Organoid cultures
EP3907007A1 (de) 2020-05-08 2021-11-10 Technische Universität Wien Mikrofluidische vorrichtung
US20210394177A1 (en) * 2020-06-19 2021-12-23 The Texas A&M University System Systems and methods for mimicking a blood vessel of a patient
NL2026038B1 (en) * 2020-07-09 2022-03-15 Mimetas B V Microfluidic cell culture device
CN112143642B (zh) * 2020-08-28 2022-06-14 上海交通大学 用于体外培养的血管化肿瘤微流控器官芯片及其制备方法
CA3246410A1 (en) 2020-09-04 2025-10-31 9493662 Canada Inc. Multi-well device, kits and methods for analysis of cells
EP3998332A4 (en) * 2020-09-30 2022-09-28 Beijing Daxiang Biotech Co., Ltd 3D MULTIORGAN COCULTURE CHIP
JP7565008B2 (ja) * 2020-10-07 2024-10-10 ウシオ電機株式会社 マイクロ流体デバイス及びマイクロ流体デバイスの使用方法
CN116601287A (zh) * 2020-10-22 2023-08-15 分子装置(奥地利)有限公司 用于自动化类器官培养的微孔板
CN116457452A (zh) * 2020-10-22 2023-07-18 得克萨斯大学体系董事会 高通量细胞迁移测定板及其制造方法
CN112358966B (zh) * 2020-10-23 2022-03-22 上海交通大学 一种滑动式微流控器官芯片及其制备方法
CN117157147A (zh) * 2020-12-01 2023-12-01 新加坡科技研究局 用于血管化细胞聚集体的装置和方法
CN116981764A (zh) * 2021-02-19 2023-10-31 分子装置(奥地利)有限公司 使用微孔板孔单元进行类器官传代的方法
CA3211177A1 (en) * 2021-03-16 2022-09-22 Andrea PAVES A well insert and a device for 3d cell culture and in vitro tissue model
EP4303297A1 (en) * 2021-04-09 2024-01-10 Cellartgen Inc. Microfluidic hanging drop culture device for culturing cell aggregates
US12480079B2 (en) 2021-04-23 2025-11-25 Massachusetts Institute Of Technology Fluidic platforms for perfusable vascularized tissues with infiltrates
CN113755328A (zh) * 2021-09-08 2021-12-07 中山大学 一种类器官培养装置及类器官培养方法
EP4423234A1 (en) * 2021-10-29 2024-09-04 Universität Bern Microfluidic cell culturing device
USD1028280S1 (en) 2021-12-27 2024-05-21 Molecular Devices (Austria) GmbH Organoid microplate
US12544754B2 (en) 2022-01-18 2026-02-10 Molecular Devices (Austria) GmbH 3D printing of organoid passaging plate
WO2023144747A1 (en) * 2022-01-28 2023-08-03 Glaxosmithkline Intellectual Property Development Limited High-throughput assay for cell migration, chemotaxis, and function
CN114591836A (zh) * 2022-02-18 2022-06-07 清华大学深圳国际研究生院 体外血管床微流控芯片及其应用
WO2023178320A1 (en) * 2022-03-18 2023-09-21 Molecular Devices (Austria) GmbH Cell culture application methods of using a separation well microplate
JP2025509834A (ja) * 2022-03-21 2025-04-11 モレキュラー デバイシーズ (オーストリア) ゲーエムベーハー マイクロプレートで共培養するためのシステムおよび方法
WO2023218024A1 (en) * 2022-05-13 2023-11-16 Ecole Polytechnique Federale De Lausanne (Epfl) System for automated and dynamic cell culture
US20230383225A1 (en) * 2022-05-27 2023-11-30 University Of Utah Research Foundation Lung-on-chip device with integrated extracellular matrix membrane
DE102022209416B3 (de) * 2022-09-09 2023-12-21 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung
WO2024129942A1 (en) * 2022-12-14 2024-06-20 President And Fellows Of Harvard College Organoids in extracellular matrix droplets
DE102023200837A1 (de) * 2023-02-02 2024-08-08 Carl Zeiss Ag Probengefäß zur Kultivierung biologischer Proben, Vorrichtung zu dessen Betrieb und Mikroskop
WO2024182622A1 (en) * 2023-03-01 2024-09-06 Research Institute At Nationwide Children's Hospital Systems, devices, and processes for miniaturized physiological mimicry
NL2034328B1 (en) 2023-03-13 2024-09-24 Mimetas B V Liver vasculature
WO2024191299A1 (en) 2023-03-13 2024-09-19 Mimetas B.V. Liver vasculature
CN117586876B (zh) * 2023-10-07 2024-10-25 丹望医疗科技(上海)有限公司 一种血管化类器官芯片及血管化类器官
WO2025080829A1 (en) * 2023-10-10 2025-04-17 The Trustees Of The University Of Pennsylvania A model of the blood-brain barrier on a chip
WO2025132381A1 (en) * 2023-12-21 2025-06-26 F. Hoffmann-La Roche Ag Cell culturing device
WO2025186340A1 (de) * 2024-03-05 2025-09-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Vorrichtung zum erzeugen von drei-dimensionalen zellstrukturen in einem hydrogel, mikrosystem und/oder mikrofluidische zellkulturplattform und verfahren zum herstellen der vorrichtung
CN118374350A (zh) * 2024-04-15 2024-07-23 丹望医疗科技(上海)有限公司 血管化类器官芯片及其应用
CN118086053B (zh) * 2024-04-29 2024-07-09 四川迪亚生物科技集团有限公司 一种自灌流培养板及使用方法
TR2024007044A1 (tr) * 2024-06-04 2025-12-22 Izmir Yueksek Teknoloji Enstituesue Rektoerluegue 2 ve 3 boyutlu hücre ve doku kültürünleri̇nde kullanilmak üzere üstü açik bi̇r mi̇krofi̇zyoloji̇k si̇stem ve bu si̇stemi̇n çalişma yöntemi̇
GB202409293D0 (en) 2024-06-27 2024-08-14 Momo Biotech Ltd Device

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US7534601B2 (en) * 2002-08-27 2009-05-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
WO2007008609A2 (en) 2005-07-07 2007-01-18 The Regents Of The University Of California Methods and apparatus for cell culture array
US20110129850A1 (en) 2006-12-22 2011-06-02 UCLA Office of Intellectual Property Microfluidic platform for cell culture and assay
JP5343092B2 (ja) 2008-01-29 2013-11-13 カリフォルニア インスティチュート オブ テクノロジー 細胞分離を行う精密濾過の方法及び装置
US20110117634A1 (en) * 2008-04-21 2011-05-19 Asaf Halamish Flat cell carriers with cell traps
WO2009146911A2 (en) 2008-06-04 2009-12-10 Uwe Marx Organ-on-a-chip-device
CN104328050B (zh) * 2008-07-16 2017-12-15 儿童医疗中心有限公司 具有微通道的器官模仿装置及其使用和制造方法
WO2009118015A2 (en) * 2008-08-01 2009-10-01 Smart Biosystems Aps A sample port of a cell culture system
GB0815427D0 (en) * 2008-08-22 2008-10-01 Capsant Neurotechnologies S A Device
DK2342317T3 (da) 2008-09-22 2013-03-18 Univ Zurich Prorektorat Forschung Hængende-dråbe-plade
WO2010062911A2 (en) 2008-11-26 2010-06-03 Hurel Corporation Compositions and methods of functionally enhanced in vitro cell culture system
EP2213364A1 (en) 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
JP2010253572A (ja) 2009-04-21 2010-11-11 Makita Corp 切断機における割り刃の固定具脱落防止構造
GB0910330D0 (en) 2009-06-16 2009-07-29 Univ Leiden A biological microfluidics chip and related methods
US9261496B2 (en) 2010-09-29 2016-02-16 Massachusetts Institute Of Technology Device for high throughput investigations of multi-cellular interactions
KR102117921B1 (ko) 2011-02-28 2020-06-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포 배양 시스템
GB201103917D0 (en) 2011-03-08 2011-04-20 Univ Leiden Apparatus for and methods of processing liquids or liquid based substances
US20140348706A1 (en) * 2011-10-24 2014-11-27 Agency For Science, Technology And Research Microfluidic Device and Microfluidic System
WO2013085909A1 (en) * 2011-12-05 2013-06-13 Research Triangle Institute Human conducting airway model comprising multiple fluidic pathways
WO2013134778A1 (en) * 2012-03-09 2013-09-12 Si-Bone Inc. Impactor
CN106399094A (zh) 2012-04-01 2017-02-15 Emd密理博公司 细胞培养和梯度迁移化验方法和装置
GB2505706A (en) 2012-09-10 2014-03-12 Univ Leiden Apparatus comprising meniscus alignment barriers
WO2014127250A1 (en) * 2013-02-14 2014-08-21 Cfd Research Corporation Cell culture device with an array of microfluidic networks
EP2811012A1 (en) 2013-06-07 2014-12-10 Eidgenossisch Technische Hochschule Zürich Hanging network plate
EP3041926B1 (en) * 2013-09-05 2020-03-04 Universität Bern Device for in-vitro modelling in-vivo tissues of organs
GB2583047B (en) * 2013-12-20 2021-03-24 Harvard College Organomimetic devices and methods of use and manufacturing thereof
EP3218714A4 (en) 2014-11-10 2018-07-04 The Government of the United States of America as represented by the Secretary of the Navy Modular microtube network for vascularized organ-on-a-chip models
WO2016081751A1 (en) 2014-11-19 2016-05-26 Nortis, Inc. Method for vascularizing in-vitro generated or ex-vivo tissue fragments in a microfluidic device
RU2584598C1 (ru) 2015-03-27 2016-05-20 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Микрофлюидный чип для создания клеточных моделей органов млекопитающих
CN104877905A (zh) 2015-05-04 2015-09-02 清华大学深圳研究生院 细胞体外共培养微流控芯片、系统及方法
NL2014840B1 (en) * 2015-05-21 2017-01-31 Intecrypt B V Microfluidic device for in vitro 3D cell culture experimentation.
JP6640998B2 (ja) 2015-06-05 2020-02-05 ミメタス ビー.ブイ. マイクロ流体プレート

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