JP2019517808A5 - - Google Patents
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- JP2019517808A5 JP2019517808A5 JP2018565659A JP2018565659A JP2019517808A5 JP 2019517808 A5 JP2019517808 A5 JP 2019517808A5 JP 2018565659 A JP2018565659 A JP 2018565659A JP 2018565659 A JP2018565659 A JP 2018565659A JP 2019517808 A5 JP2019517808 A5 JP 2019517808A5
- Authority
- JP
- Japan
- Prior art keywords
- microfluidic
- gel
- cell
- microfluidic channel
- capillary pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 25
- 230000004888 barrier function Effects 0.000 claims 12
- 238000004113 cell culture Methods 0.000 claims 11
- 238000000034 method Methods 0.000 claims 8
- 239000010410 layer Substances 0.000 claims 7
- 210000002220 organoid Anatomy 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 210000002889 endothelial cell Anatomy 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 210000004088 microvessel Anatomy 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2016965 | 2016-06-15 | ||
| NL2016965A NL2016965B1 (en) | 2016-06-15 | 2016-06-15 | Cell culture device. |
| NL2018033 | 2016-12-21 | ||
| NL2018033 | 2016-12-21 | ||
| PCT/EP2017/064302 WO2017216113A2 (en) | 2016-06-15 | 2017-06-12 | Cell culture device and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019517808A JP2019517808A (ja) | 2019-06-27 |
| JP2019517808A5 true JP2019517808A5 (https=) | 2020-07-27 |
| JP6967535B2 JP6967535B2 (ja) | 2021-11-17 |
Family
ID=59215734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565659A Active JP6967535B2 (ja) | 2016-06-15 | 2017-06-12 | 細胞培養装置及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11629319B2 (https=) |
| EP (1) | EP3472301B1 (https=) |
| JP (1) | JP6967535B2 (https=) |
| CN (1) | CN109804057B (https=) |
| AU (1) | AU2017286096B2 (https=) |
| BR (1) | BR112018075920A2 (https=) |
| CA (1) | CA3027616A1 (https=) |
| RU (1) | RU2741806C2 (https=) |
| WO (1) | WO2017216113A2 (https=) |
Families Citing this family (53)
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| US11760965B2 (en) | 2017-10-19 | 2023-09-19 | Georgia Tech Research Corporation | Mesofluidic device for culture of cell aggregates |
| NL2020518B1 (en) | 2018-03-02 | 2019-09-12 | Mimetas B V | Device and method for performing electrical measurements |
| CN108486035B (zh) * | 2018-03-26 | 2021-11-26 | 西北大学 | 一种三维类器官的液滴培养方法 |
| NL2022085B1 (en) * | 2018-11-28 | 2020-06-25 | Mimetas B V | Device for assessing mechanical strain induced in or by cells |
| KR102209346B1 (ko) * | 2019-03-13 | 2021-01-29 | 재단법인대구경북과학기술원 | 미세관통막 기반의 수화젤 마이크로웰 어레이 및 이를 이용한 3차원 단일세포 분리 및 배양방법 |
| US12024696B2 (en) * | 2019-05-08 | 2024-07-02 | Molecular Devices (Austria) GmbH | System and method for organoid culture |
| US20220238042A1 (en) * | 2019-05-10 | 2022-07-28 | Oregon Health & Science University | Engineered bone marrow model |
| JP2022534778A (ja) * | 2019-05-28 | 2022-08-03 | シリン・シェン | 患者由来ミクロオルガノスフェアのための方法及び装置 |
| KR102233992B1 (ko) * | 2019-06-28 | 2021-03-29 | 건양대학교 산학협력단 | 면역화학진단 세포 칩 구조체 |
| WO2021040874A1 (en) * | 2019-08-28 | 2021-03-04 | Massachusetts Institute Of Technology | In vitro tissue plate |
| CN110564674B (zh) * | 2019-09-29 | 2021-05-11 | 广东工业大学 | 一种干细胞铺底工作液及其应用 |
| EP4047082A4 (en) * | 2019-10-17 | 2023-08-16 | Public University Corporation Yokohama City University | METHOD OF EVALUATION OF TOXICITY OF DRUG |
| NL2024202B1 (en) * | 2019-11-08 | 2021-07-20 | Mimetas B V | Microfluidic cell culture system |
| US20230029554A1 (en) * | 2019-12-12 | 2023-02-02 | The Walter And Eliza Hall Institute Of Medecal Research | Organoid cultures |
| EP3907007A1 (de) | 2020-05-08 | 2021-11-10 | Technische Universität Wien | Mikrofluidische vorrichtung |
| US20210394177A1 (en) * | 2020-06-19 | 2021-12-23 | The Texas A&M University System | Systems and methods for mimicking a blood vessel of a patient |
| NL2026038B1 (en) * | 2020-07-09 | 2022-03-15 | Mimetas B V | Microfluidic cell culture device |
| CN112143642B (zh) * | 2020-08-28 | 2022-06-14 | 上海交通大学 | 用于体外培养的血管化肿瘤微流控器官芯片及其制备方法 |
| CA3246410A1 (en) | 2020-09-04 | 2025-10-31 | 9493662 Canada Inc. | Multi-well device, kits and methods for analysis of cells |
| EP3998332A4 (en) * | 2020-09-30 | 2022-09-28 | Beijing Daxiang Biotech Co., Ltd | 3D MULTIORGAN COCULTURE CHIP |
| JP7565008B2 (ja) * | 2020-10-07 | 2024-10-10 | ウシオ電機株式会社 | マイクロ流体デバイス及びマイクロ流体デバイスの使用方法 |
| CN116601287A (zh) * | 2020-10-22 | 2023-08-15 | 分子装置(奥地利)有限公司 | 用于自动化类器官培养的微孔板 |
| CN116457452A (zh) * | 2020-10-22 | 2023-07-18 | 得克萨斯大学体系董事会 | 高通量细胞迁移测定板及其制造方法 |
| CN112358966B (zh) * | 2020-10-23 | 2022-03-22 | 上海交通大学 | 一种滑动式微流控器官芯片及其制备方法 |
| CN117157147A (zh) * | 2020-12-01 | 2023-12-01 | 新加坡科技研究局 | 用于血管化细胞聚集体的装置和方法 |
| CN116981764A (zh) * | 2021-02-19 | 2023-10-31 | 分子装置(奥地利)有限公司 | 使用微孔板孔单元进行类器官传代的方法 |
| CA3211177A1 (en) * | 2021-03-16 | 2022-09-22 | Andrea PAVES | A well insert and a device for 3d cell culture and in vitro tissue model |
| EP4303297A1 (en) * | 2021-04-09 | 2024-01-10 | Cellartgen Inc. | Microfluidic hanging drop culture device for culturing cell aggregates |
| US12480079B2 (en) | 2021-04-23 | 2025-11-25 | Massachusetts Institute Of Technology | Fluidic platforms for perfusable vascularized tissues with infiltrates |
| CN113755328A (zh) * | 2021-09-08 | 2021-12-07 | 中山大学 | 一种类器官培养装置及类器官培养方法 |
| EP4423234A1 (en) * | 2021-10-29 | 2024-09-04 | Universität Bern | Microfluidic cell culturing device |
| USD1028280S1 (en) | 2021-12-27 | 2024-05-21 | Molecular Devices (Austria) GmbH | Organoid microplate |
| US12544754B2 (en) | 2022-01-18 | 2026-02-10 | Molecular Devices (Austria) GmbH | 3D printing of organoid passaging plate |
| WO2023144747A1 (en) * | 2022-01-28 | 2023-08-03 | Glaxosmithkline Intellectual Property Development Limited | High-throughput assay for cell migration, chemotaxis, and function |
| CN114591836A (zh) * | 2022-02-18 | 2022-06-07 | 清华大学深圳国际研究生院 | 体外血管床微流控芯片及其应用 |
| WO2023178320A1 (en) * | 2022-03-18 | 2023-09-21 | Molecular Devices (Austria) GmbH | Cell culture application methods of using a separation well microplate |
| JP2025509834A (ja) * | 2022-03-21 | 2025-04-11 | モレキュラー デバイシーズ (オーストリア) ゲーエムベーハー | マイクロプレートで共培養するためのシステムおよび方法 |
| WO2023218024A1 (en) * | 2022-05-13 | 2023-11-16 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for automated and dynamic cell culture |
| US20230383225A1 (en) * | 2022-05-27 | 2023-11-30 | University Of Utah Research Foundation | Lung-on-chip device with integrated extracellular matrix membrane |
| DE102022209416B3 (de) * | 2022-09-09 | 2023-12-21 | Robert Bosch Gesellschaft mit beschränkter Haftung | Mikrofluidische Vorrichtung |
| WO2024129942A1 (en) * | 2022-12-14 | 2024-06-20 | President And Fellows Of Harvard College | Organoids in extracellular matrix droplets |
| DE102023200837A1 (de) * | 2023-02-02 | 2024-08-08 | Carl Zeiss Ag | Probengefäß zur Kultivierung biologischer Proben, Vorrichtung zu dessen Betrieb und Mikroskop |
| WO2024182622A1 (en) * | 2023-03-01 | 2024-09-06 | Research Institute At Nationwide Children's Hospital | Systems, devices, and processes for miniaturized physiological mimicry |
| NL2034328B1 (en) | 2023-03-13 | 2024-09-24 | Mimetas B V | Liver vasculature |
| WO2024191299A1 (en) | 2023-03-13 | 2024-09-19 | Mimetas B.V. | Liver vasculature |
| CN117586876B (zh) * | 2023-10-07 | 2024-10-25 | 丹望医疗科技(上海)有限公司 | 一种血管化类器官芯片及血管化类器官 |
| WO2025080829A1 (en) * | 2023-10-10 | 2025-04-17 | The Trustees Of The University Of Pennsylvania | A model of the blood-brain barrier on a chip |
| WO2025132381A1 (en) * | 2023-12-21 | 2025-06-26 | F. Hoffmann-La Roche Ag | Cell culturing device |
| WO2025186340A1 (de) * | 2024-03-05 | 2025-09-12 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Vorrichtung zum erzeugen von drei-dimensionalen zellstrukturen in einem hydrogel, mikrosystem und/oder mikrofluidische zellkulturplattform und verfahren zum herstellen der vorrichtung |
| CN118374350A (zh) * | 2024-04-15 | 2024-07-23 | 丹望医疗科技(上海)有限公司 | 血管化类器官芯片及其应用 |
| CN118086053B (zh) * | 2024-04-29 | 2024-07-09 | 四川迪亚生物科技集团有限公司 | 一种自灌流培养板及使用方法 |
| TR2024007044A1 (tr) * | 2024-06-04 | 2025-12-22 | Izmir Yueksek Teknoloji Enstituesue Rektoerluegue | 2 ve 3 boyutlu hücre ve doku kültürünleri̇nde kullanilmak üzere üstü açik bi̇r mi̇krofi̇zyoloji̇k si̇stem ve bu si̇stemi̇n çalişma yöntemi̇ |
| GB202409293D0 (en) | 2024-06-27 | 2024-08-14 | Momo Biotech Ltd | Device |
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| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
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| GB0321158D0 (en) * | 2003-09-10 | 2003-10-08 | Central Research Lab Ltd | Apparatus and method for handling cells,embryos or oocytes |
| WO2007008609A2 (en) | 2005-07-07 | 2007-01-18 | The Regents Of The University Of California | Methods and apparatus for cell culture array |
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| JP5343092B2 (ja) | 2008-01-29 | 2013-11-13 | カリフォルニア インスティチュート オブ テクノロジー | 細胞分離を行う精密濾過の方法及び装置 |
| US20110117634A1 (en) * | 2008-04-21 | 2011-05-19 | Asaf Halamish | Flat cell carriers with cell traps |
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| CN104328050B (zh) * | 2008-07-16 | 2017-12-15 | 儿童医疗中心有限公司 | 具有微通道的器官模仿装置及其使用和制造方法 |
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| EP2213364A1 (en) | 2009-01-30 | 2010-08-04 | Albert-Ludwigs-Universität Freiburg | Phase guide patterns for liquid manipulation |
| JP2010253572A (ja) | 2009-04-21 | 2010-11-11 | Makita Corp | 切断機における割り刃の固定具脱落防止構造 |
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| KR102117921B1 (ko) | 2011-02-28 | 2020-06-03 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세포 배양 시스템 |
| GB201103917D0 (en) | 2011-03-08 | 2011-04-20 | Univ Leiden | Apparatus for and methods of processing liquids or liquid based substances |
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| WO2013085909A1 (en) * | 2011-12-05 | 2013-06-13 | Research Triangle Institute | Human conducting airway model comprising multiple fluidic pathways |
| WO2013134778A1 (en) * | 2012-03-09 | 2013-09-12 | Si-Bone Inc. | Impactor |
| CN106399094A (zh) | 2012-04-01 | 2017-02-15 | Emd密理博公司 | 细胞培养和梯度迁移化验方法和装置 |
| GB2505706A (en) | 2012-09-10 | 2014-03-12 | Univ Leiden | Apparatus comprising meniscus alignment barriers |
| WO2014127250A1 (en) * | 2013-02-14 | 2014-08-21 | Cfd Research Corporation | Cell culture device with an array of microfluidic networks |
| EP2811012A1 (en) | 2013-06-07 | 2014-12-10 | Eidgenossisch Technische Hochschule Zürich | Hanging network plate |
| EP3041926B1 (en) * | 2013-09-05 | 2020-03-04 | Universität Bern | Device for in-vitro modelling in-vivo tissues of organs |
| GB2583047B (en) * | 2013-12-20 | 2021-03-24 | Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
| EP3218714A4 (en) | 2014-11-10 | 2018-07-04 | The Government of the United States of America as represented by the Secretary of the Navy | Modular microtube network for vascularized organ-on-a-chip models |
| WO2016081751A1 (en) | 2014-11-19 | 2016-05-26 | Nortis, Inc. | Method for vascularizing in-vitro generated or ex-vivo tissue fragments in a microfluidic device |
| RU2584598C1 (ru) | 2015-03-27 | 2016-05-20 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Микрофлюидный чип для создания клеточных моделей органов млекопитающих |
| CN104877905A (zh) | 2015-05-04 | 2015-09-02 | 清华大学深圳研究生院 | 细胞体外共培养微流控芯片、系统及方法 |
| NL2014840B1 (en) * | 2015-05-21 | 2017-01-31 | Intecrypt B V | Microfluidic device for in vitro 3D cell culture experimentation. |
| JP6640998B2 (ja) | 2015-06-05 | 2020-02-05 | ミメタス ビー.ブイ. | マイクロ流体プレート |
-
2017
- 2017-06-12 JP JP2018565659A patent/JP6967535B2/ja active Active
- 2017-06-12 EP EP17732821.8A patent/EP3472301B1/en active Active
- 2017-06-12 RU RU2019100603A patent/RU2741806C2/ru active
- 2017-06-12 AU AU2017286096A patent/AU2017286096B2/en active Active
- 2017-06-12 CN CN201780045603.5A patent/CN109804057B/zh active Active
- 2017-06-12 US US16/309,298 patent/US11629319B2/en active Active
- 2017-06-12 CA CA3027616A patent/CA3027616A1/en active Pending
- 2017-06-12 BR BR112018075920-1A patent/BR112018075920A2/pt not_active Application Discontinuation
- 2017-06-12 WO PCT/EP2017/064302 patent/WO2017216113A2/en not_active Ceased
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