JP2019517544A5 - - Google Patents
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- JP2019517544A5 JP2019517544A5 JP2018564211A JP2018564211A JP2019517544A5 JP 2019517544 A5 JP2019517544 A5 JP 2019517544A5 JP 2018564211 A JP2018564211 A JP 2018564211A JP 2018564211 A JP2018564211 A JP 2018564211A JP 2019517544 A5 JP2019517544 A5 JP 2019517544A5
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- 150000001413 amino acids Chemical class 0.000 claims description 71
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- 101000793651 Homo sapiens Calreticulin Proteins 0.000 claims description 38
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
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| PCT/DK2017/050190 WO2017211371A2 (en) | 2016-06-10 | 2017-06-09 | Calr and jak2 vaccine compositions |
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| JP2019517544A JP2019517544A (ja) | 2019-06-24 |
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| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| KR20220115569A (ko) * | 2019-11-18 | 2022-08-17 | 얀센 바이오테크 인코포레이티드 | 돌연변이 calr 및 jak2에 기반한 백신 및 이의 용도 |
| CN111087448A (zh) * | 2019-12-23 | 2020-05-01 | 维塔恩(广州)医药有限公司 | 肿瘤相关基因jak2突变相关抗原短肽及其应用 |
| US20230139506A1 (en) * | 2020-03-17 | 2023-05-04 | Memorial Sloan Kettering Cancer Center | Heteroclitic cancer vaccines |
| WO2021211715A1 (en) | 2020-04-15 | 2021-10-21 | 3M Innovative Properties Company | Compostable compositions, articles and methods of making compostable articles |
| WO2021231798A1 (en) | 2020-05-13 | 2021-11-18 | Disc Medicine, Inc. | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| CN112168829B (zh) * | 2020-09-24 | 2022-02-15 | 华南理工大学 | 抗病毒药物在制备治疗骨髓增生异常综合征药物中的应用及制得的骨髓增生异常综合征药物 |
| EP4320144A4 (en) * | 2021-04-05 | 2025-04-09 | Janssen Biotech, Inc. | T CELL RECEPTORS CALR AND JAK2 |
| US20230285548A1 (en) * | 2021-12-16 | 2023-09-14 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
| US20250352627A1 (en) * | 2022-06-17 | 2025-11-20 | Ichan School Of Medicine At Mount Sinai | Mutant calr-peptide based vaccine |
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| US58767A (en) | 1866-10-16 | John brougjbton | ||
| US5554372A (en) | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| JPH11507513A (ja) * | 1995-06-05 | 1999-07-06 | インサイト・ファーマスーティカルズ・インコーポレイテッド | Ｃ５ａ様７膜貫通受容体 |
| US6096313A (en) | 1996-02-09 | 2000-08-01 | Ludwig Institute For Cancer Research | Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant |
| FR2877013A1 (fr) * | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
| WO2007047653A2 (en) * | 2005-10-17 | 2007-04-26 | Sloan-Kettering Institute For Cancer Research | Synthetic hla binding peptide analogues of mutant v617f jak2 enzyme and uses therefor |
| ES2657963T3 (es) | 2008-04-17 | 2018-03-07 | Io Biotech Aps | Inmunoterapia basada en indolamina 2,3-dioxigenasa |
| HUE059406T2 (hu) | 2011-10-17 | 2022-11-28 | Io Biotech Aps | PD-L1 alapú immunterápia |
| US9567641B2 (en) * | 2013-07-03 | 2017-02-14 | Samsung Electronics Co., Ltd. | Combination therapy for the treatment of cancer using an anti-C-met antibody |
| PT2808338E (pt) * | 2013-09-16 | 2016-06-15 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Calreticulina mutante para o diagnóstico de malignidades mieloides |
| US20170269092A1 (en) * | 2014-12-02 | 2017-09-21 | Cemm - Forschungszentrum Fuer Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
| CN104561287A (zh) * | 2014-12-26 | 2015-04-29 | 南京艾迪康医学检验所有限公司 | 检测calr基因第9外显子突变的试剂和方法 |
| CN105441562A (zh) * | 2015-12-31 | 2016-03-30 | 德赛诊断系统(上海)有限公司 | Carl基因缺失、插入突变的检测方法及试剂盒 |
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- 2017-06-09 EP EP17735379.4A patent/EP3468585A2/en not_active Withdrawn
- 2017-06-09 WO PCT/DK2017/050190 patent/WO2017211371A2/en not_active Ceased
- 2017-06-09 CN CN201780048646.9A patent/CN109803674A/zh active Pending
- 2017-06-09 CA CA3026572A patent/CA3026572A1/en not_active Abandoned
- 2017-06-09 JP JP2018564211A patent/JP2019517544A/ja not_active Withdrawn
- 2017-06-09 US US16/308,164 patent/US20190328857A1/en not_active Abandoned
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2018
- 2018-12-09 IL IL263574A patent/IL263574A/en unknown
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