JP2019517464A5 - - Google Patents
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- JP2019517464A5 JP2019517464A5 JP2018560068A JP2018560068A JP2019517464A5 JP 2019517464 A5 JP2019517464 A5 JP 2019517464A5 JP 2018560068 A JP2018560068 A JP 2018560068A JP 2018560068 A JP2018560068 A JP 2018560068A JP 2019517464 A5 JP2019517464 A5 JP 2019517464A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- solvates
- acceptable salts
- selection
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 102000003827 Plasma Kallikrein Human genes 0.000 claims 5
- 108090000113 Plasma Kallikrein Proteins 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 3
- 201000011190 diabetic macular edema Diseases 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
- 206010019860 Hereditary angioedema Diseases 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000001399 Kallikrein Human genes 0.000 claims 1
- 108060005987 Kallikrein Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010051077 Post procedural haemorrhage Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010047571 Visual impairment Diseases 0.000 claims 1
- 239000005862 Whey Substances 0.000 claims 1
- 102000007544 Whey Proteins Human genes 0.000 claims 1
- 108010046377 Whey Proteins Proteins 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000008728 vascular permeability Effects 0.000 claims 1
- 208000029257 vision disease Diseases 0.000 claims 1
- 230000004393 visual impairment Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021080175A JP7109012B2 (ja) | 2016-05-31 | 2021-05-11 | 血漿カリクレインインヒビターとしてのピラゾール誘導体 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343363P | 2016-05-31 | 2016-05-31 | |
| US62/343,363 | 2016-05-31 | ||
| GB1609517.6 | 2016-05-31 | ||
| GBGB1609517.6A GB201609517D0 (en) | 2016-05-31 | 2016-05-31 | Enzyme inhibitors |
| US201762456219P | 2017-02-08 | 2017-02-08 | |
| GBGB1702044.7A GB201702044D0 (en) | 2017-02-08 | 2017-02-08 | Enzyme inhibitors |
| GB1702044.7 | 2017-02-08 | ||
| US62/456,219 | 2017-02-08 | ||
| PCT/GB2017/051546 WO2017207983A1 (en) | 2016-05-31 | 2017-05-31 | Pyrazole derivatives as plasma kallikrein inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021080175A Division JP7109012B2 (ja) | 2016-05-31 | 2021-05-11 | 血漿カリクレインインヒビターとしてのピラゾール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019517464A JP2019517464A (ja) | 2019-06-24 |
| JP2019517464A5 true JP2019517464A5 (https=) | 2020-07-09 |
| JP6884801B2 JP6884801B2 (ja) | 2021-06-09 |
Family
ID=60478506
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560068A Expired - Fee Related JP6884801B2 (ja) | 2016-05-31 | 2017-05-31 | 血漿カリクレインインヒビターとしてのピラゾール誘導体 |
| JP2021080175A Expired - Fee Related JP7109012B2 (ja) | 2016-05-31 | 2021-05-11 | 血漿カリクレインインヒビターとしてのピラゾール誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021080175A Expired - Fee Related JP7109012B2 (ja) | 2016-05-31 | 2021-05-11 | 血漿カリクレインインヒビターとしてのピラゾール誘導体 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US11180484B2 (https=) |
| EP (2) | EP3464271B1 (https=) |
| JP (2) | JP6884801B2 (https=) |
| KR (2) | KR20220107319A (https=) |
| CN (2) | CN109311847B (https=) |
| AU (2) | AU2017275820B2 (https=) |
| BR (1) | BR112018074395A2 (https=) |
| CA (1) | CA3025718A1 (https=) |
| CL (1) | CL2018003213A1 (https=) |
| CO (1) | CO2018012894A2 (https=) |
| CY (1) | CY1123223T1 (https=) |
| DK (1) | DK3464271T3 (https=) |
| EC (1) | ECSP18094983A (https=) |
| ES (1) | ES2805027T3 (https=) |
| HR (1) | HRP20201131T1 (https=) |
| HU (1) | HUE049918T2 (https=) |
| IL (2) | IL263235B (https=) |
| LT (1) | LT3464271T (https=) |
| MD (1) | MD3464271T2 (https=) |
| ME (1) | ME03794B (https=) |
| MX (2) | MX384624B (https=) |
| PH (2) | PH12018502355A1 (https=) |
| PL (1) | PL3464271T3 (https=) |
| PT (1) | PT3464271T (https=) |
| RS (1) | RS60600B1 (https=) |
| RU (2) | RU2739447C2 (https=) |
| SG (2) | SG10201913616UA (https=) |
| SI (1) | SI3464271T1 (https=) |
| SM (1) | SMT202000382T1 (https=) |
| UA (1) | UA123735C2 (https=) |
| WO (1) | WO2017207983A1 (https=) |
| ZA (1) | ZA201808639B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| IL263235B (en) | 2016-05-31 | 2022-07-01 | Kalvista Pharmaceuticals Ltd | History of pyrazoles as plasma kallikrein inhibitors |
| GB201609603D0 (en) * | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201719881D0 (en) * | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| WO2019106359A1 (en) * | 2017-11-29 | 2019-06-06 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
| GB201719882D0 (en) * | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of a plasma kallikrein inhibitor and salts thereof |
| HUE057912T2 (hu) | 2017-11-29 | 2022-06-28 | Kalvista Pharmaceuticals Ltd | Plazma kallikrein inhibitort tartalmazó dózisformák |
| KR20200143376A (ko) | 2018-03-13 | 2020-12-23 | 샤이어 휴먼 지네틱 테라피즈 인크. | 혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도 |
| CN112839711A (zh) | 2018-10-10 | 2021-05-25 | 勃林格殷格翰国际有限公司 | 作为血浆激肽释放酶抑制剂的苯基四唑衍生物 |
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| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| CN114667289B (zh) | 2019-09-18 | 2025-08-26 | 武田药品工业有限公司 | 杂芳基血浆激肽释放酶抑制剂 |
| EP4031547B1 (en) | 2019-09-18 | 2024-07-17 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof |
| TWI873290B (zh) | 2020-02-13 | 2025-02-21 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| TW202144331A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| JP7245397B2 (ja) * | 2020-03-04 | 2023-03-23 | メッドシャイン ディスカバリー インコーポレイテッド | 複素環化合物 |
| JP7776453B2 (ja) * | 2020-06-16 | 2025-11-26 | メルク・シャープ・アンド・ドーム・エルエルシー | 血漿カリクレイン阻害剤 |
| US20230416227A1 (en) * | 2020-09-10 | 2023-12-28 | Merck Sharp & Dohme Llc | Plasma kallikrein inhibitors |
| TW202228686A (zh) | 2020-10-15 | 2022-08-01 | 英商卡爾維斯塔製藥有限公司 | 血管性水腫之治療 |
| JP2024505596A (ja) | 2021-02-09 | 2024-02-06 | カルビスタ・ファーマシューティカルズ・リミテッド | 遺伝性血管性浮腫の治療 |
| US20240382482A1 (en) | 2021-03-17 | 2024-11-21 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors |
| WO2023002219A1 (en) | 2021-07-23 | 2023-01-26 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
| CN116003386B (zh) * | 2022-11-20 | 2024-03-26 | 药康众拓(北京)医药科技有限公司 | 一种氘代n-苄基吡啶酮吡唑甲酰胺类化合物、药物组合物和用途 |
| WO2025001956A1 (zh) | 2023-06-30 | 2025-01-02 | 远森制药（杭州）有限公司 | 杂芳族甲酰胺类化合物及其在医药上的应用 |
| WO2025153806A1 (en) | 2024-01-15 | 2025-07-24 | Kalvista Pharmaceuticals Limited | Methods for determining amidolytic activity |
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