ME00591B - Upotreba dii4 antagonista kod ishemijske povrede ili vaskularne insuficijencije - Google Patents

Upotreba dii4 antagonista kod ishemijske povrede ili vaskularne insuficijencije

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Publication number
ME00591B
ME00591B MEP-2009-31A MEP3109A ME00591B ME 00591 B ME00591 B ME 00591B ME P3109 A MEP3109 A ME P3109A ME 00591 B ME00591 B ME 00591B
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ME
Montenegro
Prior art keywords
ischemic
antibody
retinopathy
dii4
antibody fragment
Prior art date
Application number
MEP-2009-31A
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English (en)
French (fr)
Inventor
Stanley J Wiegand
Nicholas J Papadopoulos
Ivan B Lobov
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Regeneron Pharma
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Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of ME00591B publication Critical patent/ME00591B/me
Publication of ME00591A publication Critical patent/ME00591A/xx

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1891Angiogenesic factors; Angiogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12Antihypertensives
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Chemical Kinetics & Catalysis (AREA)
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Abstract

Terapijs k i postupak za lečenje i shemijskih ili vaskularnih   poremećaja primenjivanjem   sredstva    koje    može    inhibisati    aktivnost    humanog    delta-sličnog liganda   4   (0114) subjektu   kome   je   to   neophodn o .    Poželjn o ,   sredstvo   je   an t i - 0114 antitelo ili fragment   antitela koji mogu inhibisati vezivanje   0114 za Notch recepto r . U jednom  ostvarenj u ,   ishemijski   ili vaskularni   poremećaj j e : ishemijska   povred a , cerebralna   ishemij a ,   srčana   ishemij a ,   ishemijska   stanja koja se javljaju   u udovima   i drugim   organima   ili  tkivim a ,   arteriovenske   malformacij e ,   zarastanje   ran a , transplantacija  organa ili tkiv a , insuficijencija placent e , arterijalno sužavanje i okluzij a , ateroskleroza   i sistemska   ili plućna hipertenzij a . U drugom ostvarenj u ,   lečena bolest je   bolest   oka   ili   stanje   kao   što   j e :   retinopatija   kod   preranog   rođenj a ,   ishemijska retinopatij a ,    okluzija    vene    ili   arterije    mrežnjač e ,    retinopatija    posledica    dijabet a , horoidna neovaskula r i zacij a , makularna degeneracija   povezana sa starenje m , neovaskulariza c i j a rož n j ač e , neovaskularni   glaukom i transplantacija   rožnjače .

Claims (7)

1.Upotreba sredstva koje može da inhibira DII4 aktivnost za proizvodnju leka za lečenje, inhibiranje ili poboljšavanje ishemijskog ili vaskularnog poremećaja, u kojoj DII4 antagonist sadrži antitelo ili fragment antitela koji mogu blokirati vezivanje DII4 za Notch receptor ili sadrži fragment DII4, opciono povezan za multimerizujuću komponentu.
2.Upotreba, kao u patentnom zahtevu 1, u kojoj je DII4 antitelo ili fragment antitela poliklonsko ili monoklonsko.
3.Upotreba, kao u patentnom zahtevu 2, u kojoj je antitelo ili fragment antitela humanizovan, himerični ili potpuno humano antitelo ili fragment antitela.
4.Upotreba, kao u ma kom od patentnih zahteva 1 do 3, gde je ishemijski ili vaskularni poremećaj bolest oka ili stanje koje se opisuje prisustvom abnormalnih krvnih sudova i/ili gubitkom normalnih krvnih sudova ili sudovne funkcije.
5.Upotreba, kao u patentnom zahtevu 4, gde je bolest oka: retinopatija preranog rođenja, ishemijska retinopatija, venska ili arterijska okluzija u mrežnjači, retinopatija kao posledica dijabeta, horoidna neovaskularizacija, makularna degeneracija povezana sa starenjem, neovaskularizacija rožnjače, neovaskularni glaukom ili transplantacija rožnjače.
6.Upotreba, kao u ma kom od patentnih zahteva 1 do 5, pri kojoj je subjekt koji se leči ljudsko biće.
7.Upotreba, kao u ma kom od patentnih zahteva 1 do 3, gde je ishemijski ili vaskularni poremećaj: ishemijska povreda, cerebralna ishemija, ishemija srca, ishemijska stanja koja pogađaju udove i druge organe ili tkiva, arteriovenske malformacije, zarastanje rana, transplantacija organa ili tkiva, insuficijencija placente, arterialno sužavanje ili okluzija, ateroskleroza i sistemska ili plućna hipertenzija.
MEP-31/09A 2006-08-07 2007-08-07 Use of dii4 antagonists in ishemic injury or vascular insufficiency ME00591A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83600306P 2006-08-07 2006-08-07
PCT/US2007/017546 WO2008019144A2 (en) 2006-08-07 2007-08-07 Threapeutic methods for treating vascular eye disorders with dll4 antagonists

Publications (2)

Publication Number Publication Date
ME00591B true ME00591B (me) 2011-12-20
ME00591A ME00591A (en) 2011-12-20

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MEP-31/09A ME00591A (en) 2006-08-07 2007-08-07 Use of dii4 antagonists in ishemic injury or vascular insufficiency

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US (1) US20080181893A1 (me)
EP (1) EP2054082B1 (me)
JP (1) JP5529536B2 (me)
KR (1) KR101497355B1 (me)
CN (1) CN101500605B (me)
AU (1) AU2007281916B2 (me)
BR (1) BRPI0716424B8 (me)
CA (1) CA2660235C (me)
CO (1) CO6150190A2 (me)
CR (1) CR10627A (me)
DK (1) DK2054082T3 (me)
ES (1) ES2398253T3 (me)
GT (1) GT200900029A (me)
HR (1) HRP20130271T1 (me)
IL (1) IL196612A (me)
MA (1) MA30667B1 (me)
ME (1) ME00591A (me)
MX (1) MX2009000674A (me)
MY (1) MY150092A (me)
NO (1) NO341857B1 (me)
NZ (1) NZ574794A (me)
PL (1) PL2054082T3 (me)
PT (1) PT2054082E (me)
RS (1) RS52685B (me)
RU (1) RU2429876C2 (me)
SG (1) SG174033A1 (me)
SI (1) SI2054082T1 (me)
SV (1) SV2009003161A (me)
TN (1) TN2009000036A1 (me)
UA (1) UA95304C2 (me)
WO (1) WO2008019144A2 (me)
ZA (1) ZA200900337B (me)

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GT200900029A (es) 2009-11-17
WO2008019144A3 (en) 2008-03-27
RS52685B (sr) 2013-08-30
CN101500605B (zh) 2014-04-30
CN101500605A (zh) 2009-08-05
TN2009000036A1 (en) 2010-08-19
BRPI0716424B1 (pt) 2018-06-26
SV2009003161A (es) 2010-02-01
RU2429876C2 (ru) 2011-09-27
NO341857B1 (no) 2018-02-12
EP2054082A2 (en) 2009-05-06
US20080181893A1 (en) 2008-07-31
MY150092A (en) 2013-11-29
ES2398253T3 (es) 2013-03-14
IL196612A0 (en) 2011-08-01
CA2660235C (en) 2015-09-22
SG174033A1 (en) 2011-09-29
MA30667B1 (fr) 2009-08-03
CO6150190A2 (es) 2010-04-20
RU2009107921A (ru) 2010-09-20
NO20090984L (no) 2009-03-04
PT2054082E (pt) 2013-03-07
DK2054082T3 (da) 2013-01-21
BRPI0716424A2 (pt) 2014-05-20
NZ574794A (en) 2011-06-30
KR20090039823A (ko) 2009-04-22
JP5529536B2 (ja) 2014-06-25
BRPI0716424B8 (pt) 2021-05-25
ZA200900337B (en) 2009-12-30
ME00591A (en) 2011-12-20
JP2010500355A (ja) 2010-01-07
CA2660235A1 (en) 2008-02-14
HK1137339A1 (en) 2010-07-30
MX2009000674A (es) 2009-02-04
SI2054082T1 (sl) 2013-04-30
AU2007281916A1 (en) 2008-02-14
UA95304C2 (ru) 2011-07-25
WO2008019144A2 (en) 2008-02-14
AU2007281916B2 (en) 2012-06-28
EP2054082B1 (en) 2012-12-26
PL2054082T3 (pl) 2013-05-31
CR10627A (es) 2009-04-14
IL196612A (en) 2012-02-29
HRP20130271T1 (hr) 2013-04-30
KR101497355B1 (ko) 2015-03-02

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