JP2019516757A5 - - Google Patents

Download PDF

Info

Publication number
JP2019516757A5
JP2019516757A5 JP2018561543A JP2018561543A JP2019516757A5 JP 2019516757 A5 JP2019516757 A5 JP 2019516757A5 JP 2018561543 A JP2018561543 A JP 2018561543A JP 2018561543 A JP2018561543 A JP 2018561543A JP 2019516757 A5 JP2019516757 A5 JP 2019516757A5
Authority
JP
Japan
Prior art keywords
compound
alkyl
membered
oxo
arbitrary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018561543A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019516757A (ja
JP7160688B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/034320 external-priority patent/WO2017205536A2/en
Publication of JP2019516757A publication Critical patent/JP2019516757A/ja
Publication of JP2019516757A5 publication Critical patent/JP2019516757A5/ja
Priority to JP2022164864A priority Critical patent/JP2023002643A/ja
Application granted granted Critical
Publication of JP7160688B2 publication Critical patent/JP7160688B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018561543A 2016-05-24 2017-05-24 Cbp/ep300の複素環式インヒビターおよびがんの処置におけるそれらの使用 Active JP7160688B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022164864A JP2023002643A (ja) 2016-05-24 2022-10-13 Cbp/ep300の複素環式インヒビターおよびがんの処置におけるそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/083124 2016-05-24
CN2016083124 2016-05-24
PCT/US2017/034320 WO2017205536A2 (en) 2016-05-24 2017-05-24 Therapeutic compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022164864A Division JP2023002643A (ja) 2016-05-24 2022-10-13 Cbp/ep300の複素環式インヒビターおよびがんの処置におけるそれらの使用

Publications (3)

Publication Number Publication Date
JP2019516757A JP2019516757A (ja) 2019-06-20
JP2019516757A5 true JP2019516757A5 (cg-RX-API-DMAC7.html) 2020-07-09
JP7160688B2 JP7160688B2 (ja) 2022-10-25

Family

ID=59014798

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018561543A Active JP7160688B2 (ja) 2016-05-24 2017-05-24 Cbp/ep300の複素環式インヒビターおよびがんの処置におけるそれらの使用
JP2022164864A Pending JP2023002643A (ja) 2016-05-24 2022-10-13 Cbp/ep300の複素環式インヒビターおよびがんの処置におけるそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022164864A Pending JP2023002643A (ja) 2016-05-24 2022-10-13 Cbp/ep300の複素環式インヒビターおよびがんの処置におけるそれらの使用

Country Status (6)

Country Link
US (2) US10696655B2 (cg-RX-API-DMAC7.html)
EP (2) EP4067347B1 (cg-RX-API-DMAC7.html)
JP (2) JP7160688B2 (cg-RX-API-DMAC7.html)
CN (2) CN115028617A (cg-RX-API-DMAC7.html)
MA (1) MA45122A (cg-RX-API-DMAC7.html)
WO (1) WO2017205536A2 (cg-RX-API-DMAC7.html)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3021645A1 (en) 2016-04-29 2017-11-02 Icahn School Of Medicine At Mount Sinai Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
CN115028617A (zh) 2016-05-24 2022-09-09 基因泰克公司 Cbp/ep300的杂环抑制剂及其在治疗癌症中的用途
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
KR102563325B1 (ko) * 2017-06-30 2023-08-03 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 Rho-관련 단백질 키나아제 억제제, Rho-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도
AU2018294054B2 (en) * 2017-06-30 2022-05-26 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
KR102469161B1 (ko) 2017-06-30 2022-11-23 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 Rho-관련 단백질 키나아제 억제제, Rho-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도
CA3075880A1 (en) 2017-09-15 2019-03-21 Forma Therapeutics, Inc. Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors
WO2019161157A1 (en) * 2018-02-16 2019-08-22 Constellation Pharmceuticals, Inc. P300/cbp hat inhibitors
SMT202400371T1 (it) * 2018-02-16 2024-11-15 Constellation Pharmaceuticals Inc Inibitori di hat p300/cbp
WO2019191667A1 (en) 2018-03-29 2019-10-03 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
WO2019195846A1 (en) 2018-04-06 2019-10-10 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
EP3782995B1 (en) * 2018-04-20 2023-11-22 Shanghai Institute of Materia Medica, Chinese Academy of Sciences Spiro condensed imidazoline-2,4-dione derivatives as histone acetyltransferase inhibitors for the treatment of cancer diseases
WO2019220412A2 (en) * 2018-05-18 2019-11-21 Janssen Biotech, Inc. Safe and effective method of treating lupus with anti-il12/il23 antibody
MX2023013508A (es) 2018-06-29 2023-12-13 Forma Therapeutics Inc Inhibicion de la proteina de union a creb (cbp).
IL280539B2 (en) 2018-08-02 2024-08-01 Univ Boston Late sv40 factor (lsf) inhibitors
CN109336836A (zh) * 2018-11-23 2019-02-15 厦门大学 Carm1小分子抑制剂的化合物及用途
WO2020173440A1 (en) * 2019-02-27 2020-09-03 Cullgen (Shanghai), Inc. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use
ES2989353T3 (es) * 2019-02-27 2024-11-26 Constellation Pharmaceuticals Inc Derivados de N-(piridinil)acetamida como inhibidores de HAT P300/CBP y métodos para su uso
EP3937940A4 (en) 2019-03-15 2022-12-21 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (creb)
CN111763180B (zh) * 2019-04-02 2023-06-09 中国医学科学院药物研究所 苯并氮杂环类化合物及其制法和药物用途
TW202120095A (zh) * 2019-08-05 2021-06-01 美商美國禮來大藥廠 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物
AU2020356575A1 (en) 2019-09-27 2022-04-14 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
CN112574189B (zh) 2019-09-27 2024-05-31 海创药业股份有限公司 一种ep300/cbp抑制剂
US11242353B2 (en) 2020-01-24 2022-02-08 Trustees Of Boston University Heterocyclic LSF inhibitors and their uses
JP7462071B2 (ja) * 2020-04-25 2024-04-04 南京薬石科技股▲フン▼有限公司 Cbp/ep300阻害剤及びその使用
EP4149548A4 (en) 2020-05-13 2024-05-08 Disc Medicine, Inc. ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
US11458132B2 (en) 2020-09-01 2022-10-04 Trustees Of Boston University Quinolin-2(1H)-one inhibitors of Late SV40 Factor
EP4210683A4 (en) * 2020-09-09 2024-10-09 Aurigene Oncology Limited Heterocyclic compounds as cbp/ep300 bromodomain inhibitors
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers
EP4221708A4 (en) * 2020-10-02 2024-11-06 Board of Regents, The University of Texas System IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION-ACTIVATING PROTEINS
CN117355298A (zh) * 2021-03-19 2024-01-05 生物治疗探索股份有限公司 用于调节训练免疫的化合物及其使用方法
CN113087683B (zh) * 2021-03-22 2022-04-22 华南理工大学 氮取代苯并噻唑啉酮类xor/urat1双重抑制剂及其制备方法与应用
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤
CN117843618A (zh) * 2022-08-29 2024-04-09 北京沐华生物科技有限责任公司 一种ep300/cbp调节剂及其制备方法和用途
AR133698A1 (es) * 2023-08-30 2025-10-22 Oncopia Therapeutics Inc D/B/A Sk Life Science Labs COMPUESTOS Y COMPOSICIONES COMO AGENTES DEGRADANTES DE CBP / p300 Y USOS DE ESTOS
WO2025111184A1 (en) 2023-11-21 2025-05-30 Fmc Corporation Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943A (en) 1847-01-26 Harness-buckle
US533A (en) 1837-12-26 Truss for hermta
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
WO1991003489A1 (en) 1989-09-08 1991-03-21 The Johns Hopkins University Structural alterations of the egf receptor gene in human gliomas
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
ATE207366T1 (de) 1993-12-24 2001-11-15 Merck Patent Gmbh Immunokonjugate
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5679683A (en) 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DE69507956T2 (de) 1994-07-21 1999-09-09 Akzo Nobel N.V. Zyklische keton peroxyde zubereitungen
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
WO1996030347A1 (en) 1995-03-30 1996-10-03 Pfizer Inc. Quinazoline derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
CA2222231A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
DE69619114T2 (de) 1995-07-06 2002-10-02 Novartis Ag, Basel Pyrolopyrimidine und verfahren zu ihrer herstellung
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
ATE213730T1 (de) 1996-04-12 2002-03-15 Warner Lambert Co Umkehrbare inhibitoren von tyrosin kinasen
PT912559E (pt) 1996-07-13 2003-03-31 Glaxo Group Ltd Compostos heterociclicos fundidos como inibidores de proteina tirosina quinase
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
PT980244E (pt) 1997-05-06 2003-10-31 Wyeth Corp Utilizacao de compostos de quinazolina para o tratamento da doenca policistica renal
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
CN1278176A (zh) 1997-11-06 2000-12-27 美国氰胺公司 喹唑啉衍生物作为用于治疗结肠息肉的酪氨酸激酶抑制剂的应用
AU763626B2 (en) 1998-11-19 2003-07-31 Warner-Lambert Company N-(4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl- propoxy)-quinazolin-6-yl)-acrylamide, an irreversible inhibitor of tyrosine kinases
EP1896582A4 (en) 2005-05-09 2009-04-08 Ono Pharmaceutical Co HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
AU2007309708A1 (en) * 2006-03-13 2008-05-02 Merck Sharp & Dohme Corp. Somatostatin agonists
US7989472B2 (en) * 2006-03-23 2011-08-02 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
CA2651072A1 (en) * 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
GB0620059D0 (en) * 2006-10-10 2006-11-22 Ucb Sa Therapeutic agents
WO2009053694A1 (en) * 2007-10-24 2009-04-30 Cancer Research Technology Limited Therapeutic oxy-phenyl-aryl compounds and their use
WO2009071890A1 (en) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Tricyclic kinase inhibitors
WO2009071895A1 (en) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Fused thiazole and thiophene derivatives as kinase inhibitors
GB0723747D0 (en) * 2007-12-04 2008-12-31 Ucb Pharma Sa Therapeutic agents
BRPI0907718A2 (pt) 2008-02-11 2017-06-13 Curetech Ltd método para tratar um tumor, método para melhorar a tolerabilidade a pelo menos um agente quimiterápico, método para aumentar a sobrevida de um indivíduo que tem um tumor, método para reduzir ou prevenir recidiva tumoral, uso de um anticorpo monoclonal humanizado ou seu fragmento e anticorpo monoclonal humanizado ou seu fragmento
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
EP2328919A2 (en) 2008-08-25 2011-06-08 Amplimmune, Inc. Pd-i antagonists and methods for treating infectious disease
TW202442680A (zh) 2008-12-09 2024-11-01 美商建南德克公司 抗pd-l1抗體及其於增進t細胞功能之用途
US8436008B2 (en) * 2008-12-22 2013-05-07 Incyte Corporation Substituted heterocyclic compounds
EP2241557A1 (de) * 2009-04-02 2010-10-20 Æterna Zentaris GmbH Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen
WO2010118208A1 (en) * 2009-04-09 2010-10-14 Exelixis, Inc. Benzoxazepin-4- (5h) -yl derivatives and their use to treat cancer
WO2010138487A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE
WO2010138490A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. Benzoxazepines as inhibitors of mtor and methods of their use and manufacture
GB0919431D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919434D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
AR079814A1 (es) * 2009-12-31 2012-02-22 Otsuka Pharma Co Ltd Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos
WO2012058671A1 (en) * 2010-10-31 2012-05-03 Endo Pharmaceuticals Inc. Substituted quinazoline and pyrido-pyrimidine derivatives
PH12013501489A1 (en) * 2010-12-17 2013-08-28 Hoffmann La Roche Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof
DK2678329T3 (da) * 2011-02-25 2016-02-22 Array Biopharma Inc Triazolopyridinforbindelser som pim-kinase-hæmmere
JP6121658B2 (ja) * 2011-06-29 2017-04-26 大塚製薬株式会社 治療用化合物、及び関連する使用の方法
TWI549944B (zh) * 2011-07-01 2016-09-21 吉李德科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
US9145411B2 (en) * 2012-08-02 2015-09-29 Asana Biosciences, Llc Substituted amino-pyrimidine derivatives
RU2543485C2 (ru) * 2013-02-26 2015-03-10 Андрей Александрович Иващенко Гетероциклические агонисты рецепторов желчных кислот tgr5, фармацевтическая композиция, способы их получения и применения
EP2970127B1 (en) * 2013-03-14 2018-10-24 Glaxosmithkline Intellectual Property (No. 2) Limited 2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
JP2017529358A (ja) * 2014-09-19 2017-10-05 ジェネンテック, インコーポレイテッド がんの処置のためのcbp/ep300阻害剤およびbet阻害剤の使用
WO2016055028A1 (en) * 2014-10-10 2016-04-14 Genentech, Inc. Therapeutic compounds and uses thereof
JP6771464B2 (ja) * 2014-11-27 2020-10-21 ジェネンテック, インコーポレイテッド Cbpおよび/またはep300インヒビターとしての、4,5,6,7−テトラヒドロ−1h−ピラゾロ[4,3−c]ピリジン−3−アミン化合物
HK1255074A1 (zh) * 2015-07-01 2019-08-02 Crinetics Pharmaceuticals, Inc. 生长抑素调节剂及其用途
CN105039258B (zh) * 2015-07-03 2018-04-17 北京大学 将非神经元细胞重编程为神经元样细胞的方法和组合物
AR108325A1 (es) * 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108326A1 (es) * 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
CN115028617A (zh) 2016-05-24 2022-09-09 基因泰克公司 Cbp/ep300的杂环抑制剂及其在治疗癌症中的用途

Similar Documents

Publication Publication Date Title
JP2019516757A5 (cg-RX-API-DMAC7.html)
JP2019516759A5 (cg-RX-API-DMAC7.html)
JP2017530176A5 (cg-RX-API-DMAC7.html)
JP2017533250A5 (cg-RX-API-DMAC7.html)
JP2018510851A5 (cg-RX-API-DMAC7.html)
JP2017537100A5 (cg-RX-API-DMAC7.html)
JP2017526696A5 (cg-RX-API-DMAC7.html)
JP2017533249A5 (cg-RX-API-DMAC7.html)
JP2018501287A5 (cg-RX-API-DMAC7.html)
JP2017533248A5 (cg-RX-API-DMAC7.html)
JP2017525740A5 (cg-RX-API-DMAC7.html)
JP2018505169A5 (cg-RX-API-DMAC7.html)
JP2017530984A5 (cg-RX-API-DMAC7.html)
JP2016529312A5 (cg-RX-API-DMAC7.html)
AU2018226470A1 (en) Compounds for treatment of cancer
KR102712584B1 (ko) 종양 치료에 사용하기 위한 코르텍솔론의 17a,21-디에스테르
JP2018507191A5 (cg-RX-API-DMAC7.html)
JP6039549B2 (ja) 化学療法または放射線療法によって誘発される嘔吐を予防および/または治療するためのシグマリガンド
JP2008528468A5 (cg-RX-API-DMAC7.html)
JP2019529444A5 (cg-RX-API-DMAC7.html)
AR063872A1 (es) Derivados de acetileno como inhibidores de estearoil coa desaturasa
JP2014510078A5 (cg-RX-API-DMAC7.html)
JP2009541223A5 (cg-RX-API-DMAC7.html)
MX2016016538A (es) Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa.
JP2011521938A5 (cg-RX-API-DMAC7.html)