JP2019515688A5 - - Google Patents
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- Publication number
- JP2019515688A5 JP2019515688A5 JP2019506546A JP2019506546A JP2019515688A5 JP 2019515688 A5 JP2019515688 A5 JP 2019515688A5 JP 2019506546 A JP2019506546 A JP 2019506546A JP 2019506546 A JP2019506546 A JP 2019506546A JP 2019515688 A5 JP2019515688 A5 JP 2019515688A5
- Authority
- JP
- Japan
- Prior art keywords
- aon
- ush2a
- mrna
- skipping
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1607141.7 | 2016-04-25 | ||
| GB201607141 | 2016-04-25 | ||
| PCT/EP2017/059830 WO2017186739A1 (en) | 2016-04-25 | 2017-04-25 | Oligonucleotides to treat eye disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515688A JP2019515688A (ja) | 2019-06-13 |
| JP2019515688A5 true JP2019515688A5 (enExample) | 2020-06-11 |
| JP7043082B2 JP7043082B2 (ja) | 2022-03-29 |
Family
ID=58672573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506546A Expired - Fee Related JP7043082B2 (ja) | 2016-04-25 | 2017-04-25 | 眼疾患を処置するオリゴヌクレオチド |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10617707B2 (enExample) |
| EP (1) | EP3448999B1 (enExample) |
| JP (1) | JP7043082B2 (enExample) |
| KR (1) | KR102368920B1 (enExample) |
| CN (1) | CN109072239A (enExample) |
| AU (1) | AU2017257292A1 (enExample) |
| CA (1) | CA3021899A1 (enExample) |
| DK (1) | DK3448999T3 (enExample) |
| EA (1) | EA201892431A1 (enExample) |
| ES (1) | ES2801823T3 (enExample) |
| IL (1) | IL262199B (enExample) |
| MX (1) | MX2018013003A (enExample) |
| PL (1) | PL3448999T3 (enExample) |
| WO (1) | WO2017186739A1 (enExample) |
| ZA (1) | ZA201806628B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102368920B1 (ko) | 2016-04-25 | 2022-02-28 | 프로큐알 테라퓨틱스 Ⅱ 비.브이. | 안 질환 치료용 올리고뉴클레오타이드 |
| CN109477103A (zh) | 2016-06-22 | 2019-03-15 | ProQR治疗上市公司Ⅱ | 单链rna-编辑寡核苷酸 |
| EP3507366B1 (en) | 2016-09-01 | 2020-10-07 | ProQR Therapeutics II B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| GB201706009D0 (en) | 2017-04-13 | 2017-05-31 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of stargardt disease |
| WO2019123430A1 (en) | 2017-12-21 | 2019-06-27 | Casebia Therapeutics Llp | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| AU2018393050A1 (en) | 2017-12-21 | 2020-06-18 | Bayer Healthcare Llc | Materials and methods for treatment of Usher Syndrome Type 2A |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| US12398393B2 (en) | 2019-01-28 | 2025-08-26 | Proqr Therapeutics Ii B.V. | RNA-editing oligonucleotides for the treatment of usher syndrome |
| JP2022520783A (ja) * | 2019-02-12 | 2022-04-01 | ウニヴェルシタ デリ ストゥディ ディ トレント | Ｃａｓ１２ａガイドＲＮＡ分子およびその使用 |
| US20220177894A1 (en) | 2019-04-02 | 2022-06-09 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for immunotherapy |
| TW202043249A (zh) | 2019-04-15 | 2020-12-01 | 大陸商博雅輯因（北京）生物科技有限公司 | 編輯rna的方法和組合物 |
| WO2020212567A1 (en) | 2019-04-18 | 2020-10-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of usher syndrome |
| WO2020254249A1 (en) | 2019-06-21 | 2020-12-24 | Proqr Therapeutics Ii B.V. | Delivery of nucleic acids for the treatment of auditory disorders |
| PH12022550059A1 (en) | 2019-07-12 | 2022-11-21 | Univ Beijing | Targeted rna editing by leveraging endogenous adar using engineered rnas |
| WO2021018750A1 (en) | 2019-07-26 | 2021-02-04 | Proqr Therapeutics Ii B.V. | Ophthalmic compositions comprising viscosifying polymers and nucleic acids |
| WO2021023863A1 (en) * | 2019-08-08 | 2021-02-11 | Stichting Katholieke Universiteit | Antisense oligonucleotides rescue aberrant splicing of abca4 |
| EP4081638A1 (en) | 2019-12-23 | 2022-11-02 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for nucleotide deamination in the treatment of stargardt disease |
| CN113122577A (zh) * | 2019-12-30 | 2021-07-16 | 博雅辑因（北京）生物科技有限公司 | 一种治疗Usher综合征的方法和其组合物 |
| TW202138561A (zh) * | 2019-12-30 | 2021-10-16 | 大陸商博雅輯因（北京）生物科技有限公司 | 治療Usher綜合症的方法和其組合物 |
| US20230134677A1 (en) | 2020-03-04 | 2023-05-04 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for use in the treatment of usher syndrome |
| EP4301856A2 (en) | 2021-03-05 | 2024-01-10 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for use in the treatment of corneal dystrophies |
| TR2022001648A2 (tr) * | 2022-02-09 | 2022-02-21 | T C Ueskuedar Ueniversitesi | Ush2a kaynaklı retinitis pigmentosa hastalığının genetik tedavisi için ekzon 13 atlama işlevi gören kseno nükleik asit antisens-oligonükleotit (xna-aso) dizileri. |
| US20250154504A1 (en) | 2022-02-14 | 2025-05-15 | Proqr Therapeutics Ii B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| AU2023357356A1 (en) * | 2022-10-06 | 2025-04-10 | Stichting Radboud Universitair Medisch Centrum | Antisense oligonucleotides for treatment of usher 2a. exon 68 |
| AU2023357354A1 (en) * | 2022-10-06 | 2025-04-10 | Stichting Radboud Universitair Medisch Centrum | Antisense oligonucleotides for treatment of usher 2a. exons 30-31 |
| CN120129747A (zh) * | 2022-10-11 | 2025-06-10 | 广州瑞风生物科技有限公司 | snRNA核酸分子及其应用 |
| EP4619522A1 (en) * | 2022-11-15 | 2025-09-24 | Stichting Radboud universitair medisch centrum | Antisense oligonucleotides for treatment of usher 2a. exons 39-40 |
| WO2025007937A1 (zh) * | 2023-07-04 | 2025-01-09 | 广州瑞风生物科技有限公司 | 靶向USH2A pre-mRNA假外显子PE40的snRNA及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE432993T1 (de) | 1999-10-04 | 2009-06-15 | Univ New Jersey Med | Tar rna bindende peptide |
| EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| US20100196889A1 (en) | 2006-11-13 | 2010-08-05 | Bankaitis-Davis Danute M | Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer |
| US8093000B2 (en) | 2008-05-09 | 2012-01-10 | The Regents Of The University Of California | Methods for predicting and treating tumors resistant to drug, immunotherapy, and radiation |
| US20110070582A1 (en) | 2008-11-03 | 2011-03-24 | Source Precision Medicine, Inc. d/b/d Source MDX | Gene Expression Profiling for Predicting the Response to Immunotherapy and/or the Survivability of Melanoma Subjects |
| SI2425814T1 (sl) | 2010-09-03 | 2013-10-30 | Novagali Pharma S.A. | Emulzija vrste voda-v-olju za zdravljenje bolezni očesa |
| US10131910B2 (en) * | 2014-07-10 | 2018-11-20 | Stichting Katholieke Universiteit | Antisense oligonucleotides for the treatment of Usher syndrome type 2 |
| US9927034B2 (en) | 2015-08-25 | 2018-03-27 | Mueller International, Llc | Valve seat stiffener |
| JP7089763B2 (ja) | 2015-10-05 | 2022-06-23 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | トリヌクレオチドリピート伸長が関与する遺伝的疾患の予防または治療における一本鎖アンチセンスオリゴヌクレオチドの使用 |
| KR102368920B1 (ko) | 2016-04-25 | 2022-02-28 | 프로큐알 테라퓨틱스 Ⅱ 비.브이. | 안 질환 치료용 올리고뉴클레오타이드 |
-
2017
- 2017-04-25 KR KR1020187031243A patent/KR102368920B1/ko not_active Expired - Fee Related
- 2017-04-25 PL PL17721984T patent/PL3448999T3/pl unknown
- 2017-04-25 EP EP17721984.7A patent/EP3448999B1/en active Active
- 2017-04-25 MX MX2018013003A patent/MX2018013003A/es unknown
- 2017-04-25 DK DK17721984.7T patent/DK3448999T3/da active
- 2017-04-25 US US16/096,038 patent/US10617707B2/en active Active
- 2017-04-25 WO PCT/EP2017/059830 patent/WO2017186739A1/en not_active Ceased
- 2017-04-25 JP JP2019506546A patent/JP7043082B2/ja not_active Expired - Fee Related
- 2017-04-25 CN CN201780025611.3A patent/CN109072239A/zh active Pending
- 2017-04-25 CA CA3021899A patent/CA3021899A1/en active Pending
- 2017-04-25 ES ES17721984T patent/ES2801823T3/es active Active
- 2017-04-25 EA EA201892431A patent/EA201892431A1/ru unknown
- 2017-04-25 AU AU2017257292A patent/AU2017257292A1/en not_active Abandoned
-
2018
- 2018-10-05 ZA ZA2018/06628A patent/ZA201806628B/en unknown
- 2018-10-08 IL IL262199A patent/IL262199B/en unknown
-
2020
- 2020-03-06 US US16/811,848 patent/US11123360B2/en not_active Expired - Fee Related
-
2021
- 2021-09-15 US US17/475,795 patent/US20210401871A1/en not_active Abandoned
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