JP2019512546A - Ｋｄｍ１ａ標的会合を決定するための方法、およびそれに有用な化学プローブ - Google Patents

Ｋｄｍ１ａ標的会合を決定するための方法、およびそれに有用な化学プローブ Download PDF

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JP2019512546A
JP2019512546A JP2019500019A JP2019500019A JP2019512546A JP 2019512546 A JP2019512546 A JP 2019512546A JP 2019500019 A JP2019500019 A JP 2019500019A JP 2019500019 A JP2019500019 A JP 2019500019A JP 2019512546 A JP2019512546 A JP 2019512546A
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kdm1a
trans
cyclyl
formula
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JP2019512546A5 (enExample
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カルセリャール・ゴンサレス，エレナ
マエス，タマラ
マスカーロ・クルサット，クリスティナ
オルテガ・ムニョス，アルベルト
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オリゾン・ゲノミクス・ソシエダッド・アノニマ
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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JP2019500019A 2016-03-16 2017-03-16 Ｋｄｍ１ａ標的会合を決定するための方法、およびそれに有用な化学プローブ Pending JP2019512546A (ja)

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EP16382119 2016-03-16
EP16382119.2 2016-03-16
PCT/EP2017/056330 WO2017158136A1 (en) 2016-03-16 2017-03-16 Methods to determine kdm1a target engagement and chemoprobes useful therefor

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EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
EP3307267B1 (en) 2016-06-10 2019-04-10 Oryzon Genomics, S.A. Multiple sclerosis treatment
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
AU2017233886B2 (en) 2016-03-15 2022-10-20 Oryzon Genomics, S.A. Combinations of LSD1 inhibitors for the treatment of hematological malignancies
ES3042059T3 (en) * 2016-03-16 2025-11-18 Oryzon Genomics Sa Methods to determine kdm1a target engagement and chemoprobes useful therefor
WO2020152280A1 (en) * 2019-01-24 2020-07-30 Fundación Pública Andaluza Progreso Y Salud Lsd1 inhibitors for use in the treatment of type 2 diabetes
WO2021197371A1 (zh) * 2020-03-31 2021-10-07 南京金斯瑞生物科技有限公司 一种含有刚性连接子的生物偶联物

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WO2017158136A1 (en) 2017-09-21
US20220389478A1 (en) 2022-12-08
EP3430015C0 (en) 2025-08-06
US11034991B2 (en) 2021-06-15
EP3430015A1 (en) 2019-01-23
ES3042059T3 (en) 2025-11-18
US12195783B2 (en) 2025-01-14
EP3430015B1 (en) 2025-08-06
EP3430015B9 (en) 2025-12-31
US20190085372A1 (en) 2019-03-21

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