JP2019512542A5 - - Google Patents
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- Publication number
- JP2019512542A5 JP2019512542A5 JP2018567022A JP2018567022A JP2019512542A5 JP 2019512542 A5 JP2019512542 A5 JP 2019512542A5 JP 2018567022 A JP2018567022 A JP 2018567022A JP 2018567022 A JP2018567022 A JP 2018567022A JP 2019512542 A5 JP2019512542 A5 JP 2019512542A5
- Authority
- JP
- Japan
- Prior art keywords
- theta
- values
- xrpd pattern
- crystalline form
- characteristic peaks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000634 powder X-ray diffraction Methods 0.000 claims description 86
- 239000013078 crystal Substances 0.000 claims description 35
- 150000001875 compounds Chemical class 0.000 claims description 34
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 3
- BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 claims description 3
- 229940080277 cholesteryl sulfate Drugs 0.000 claims description 3
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical class CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 3
- 150000003891 oxalate salts Chemical class 0.000 claims description 3
- 125000005490 tosylate group Chemical class 0.000 claims description 3
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 150000003890 succinate salts Chemical class 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 description 3
- 230000002407 ATP formation Effects 0.000 description 1
- 208000012268 mitochondrial disease Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307095P | 2016-03-11 | 2016-03-11 | |
| US62/307,095 | 2016-03-11 | ||
| PCT/US2017/021790 WO2017156403A1 (en) | 2016-03-11 | 2017-03-10 | Crystalline salt forms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512542A JP2019512542A (ja) | 2019-05-16 |
| JP2019512542A5 true JP2019512542A5 (enExample) | 2020-03-26 |
| JP7038675B2 JP7038675B2 (ja) | 2022-03-18 |
Family
ID=59789873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567022A Active JP7038675B2 (ja) | 2016-03-11 | 2017-03-10 | 結晶塩形態 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10683326B2 (enExample) |
| EP (1) | EP3426675B1 (enExample) |
| JP (1) | JP7038675B2 (enExample) |
| CN (2) | CN115160402A (enExample) |
| CA (1) | CA3017359A1 (enExample) |
| WO (1) | WO2017156403A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017156403A1 (en) | 2016-03-11 | 2017-09-14 | Stealth Biotherapeutics | Crystalline salt forms |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| ES2941266T3 (es) * | 2018-04-02 | 2023-05-19 | Stealth Biotherapeutics Inc | Dipéptidos cristalinos útiles en la síntesis elamipretide |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG64368A1 (en) * | 1988-06-30 | 1999-04-27 | Astra Ab | Dermorphin analogs their methods of preparation pharmaceutical compositions and methods of therapeutic treatment using the same |
| SI2656854T1 (sl) | 2003-02-04 | 2015-09-30 | Cornell Research Foundation, Inc. | Uporabe aromatsko-kationskega peptida |
| US20120178762A1 (en) * | 2006-12-15 | 2012-07-12 | Warner Chilcott Company, Llc | Compositions of azimilide dihydrochloride |
| EP3563862B1 (en) * | 2009-03-20 | 2021-05-05 | The General Hospital Corporation d/b/a Massachusetts General Hospital | D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries |
| WO2010125004A1 (en) | 2009-04-29 | 2010-11-04 | Nerviano Medical Sciences S.R.L. | Cdk inhibitor salts |
| SI3708178T1 (sl) | 2009-08-24 | 2024-01-31 | Stealth Biotherapeutics Inc. | Peptid za uporabo pri preprečevanju ali zdravljenju degeneracije makule |
| US20130195837A1 (en) * | 2009-12-31 | 2013-08-01 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| CA2787331A1 (en) * | 2010-01-25 | 2011-07-28 | Hazel H. Szeto | Aromatic-cationic peptides and uses of same |
| EP2808029A3 (en) * | 2010-03-15 | 2015-04-01 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| CN103003283A (zh) * | 2010-06-09 | 2013-03-27 | Abbvie公司 | 激酶抑制剂的结晶形式 |
| HK1204988A1 (en) * | 2012-02-22 | 2015-12-11 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
| US10793597B2 (en) * | 2013-03-01 | 2020-10-06 | Stealth Biotherapeutics Corp | Methods for the treatment of mitochondrial diseases associated with a mutation in SURF 1 or POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation |
| EP3060573B1 (en) * | 2013-10-23 | 2019-07-17 | Kaneka Corporation | Tetrapeptide compound and method for producing same |
| SG11201604517WA (en) * | 2013-12-03 | 2016-07-28 | Amgen Inc | Crystalline forms of n-(4-((3-(2-amino-4-pyrimidinyl) - 2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1 -phthalazinamine pharmaceutically acceptable salts and uses thereof |
| PL3160985T3 (pl) * | 2014-06-30 | 2021-12-27 | Flamma S.P.A. | Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu |
| WO2016004067A1 (en) * | 2014-06-30 | 2016-01-07 | Stealth Biotherapeutics Corp | Aromatic-cationic peptide formulations, compositions and methods of use |
| WO2016007921A1 (en) * | 2014-07-10 | 2016-01-14 | Rhodel Island Hospital | Treating arrhythmia with mitochondrial-targeted antioxidants |
| JP6854771B2 (ja) | 2015-03-06 | 2021-04-07 | ステルス バイオセラピューティックス コープ | 薬学的に適切なペプチドを調製するための方法 |
| WO2017156403A1 (en) | 2016-03-11 | 2017-09-14 | Stealth Biotherapeutics | Crystalline salt forms |
| CN110087667A (zh) * | 2016-08-16 | 2019-08-02 | 隐形生物治疗公司 | Elamipretide的基于N-羧基酸酐的规模合成 |
| US11034724B2 (en) * | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| US10676506B2 (en) * | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| ES2941266T3 (es) * | 2018-04-02 | 2023-05-19 | Stealth Biotherapeutics Inc | Dipéptidos cristalinos útiles en la síntesis elamipretide |
-
2017
- 2017-03-10 WO PCT/US2017/021790 patent/WO2017156403A1/en not_active Ceased
- 2017-03-10 EP EP17764188.3A patent/EP3426675B1/en active Active
- 2017-03-10 CA CA3017359A patent/CA3017359A1/en active Pending
- 2017-03-10 CN CN202210620260.3A patent/CN115160402A/zh active Pending
- 2017-03-10 US US16/084,168 patent/US10683326B2/en active Active
- 2017-03-10 JP JP2018567022A patent/JP7038675B2/ja active Active
- 2017-03-10 CN CN201780029335.8A patent/CN109476700A/zh active Pending
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2020
- 2020-05-04 US US16/866,164 patent/US11555053B2/en active Active
-
2022
- 2022-12-02 US US18/074,151 patent/US12252553B2/en active Active
-
2025
- 2025-02-14 US US19/053,773 patent/US20260015385A1/en active Pending