JP2019511474A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019511474A5 JP2019511474A5 JP2018543674A JP2018543674A JP2019511474A5 JP 2019511474 A5 JP2019511474 A5 JP 2019511474A5 JP 2018543674 A JP2018543674 A JP 2018543674A JP 2018543674 A JP2018543674 A JP 2018543674A JP 2019511474 A5 JP2019511474 A5 JP 2019511474A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- targeting agent
- receptor
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims 224
- 239000012634 fragment Substances 0.000 claims 221
- 230000008685 targeting Effects 0.000 claims 209
- 206010028980 Neoplasm Diseases 0.000 claims 39
- -1 cis knot Proteins 0.000 claims 38
- 239000000427 antigen Substances 0.000 claims 36
- 108091007433 antigens Proteins 0.000 claims 36
- 102000036639 antigens Human genes 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 150000007523 nucleic acids Chemical class 0.000 claims 36
- 108091034117 Oligonucleotide Proteins 0.000 claims 28
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 24
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 24
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 21
- 201000011510 cancer Diseases 0.000 claims 21
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 20
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 20
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 20
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 18
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 18
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 18
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 18
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 18
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 17
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 17
- 102100025390 Integrin beta-2 Human genes 0.000 claims 16
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 14
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 14
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 14
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 13
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 13
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 13
- 102100034256 Mucin-1 Human genes 0.000 claims 13
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 13
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 12
- 208000032612 Glial tumor Diseases 0.000 claims 11
- 206010018338 Glioma Diseases 0.000 claims 11
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 11
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 10
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 10
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 10
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 10
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 9
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 9
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 9
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims 9
- 229940014144 folate Drugs 0.000 claims 9
- 235000019152 folic acid Nutrition 0.000 claims 9
- 239000011724 folic acid Substances 0.000 claims 9
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 8
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims 8
- 108700012439 CA9 Proteins 0.000 claims 8
- 102100032937 CD40 ligand Human genes 0.000 claims 8
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 8
- 102100023688 Eotaxin Human genes 0.000 claims 8
- 102000010451 Folate receptor alpha Human genes 0.000 claims 8
- 108050001931 Folate receptor alpha Proteins 0.000 claims 8
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 8
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 8
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 8
- 101000773083 Homo sapiens 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 claims 8
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 8
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 8
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 8
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 8
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 8
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 8
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 8
- 108010073816 IgE Receptors Proteins 0.000 claims 8
- 102000009438 IgE Receptors Human genes 0.000 claims 8
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 8
- 102000006992 Interferon-alpha Human genes 0.000 claims 8
- 108010074328 Interferon-gamma Proteins 0.000 claims 8
- 102000003816 Interleukin-13 Human genes 0.000 claims 8
- 108090000176 Interleukin-13 Proteins 0.000 claims 8
- 102000004889 Interleukin-6 Human genes 0.000 claims 8
- 108090001005 Interleukin-6 Proteins 0.000 claims 8
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 8
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 8
- 102100027159 Membrane primary amine oxidase Human genes 0.000 claims 8
- 102100023123 Mucin-16 Human genes 0.000 claims 8
- 108010056852 Myostatin Proteins 0.000 claims 8
- 239000002202 Polyethylene glycol Substances 0.000 claims 8
- 229920002873 Polyethylenimine Polymers 0.000 claims 8
- 229920000954 Polyglycolide Polymers 0.000 claims 8
- 102000014128 RANK Ligand Human genes 0.000 claims 8
- 108010025832 RANK Ligand Proteins 0.000 claims 8
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 8
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 8
- 102100029198 SLAM family member 7 Human genes 0.000 claims 8
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 8
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 8
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 8
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000002158 endotoxin Substances 0.000 claims 8
- 108020001507 fusion proteins Proteins 0.000 claims 8
- 102000037865 fusion proteins Human genes 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 8
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- 239000004633 polyglycolic acid Substances 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 8
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 7
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 7
- 108050003558 Interleukin-17 Proteins 0.000 claims 6
- 102000013691 Interleukin-17 Human genes 0.000 claims 6
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
- 230000001268 conjugating effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 5
- 208000026310 Breast neoplasm Diseases 0.000 claims 5
- 108010008707 Mucin-1 Proteins 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 5
- 102000006815 folate receptor Human genes 0.000 claims 5
- 108020005243 folate receptor Proteins 0.000 claims 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
- FFILOTSTFMXQJC-QCFYAKGBSA-N (2r,4r,5s,6s)-2-[3-[(2s,3s,4r,6s)-6-[(2s,3r,4r,5s,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2r,3s,4r,5r,6r)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(e)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims 4
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims 4
- 102100040079 A-kinase anchor protein 4 Human genes 0.000 claims 4
- 102000000074 ADP-ribosyl Cyclase Human genes 0.000 claims 4
- 108010080394 ADP-ribosyl Cyclase Proteins 0.000 claims 4
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 4
- 102100027647 Activin receptor type-2B Human genes 0.000 claims 4
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 4
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 4
- 102100034608 Angiopoietin-2 Human genes 0.000 claims 4
- 108010048036 Angiopoietin-2 Proteins 0.000 claims 4
- 102100025665 Angiopoietin-related protein 1 Human genes 0.000 claims 4
- 101100059333 Arabidopsis thaliana CYCA1-2 gene Proteins 0.000 claims 4
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 claims 4
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 claims 4
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 4
- 102100035526 B melanoma antigen 1 Human genes 0.000 claims 4
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims 4
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 4
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 4
- 102100032412 Basigin Human genes 0.000 claims 4
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims 4
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 4
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 4
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 4
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 4
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 4
- 102100038078 CD276 antigen Human genes 0.000 claims 4
- 101710185679 CD276 antigen Proteins 0.000 claims 4
- 108010029697 CD40 Ligand Proteins 0.000 claims 4
- 101150013553 CD40 gene Proteins 0.000 claims 4
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- 108010065524 CD52 Antigen Proteins 0.000 claims 4
- 102100025221 CD70 antigen Human genes 0.000 claims 4
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 4
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 4
- 102000010864 Carbonic anhydrase 9 Human genes 0.000 claims 4
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 4
- 108010082548 Chemokine CCL11 Proteins 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 102000034534 Cotransporters Human genes 0.000 claims 4
- 108020003264 Cotransporters Proteins 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 4
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 4
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 claims 4
- 102100021811 E3 ubiquitin-protein ligase RNF5 Human genes 0.000 claims 4
- 102000001301 EGF receptor Human genes 0.000 claims 4
- 102100038083 Endosialin Human genes 0.000 claims 4
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 4
- 102100032031 Epidermal growth factor-like protein 7 Human genes 0.000 claims 4
- 102100037362 Fibronectin Human genes 0.000 claims 4
- 108010067306 Fibronectins Proteins 0.000 claims 4
- 101710088083 Glomulin Proteins 0.000 claims 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 4
- 102100022662 Guanylyl cyclase C Human genes 0.000 claims 4
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 4
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 4
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 4
- 101150051208 HSPH1 gene Proteins 0.000 claims 4
- 102100031624 Heat shock protein 105 kDa Human genes 0.000 claims 4
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 4
- 101710154606 Hemagglutinin Proteins 0.000 claims 4
- 108010061414 Hepatocyte Nuclear Factor 1-beta Proteins 0.000 claims 4
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims 4
- 108010033040 Histones Proteins 0.000 claims 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 4
- 101000890604 Homo sapiens A-kinase anchor protein 4 Proteins 0.000 claims 4
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 4
- 101000937269 Homo sapiens Activin receptor type-2B Proteins 0.000 claims 4
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 4
- 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 claims 4
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 4
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 4
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 4
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 4
- 101001107084 Homo sapiens E3 ubiquitin-protein ligase RNF5 Proteins 0.000 claims 4
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 4
- 101000884275 Homo sapiens Endosialin Proteins 0.000 claims 4
- 101000978392 Homo sapiens Eotaxin Proteins 0.000 claims 4
- 101000921195 Homo sapiens Epidermal growth factor-like protein 7 Proteins 0.000 claims 4
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 4
- 101000899808 Homo sapiens Guanylyl cyclase C Proteins 0.000 claims 4
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 4
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 4
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 4
- 101001055308 Homo sapiens Immunoglobulin heavy constant epsilon Proteins 0.000 claims 4
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 4
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 4
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 4
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 4
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 4
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims 4
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 4
- 101001065550 Homo sapiens Lymphocyte antigen 6K Proteins 0.000 claims 4
- 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 claims 4
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 4
- 101001106413 Homo sapiens Macrophage-stimulating protein receptor Proteins 0.000 claims 4
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 4
- 101001057156 Homo sapiens Melanoma-associated antigen C2 Proteins 0.000 claims 4
- 101000694615 Homo sapiens Membrane primary amine oxidase Proteins 0.000 claims 4
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims 4
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims 4
- 101000972286 Homo sapiens Mucin-4 Proteins 0.000 claims 4
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 4
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 4
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims 4
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 4
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 4
- 101000880769 Homo sapiens Protein SSX1 Proteins 0.000 claims 4
- 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 claims 4
- 101000711796 Homo sapiens Sclerostin Proteins 0.000 claims 4
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 4
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 4
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 4
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 4
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 4
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 4
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims 4
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 claims 4
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 4
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 4
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 4
- 102000004157 Hydrolases Human genes 0.000 claims 4
- 108090000604 Hydrolases Proteins 0.000 claims 4
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 4
- 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 102100026212 Immunoglobulin heavy constant epsilon Human genes 0.000 claims 4
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 4
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 4
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 4
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 4
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 4
- 102100022337 Integrin alpha-V Human genes 0.000 claims 4
- 108010041012 Integrin alpha4 Proteins 0.000 claims 4
- 108010042918 Integrin alpha5beta1 Proteins 0.000 claims 4
- 108010047852 Integrin alphaVbeta3 Proteins 0.000 claims 4
- 108010086140 Interferon alpha-beta Receptor Proteins 0.000 claims 4
- 102100037850 Interferon gamma Human genes 0.000 claims 4
- 108010047761 Interferon-alpha Proteins 0.000 claims 4
- 102000008070 Interferon-gamma Human genes 0.000 claims 4
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 4
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 4
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 4
- 102100030703 Interleukin-22 Human genes 0.000 claims 4
- 102000013264 Interleukin-23 Human genes 0.000 claims 4
- 108010065637 Interleukin-23 Proteins 0.000 claims 4
- 102000004388 Interleukin-4 Human genes 0.000 claims 4
- 108090000978 Interleukin-4 Proteins 0.000 claims 4
- 102100039881 Interleukin-5 receptor subunit alpha Human genes 0.000 claims 4
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 4
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 4
- 108010002335 Interleukin-9 Proteins 0.000 claims 4
- 102000000585 Interleukin-9 Human genes 0.000 claims 4
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims 4
- 108010043610 KIR Receptors Proteins 0.000 claims 4
- 102000017578 LAG3 Human genes 0.000 claims 4
- 101150030213 Lag3 gene Proteins 0.000 claims 4
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 4
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 4
- 102100032129 Lymphocyte antigen 6K Human genes 0.000 claims 4
- 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 claims 4
- 108010010995 MART-1 Antigen Proteins 0.000 claims 4
- 102000034655 MIF Human genes 0.000 claims 4
- 108060004872 MIF Proteins 0.000 claims 4
- 241000282560 Macaca mulatta Species 0.000 claims 4
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 4
- 102100021435 Macrophage-stimulating protein receptor Human genes 0.000 claims 4
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 4
- 102100027252 Melanoma-associated antigen C2 Human genes 0.000 claims 4
- 101710132836 Membrane primary amine oxidase Proteins 0.000 claims 4
- 102000003735 Mesothelin Human genes 0.000 claims 4
- 108090000015 Mesothelin Proteins 0.000 claims 4
- 102100025096 Mesothelin Human genes 0.000 claims 4
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims 4
- 102100022693 Mucin-4 Human genes 0.000 claims 4
- 108010063954 Mucins Proteins 0.000 claims 4
- 102000015728 Mucins Human genes 0.000 claims 4
- 108010083674 Myelin Proteins Proteins 0.000 claims 4
- 102000006386 Myelin Proteins Human genes 0.000 claims 4
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 4
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 4
- 102000005650 Notch Receptors Human genes 0.000 claims 4
- 108010070047 Notch Receptors Proteins 0.000 claims 4
- RMINQIRDFIBNLE-NNRWGFCXSA-N O-[N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-serine Chemical compound O1[C@H](OC[C@H](N)C(O)=O)[C@H](NC(=O)C)[C@@H](O)[C@@H](O)[C@H]1CO[C@@]1(C(O)=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C1 RMINQIRDFIBNLE-NNRWGFCXSA-N 0.000 claims 4
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims 4
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 4
- 108060006580 PRAME Proteins 0.000 claims 4
- 102000036673 PRAME Human genes 0.000 claims 4
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims 4
- 108010022425 Platelet Glycoprotein GPIIb-IIIa Complex Proteins 0.000 claims 4
- 108010035030 Platelet Membrane Glycoprotein IIb Proteins 0.000 claims 4
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 4
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 4
- 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 claims 4
- 108010039918 Polylysine Proteins 0.000 claims 4
- 108091000054 Prion Proteins 0.000 claims 4
- 102000029797 Prion Human genes 0.000 claims 4
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 4
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 4
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 4
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 4
- 101710176177 Protein A56 Proteins 0.000 claims 4
- 102100037687 Protein SSX1 Human genes 0.000 claims 4
- 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 4
- 102000019307 Sclerostin Human genes 0.000 claims 4
- 102100034201 Sclerostin Human genes 0.000 claims 4
- 108050006698 Sclerostin Proteins 0.000 claims 4
- 102100034136 Serine/threonine-protein kinase receptor R3 Human genes 0.000 claims 4
- 101710082813 Serine/threonine-protein kinase receptor R3 Proteins 0.000 claims 4
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 4
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 claims 4
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 claims 4
- 101800001271 Surface protein Proteins 0.000 claims 4
- 108010002687 Survivin Proteins 0.000 claims 4
- 102100035721 Syndecan-1 Human genes 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 4
- 108010014401 TWEAK Receptor Proteins 0.000 claims 4
- 102000007000 Tenascin Human genes 0.000 claims 4
- 108010008125 Tenascin Proteins 0.000 claims 4
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 4
- 102000002689 Toll-like receptor Human genes 0.000 claims 4
- 108020000411 Toll-like receptor Proteins 0.000 claims 4
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 4
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 4
- 101710181056 Tumor necrosis factor ligand superfamily member 13B Proteins 0.000 claims 4
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims 4
- 102100028786 Tumor necrosis factor receptor superfamily member 12A Human genes 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 4
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 4
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 4
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 108700020467 WT1 Proteins 0.000 claims 4
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 4
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 4
- MXKCYTKUIDTFLY-ZNNSSXPHSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc-(1->3)-D-Galp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O[C@H]3[C@H]([C@@H](CO)OC(O)[C@@H]3O)O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O MXKCYTKUIDTFLY-ZNNSSXPHSA-N 0.000 claims 4
- 108010069801 angiopoietin 4 Proteins 0.000 claims 4
- 239000000611 antibody drug conjugate Substances 0.000 claims 4
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 4
- 210000003651 basophil Anatomy 0.000 claims 4
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 4
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 230000028956 calcium-mediated signaling Effects 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- 210000003979 eosinophil Anatomy 0.000 claims 4
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 4
- 230000002538 fungal effect Effects 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 4
- 239000000185 hemagglutinin Substances 0.000 claims 4
- 210000003630 histaminocyte Anatomy 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 4
- 229960003160 hyaluronic acid Drugs 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 108010043603 integrin alpha4beta7 Proteins 0.000 claims 4
- 102000006495 integrins Human genes 0.000 claims 4
- 108010044426 integrins Proteins 0.000 claims 4
- 229960003130 interferon gamma Drugs 0.000 claims 4
- 102000004114 interleukin 20 Human genes 0.000 claims 4
- 108090000681 interleukin 20 Proteins 0.000 claims 4
- 108010074109 interleukin-22 Proteins 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 229920006008 lipopolysaccharide Polymers 0.000 claims 4
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 4
- 210000002540 macrophage Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 210000005012 myelin Anatomy 0.000 claims 4
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 4
- 210000000822 natural killer cell Anatomy 0.000 claims 4
- 230000009223 neuronal apoptosis Effects 0.000 claims 4
- 210000000440 neutrophil Anatomy 0.000 claims 4
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 4
- 108010011110 polyarginine Proteins 0.000 claims 4
- 239000004626 polylactic acid Substances 0.000 claims 4
- 229920000656 polylysine Polymers 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 claims 4
- 101150047061 tag-72 gene Proteins 0.000 claims 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 4
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 229940088594 vitamin Drugs 0.000 claims 4
- 235000013343 vitamin Nutrition 0.000 claims 4
- 239000011782 vitamin Substances 0.000 claims 4
- 229930003231 vitamin Natural products 0.000 claims 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims 4
- 102100036537 von Willebrand factor Human genes 0.000 claims 4
- 101150066398 CXCR4 gene Proteins 0.000 claims 3
- 102000005698 Frizzled receptors Human genes 0.000 claims 3
- 108010045438 Frizzled receptors Proteins 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 3
- 108090000288 Glycoproteins Proteins 0.000 claims 3
- 102000010956 Glypican Human genes 0.000 claims 3
- 108050001154 Glypican Proteins 0.000 claims 3
- 108050007237 Glypican-3 Proteins 0.000 claims 3
- 101000972946 Homo sapiens Hepatocyte growth factor receptor Proteins 0.000 claims 3
- 102000013462 Interleukin-12 Human genes 0.000 claims 3
- 108010065805 Interleukin-12 Proteins 0.000 claims 3
- 102100039897 Interleukin-5 Human genes 0.000 claims 3
- 108010002616 Interleukin-5 Proteins 0.000 claims 3
- SUHQNCLNRUAGOO-UHFFFAOYSA-N N-glycoloyl-neuraminic acid Natural products OCC(O)C(O)C(O)C(NC(=O)CO)C(O)CC(=O)C(O)=O SUHQNCLNRUAGOO-UHFFFAOYSA-N 0.000 claims 3
- FDJKUWYYUZCUJX-UHFFFAOYSA-N N-glycolyl-beta-neuraminic acid Natural products OCC(O)C(O)C1OC(O)(C(O)=O)CC(O)C1NC(=O)CO FDJKUWYYUZCUJX-UHFFFAOYSA-N 0.000 claims 3
- FDJKUWYYUZCUJX-KVNVFURPSA-N N-glycolylneuraminic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H]1O[C@](O)(C(O)=O)C[C@H](O)[C@H]1NC(=O)CO FDJKUWYYUZCUJX-KVNVFURPSA-N 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 102000035195 Peptidases Human genes 0.000 claims 3
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 3
- 102000013127 Vimentin Human genes 0.000 claims 3
- 108010065472 Vimentin Proteins 0.000 claims 3
- 102000040856 WT1 Human genes 0.000 claims 3
- 101150084041 WT1 gene Proteins 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 230000009977 dual effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 235000019833 protease Nutrition 0.000 claims 3
- 210000005048 vimentin Anatomy 0.000 claims 3
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 108091008606 PDGF receptors Proteins 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 108010017842 Telomerase Proteins 0.000 claims 2
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
- 101150045640 VWF gene Proteins 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 102000055501 telomere Human genes 0.000 claims 2
- 108091035539 telomere Proteins 0.000 claims 2
- 210000003411 telomere Anatomy 0.000 claims 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 108091008928 CXC chemokine receptors Proteins 0.000 claims 1
- 102000054900 CXCR Receptors Human genes 0.000 claims 1
- 241000511343 Chondrostoma nasus Species 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 108091005682 Receptor kinases Proteins 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 102000016548 Vascular Endothelial Growth Factor Receptor-1 Human genes 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000010893 malignant breast melanoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000017426 precursor B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022001374A JP2022050550A (ja) | 2016-02-19 | 2022-01-07 | 核酸キャリア及び治療上の使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297194P | 2016-02-19 | 2016-02-19 | |
| US62/297,194 | 2016-02-19 | ||
| PCT/US2017/018323 WO2017143156A1 (en) | 2016-02-19 | 2017-02-17 | Nucleic acid carriers and therapeutic methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001374A Division JP2022050550A (ja) | 2016-02-19 | 2022-01-07 | 核酸キャリア及び治療上の使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511474A JP2019511474A (ja) | 2019-04-25 |
| JP2019511474A5 true JP2019511474A5 (enExample) | 2020-03-12 |
| JP7366541B2 JP7366541B2 (ja) | 2023-10-23 |
Family
ID=59625528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543674A Active JP7366541B2 (ja) | 2016-02-19 | 2017-02-17 | 核酸キャリア及び治療上の使用方法 |
| JP2022001374A Pending JP2022050550A (ja) | 2016-02-19 | 2022-01-07 | 核酸キャリア及び治療上の使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001374A Pending JP2022050550A (ja) | 2016-02-19 | 2022-01-07 | 核酸キャリア及び治療上の使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12338435B2 (enExample) |
| EP (1) | EP3416671A4 (enExample) |
| JP (2) | JP7366541B2 (enExample) |
| AU (2) | AU2017220012B2 (enExample) |
| IL (1) | IL260983B (enExample) |
| WO (1) | WO2017143156A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3416691A4 (en) * | 2016-02-19 | 2020-02-26 | Genisphere, LLC | SUPPORTS OF NUCLEIC ACIDS AND THEIR THERAPEUTIC METHODS OF USE |
| JP7366541B2 (ja) | 2016-02-19 | 2023-10-23 | コード バイオセラピューティクス インコーポレイテッド | 核酸キャリア及び治療上の使用方法 |
| WO2017189805A1 (en) | 2016-04-27 | 2017-11-02 | Abbvie Inc. | Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies |
| CN108866635B (zh) * | 2017-05-09 | 2021-11-26 | 安升（上海）医药科技有限公司 | 多特异性蛋白药物及其文库、以及制备方法和应用 |
| US20190269728A1 (en) | 2018-03-02 | 2019-09-05 | Sixfold Bioscience Ltd. | Compositions for delivery of cargo to cells |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US20210308273A1 (en) | 2018-08-02 | 2021-10-07 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| JP2021533200A (ja) | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | 顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用 |
| CA3112793A1 (en) * | 2018-09-14 | 2020-03-19 | Northwestern University | Programming protein polymerization with dna |
| CN111196855B (zh) * | 2018-11-19 | 2022-11-15 | 三生国健药业（上海）股份有限公司 | 抗egfr/pd-1双特异性抗体 |
| AU2020329466B2 (en) * | 2019-08-12 | 2024-08-01 | Abl Bio Inc. | Anti-claudin 18.2 and anti-4-1BB bispecific antibodies and uses thereof |
| US20230183746A1 (en) | 2019-08-30 | 2023-06-15 | Sixfold Bioscience Ltd. | Compositions for transfer of cargo to cells |
| CN116249547B (zh) | 2019-11-04 | 2025-11-14 | 代码生物疗法公司 | 脑特异性血管生成抑制剂1(bai1)抗体及其用途 |
| EP4143316A2 (en) | 2020-04-27 | 2023-03-08 | Sixfold Bioscience Ltd. | Compositions containing nucleic acid nanoparticles with modular functionality |
| CN115177740A (zh) * | 2021-04-01 | 2022-10-14 | 安升（上海）医药科技有限公司 | 核酸自组装介导的adc药物的构建方法及应用 |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| EP4366784A1 (en) | 2021-07-09 | 2024-05-15 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating dystrophinopathies |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11648318B2 (en) | 2021-07-09 | 2023-05-16 | Dyne Therapeutics, Inc. | Anti-transferrin receptor (TFR) antibody and uses thereof |
| KR20250004770A (ko) | 2022-04-15 | 2025-01-08 | 다인 세라퓨틱스, 인크. | 근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체 및 제제 |
Family Cites Families (176)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3641235A (en) | 1968-11-01 | 1972-02-08 | Miles Lab | Immunological reagent and process for making same |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3966897A (en) | 1973-04-02 | 1976-06-29 | Marine Colloids, Inc. | Medium for use in bioassay and method of using same |
| US3959078A (en) | 1973-05-18 | 1976-05-25 | Midwest Research Institute | Enzyme immobilization with a thermochemical-photochemical bifunctional agent |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| SE388694B (sv) | 1975-01-27 | 1976-10-11 | Kabi Ab | Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| IL52322A (en) | 1976-06-18 | 1980-10-26 | Alfa Laval Ab | Method of making reagent test device and device made accorording to this method |
| US4094647A (en) | 1976-07-02 | 1978-06-13 | Thyroid Diagnostics, Inc. | Test device |
| US4196281A (en) | 1976-10-20 | 1980-04-01 | Regents Of The University Of California | Psoralens |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4299916A (en) | 1979-12-26 | 1981-11-10 | Syva Company | Preferential signal production on a surface in immunoassays |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4347312A (en) | 1980-03-20 | 1982-08-31 | Research Triangle Institute | Detection of antibiotics in milk |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| US4425438A (en) | 1981-03-13 | 1984-01-10 | Bauman David S | Assay method and device |
| US5141875A (en) | 1982-01-08 | 1992-08-25 | Environmental Diagnostics, Inc. | Rotary fluid manipulator |
| US5073484A (en) | 1982-03-09 | 1991-12-17 | Bio-Metric Systems, Inc. | Quantitative analysis apparatus and method |
| DE3327642A1 (de) | 1983-07-30 | 1985-02-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung eines partners einer immunreaktion sowie reagens zur durchfuehrung dieses verfahrens |
| EP0149168B1 (en) | 1983-12-19 | 1991-04-24 | Daiichi Pure Chemicals Co. Ltd. | Immunoassay |
| US4695554A (en) | 1984-02-14 | 1987-09-22 | Becton Dickinson And Company | Sac or liposome containing dye (sulforhodamine) for immunoassay |
| US4703017C1 (en) | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| US4743560A (en) | 1984-03-26 | 1988-05-10 | Becton Dickinson And Company | Solid phase assay |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| AU602694B2 (en) | 1986-06-09 | 1990-10-25 | Ortho Diagnostic Systems Inc. | Improved colloidal gold membrane assay |
| US5514602A (en) | 1986-06-09 | 1996-05-07 | Ortho Diagnostic Systems, Inc. | Method of producing a metal sol reagent containing colloidal metal particles |
| US5175270A (en) | 1986-09-10 | 1992-12-29 | Polyprobe, Inc. | Reagents for detecting and assaying nucleic acid sequences |
| US4960691A (en) | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| USRE38430E1 (en) | 1987-03-27 | 2004-02-17 | Becton, Dickinson And Company | Solid phase chromatographic immunoassay |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| US4857453A (en) | 1987-04-07 | 1989-08-15 | Syntex (U.S.A.) Inc. | Immunoassay device |
| ES2150428T3 (es) | 1987-04-27 | 2000-12-01 | Unilever Nv | Ensayos de union especifica. |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US4956302A (en) | 1987-09-11 | 1990-09-11 | Abbott Laboratories | Lateral flow chromatographic binding assay device |
| US5275785A (en) | 1987-10-30 | 1994-01-04 | Unilever Patent Holdings B.V. | Test device for detecting an analyte in a liquid sample |
| ES2050697T3 (es) | 1987-12-21 | 1994-06-01 | Abbott Lab | Metodos y dispositivos de ensayo de fijacion cromatografico. |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| ATE118824T1 (de) | 1989-03-10 | 1995-03-15 | Amoco Corp | Immobilisierte oligonukleotidsonden und ihre verwendungen. |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5168053A (en) | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5075078A (en) | 1989-10-05 | 1991-12-24 | Abbott Laboratories | Self-performing immunochromatographic device |
| US5252496A (en) | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| KR910014706A (ko) | 1990-01-10 | 1991-08-31 | 원본미기재 | 세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치 |
| US6395492B1 (en) | 1990-01-11 | 2002-05-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| DE69123979T2 (de) | 1990-10-12 | 1997-04-30 | Max Planck Gesellschaft | Abgeänderte ribozyme |
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| JP3267613B2 (ja) | 1991-05-30 | 2002-03-18 | アボツト・ラボラトリーズ | イオン捕獲結合アッセイにおける非特異的結合遮断薬を含む試薬 |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| FI92882C (fi) | 1992-12-29 | 1995-01-10 | Medix Biochemica Ab Oy | Kertakäyttöinen testiliuska ja menetelmä sen valmistamiseksi |
| DE69433036T2 (de) | 1993-09-03 | 2004-05-27 | Isis Pharmaceuticals, Inc., Carlsbad | Aminoderivatisierte nukleoside und oligonukleoside |
| PT653639E (pt) | 1993-11-12 | 2000-06-30 | Unilever Nv | Equipamentos analiticos e metodos para a sua utilizacao |
| PL182237B1 (pl) | 1994-03-07 | 2001-11-30 | Dow Chemical Co | Sposób przeprowadzania transfekcji komórek i osiagniecia biodostepnosci materialu genetycznego in vitro i ex vivo PL PL |
| GB9419267D0 (en) | 1994-09-23 | 1994-11-09 | Unilever Plc | Assay devices |
| GB9505425D0 (en) | 1995-03-17 | 1995-05-03 | Unilever Plc | Assay devices |
| US5653979A (en) | 1995-03-30 | 1997-08-05 | Trustees Of The University Of Pennsylvania | Immunotargeting of plasminogen activators to the pulmonary endothelium |
| US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
| SE9501671D0 (sv) | 1995-05-05 | 1995-05-05 | Pharmacia Ab | Method and composition for prevention of posterior capsule opacification |
| AU6720096A (en) | 1995-08-09 | 1997-03-05 | Quidel Corporation | Test strip and method for one step lateral flow assay |
| US6072043A (en) | 1996-06-04 | 2000-06-06 | Polyprobe, Inc. | Optimally fluorescent oligonucleotides |
| US5846737A (en) | 1996-07-26 | 1998-12-08 | Molecular Probes, Inc. | Conjugates of sulforhodamine fluorophores with enhanced fluorescence |
| US6117631A (en) | 1996-10-29 | 2000-09-12 | Polyprobe, Inc. | Detection of antigens via oligonucleotide antibody conjugates |
| GB2322192B (en) | 1997-02-14 | 2001-01-31 | Unilever Plc | Assay devices |
| US6924153B1 (en) | 1997-03-06 | 2005-08-02 | Quidel Corporation | Quantitative lateral flow assays and devices |
| WO1999005284A1 (fr) | 1997-07-25 | 1999-02-04 | Agene Research Institute, Co., Ltd. | GENE HUMAIN RecQ4 CODANT HELICASE |
| EP1005573B1 (en) * | 1997-07-29 | 2006-05-24 | Polyprobe, Inc. | Dendritic nucleic acids exhibiting maximal self-assembly |
| WO1999040438A1 (en) | 1998-02-03 | 1999-08-12 | Synbiotics Corporation | Device and method to detect immunoprotective antibody titers |
| AU753303B2 (en) | 1998-03-10 | 2002-10-17 | Trustees Of The University Of Pennsylvania, The | Enhancement of intracellular delivery and tissue targeting of drugs and genes |
| US6287765B1 (en) | 1998-05-20 | 2001-09-11 | Molecular Machines, Inc. | Methods for detecting and identifying single molecules |
| US7041287B2 (en) | 1998-05-21 | 2006-05-09 | Trustees Of The University Of Pennsylvania | Compositions and methods for selective dissolution of nascent intravascular blood clots |
| AU762670B2 (en) | 1998-05-21 | 2003-07-03 | Trustees Of The University Of Pennsylvania, The | Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots |
| ATE310536T1 (de) | 1998-08-04 | 2005-12-15 | Univ Pennsylvania | Zielrichtung und verlängerte assoziation von wirkstoffen an die luminale oberfläche der pulmonaren vaskularen endothelzellen |
| US6656730B1 (en) | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
| US7674466B2 (en) | 1999-08-05 | 2010-03-09 | The Trustees Of The University Of Pennsylvania | Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells using antibodies that bind to ICAM-1 |
| US6822086B1 (en) | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| US6773928B1 (en) | 1999-09-22 | 2004-08-10 | The United States Of America As Represented By The Secretary Of The Army | Compositions and methods for enhancing bioassay performance |
| US6180357B1 (en) | 1999-10-08 | 2001-01-30 | Arius Research, Inc. | Individualized patient-specific anti-cancer antibodies |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US6506600B2 (en) | 2000-03-22 | 2003-01-14 | University Of Arkansas | Secreting products from skin by adeno-associated virus (AAV) gene transfer |
| US20010036460A1 (en) | 2000-04-06 | 2001-11-01 | Sawicki Janet A. | Targeted death cancer cells |
| EP1282449A2 (en) | 2000-05-12 | 2003-02-12 | The Regents Of The University Of California | Treatment of human papillomavirus (hpv)-infected cells |
| ATE375516T1 (de) | 2000-06-12 | 2007-10-15 | Fujirebio Kk | Immuntest zur messung des humanen c-peptides sowie reagenzienkit hierfür |
| ATE388402T1 (de) | 2000-07-19 | 2008-03-15 | Genisphere Inc | Verfahren zur erkennung und zum assay von nukleinsäuresequenzen |
| US6770487B2 (en) | 2001-05-01 | 2004-08-03 | Ischemia Technologies, Inc. | Bar code readable diagnostic strip test |
| US20070173473A1 (en) | 2001-05-18 | 2007-07-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA) |
| AU2002345847B2 (en) | 2001-06-21 | 2008-05-29 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
| GR1003966B (el) | 2001-10-16 | 2002-08-06 | Εμβαπτιζομενος χαρτης αποξηραμενων αντιδραστηριων και μεθοδος για την ανιχνευση η και προσδιορισμο ειδικων αλληλουχιων νουκλεικων οξεων | |
| EP1461606A4 (en) | 2001-12-05 | 2005-06-29 | Univ Washington | MICROFLUIDIC DEVICE AND SURFACE DECORATION PROCESS FOR SOLID PHASE AFFINITY BINDING ASSAYS |
| US20040023248A1 (en) | 2001-12-07 | 2004-02-05 | Whitehead Institiute For Biomedical Research | Methods and reagents for improving nucleic acid detection |
| AU2002357932A1 (en) | 2001-12-18 | 2003-06-30 | Whitehead Institute For Biomedical Research | Fusion partner cells and uses thereof |
| US7175992B2 (en) | 2002-04-10 | 2007-02-13 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| EP1530581A4 (en) | 2002-06-12 | 2006-08-30 | Datascope Investment Corp | POLYMERIC MARKING MOLECULES |
| EP2392345A3 (en) | 2002-07-18 | 2012-03-07 | Cytos Biotechnology AG | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| AU2003269557A1 (en) | 2002-10-18 | 2004-05-04 | Lg Life Sciences Ltd. | Gene families associated with cancers |
| MXPA05004588A (es) | 2002-10-29 | 2005-12-14 | Coley Pharmaceutical Group Ltd | Metodos y productos relacionados con el tratamiento y prevencion de infeccion de virus de hepatitis c. |
| DK2284266T3 (da) | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| WO2004053104A2 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5’ cpg nucleic acids and methods of use |
| WO2004062602A2 (en) | 2003-01-09 | 2004-07-29 | Arizeke Pharmaceuticals Inc. | Compositions and methods for targeted biological delivery of molecular carriers |
| BRPI0407446A (pt) | 2003-02-13 | 2006-01-31 | Pharmacia Corp | Anticorpos para c-met para o tratamento de cânceres |
| US20040220084A1 (en) | 2003-05-02 | 2004-11-04 | Jasbir Sandhu | Methods for nucleic acid delivery |
| CA2525367A1 (en) | 2003-05-09 | 2004-11-25 | The Trustees Of The University Of Pennsylvania | Use of citrate lyase inhibitors and tricarboxylate transporter inhibitors in the treatment of cancer |
| US7317532B2 (en) | 2003-06-04 | 2008-01-08 | Inverness Medical Switzerland Gmbh | Flow sensing for determination of assay results |
| US7223544B2 (en) | 2003-06-27 | 2007-05-29 | Cornell Research Foundation, Inc. | Nucleic acid-engineered materials |
| US7445906B2 (en) | 2003-06-30 | 2008-11-04 | East Carolina University | Method of detecting cancer using delta-catenin |
| US7238538B2 (en) | 2003-09-19 | 2007-07-03 | Freitag Helmut E | Chromatographic assay device and methods |
| US20060228404A1 (en) | 2004-03-04 | 2006-10-12 | Anderson Daniel G | Compositions and methods for treatment of hypertrophic tissues |
| US20050215507A1 (en) | 2004-03-04 | 2005-09-29 | Massachusetts Institute Of Technology | Therapeutic anti-cancer DNA |
| KR101147147B1 (ko) | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| WO2005113571A2 (en) | 2004-05-13 | 2005-12-01 | The University Of North Carolina At Chapel Hill | Methods for the delivery of oligomeric compounds |
| US20060040879A1 (en) | 2004-08-21 | 2006-02-23 | Kosak Kenneth M | Chloroquine coupled nucleic acids and methods for their synthesis |
| US8445293B2 (en) | 2005-02-09 | 2013-05-21 | Rapid Pathogen Screening, Inc. | Method to increase specificity and/or accuracy of lateral flow immunoassays |
| WO2006098804A2 (en) | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US8067572B2 (en) | 2005-05-25 | 2011-11-29 | The University Of York | Hybrid interfering RNA |
| EP1893292A2 (en) | 2005-05-26 | 2008-03-05 | Thomas Jefferson University | Method to treat and prevent posterior capsule opacification |
| US20070015166A1 (en) | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
| US20100136614A1 (en) | 2005-10-18 | 2010-06-03 | Dan Luo | Dendrimer-like modular delivery vector |
| WO2008039206A2 (en) | 2005-10-05 | 2008-04-03 | The Trustees Of The University Of Pennsylvania | Fusion proteins for inhibition and dissolution of coagulation |
| US20120003727A1 (en) | 2006-03-10 | 2012-01-05 | Javanbakhsh Esfandiari | Immunoassay Device for Detecting Antibodies and Antigens |
| US20070225213A1 (en) | 2006-03-23 | 2007-09-27 | Kosak Matthew K | Nucleic acid carriers for delivery of therapeutic agents |
| JP2008195613A (ja) | 2006-12-19 | 2008-08-28 | Nissei Bio Kk | マイクロ微粒子製剤および医薬組成物 |
| DK2308514T3 (da) | 2007-03-23 | 2013-09-02 | To Bbb Holding B V | Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren |
| US9217151B2 (en) * | 2007-05-16 | 2015-12-22 | California Institute Of Technology | Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| WO2008147526A1 (en) | 2007-05-23 | 2008-12-04 | The Trustees Of The University Of Pennsylvania | Targeted carriers for intracellular drug delivery |
| MX2010001194A (es) * | 2007-07-31 | 2010-07-30 | Univ Louisiana State | Conjugado de polipeptido-acido nucleico para inmunoprofilaxis o inmunoterapia para desordenes neoplasicos o infecciones. |
| US9029524B2 (en) | 2007-12-10 | 2015-05-12 | California Institute Of Technology | Signal activated RNA interference |
| BRPI0821417A2 (pt) | 2007-12-26 | 2015-06-16 | Biotest Ag | Método para diminuir a adesão de células de estroma a células tumorais que expressam cd138 em células tumorais de um indivíduo em necessidade do mesmo |
| WO2009086552A1 (en) | 2008-01-02 | 2009-07-09 | The Trustees Of The University Of Pennsylvania | Targeting recombinant therapeutics to circulating red blood cells |
| US20090297479A1 (en) | 2008-03-28 | 2009-12-03 | Kiyoshi Ariizumi | Dc-hil conjugates for treatment of t-cell disorders |
| US20110160090A1 (en) | 2008-05-05 | 2011-06-30 | Los Alamos National Laboratory | Nanocrystal-Based Lateral Flow Microarrays and Low-Voltage Signal Detection Systems |
| EP2657342B1 (en) * | 2008-08-08 | 2015-11-18 | Genisphere, LLC | DNA dendrimers protected against nuclease degradation |
| WO2010045518A1 (en) | 2008-10-16 | 2010-04-22 | The Trustees Of The University Of Pennsylvania | Compositions containing thrombomodulin domains and uses thereof |
| WO2010065920A1 (en) | 2008-12-04 | 2010-06-10 | Lankenau Institute For Medical Research | Compositions and methods for the treatment and prevention of lens fibrotic diseases |
| WO2010107960A1 (en) | 2009-03-17 | 2010-09-23 | Brody Jonathan R | Methods for assessing the efficacy of gemcitabine or ara-c treatment of cancer using human antigen r levels |
| AU2010244428B2 (en) | 2009-05-06 | 2015-01-29 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| US20100323018A1 (en) | 2009-06-17 | 2010-12-23 | Massachusetts Institute Of Technology | Branched DNA/RNA monomers and uses thereof |
| US20110206611A1 (en) | 2010-02-24 | 2011-08-25 | Genisphere, Llc | DNA Dendrimers as Thermal Ablation Devices |
| US20130018086A1 (en) | 2010-03-16 | 2013-01-17 | Massachusette Institute Of Technology | Sirnas targeting exon 10 of pyruvate kinase m2 |
| JP4638555B1 (ja) | 2010-09-08 | 2011-02-23 | 田中貴金属工業株式会社 | 核酸又は免疫クロマトグラフィー用試薬組成物、核酸又は免疫クロマトグラフィー測定方法及び核酸又は免疫クロマトグラフィー測定用キット |
| WO2012061402A2 (en) | 2010-11-01 | 2012-05-10 | Syracuse University | System and method for delivery of dna-binding chemotherapy drugs using nanoparticles |
| US20140212503A1 (en) | 2011-03-17 | 2014-07-31 | Hyukjin Lee | Delivery system |
| EP2998320B1 (en) | 2011-04-19 | 2018-07-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| WO2013134768A1 (en) | 2012-03-09 | 2013-09-12 | Lankenau Institute For Medical Research | Compositions and methods for treating cancer |
| RU2644263C2 (ru) | 2012-06-27 | 2018-02-08 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения селективных и мультиспецифических терапевтических молекул с заданными свойствами, включающих по меньшей мере две различные нацеливающие группировки, и их применения |
| US9651549B2 (en) | 2012-07-13 | 2017-05-16 | Genisphere, Llc | Lateral flow assays using DNA dendrimers |
| EP2895211B1 (en) | 2012-09-12 | 2017-10-18 | Boston Scientific Scimed, Inc. | Adhesive stent coating for anti-migration |
| HK1214628A1 (zh) | 2012-11-05 | 2016-07-29 | Pronai Therapeutics, Inc. | 寡核苷酸癌症療法的給藥和施用 |
| CN105073141A (zh) | 2013-02-01 | 2015-11-18 | 詹尼斯费尔公司 | 用于将基因递送到细胞的功能化dna树状聚合物 |
| EP2976109B1 (en) | 2013-03-21 | 2018-07-25 | Genisphere, LLC | Cellular delivery of dna intercalating agents |
| MX376384B (es) | 2013-11-27 | 2025-03-07 | Zymeworks Bc Inc | Construcciones de union a antigenos biespecificas dirigidas a her2. |
| GB201502645D0 (en) | 2015-02-17 | 2015-04-01 | Touchlight Genetics Ltd | Method |
| EP3289084B1 (en) | 2015-04-17 | 2020-09-16 | Genisphere, LLC | siRNA INHIBITION OF HUMAN ANTIGEN R EXPRESSION FOR TREATMENT OF CANCER |
| JP7366541B2 (ja) | 2016-02-19 | 2023-10-23 | コード バイオセラピューティクス インコーポレイテッド | 核酸キャリア及び治療上の使用方法 |
| EP3416691A4 (en) | 2016-02-19 | 2020-02-26 | Genisphere, LLC | SUPPORTS OF NUCLEIC ACIDS AND THEIR THERAPEUTIC METHODS OF USE |
| CN116249547B (zh) * | 2019-11-04 | 2025-11-14 | 代码生物疗法公司 | 脑特异性血管生成抑制剂1(bai1)抗体及其用途 |
-
2017
- 2017-02-17 JP JP2018543674A patent/JP7366541B2/ja active Active
- 2017-02-17 EP EP17753899.8A patent/EP3416671A4/en active Pending
- 2017-02-17 WO PCT/US2017/018323 patent/WO2017143156A1/en not_active Ceased
- 2017-02-17 US US15/999,774 patent/US12338435B2/en active Active
- 2017-02-17 AU AU2017220012A patent/AU2017220012B2/en active Active
- 2017-02-17 IL IL260983A patent/IL260983B/en unknown
-
2022
- 2022-01-07 JP JP2022001374A patent/JP2022050550A/ja active Pending
- 2022-06-09 US US17/836,304 patent/US20230136794A1/en active Pending
-
2024
- 2024-04-11 AU AU2024202345A patent/AU2024202345A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019511474A5 (enExample) | ||
| JP2019513692A5 (enExample) | ||
| JP7366541B2 (ja) | 核酸キャリア及び治療上の使用方法 | |
| JP7516459B2 (ja) | 核酸キャリア及び治療上の使用方法 | |
| JP7691757B2 (ja) | 改変された免疫細胞およびその使用 | |
| JP2025102836A (ja) | 抗ｃｔｌａ４／抗ｐｄ－１二重特異性抗体及びその使用 | |
| CN111315395A (zh) | 白细胞介素-18变体和使用方法 | |
| IL302639A (en) | Engineered chimeric fusion protein compositions and methods of use thereof | |
| CN112654346B (zh) | 生物分子包覆颗粒和薄膜及其用途 | |
| EP3768328A1 (en) | Gene regulation via conditional nuclear localization of gene modulating polypeptides | |
| TWI771643B (zh) | 一種新穎的ｃｄ１６陽性自然殺手細胞及一種培養ｃｄ１６陽性自然殺手細胞的方法 | |
| JP7551066B2 (ja) | 血液悪性腫瘍の治療のための二重特異性ｃｄ１２３×ｃｄ３ダイアボディ | |
| CN113061580A (zh) | 一种经修饰的免疫效应细胞及其制备方法 | |
| WO2021223376A1 (zh) | 嵌合性抗原受体及表达其的巨噬细胞、调节巨噬细胞极化的方法和应用 | |
| CN110494158A (zh) | 使用包含优化的多功能t细胞的嵌合受体t细胞进行治疗 | |
| EP3927830A2 (en) | Chimeric polypeptides and methods of using the same | |
| CA3229746A1 (en) | Methods of making chimeric antigen receptor-expressing cells | |
| WO2019238023A1 (en) | Neoantigen vaccines and uses thereof | |
| WO2021146521A1 (en) | A novel cd16+ natural killer cell and a method of culturing cd16+ natural killer cell | |
| US20210180067A1 (en) | Nucleic acid aptamers | |
| WO2021119349A1 (en) | Chimeric receptor polypeptide and methods of activation thereof | |
| CN117425481A (zh) | 工程化嵌合融合蛋白组合物及其使用方法 | |
| WO2022192691A1 (en) | Engineered immune cells and uses thereof | |
| KR20250107811A (ko) | 조작된 키메라 융합 단백질 조성물 및 그의 사용 방법 | |
| WO2025026102A1 (zh) | EGFR/c-Met双特异性抗体及其应用 |