JP2019511460A5 - - Google Patents
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- Publication number
- JP2019511460A5 JP2019511460A5 JP2018540011A JP2018540011A JP2019511460A5 JP 2019511460 A5 JP2019511460 A5 JP 2019511460A5 JP 2018540011 A JP2018540011 A JP 2018540011A JP 2018540011 A JP2018540011 A JP 2018540011A JP 2019511460 A5 JP2019511460 A5 JP 2019511460A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cancer
- group
- tumor
- heterocycloalkylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021200772A JP7825984B2 (ja) | 2016-01-29 | 2021-12-10 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
| JP2025176252A JP2026016502A (ja) | 2016-01-29 | 2025-10-20 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2016/015817 | 2016-01-29 | ||
| PCT/US2016/015817 WO2016123571A1 (en) | 2015-01-30 | 2016-01-29 | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy |
| US201662308325P | 2016-03-15 | 2016-03-15 | |
| US62/308,325 | 2016-03-15 | ||
| US201662425403P | 2016-11-22 | 2016-11-22 | |
| US62/425,403 | 2016-11-22 | ||
| PCT/US2017/015608 WO2017132661A2 (en) | 2016-01-29 | 2017-01-30 | G protein-coupled receptor (gpcr) modulation by imipridones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021200772A Division JP7825984B2 (ja) | 2016-01-29 | 2021-12-10 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511460A JP2019511460A (ja) | 2019-04-25 |
| JP2019511460A5 true JP2019511460A5 (enExample) | 2020-03-05 |
| JP7030701B2 JP7030701B2 (ja) | 2022-03-07 |
Family
ID=59398848
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540011A Active JP7030701B2 (ja) | 2016-01-29 | 2017-01-30 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
| JP2021200772A Active JP7825984B2 (ja) | 2016-01-29 | 2021-12-10 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
| JP2025176252A Pending JP2026016502A (ja) | 2016-01-29 | 2025-10-20 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021200772A Active JP7825984B2 (ja) | 2016-01-29 | 2021-12-10 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
| JP2025176252A Pending JP2026016502A (ja) | 2016-01-29 | 2025-10-20 | イミプリドンによるｇタンパク質共役受容体（ｇｐｃｒ）の調節 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11116771B2 (enExample) |
| EP (2) | EP4524567A3 (enExample) |
| JP (3) | JP7030701B2 (enExample) |
| KR (2) | KR20250065717A (enExample) |
| CN (2) | CN115844895B (enExample) |
| AU (2) | AU2017211423B2 (enExample) |
| BR (1) | BR112018015590A2 (enExample) |
| CA (2) | CA3294566A1 (enExample) |
| DK (1) | DK3408298T3 (enExample) |
| ES (1) | ES3012491T3 (enExample) |
| FI (1) | FI3408298T3 (enExample) |
| HR (1) | HRP20250207T1 (enExample) |
| HU (1) | HUE070208T2 (enExample) |
| IL (3) | IL286923B2 (enExample) |
| LT (1) | LT3408298T (enExample) |
| MA (1) | MA43879B1 (enExample) |
| MX (2) | MX2018009227A (enExample) |
| NZ (1) | NZ745425A (enExample) |
| PL (1) | PL3408298T3 (enExample) |
| PT (1) | PT3408298T (enExample) |
| RS (1) | RS66519B1 (enExample) |
| SG (2) | SG11201806401YA (enExample) |
| SI (1) | SI3408298T1 (enExample) |
| SM (1) | SMT202500086T1 (enExample) |
| WO (1) | WO2017132661A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3408298T3 (en) * | 2016-01-29 | 2025-03-03 | Oncoceutics Inc | G protein-coupled receptor (gpcr) modulation by imipridones |
| US10172862B2 (en) * | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| WO2019055835A1 (en) * | 2017-09-15 | 2019-03-21 | The Regents Of The University Of California | DETECTION OF SOMATIC MONONUCLEOTIDE VARIANTS FROM ACELLULAR NUCLEIC ACID WITH APPLICATION TO MINIMUM RESIDUAL DISEASE SURVEILLANCE |
| US11674963B2 (en) | 2017-09-27 | 2023-06-13 | The Regents Of The University Of California | GPCRs in cancer-associated fibroblasts |
| CA3089864A1 (en) | 2018-01-31 | 2019-08-08 | Mayo Foundation For Medical Education And Research | Methods of treating fibrotic pathologies |
| JP2021521141A (ja) * | 2018-04-09 | 2021-08-26 | オージェネシス インコーポレイテッド | バイオキソーム粒子、レドキソーム、それらの作製方法、及びそれらを含む組成物 |
| CN109157656B (zh) * | 2018-10-15 | 2021-08-27 | 重庆医科大学附属永川医院 | 一种双靶标肿瘤疫苗及其制备方法和应用 |
| JP2022520997A (ja) * | 2019-02-22 | 2022-04-04 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | イミプリドンを使用する方法 |
| KR20220041847A (ko) | 2019-07-30 | 2022-04-01 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 섬유성 병리를 치료하기 위한 화합물 및 방법 |
| KR102403686B1 (ko) | 2020-05-15 | 2022-05-31 | 뉴로핏 주식회사 | 뇌자극 위치 제공장치 및 방법 |
| MX2023001576A (es) | 2020-08-06 | 2023-05-09 | Eoetvoes Lorand Tudomanyegyetem | Síntesis de nuevos derivados de imipridona y su evaluación de su actividad anticáncerigena. |
| CN112402439A (zh) * | 2020-11-18 | 2021-02-26 | 西安组织工程与再生医学研究所 | miR-325核酸类似物在制备改善肝胶原沉积相关产品中的应用 |
| US11648248B1 (en) | 2022-01-12 | 2023-05-16 | King Abdulaziz University | Potent antimicrobial compounds with a pyridazine nucleus |
| CA3263639A1 (en) * | 2022-08-03 | 2024-02-08 | Xiandong SHI | QUANTITATIVE METHOD FOR DETERMINING A MENTAL STATE BASED ON DRD1 AND/OR DRD5, AND ITS APPLICATION |
| CN115531378B (zh) * | 2022-10-19 | 2023-10-13 | 中国医学科学院医药生物技术研究所 | Pht427作为ndm-1与kpc-2双重抑制剂的应用 |
| WO2024157207A1 (en) * | 2023-01-25 | 2024-08-02 | Gpcr Therapeutics, Inc. | Gpcr inhibitors and uses thereof |
| EP4698146A1 (en) * | 2023-04-20 | 2026-02-25 | Institut Gustave-Roussy | Liquid and solid compositions of imipridone derivatives |
| CN116731136B (zh) * | 2023-08-04 | 2023-12-05 | 齐鲁工业大学(山东省科学院) | H3k23a组蛋白点突变在提高酿酒酵母乙酸耐受性及木糖发酵性能中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2150062A1 (de) | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US4783450A (en) | 1987-04-13 | 1988-11-08 | Warner-Lambert Company | Use of commercial lecithin as skin penetration enhancer |
| WO2004014909A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
| WO2004082570A2 (en) | 2003-03-17 | 2004-09-30 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dopamine receptor d2 (drd2) |
| US20070026402A1 (en) | 2003-07-08 | 2007-02-01 | Noble Ernest P | Genetic marker of response to atypical antipsychotics and antidepressants methods for use thereof |
| US8088895B2 (en) | 2006-10-18 | 2012-01-03 | Chemocentryx, Inc. | Antibodies that bind CXCR7 epitopes |
| WO2009039207A1 (en) | 2007-09-19 | 2009-03-26 | Oncofluor, Inc. | Method for imaging and treating organs and tissues |
| JP2014509323A (ja) | 2011-02-28 | 2014-04-17 | マックマスター ユニヴァーシティ | ドーパミン受容体遮断薬による癌の処置 |
| SMT202000272T1 (it) * | 2011-04-29 | 2020-07-08 | Penn State Res Found | Induzione del gene trail da parte di cellule normali e tumorali mediante una piccola molecola come terapia anticancro |
| US9688679B2 (en) | 2013-03-13 | 2017-06-27 | Oncoceutics, Inc. | 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy |
| KR20220123335A (ko) | 2013-03-13 | 2022-09-06 | 온코슈틱스 인코포레이티드 | 7-벤질-10-(2-메틸벤질)-2,6,7,8,9,10-헥사하이드로이미다조[1,2-a]피리도[4,3-d]피리미딘-5(3h)-온과의 조합 치료요법 |
| WO2015073072A1 (en) * | 2013-11-15 | 2015-05-21 | Oncoceutics, Inc. | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one |
| US9376437B2 (en) * | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| ES2724331T3 (es) | 2013-11-15 | 2019-09-10 | Oncoceutics Inc | 7-Bencil-4-(2-metilbencil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1H)-ona, sales de la misma y procedimientos de uso |
| ES2999685T3 (en) * | 2014-03-31 | 2025-02-26 | Scripps Research Inst | Pharmacophore for trail induction |
| MD3805222T2 (ro) * | 2015-01-30 | 2025-04-30 | Oncoceutics Inc | Derivați de 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1H)-ona, sărurile acestora și utilizarea acestora în terapie |
| CN104860948B (zh) * | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
| DK3408298T3 (en) * | 2016-01-29 | 2025-03-03 | Oncoceutics Inc | G protein-coupled receptor (gpcr) modulation by imipridones |
| US10172862B2 (en) | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
-
2017
- 2017-01-30 DK DK17745078.0T patent/DK3408298T3/da active
- 2017-01-30 LT LTEPPCT/US2017/015608T patent/LT3408298T/lt unknown
- 2017-01-30 EP EP24210288.7A patent/EP4524567A3/en active Pending
- 2017-01-30 FI FIEP17745078.0T patent/FI3408298T3/fi active
- 2017-01-30 MX MX2018009227A patent/MX2018009227A/es unknown
- 2017-01-30 SG SG11201806401YA patent/SG11201806401YA/en unknown
- 2017-01-30 MA MA43879A patent/MA43879B1/fr unknown
- 2017-01-30 HR HRP20250207TT patent/HRP20250207T1/hr unknown
- 2017-01-30 SM SM20250086T patent/SMT202500086T1/it unknown
- 2017-01-30 IL IL286923A patent/IL286923B2/en unknown
- 2017-01-30 WO PCT/US2017/015608 patent/WO2017132661A2/en not_active Ceased
- 2017-01-30 SI SI201731593T patent/SI3408298T1/sl unknown
- 2017-01-30 EP EP17745078.0A patent/EP3408298B1/en active Active
- 2017-01-30 PL PL17745078.0T patent/PL3408298T3/pl unknown
- 2017-01-30 HU HUE17745078A patent/HUE070208T2/hu unknown
- 2017-01-30 CN CN202211658374.3A patent/CN115844895B/zh active Active
- 2017-01-30 PT PT177450780T patent/PT3408298T/pt unknown
- 2017-01-30 NZ NZ745425A patent/NZ745425A/en unknown
- 2017-01-30 RS RS20250172A patent/RS66519B1/sr unknown
- 2017-01-30 ES ES17745078T patent/ES3012491T3/es active Active
- 2017-01-30 CN CN201780015327.8A patent/CN109311980B/zh active Active
- 2017-01-30 CA CA3294566A patent/CA3294566A1/en active Pending
- 2017-01-30 BR BR112018015590-0A patent/BR112018015590A2/pt not_active Application Discontinuation
- 2017-01-30 CA CA3013044A patent/CA3013044A1/en active Pending
- 2017-01-30 AU AU2017211423A patent/AU2017211423B2/en active Active
- 2017-01-30 JP JP2018540011A patent/JP7030701B2/ja active Active
- 2017-01-30 US US16/073,228 patent/US11116771B2/en active Active
- 2017-01-30 IL IL316540A patent/IL316540A/en unknown
- 2017-01-30 KR KR1020257013550A patent/KR20250065717A/ko active Pending
- 2017-01-30 SG SG10202108306UA patent/SG10202108306UA/en unknown
- 2017-01-30 KR KR1020187024948A patent/KR102801670B1/ko active Active
-
2018
- 2018-07-26 IL IL260815A patent/IL260815B/en unknown
- 2018-07-27 MX MX2023004443A patent/MX2023004443A/es unknown
-
2021
- 2021-07-29 US US17/388,551 patent/US20220072001A1/en active Pending
- 2021-12-10 JP JP2021200772A patent/JP7825984B2/ja active Active
-
2022
- 2022-01-28 AU AU2022200583A patent/AU2022200583B2/en active Active
-
2025
- 2025-10-20 JP JP2025176252A patent/JP2026016502A/ja active Pending
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