JP2019510086A5 - - Google Patents
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- Publication number
- JP2019510086A5 JP2019510086A5 JP2018567019A JP2018567019A JP2019510086A5 JP 2019510086 A5 JP2019510086 A5 JP 2019510086A5 JP 2018567019 A JP2018567019 A JP 2018567019A JP 2018567019 A JP2018567019 A JP 2018567019A JP 2019510086 A5 JP2019510086 A5 JP 2019510086A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- naphthalene
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 102000030914 Fatty Acid-Binding Human genes 0.000 claims 8
- 108091022862 fatty acid binding Proteins 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- -1 and R 14 is CF 3 Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307262P | 2016-03-11 | 2016-03-11 | |
| US62/307,262 | 2016-03-11 | ||
| PCT/US2017/021711 WO2017156354A1 (en) | 2016-03-11 | 2017-03-10 | α-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510086A JP2019510086A (ja) | 2019-04-11 |
| JP2019510086A5 true JP2019510086A5 (enExample) | 2020-04-16 |
| JP6976581B2 JP6976581B2 (ja) | 2021-12-08 |
Family
ID=59789897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567019A Active JP6976581B2 (ja) | 2016-03-11 | 2017-03-10 | α−トルキシル酸誘導体およびその医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10968163B2 (enExample) |
| EP (1) | EP3452441B1 (enExample) |
| JP (1) | JP6976581B2 (enExample) |
| KR (1) | KR102365059B1 (enExample) |
| CN (1) | CN109415295B (enExample) |
| AU (1) | AU2017230790B2 (enExample) |
| BR (1) | BR112018068414B1 (enExample) |
| CA (1) | CA3017496A1 (enExample) |
| EA (1) | EA201892045A1 (enExample) |
| ES (1) | ES3055898T3 (enExample) |
| MX (1) | MX2018010801A (enExample) |
| PL (1) | PL3452441T3 (enExample) |
| SG (2) | SG10202008700VA (enExample) |
| WO (1) | WO2017156354A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2874987B1 (en) | 2012-07-20 | 2020-03-25 | The Research Foundation Of State University Of New York | alpha-AND gamma-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
| JP6976581B2 (ja) * | 2016-03-11 | 2021-12-08 | ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク | α−トルキシル酸誘導体およびその医薬組成物 |
| US20230017948A1 (en) * | 2019-11-25 | 2023-01-19 | The Research Foundation For The State University Of New York | Combination therapy using fabp5 inhibitors with taxanes for treatment of cancer |
| MX2023004171A (es) * | 2020-10-08 | 2023-07-07 | Univ New York State Res Found | Derivados de monoéster de ácido truxílico como inhibidores selectivos de fabp5 y composiciones farmacéuticas y usos de estos. |
| CN117298091A (zh) * | 2023-11-01 | 2023-12-29 | 张凯楠 | Sbfi-26在制备用于预防肝纤维化药物中的用途 |
| WO2025193881A1 (en) * | 2024-03-12 | 2025-09-18 | Artelo Biosciences Incorporated | Enantiomers that inhibit fatty acid binding protein 5 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903297A (en) | 1973-11-01 | 1975-09-02 | Upjohn Co | Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs |
| JP2001199884A (ja) | 2000-01-21 | 2001-07-24 | Seiwa Yakuhin Kk | 鎮痛作用剤 |
| ES2189602B1 (es) * | 2000-10-11 | 2004-08-01 | Universidad De Murcia | Procedimiento para la inmovilizacion de un ligando sobre un soporte. |
| JP2002154959A (ja) * | 2000-11-15 | 2002-05-28 | Seiwa Yakuhin Kk | 鎮痛抗炎症作用剤 |
| US6984645B2 (en) | 2001-11-16 | 2006-01-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2010083532A1 (en) | 2009-01-19 | 2010-07-22 | The Research Foundaton Of State University Of New York | Fatty acid binding proteins as drug targets for modulation of endocannabinoids |
| CN101838239B (zh) | 2010-02-02 | 2012-03-21 | 中国科学院广州生物医药与健康研究院 | 一种吡唑类化合物及其组合物和应用 |
| EP2874987B1 (en) * | 2012-07-20 | 2020-03-25 | The Research Foundation Of State University Of New York | alpha-AND gamma-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
| BR112015004008A8 (pt) * | 2012-09-12 | 2018-01-23 | Hoffmann La Roche | novas tiofenilamidas não anuladas |
| JP6976581B2 (ja) * | 2016-03-11 | 2021-12-08 | ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク | α−トルキシル酸誘導体およびその医薬組成物 |
-
2017
- 2017-03-10 JP JP2018567019A patent/JP6976581B2/ja active Active
- 2017-03-10 WO PCT/US2017/021711 patent/WO2017156354A1/en not_active Ceased
- 2017-03-10 BR BR112018068414-7A patent/BR112018068414B1/pt active IP Right Grant
- 2017-03-10 SG SG10202008700VA patent/SG10202008700VA/en unknown
- 2017-03-10 EA EA201892045A patent/EA201892045A1/ru unknown
- 2017-03-10 CN CN201780016751.4A patent/CN109415295B/zh active Active
- 2017-03-10 KR KR1020187028746A patent/KR102365059B1/ko active Active
- 2017-03-10 PL PL17764162.8T patent/PL3452441T3/pl unknown
- 2017-03-10 MX MX2018010801A patent/MX2018010801A/es unknown
- 2017-03-10 US US16/080,493 patent/US10968163B2/en active Active
- 2017-03-10 SG SG11201807365QA patent/SG11201807365QA/en unknown
- 2017-03-10 CA CA3017496A patent/CA3017496A1/en active Pending
- 2017-03-10 EP EP17764162.8A patent/EP3452441B1/en active Active
- 2017-03-10 ES ES17764162T patent/ES3055898T3/es active Active
- 2017-03-10 AU AU2017230790A patent/AU2017230790B2/en active Active
-
2021
- 2021-02-11 US US17/174,030 patent/US11739047B2/en active Active
-
2023
- 2023-07-03 US US18/346,363 patent/US20240092725A1/en active Pending