JP2019509978A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019509978A5 JP2019509978A5 JP2018536481A JP2018536481A JP2019509978A5 JP 2019509978 A5 JP2019509978 A5 JP 2019509978A5 JP 2018536481 A JP2018536481 A JP 2018536481A JP 2018536481 A JP2018536481 A JP 2018536481A JP 2019509978 A5 JP2019509978 A5 JP 2019509978A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocycle
- nhco
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCN(CC)S(*)CC Chemical compound CCCCN(CC)S(*)CC 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021182946A JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662278122P | 2016-01-13 | 2016-01-13 | |
| US62/278,122 | 2016-01-13 | ||
| PCT/US2017/013323 WO2017123860A1 (en) | 2016-01-13 | 2017-01-13 | Spiroheptane salicylamides and related compounds as inhibitors of rock |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182946A Division JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509978A JP2019509978A (ja) | 2019-04-11 |
| JP2019509978A5 true JP2019509978A5 (enExample) | 2020-02-20 |
| JP6976953B2 JP6976953B2 (ja) | 2021-12-08 |
Family
ID=57907009
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536481A Active JP6976953B2 (ja) | 2016-01-13 | 2017-01-13 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
| JP2021182946A Active JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182946A Active JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10611776B2 (enExample) |
| EP (2) | EP3954681A1 (enExample) |
| JP (2) | JP6976953B2 (enExample) |
| KR (1) | KR102725741B1 (enExample) |
| CN (1) | CN108699038B (enExample) |
| AR (1) | AR107354A1 (enExample) |
| AU (2) | AU2017206820B2 (enExample) |
| BR (1) | BR112018013780B1 (enExample) |
| CA (1) | CA3010900A1 (enExample) |
| CL (1) | CL2018001899A1 (enExample) |
| CO (1) | CO2018008173A2 (enExample) |
| CY (1) | CY1124858T1 (enExample) |
| EA (1) | EA036172B1 (enExample) |
| ES (1) | ES2898698T3 (enExample) |
| HR (1) | HRP20211888T1 (enExample) |
| HU (1) | HUE057455T2 (enExample) |
| IL (1) | IL260448B (enExample) |
| LT (1) | LT3402790T (enExample) |
| MA (2) | MA43862A (enExample) |
| MX (2) | MX382434B (enExample) |
| PL (1) | PL3402790T3 (enExample) |
| PT (1) | PT3402790T (enExample) |
| RS (1) | RS62690B1 (enExample) |
| SG (1) | SG11201805927YA (enExample) |
| SI (1) | SI3402790T1 (enExample) |
| SM (1) | SMT202100660T1 (enExample) |
| TW (1) | TWI730032B (enExample) |
| UY (1) | UY37073A (enExample) |
| WO (1) | WO2017123860A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR103990A1 (es) | 2015-01-09 | 2017-06-21 | Bristol Myers Squibb Co | Ureas cíclicas como inhibidoras de rock |
| US10112929B2 (en) | 2015-03-09 | 2018-10-30 | Bristol-Myers Squibb Company | Lactams as inhibitors of rock |
| PL3722284T3 (pl) | 2016-01-13 | 2025-03-31 | Grünenthal GmbH | Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu |
| AR107354A1 (es) * | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| LT3402782T (lt) | 2016-01-13 | 2020-10-12 | Grünenthal GmbH | 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekano dariniai |
| MX378995B (es) | 2016-01-13 | 2025-03-11 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. |
| PL3402784T3 (pl) | 2016-01-13 | 2020-09-21 | Grünenthal GmbH | Pochodne 3-((hetero-)arylo)-alkilo-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekanu |
| BR112018068703B1 (pt) | 2016-03-16 | 2024-02-06 | Kura Oncology, Inc. | Inibidores substituídos de menin-mll e métodos de uso |
| CN109153663B (zh) | 2016-05-27 | 2021-08-13 | 百时美施贵宝公司 | 作为rock抑制剂的三唑酮类化合物和四唑酮类化合物 |
| ES2829550T3 (es) | 2016-07-07 | 2021-06-01 | Bristol Myers Squibb Co | Ureas cíclicas espiro-condensadas como inhibidores de ROCK |
| JP7113810B2 (ja) | 2016-07-07 | 2022-08-05 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロラクタム |
| ES2814325T3 (es) | 2016-07-07 | 2021-03-26 | Bristol Myers Squibb Co | Derivados de lactama, urea cíclica y carbamato y de triazolona como inhibidores potentes y selectivos de ROCK |
| WO2018102325A1 (en) | 2016-11-30 | 2018-06-07 | Bristol-Myers Squibb Company | Tricyclic rho kinase inhibitors |
| US12060341B2 (en) | 2017-07-12 | 2024-08-13 | Bristol-Myers Squibb Company | Spiroheptanyl hydantoins as ROCK inhibitors |
| EP3652167B1 (en) * | 2017-07-12 | 2021-06-02 | Bristol-Myers Squibb Company | Spiroheptanyl hydantoins as rock inhibitors |
| TW201908293A (zh) * | 2017-07-12 | 2019-03-01 | 美商必治妥美雅史谷比公司 | 作為rock抑制劑之5員及雙環雜環醯胺 |
| WO2019014303A1 (en) * | 2017-07-12 | 2019-01-17 | Bristol-Myers Squibb Company | 5-OR 6,6-CHANNEL BICYCLIC CHAINS AND AMINOHETEROCYCLIC AMINOHETEROCYCLIC INHIBITORS FOR THE TREATMENT OF CARDIAC INSUFFICIENCY |
| CN110869360B (zh) | 2017-07-12 | 2023-12-15 | 百时美施贵宝公司 | 作为rock抑制剂的苯乙酰胺类 |
| WO2019060365A1 (en) * | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE |
| US11192891B2 (en) | 2017-11-03 | 2021-12-07 | Bristol-Myers Squibb Company | Diazaspiro ROCK inhibitors |
| KR102815312B1 (ko) * | 2018-04-17 | 2025-05-30 | 템페스트 테라퓨틱스, 인크. | 비시클릭 카르복스아미드 및 그의 사용 방법 |
| AU2022385051A1 (en) | 2021-11-11 | 2024-06-20 | Actualeyes Inc. | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
| JP7797234B2 (ja) | 2022-02-18 | 2026-01-13 | キヤノン株式会社 | 保持装置、リソグラフィ装置、および物品製造方法 |
| WO2024013736A1 (en) * | 2022-07-12 | 2024-01-18 | Adama Makhteshim Ltd. | Process for preparing substituted benzamides |
| WO2024229439A2 (en) * | 2023-05-03 | 2024-11-07 | The University Of Chicago | Inhibitors of nsun1- and nsun2-mediated active structures |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025247783A1 (en) | 2024-05-29 | 2025-12-04 | Syngenta Crop Protection Ag | Pesticidally active dihydro-benzoxazinone compounds |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2007142323A1 (ja) * | 2006-06-08 | 2009-10-29 | 宇部興産株式会社 | 側鎖にスピロ環構造を有する新規インダゾール誘導体 |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| JP5405314B2 (ja) * | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノロン誘導体 |
| CL2007003874A1 (es) | 2007-01-03 | 2008-05-16 | Boehringer Ingelheim Int | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
| RU2010131010A (ru) * | 2007-12-26 | 2012-02-10 | Санофи-Авентис (Fr) | Способ получения 6-замещенных-1-(2н)-изохинолинонов |
| PE20140913A1 (es) | 2010-11-15 | 2014-08-22 | Abbvie Inc | Inhibidores de nampt y rock |
| US9221767B2 (en) | 2013-01-18 | 2015-12-29 | Bristol-Myers Squibb Company | Substituted phthalazinones as rock inhibitors |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| TW201506024A (zh) | 2013-07-02 | 2015-02-16 | 必治妥美雅史谷比公司 | 作為有效ｒｏｃｋ抑制劑的三環甲醯胺衍生物 |
| JP6522602B2 (ja) | 2013-07-02 | 2019-05-29 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としての三環式ピリド−カルボキサミド誘導体 |
| US9902702B2 (en) * | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| US10112939B2 (en) | 2014-08-21 | 2018-10-30 | Bristol-Myers Squibb Company | Tied-back benzamide derivatives as potent rock inhibitors |
| AR103990A1 (es) | 2015-01-09 | 2017-06-21 | Bristol Myers Squibb Co | Ureas cíclicas como inhibidoras de rock |
| US10112929B2 (en) | 2015-03-09 | 2018-10-30 | Bristol-Myers Squibb Company | Lactams as inhibitors of rock |
| AR107354A1 (es) * | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| CN109153663B (zh) | 2016-05-27 | 2021-08-13 | 百时美施贵宝公司 | 作为rock抑制剂的三唑酮类化合物和四唑酮类化合物 |
| JP7113810B2 (ja) | 2016-07-07 | 2022-08-05 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロラクタム |
| ES2814325T3 (es) | 2016-07-07 | 2021-03-26 | Bristol Myers Squibb Co | Derivados de lactama, urea cíclica y carbamato y de triazolona como inhibidores potentes y selectivos de ROCK |
| ES2829550T3 (es) | 2016-07-07 | 2021-06-01 | Bristol Myers Squibb Co | Ureas cíclicas espiro-condensadas como inhibidores de ROCK |
| WO2018102325A1 (en) | 2016-11-30 | 2018-06-07 | Bristol-Myers Squibb Company | Tricyclic rho kinase inhibitors |
-
2017
- 2017-01-12 AR ARP170100088A patent/AR107354A1/es unknown
- 2017-01-12 TW TW106101072A patent/TWI730032B/zh active
- 2017-01-12 UY UY0001037073A patent/UY37073A/es unknown
- 2017-01-13 WO PCT/US2017/013323 patent/WO2017123860A1/en not_active Ceased
- 2017-01-13 EA EA201891557A patent/EA036172B1/ru not_active IP Right Cessation
- 2017-01-13 PL PL17701785T patent/PL3402790T3/pl unknown
- 2017-01-13 SG SG11201805927YA patent/SG11201805927YA/en unknown
- 2017-01-13 BR BR112018013780-4A patent/BR112018013780B1/pt active IP Right Grant
- 2017-01-13 AU AU2017206820A patent/AU2017206820B2/en active Active
- 2017-01-13 EP EP21193297.5A patent/EP3954681A1/en active Pending
- 2017-01-13 PT PT177017852T patent/PT3402790T/pt unknown
- 2017-01-13 HR HRP20211888TT patent/HRP20211888T1/hr unknown
- 2017-01-13 MA MA043862A patent/MA43862A/fr unknown
- 2017-01-13 CA CA3010900A patent/CA3010900A1/en active Pending
- 2017-01-13 US US16/067,619 patent/US10611776B2/en active Active
- 2017-01-13 LT LTEPPCT/US2017/013323T patent/LT3402790T/lt unknown
- 2017-01-13 MX MX2018008219A patent/MX382434B/es unknown
- 2017-01-13 SI SI201730984T patent/SI3402790T1/sl unknown
- 2017-01-13 ES ES17701785T patent/ES2898698T3/es active Active
- 2017-01-13 SM SM20210660T patent/SMT202100660T1/it unknown
- 2017-01-13 CN CN201780015453.3A patent/CN108699038B/zh active Active
- 2017-01-13 HU HUE17701785A patent/HUE057455T2/hu unknown
- 2017-01-13 MA MA055633A patent/MA55633A/fr unknown
- 2017-01-13 EP EP17701785.2A patent/EP3402790B1/en active Active
- 2017-01-13 JP JP2018536481A patent/JP6976953B2/ja active Active
- 2017-01-13 KR KR1020187022838A patent/KR102725741B1/ko active Active
- 2017-01-13 RS RS20211514A patent/RS62690B1/sr unknown
-
2018
- 2018-07-02 MX MX2021005311A patent/MX2021005311A/es unknown
- 2018-07-05 IL IL260448A patent/IL260448B/en active IP Right Grant
- 2018-07-12 CL CL2018001899A patent/CL2018001899A1/es unknown
- 2018-08-01 CO CONC2018/0008173A patent/CO2018008173A2/es unknown
-
2020
- 2020-01-10 US US16/739,363 patent/US10829501B2/en active Active
-
2021
- 2021-08-26 AU AU2021221872A patent/AU2021221872A1/en not_active Abandoned
- 2021-11-10 JP JP2021182946A patent/JP7268116B2/ja active Active
- 2021-12-09 CY CY20211101084T patent/CY1124858T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019509978A5 (enExample) | ||
| JP2020526565A5 (enExample) | ||
| JP2016505042A5 (enExample) | ||
| JP2017504641A5 (enExample) | ||
| JP2017525744A5 (enExample) | ||
| JP2017504642A5 (enExample) | ||
| JP2014532070A5 (enExample) | ||
| JP2014521701A5 (enExample) | ||
| HRP20211888T1 (hr) | Spiroheptan salicilamidi i srodni spojevi kao rock inhibitori | |
| JP2009524694A5 (enExample) | ||
| IL298983A (en) | Macrocyclines with P2' heterocyclic groups as factor XIA inhibitors | |
| JP2007528379A5 (enExample) | ||
| JP2019520396A5 (enExample) | ||
| JP2018507238A5 (enExample) | ||
| RU2356891C9 (ru) | Производные пиридинкарбоксамида и их соли для применения в качестве инсектицида | |
| JP2020526547A5 (enExample) | ||
| JP2019094345A5 (enExample) | ||
| JP2019517475A5 (enExample) | ||
| JP2020527560A5 (enExample) | ||
| JP2020521730A5 (enExample) | ||
| JP2019518041A5 (enExample) | ||
| JP2010513447A5 (enExample) | ||
| JP2017505762A5 (enExample) | ||
| SI3022192T1 (en) | Piperidinyl indole derivatives and their use as inhibitors of complementary factor B | |
| JP2006506373A5 (enExample) |