JP2019509978A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019509978A5 JP2019509978A5 JP2018536481A JP2018536481A JP2019509978A5 JP 2019509978 A5 JP2019509978 A5 JP 2019509978A5 JP 2018536481 A JP2018536481 A JP 2018536481A JP 2018536481 A JP2018536481 A JP 2018536481A JP 2019509978 A5 JP2019509978 A5 JP 2019509978A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocycle
- nhco
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCN(CC)S(*)CC Chemical compound CCCCN(CC)S(*)CC 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021182946A JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662278122P | 2016-01-13 | 2016-01-13 | |
| US62/278,122 | 2016-01-13 | ||
| PCT/US2017/013323 WO2017123860A1 (en) | 2016-01-13 | 2017-01-13 | Spiroheptane salicylamides and related compounds as inhibitors of rock |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182946A Division JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509978A JP2019509978A (ja) | 2019-04-11 |
| JP2019509978A5 true JP2019509978A5 (enExample) | 2020-02-20 |
| JP6976953B2 JP6976953B2 (ja) | 2021-12-08 |
Family
ID=57907009
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536481A Active JP6976953B2 (ja) | 2016-01-13 | 2017-01-13 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
| JP2021182946A Active JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182946A Active JP7268116B2 (ja) | 2016-01-13 | 2021-11-10 | Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10611776B2 (enExample) |
| EP (2) | EP3954681A1 (enExample) |
| JP (2) | JP6976953B2 (enExample) |
| KR (1) | KR102725741B1 (enExample) |
| CN (1) | CN108699038B (enExample) |
| AR (1) | AR107354A1 (enExample) |
| AU (2) | AU2017206820B2 (enExample) |
| BR (1) | BR112018013780B1 (enExample) |
| CA (1) | CA3010900A1 (enExample) |
| CL (1) | CL2018001899A1 (enExample) |
| CO (1) | CO2018008173A2 (enExample) |
| CY (1) | CY1124858T1 (enExample) |
| EA (1) | EA036172B1 (enExample) |
| ES (1) | ES2898698T3 (enExample) |
| HR (1) | HRP20211888T1 (enExample) |
| HU (1) | HUE057455T2 (enExample) |
| IL (1) | IL260448B (enExample) |
| LT (1) | LT3402790T (enExample) |
| MA (2) | MA43862A (enExample) |
| MX (2) | MX382434B (enExample) |
| PE (1) | PE20181562A1 (enExample) |
| PL (1) | PL3402790T3 (enExample) |
| PT (1) | PT3402790T (enExample) |
| RS (1) | RS62690B1 (enExample) |
| SG (1) | SG11201805927YA (enExample) |
| SI (1) | SI3402790T1 (enExample) |
| SM (1) | SMT202100660T1 (enExample) |
| TW (1) | TWI730032B (enExample) |
| UY (1) | UY37073A (enExample) |
| WO (1) | WO2017123860A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6779214B2 (ja) | 2015-01-09 | 2020-11-04 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としての環状ウレア |
| ES2730112T3 (es) | 2015-03-09 | 2019-11-08 | Bristol Myers Squibb Co | Lactamas como inhibidores de ROCK |
| JP6893517B2 (ja) | 2016-01-13 | 2021-06-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
| RS60855B1 (sr) | 2016-01-13 | 2020-10-30 | Gruenenthal Gmbh | Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| TWI635082B (zh) | 2016-01-13 | 2018-09-11 | 歌林達有限公司 | ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 |
| MX378995B (es) | 2016-01-13 | 2025-03-11 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. |
| TWI730032B (zh) * | 2016-01-13 | 2021-06-11 | 美商必治妥美雅史谷比公司 | 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物 |
| WO2017161028A1 (en) | 2016-03-16 | 2017-09-21 | Kura Oncology, Inc. | Substituted inhibitors of menin-mll and methods of use |
| WO2017205709A1 (en) | 2016-05-27 | 2017-11-30 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
| ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
| EP3481816B1 (en) | 2016-07-07 | 2020-06-24 | Bristol-Myers Squibb Company | Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors |
| JP7155102B2 (ja) | 2016-07-07 | 2022-10-18 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロ縮合環尿素 |
| EP3548468B1 (en) | 2016-11-30 | 2020-09-16 | Bristol-Myers Squibb Company | Tricyclic rho kinase inhibitors |
| JP7234201B2 (ja) * | 2017-07-12 | 2023-03-07 | ブリストル－マイヤーズ スクイブ カンパニー | 心不全の治療のためのｒｏｃｋの５員アミノヘテロ環および５，６－または６，６員二環式アミノヘテロ環の阻害剤 |
| US12060341B2 (en) | 2017-07-12 | 2024-08-13 | Bristol-Myers Squibb Company | Spiroheptanyl hydantoins as ROCK inhibitors |
| CN110914257B (zh) | 2017-07-12 | 2023-05-26 | 百时美施贵宝公司 | 作为rock抑制剂的螺庚基乙内酰脲 |
| TW201908293A (zh) | 2017-07-12 | 2019-03-01 | 美商必治妥美雅史谷比公司 | 作為rock抑制劑之5員及雙環雜環醯胺 |
| WO2019014300A1 (en) | 2017-07-12 | 2019-01-17 | Bristol-Myers Squibb Company | PHENYLACETAMIDES AS ROCK INHIBITORS |
| TW201920170A (zh) * | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
| ES2937039T3 (es) | 2017-11-03 | 2023-03-23 | Bristol Myers Squibb Co | Inhibidores diazaespiro de ROCK |
| CN112313208B (zh) * | 2018-04-17 | 2024-04-19 | 泰普斯特医疗公司 | 双环羧酰胺及其使用方法 |
| CA3238227A1 (en) | 2021-11-11 | 2023-05-19 | The Doshisha | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
| JP7797234B2 (ja) | 2022-02-18 | 2026-01-13 | キヤノン株式会社 | 保持装置、リソグラフィ装置、および物品製造方法 |
| IL318203A (en) * | 2022-07-12 | 2025-03-01 | Adama Makhteshim Ltd | Process for preparing modified benzamides |
| WO2024229439A2 (en) * | 2023-05-03 | 2024-11-07 | The University Of Chicago | Inhibitors of nsun1- and nsun2-mediated active structures |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025247783A1 (en) | 2024-05-29 | 2025-12-04 | Syngenta Crop Protection Ag | Pesticidally active dihydro-benzoxazinone compounds |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2007142323A1 (ja) * | 2006-06-08 | 2009-10-29 | 宇部興産株式会社 | 側鎖にスピロ環構造を有する新規インダゾール誘導体 |
| EP2526948A1 (en) | 2006-09-20 | 2012-11-28 | Aerie Pharmaceuticals, Inc. | RHO kinase inhibitors |
| CN101595094B (zh) * | 2006-12-27 | 2013-02-20 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹诺酮衍生物 |
| CL2007003874A1 (es) | 2007-01-03 | 2008-05-16 | Boehringer Ingelheim Int | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
| KR20100103646A (ko) * | 2007-12-26 | 2010-09-27 | 사노피-아벤티스 | ６치환된１（２ｈ）이소퀴놀리논의 제조 방법 |
| SG10202010119TA (en) | 2010-11-15 | 2020-11-27 | Abbvie Inc | NAMPT And Rock Inhibitors |
| ES2684776T3 (es) | 2013-01-18 | 2018-10-04 | Bristol-Myers Squibb Company | Ftalazinonas e isoquinolinonas como inhibidores de ROCK |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| WO2015002926A1 (en) | 2013-07-02 | 2015-01-08 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
| JP6434968B2 (ja) | 2013-07-02 | 2018-12-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としての三環式ピリド−カルボキサミド誘導体 |
| US9902702B2 (en) * | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| CN107108581B (zh) | 2014-08-21 | 2020-06-23 | 百时美施贵宝公司 | 作为强效rock抑制剂的回接苯甲酰胺衍生物 |
| JP6779214B2 (ja) | 2015-01-09 | 2020-11-04 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としての環状ウレア |
| ES2730112T3 (es) | 2015-03-09 | 2019-11-08 | Bristol Myers Squibb Co | Lactamas como inhibidores de ROCK |
| TWI730032B (zh) * | 2016-01-13 | 2021-06-11 | 美商必治妥美雅史谷比公司 | 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物 |
| WO2017205709A1 (en) | 2016-05-27 | 2017-11-30 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
| JP7155102B2 (ja) | 2016-07-07 | 2022-10-18 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロ縮合環尿素 |
| EP3481816B1 (en) | 2016-07-07 | 2020-06-24 | Bristol-Myers Squibb Company | Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors |
| ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
| EP3548468B1 (en) | 2016-11-30 | 2020-09-16 | Bristol-Myers Squibb Company | Tricyclic rho kinase inhibitors |
-
2017
- 2017-01-12 TW TW106101072A patent/TWI730032B/zh active
- 2017-01-12 AR ARP170100088A patent/AR107354A1/es unknown
- 2017-01-12 UY UY0001037073A patent/UY37073A/es unknown
- 2017-01-13 SI SI201730984T patent/SI3402790T1/sl unknown
- 2017-01-13 PL PL17701785T patent/PL3402790T3/pl unknown
- 2017-01-13 ES ES17701785T patent/ES2898698T3/es active Active
- 2017-01-13 EA EA201891557A patent/EA036172B1/ru not_active IP Right Cessation
- 2017-01-13 PE PE2018001279A patent/PE20181562A1/es unknown
- 2017-01-13 WO PCT/US2017/013323 patent/WO2017123860A1/en not_active Ceased
- 2017-01-13 CN CN201780015453.3A patent/CN108699038B/zh active Active
- 2017-01-13 MX MX2018008219A patent/MX382434B/es unknown
- 2017-01-13 PT PT177017852T patent/PT3402790T/pt unknown
- 2017-01-13 RS RS20211514A patent/RS62690B1/sr unknown
- 2017-01-13 CA CA3010900A patent/CA3010900A1/en active Pending
- 2017-01-13 SG SG11201805927YA patent/SG11201805927YA/en unknown
- 2017-01-13 SM SM20210660T patent/SMT202100660T1/it unknown
- 2017-01-13 MA MA043862A patent/MA43862A/fr unknown
- 2017-01-13 BR BR112018013780-4A patent/BR112018013780B1/pt active IP Right Grant
- 2017-01-13 KR KR1020187022838A patent/KR102725741B1/ko active Active
- 2017-01-13 MA MA055633A patent/MA55633A/fr unknown
- 2017-01-13 HR HRP20211888TT patent/HRP20211888T1/hr unknown
- 2017-01-13 HU HUE17701785A patent/HUE057455T2/hu unknown
- 2017-01-13 EP EP21193297.5A patent/EP3954681A1/en active Pending
- 2017-01-13 AU AU2017206820A patent/AU2017206820B2/en active Active
- 2017-01-13 LT LTEPPCT/US2017/013323T patent/LT3402790T/lt unknown
- 2017-01-13 JP JP2018536481A patent/JP6976953B2/ja active Active
- 2017-01-13 US US16/067,619 patent/US10611776B2/en active Active
- 2017-01-13 EP EP17701785.2A patent/EP3402790B1/en active Active
-
2018
- 2018-07-02 MX MX2021005311A patent/MX2021005311A/es unknown
- 2018-07-05 IL IL260448A patent/IL260448B/en active IP Right Grant
- 2018-07-12 CL CL2018001899A patent/CL2018001899A1/es unknown
- 2018-08-01 CO CONC2018/0008173A patent/CO2018008173A2/es unknown
-
2020
- 2020-01-10 US US16/739,363 patent/US10829501B2/en active Active
-
2021
- 2021-08-26 AU AU2021221872A patent/AU2021221872A1/en not_active Abandoned
- 2021-11-10 JP JP2021182946A patent/JP7268116B2/ja active Active
- 2021-12-09 CY CY20211101084T patent/CY1124858T1/el unknown