JP2009524694A5 - - Google Patents
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- Publication number
- JP2009524694A5 JP2009524694A5 JP2008552602A JP2008552602A JP2009524694A5 JP 2009524694 A5 JP2009524694 A5 JP 2009524694A5 JP 2008552602 A JP2008552602 A JP 2008552602A JP 2008552602 A JP2008552602 A JP 2008552602A JP 2009524694 A5 JP2009524694 A5 JP 2009524694A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- cyano
- isoquinoline
- carbonyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(*)=O)NC(c1nc(CC2=NC2)c(c(*)c(*)c(*)c2*)c2c1O*)=* Chemical compound *C(C(*)=O)NC(c1nc(CC2=NC2)c(c(*)c(*)c(*)c2*)c2c1O*)=* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76278006P | 2006-01-27 | 2006-01-27 | |
| US60/762,780 | 2006-01-27 | ||
| PCT/US2007/061171 WO2007090068A2 (en) | 2006-01-27 | 2007-01-26 | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524694A JP2009524694A (ja) | 2009-07-02 |
| JP2009524694A5 true JP2009524694A5 (enExample) | 2011-03-10 |
| JP5161793B2 JP5161793B2 (ja) | 2013-03-13 |
Family
ID=38042727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552602A Expired - Fee Related JP5161793B2 (ja) | 2006-01-27 | 2007-01-26 | 低酸素症誘導因子(hif)を安定化するシアノイソキノリン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US7928120B2 (enExample) |
| EP (2) | EP2476669A1 (enExample) |
| JP (1) | JP5161793B2 (enExample) |
| KR (2) | KR101446499B1 (enExample) |
| CN (3) | CN103382216B (enExample) |
| AU (1) | AU2007211077B2 (enExample) |
| BR (1) | BRPI0707302B8 (enExample) |
| CA (1) | CA2640435C (enExample) |
| DK (1) | DK2044028T3 (enExample) |
| IL (1) | IL193047A (enExample) |
| MX (1) | MX2008009581A (enExample) |
| NO (1) | NO342678B1 (enExample) |
| RU (1) | RU2457204C2 (enExample) |
| WO (1) | WO2007090068A2 (enExample) |
| ZA (1) | ZA200806752B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1644336T3 (pl) | 2003-06-06 | 2011-07-29 | Fibrogen Inc | Związki heteroarylowe zawierające azot i ich zastosowanie w zwiększaniu poziomu endogennej erytropoetyny |
| US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| KR101446499B1 (ko) * | 2006-01-27 | 2014-10-06 | 피브로겐, 인크. | 저산소증 유발가능 인자(hif)를 안정시키는 시아노이소퀴놀린 화합물 |
| AU2007218051A1 (en) * | 2006-02-16 | 2007-08-30 | Fibrogen, Inc. | Compounds and methods for treatment of stroke |
| CA2647596C (en) * | 2006-04-04 | 2012-06-12 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as hif modulators |
| WO2009002533A1 (en) * | 2007-06-27 | 2008-12-31 | The Brigham And Women's Hospital, Inc. | Inflammatory bowel disease therapies |
| US20110039878A1 (en) * | 2007-11-02 | 2011-02-17 | Volkmar Guenzler-Pukall | Methods for reducing blood pressure |
| US8269008B2 (en) * | 2007-12-03 | 2012-09-18 | Fibrogen, Inc. | Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions |
| US20110039885A1 (en) * | 2007-12-06 | 2011-02-17 | Fibrogen, Inc. | Methods for increasing endothelial progenitor cells |
| WO2009075826A1 (en) * | 2007-12-07 | 2009-06-18 | Fibrogen, Inc. | Methods for increasing white blood cells |
| EP2252619B1 (en) | 2008-01-11 | 2013-10-09 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity |
| WO2009100250A1 (en) | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
| ES2524883T3 (es) * | 2008-03-18 | 2014-12-15 | Merck Sharp & Dohme Corp. | 4-Hidroxipirimidina-5-carboxamidas sustituidas |
| WO2009134750A1 (en) | 2008-04-28 | 2009-11-05 | Janssen Pharmaceutica Nv | Benzoimidazoles as prolyl hydroxylase inhibitors |
| EP2334682B1 (en) | 2008-08-20 | 2017-10-04 | Fibrogen, Inc. | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators |
| WO2010024911A1 (en) * | 2008-08-26 | 2010-03-04 | Fibrogen, Inc. | Methods for increasing neurogenesis |
| EP2370422B1 (en) | 2008-11-14 | 2019-06-05 | Fibrogen, Inc. | Thiochromene derivatives as hif hydroxylase inhibitors |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| EP2670750B1 (en) | 2011-02-02 | 2016-09-14 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor |
| GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
| WO2012150221A2 (de) | 2011-05-04 | 2012-11-08 | Bayer Cropscience Ag | Neue halogenierte benzylalkoholester der cyclopropancarbonsäure als schädlingsbekämpfungsmittel |
| WO2012150208A1 (de) | 2011-05-04 | 2012-11-08 | Bayer Cropscience Ag | Verwendung von substituierten benzylalkoholestern der cyclopropancarbonsäure zur bekämpfung von insektizid-resistenten insekten |
| KR102029951B1 (ko) * | 2011-07-22 | 2019-11-08 | 베이징 베타 파머수티컬 컴퍼니 리미티드 | 프로릴 히드록실라제 억제제로서 화합물의 다형체형, 및 이의 용도 |
| GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
| ES2818977T3 (es) | 2011-10-25 | 2021-04-14 | Janssen Pharmaceutica Nv | Método para obtener cristales de sal de meglumina de ácido 1-(5,6-dicloro-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-carboxílico |
| NZ700760A (en) | 2012-03-09 | 2016-08-26 | Fibrogen Inc | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| SG10201700873UA (en) | 2012-07-16 | 2017-04-27 | Fibrogen Inc | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
| CA2879238C (en) | 2012-07-16 | 2021-08-10 | Fibrogen, Inc. | Process for making isoquinoline compounds |
| ES2668694T3 (es) * | 2012-07-27 | 2018-05-21 | Biogen Ma Inc. | Derivados de ácido 1-[7-(cis-4-metil-ciclohexiloxi)-8-trifluorometil-naftalen-2-ilmetil]-piperidin-4-carboxílico como moduladores de autotaxina (ATX) para tratar inflamaciones y trastornos autoinmunitarios |
| JP6437456B2 (ja) * | 2013-01-24 | 2018-12-12 | フィブロジェン インコーポレイテッド | {[1−シアノ−5−(4−クロロフェノキシ)−4−ヒドロキシ−イソキノリン−3−カルボニル]−アミノ}−酢酸の結晶形態 |
| CN110448537A (zh) | 2013-06-06 | 2019-11-15 | 菲布罗根有限公司 | Hif羟化酶抑制剂的药物制剂 |
| EP2915878A1 (en) | 2014-03-07 | 2015-09-09 | Institut Pasteur | Method and device for conserving viable and functional human polymorphonuclear neutrophils |
| WO2016034108A1 (zh) | 2014-09-02 | 2016-03-10 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其应用 |
| TWI770552B (zh) | 2014-12-24 | 2022-07-11 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| PT3237397T (pt) * | 2014-12-24 | 2019-02-08 | Gilead Sciences Inc | Compostos de isoquinolina para o tratamento de hiv |
| JP6385584B2 (ja) | 2014-12-24 | 2018-09-05 | ギリアード サイエンシーズ, インコーポレイテッド | Hivの処置のための縮合ピリミジン化合物 |
| CN106146395B (zh) | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| CN104892509B (zh) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
| KR102333180B1 (ko) * | 2015-08-05 | 2021-11-30 | 삼성전자주식회사 | 플렉서블 디스플레이 장치를 구비한 전자 장치 |
| CN106083720B (zh) * | 2016-02-28 | 2018-09-11 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的杂芳基化合物及包含该化合物的组合物及其用途 |
| CN106478503A (zh) * | 2016-09-29 | 2017-03-08 | 上海勋和医药科技有限公司 | Roxadustat中间体的制备方法 |
| CN107954931B (zh) * | 2016-10-17 | 2021-06-22 | 上海医药集团青岛国风药业股份有限公司 | 一种诺得司他的制备方法 |
| CN108017583B (zh) * | 2016-11-01 | 2021-04-06 | 徐州万邦金桥制药有限公司 | 一种可博美的制备方法 |
| CN110878096A (zh) * | 2018-09-05 | 2020-03-13 | 石药集团中奇制药技术(石家庄)有限公司 | 一种1,7-萘啶类衍生物及其制备方法和用途 |
| IT201800009318A1 (it) * | 2018-10-10 | 2020-04-10 | Luigi Frati | Composizioni antiossidanti |
| AU2019375983A1 (en) | 2018-11-09 | 2021-06-10 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| KR20210133984A (ko) | 2019-02-26 | 2021-11-08 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 축합된 비시클릭 헤테로시클릭 유도체 |
| CN113710669A (zh) | 2019-02-26 | 2021-11-26 | 拜耳公司 | 作为农药的稠合双环杂环衍生物 |
| HUE070525T2 (hu) | 2019-04-16 | 2025-06-28 | Vivace Therapeutics Inc | Biciklusos vegyületek |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| CN113292494A (zh) * | 2020-02-24 | 2021-08-24 | 江苏苏中药业集团股份有限公司 | 异喹啉羧酸化合物及其制备方法与应用 |
| US12410140B2 (en) * | 2020-06-19 | 2025-09-09 | Jumpcan (Shanghai) Medical Technology Co., Ltd | Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof |
| CN118414327A (zh) * | 2021-12-17 | 2024-07-30 | 阿克比治疗有限公司 | 作为选择性phd1抑制剂的吡啶酰胺化合物、组合物和使用方法 |
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| US4036964A (en) * | 1973-10-11 | 1977-07-19 | Beecham Group Limited | Isocarbostyril-3-carboxylic acid derivatives for the prophylaxis of asthma, hayfever and rhinitis |
| US3989704A (en) * | 1973-10-30 | 1976-11-02 | Sandoz, Inc. | 3-Substituted-4-aryl isoquinolines |
| DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
| DE3233424A1 (de) * | 1982-09-09 | 1984-03-15 | Hoechst Ag, 6230 Frankfurt | Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
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| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) * | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| PL1644336T3 (pl) * | 2003-06-06 | 2011-07-29 | Fibrogen Inc | Związki heteroarylowe zawierające azot i ich zastosowanie w zwiększaniu poziomu endogennej erytropoetyny |
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| US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
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| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
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| BRPI0611670A2 (pt) * | 2005-06-15 | 2016-11-16 | Fibrogen Inc | método para o tratamento ou prevenção de câncer em um indivíduo |
| KR101446499B1 (ko) * | 2006-01-27 | 2014-10-06 | 피브로겐, 인크. | 저산소증 유발가능 인자(hif)를 안정시키는 시아노이소퀴놀린 화합물 |
| CA2647596C (en) * | 2006-04-04 | 2012-06-12 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as hif modulators |
| US7713986B2 (en) * | 2006-06-15 | 2010-05-11 | Fibrogen, Inc. | Compounds and methods for treatment of chemotherapy-induced anemia |
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-
2007
- 2007-01-26 KR KR1020087020971A patent/KR101446499B1/ko not_active Expired - Fee Related
- 2007-01-26 AU AU2007211077A patent/AU2007211077B2/en not_active Ceased
- 2007-01-26 BR BRPI0707302A patent/BRPI0707302B8/pt not_active IP Right Cessation
- 2007-01-26 US US11/627,906 patent/US7928120B2/en active Active
- 2007-01-26 RU RU2008134664/04A patent/RU2457204C2/ru active IP Right Revival
- 2007-01-26 ZA ZA200806752A patent/ZA200806752B/xx unknown
- 2007-01-26 WO PCT/US2007/061171 patent/WO2007090068A2/en not_active Ceased
- 2007-01-26 JP JP2008552602A patent/JP5161793B2/ja not_active Expired - Fee Related
- 2007-01-26 CN CN201310239635.2A patent/CN103382216B/zh active Active
- 2007-01-26 DK DK07717454.8T patent/DK2044028T3/da active
- 2007-01-26 KR KR1020147017534A patent/KR20140089446A/ko not_active Ceased
- 2007-01-26 EP EP11194165A patent/EP2476669A1/en not_active Withdrawn
- 2007-01-26 CA CA2640435A patent/CA2640435C/en active Active
- 2007-01-26 EP EP07717454A patent/EP2044028B1/en active Active
- 2007-01-26 CN CN2007800035992A patent/CN101374815B/zh active Active
- 2007-01-26 CN CN201110220665.XA patent/CN102351791B/zh active Active
- 2007-01-26 MX MX2008009581A patent/MX2008009581A/es active IP Right Grant
-
2008
- 2008-07-24 IL IL193047A patent/IL193047A/en active IP Right Grant
- 2008-08-25 NO NO20083658A patent/NO342678B1/no unknown
-
2011
- 2011-03-07 US US13/042,281 patent/US20110212959A1/en not_active Abandoned
-
2012
- 2012-03-26 US US13/430,568 patent/US8759373B2/en active Active
-
2014
- 2014-05-28 US US14/289,573 patent/US9174976B2/en active Active
-
2015
- 2015-09-21 US US14/860,560 patent/US20160009653A1/en not_active Abandoned
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