JP2003514893A5 - - Google Patents
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- JP2003514893A5 JP2003514893A5 JP2001539860A JP2001539860A JP2003514893A5 JP 2003514893 A5 JP2003514893 A5 JP 2003514893A5 JP 2001539860 A JP2001539860 A JP 2001539860A JP 2001539860 A JP2001539860 A JP 2001539860A JP 2003514893 A5 JP2003514893 A5 JP 2003514893A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dimethyl
- pharmaceutical composition
- phenyl
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 description 55
- 239000008194 pharmaceutical composition Substances 0.000 description 22
- 150000002148 esters Chemical class 0.000 description 13
- 150000003839 salts Chemical class 0.000 description 12
- 239000012453 solvate Substances 0.000 description 11
- -1 small molecule heterocyclic ketone Chemical class 0.000 description 10
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- KSUABKWXHGYUQL-SFHVURJKSA-N 1-[(2s)-2-[5-(4-hydroxyphenyl)pentanoyl]pyrrolidin-1-yl]-3,3-dimethylpentane-1,2-dione Chemical compound CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)CCCCC1=CC=C(O)C=C1 KSUABKWXHGYUQL-SFHVURJKSA-N 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- GDTHVMAIBQVUMV-UHFFFAOYSA-N 2-oxopentanal Chemical compound CCCC(=O)C=O GDTHVMAIBQVUMV-UHFFFAOYSA-N 0.000 description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000005064 dopaminergic neuron Anatomy 0.000 description 3
- 238000003522 neurite outgrowth assay Methods 0.000 description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 210000003594 spinal ganglia Anatomy 0.000 description 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 2
- CTLASCJYROVJFB-SFHVURJKSA-N 3,3-dimethyl-1-[(2s)-2-(5-phenylpentanoyl)pyrrolidin-1-yl]pentane-1,2-dione Chemical compound CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)CCCCC1=CC=CC=C1 CTLASCJYROVJFB-SFHVURJKSA-N 0.000 description 2
- WRVUVUSXKPMOPJ-UHFFFAOYSA-N 3,3-dimethyl-1-[2-(5-phenylpentanoyl)piperidin-1-yl]pentane-1,2-dione Chemical compound CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)CCCCC1=CC=CC=C1 WRVUVUSXKPMOPJ-UHFFFAOYSA-N 0.000 description 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 1
- 229940126639 Compound 33 Drugs 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000000521 Immunophilins Human genes 0.000 description 1
- 108010016648 Immunophilins Proteins 0.000 description 1
- 101001135571 Mus musculus Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 description 1
- PNUZDKCDAWUEGK-CYZMBNFOSA-N Sitafloxacin Chemical compound C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 PNUZDKCDAWUEGK-CYZMBNFOSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000000392 cycloalkenyl group Chemical group 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000000508 neurotrophic effect Effects 0.000 description 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/444,200 | 1999-11-22 | ||
| US09/444,200 US6218424B1 (en) | 1996-09-25 | 1999-11-22 | Heterocyclic ketone and thioester compounds and uses |
| PCT/US2000/023742 WO2001038304A1 (en) | 1999-11-22 | 2000-08-30 | Heterocyclic ketone and thioester compounds and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514893A JP2003514893A (ja) | 2003-04-22 |
| JP2003514893A5 true JP2003514893A5 (enExample) | 2007-11-01 |
Family
ID=23763911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001539860A Pending JP2003514893A (ja) | 1999-11-22 | 2000-08-30 | 複素環式ケトンおよびチオエステル化合物、およびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US6218424B1 (enExample) |
| EP (1) | EP1233945A1 (enExample) |
| JP (1) | JP2003514893A (enExample) |
| AU (1) | AU784388B2 (enExample) |
| CA (1) | CA2391575A1 (enExample) |
| HK (1) | HK1046530A1 (enExample) |
| MX (1) | MXPA02005206A (enExample) |
| WO (1) | WO2001038304A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
| US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
| MXPA03011095A (es) * | 2001-05-29 | 2005-04-28 | Guilford Pharm Inc | Metodo para tratar una lesion nerviosa causada por cirugia. |
| DE10150203A1 (de) * | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| CN1240691C (zh) * | 2001-12-06 | 2006-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代五元氮杂环类化合物及其预防和治疗神经退行性疾病的用途 |
| KR101255074B1 (ko) * | 2003-10-01 | 2013-04-16 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| US8059168B2 (en) * | 2005-03-14 | 2011-11-15 | Gtech Corporation | System and method for scene change triggering |
| PL1861809T5 (pl) | 2005-03-14 | 2013-04-30 | Gtech Corp | System i sposób przetwarzania oznakowań blankietu |
| US7598261B2 (en) * | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) * | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP2063886A2 (en) * | 2006-09-12 | 2009-06-03 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| US8481711B2 (en) | 2010-07-06 | 2013-07-09 | Hidenori Kamanishi | Neurite outgrowth agent |
| US11013673B2 (en) | 2016-11-03 | 2021-05-25 | Repairogen Corp. | Cosmetic compositions containing quinones and their topical use on skin and hair |
| CA3080897A1 (en) | 2016-11-03 | 2018-05-11 | Repairogen Corp | Cosmetic compositions containing quinones and their topical use on skin and hair |
| IT201900025066A1 (it) * | 2019-12-20 | 2021-06-20 | Univ Degli Studi Di Firenze | Composto di formula (i) e unita' sensoristica che lo comprende |
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1999
- 1999-11-22 US US09/444,200 patent/US6218424B1/en not_active Expired - Fee Related
-
2000
- 2000-08-30 HK HK02108037.6A patent/HK1046530A1/zh unknown
- 2000-08-30 WO PCT/US2000/023742 patent/WO2001038304A1/en not_active Ceased
- 2000-08-30 AU AU70869/00A patent/AU784388B2/en not_active Ceased
- 2000-08-30 EP EP00959575A patent/EP1233945A1/en not_active Withdrawn
- 2000-08-30 MX MXPA02005206A patent/MXPA02005206A/es unknown
- 2000-08-30 JP JP2001539860A patent/JP2003514893A/ja active Pending
- 2000-08-30 CA CA002391575A patent/CA2391575A1/en not_active Abandoned
- 2000-12-11 US US09/733,037 patent/US6417209B2/en not_active Expired - Fee Related
-
2002
- 2002-03-25 US US10/104,242 patent/US20020193420A1/en not_active Abandoned
-
2003
- 2003-07-10 US US10/615,803 patent/US6984639B2/en not_active Expired - Fee Related
-
2005
- 2005-03-03 US US11/070,505 patent/US20050148637A1/en not_active Abandoned
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