JP2003514893A5 - - Google Patents
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- JP2003514893A5 JP2003514893A5 JP2001539860A JP2001539860A JP2003514893A5 JP 2003514893 A5 JP2003514893 A5 JP 2003514893A5 JP 2001539860 A JP2001539860 A JP 2001539860A JP 2001539860 A JP2001539860 A JP 2001539860A JP 2003514893 A5 JP2003514893 A5 JP 2003514893A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dimethyl
- pharmaceutical composition
- phenyl
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 55
- 239000008194 pharmaceutical composition Substances 0.000 description 22
- 150000002148 esters Chemical class 0.000 description 13
- 150000003839 salts Chemical class 0.000 description 12
- 239000012453 solvate Substances 0.000 description 11
- -1 small molecule heterocyclic ketone Chemical class 0.000 description 10
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- KSUABKWXHGYUQL-SFHVURJKSA-N 1-[(2s)-2-[5-(4-hydroxyphenyl)pentanoyl]pyrrolidin-1-yl]-3,3-dimethylpentane-1,2-dione Chemical compound CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)CCCCC1=CC=C(O)C=C1 KSUABKWXHGYUQL-SFHVURJKSA-N 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- GDTHVMAIBQVUMV-UHFFFAOYSA-N 2-oxopentanal Chemical compound CCCC(=O)C=O GDTHVMAIBQVUMV-UHFFFAOYSA-N 0.000 description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000005064 dopaminergic neuron Anatomy 0.000 description 3
- 238000003522 neurite outgrowth assay Methods 0.000 description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 210000003594 spinal ganglia Anatomy 0.000 description 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 2
- CTLASCJYROVJFB-SFHVURJKSA-N 3,3-dimethyl-1-[(2s)-2-(5-phenylpentanoyl)pyrrolidin-1-yl]pentane-1,2-dione Chemical compound CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)CCCCC1=CC=CC=C1 CTLASCJYROVJFB-SFHVURJKSA-N 0.000 description 2
- WRVUVUSXKPMOPJ-UHFFFAOYSA-N 3,3-dimethyl-1-[2-(5-phenylpentanoyl)piperidin-1-yl]pentane-1,2-dione Chemical compound CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)CCCCC1=CC=CC=C1 WRVUVUSXKPMOPJ-UHFFFAOYSA-N 0.000 description 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 1
- 229940126639 Compound 33 Drugs 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000000521 Immunophilins Human genes 0.000 description 1
- 108010016648 Immunophilins Proteins 0.000 description 1
- 101001135571 Mus musculus Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 description 1
- PNUZDKCDAWUEGK-CYZMBNFOSA-N Sitafloxacin Chemical compound C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 PNUZDKCDAWUEGK-CYZMBNFOSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000000392 cycloalkenyl group Chemical group 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000000508 neurotrophic effect Effects 0.000 description 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/444,200 US6218424B1 (en) | 1996-09-25 | 1999-11-22 | Heterocyclic ketone and thioester compounds and uses |
| US09/444,200 | 1999-11-22 | ||
| PCT/US2000/023742 WO2001038304A1 (en) | 1999-11-22 | 2000-08-30 | Heterocyclic ketone and thioester compounds and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514893A JP2003514893A (ja) | 2003-04-22 |
| JP2003514893A5 true JP2003514893A5 (enExample) | 2007-11-01 |
Family
ID=23763911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001539860A Pending JP2003514893A (ja) | 1999-11-22 | 2000-08-30 | 複素環式ケトンおよびチオエステル化合物、およびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US6218424B1 (enExample) |
| EP (1) | EP1233945A1 (enExample) |
| JP (1) | JP2003514893A (enExample) |
| AU (1) | AU784388B2 (enExample) |
| CA (1) | CA2391575A1 (enExample) |
| HK (1) | HK1046530A1 (enExample) |
| MX (1) | MXPA02005206A (enExample) |
| WO (1) | WO2001038304A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
| US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
| JP2005500270A (ja) * | 2001-05-29 | 2005-01-06 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 手術の結果として発生した神経損傷を治療するための方法 |
| DE10150203A1 (de) * | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| CN1240691C (zh) | 2001-12-06 | 2006-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代五元氮杂环类化合物及其预防和治疗神经退行性疾病的用途 |
| US7338962B2 (en) * | 2003-10-01 | 2008-03-04 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| CA2600848C (en) | 2005-03-14 | 2014-09-09 | Gtech Rhode Island Corporation | System and method for processing a form |
| US8059168B2 (en) * | 2005-03-14 | 2011-11-15 | Gtech Corporation | System and method for scene change triggering |
| US7598261B2 (en) * | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP2010503669A (ja) * | 2006-09-12 | 2010-02-04 | アドラー コーポレーション | 認知機能の強化のためのｎ含有スピロ化合物の使用 |
| US8481711B2 (en) | 2010-07-06 | 2013-07-09 | Hidenori Kamanishi | Neurite outgrowth agent |
| CA3080897A1 (en) | 2016-11-03 | 2018-05-11 | Repairogen Corp | Cosmetic compositions containing quinones and their topical use on skin and hair |
| US11013673B2 (en) | 2016-11-03 | 2021-05-25 | Repairogen Corp. | Cosmetic compositions containing quinones and their topical use on skin and hair |
| IT201900025066A1 (it) * | 2019-12-20 | 2021-06-20 | Univ Degli Studi Di Firenze | Composto di formula (i) e unita' sensoristica che lo comprende |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3203961A (en) | 1963-03-21 | 1965-08-31 | Indolylethylpyrromdone compounds | |
| US3458515A (en) | 1966-07-21 | 1969-07-29 | American Home Prod | Piperazine substituted pyrroles |
| US3459770A (en) | 1966-12-07 | 1969-08-05 | American Home Prod | Indoleglyoxyloylpyrroles |
| US4053599A (en) | 1976-02-26 | 1977-10-11 | American Hoechst Corporation | Piperazionalkylpyrrolobenzoxazalkanes |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4578474A (en) | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4390695A (en) | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4310461A (en) | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4950649A (en) | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
| EP0048159A3 (en) | 1980-09-17 | 1982-05-12 | University Of Miami | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents |
| LU88621I2 (fr) | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
| ZA817261B (en) | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
| US4766110A (en) | 1981-08-21 | 1988-08-23 | Ryan James W | Novel complex amido and imido derivatives of carboxyalkyl peptides |
| ZA826022B (en) | 1981-08-21 | 1983-08-31 | Univ Miami | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides |
| EP0088350B1 (en) | 1982-03-08 | 1985-02-20 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
| AU563282B2 (en) | 1982-09-13 | 1987-07-02 | Nippon Kayaku Kabushiki Kaisha | Pyrrolidino and piperidino derivatives and condensed derivatives thereof |
| US4574079A (en) | 1983-05-27 | 1986-03-04 | Gavras Haralambos P | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites |
| IT8483334A0 (it) | 1984-03-13 | 1984-03-13 | Umberto De Faveri | Canestro perfezionato per il gioco della pallacanestro o basket. |
| US4593102A (en) | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
| DE3508251A1 (de) | 1985-03-08 | 1986-09-11 | Merck Patent Gmbh, 6100 Darmstadt | Dipeptide |
| CN86101850A (zh) | 1985-03-22 | 1987-02-04 | 森得克斯(美国)有限公司 | N，n′-二烷基胍基二肽的制造方法与用途 |
| DE3774975D1 (de) | 1986-09-10 | 1992-01-16 | Syntex Inc | Selektive amidinierung von diaminen. |
| DE3712364A1 (de) | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
| IT1206078B (it) | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
| US4857524A (en) * | 1987-08-08 | 1989-08-15 | Kissei Pharmaceutical Co., Ltd. | Thiazolidine compounds and therapeutic method |
| JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
| US5187156A (en) | 1988-03-16 | 1993-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same |
| US5232923A (en) | 1988-03-18 | 1993-08-03 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives and pharmaceutical preparations containing same |
| IL90872A0 (en) | 1988-07-08 | 1990-02-09 | Smithkline Beckman Corp | Retroviral protease binding peptides |
| DE3931051A1 (de) | 1988-09-22 | 1990-03-29 | Hoechst Ag | Salze von herbizid-saeuren mit langkettigen stickstoffbasen |
| US5166317A (en) | 1988-10-31 | 1992-11-24 | Houston Biotechnology Incorporated | Neurotrophic factor |
| CA2004028C (en) * | 1988-12-08 | 1998-09-22 | Motoki Torizuka | Condensed benzene derivative |
| EP0378318A1 (en) | 1989-01-11 | 1990-07-18 | Merck & Co. Inc. | Process for synthesis of FK-506 and tricarbonyl intermediates |
| US5359138A (en) | 1989-04-15 | 1994-10-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Poststatin and related compounds or salts thereof |
| WO1990012805A1 (fr) | 1989-04-15 | 1990-11-01 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Postostatine et son compose connexe, ou leurs sels |
| US5164525A (en) | 1989-06-30 | 1992-11-17 | Merck & Co., Inc. | Synthetic process for fk-506 type macrolide intermediates |
| US5215969A (en) | 1989-08-11 | 1993-06-01 | Hahnemann University | Dopaminergic neurotrophic factor for treatment of Parkinson's disease |
| NZ234883A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
| GB8922026D0 (en) | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
| US5115098A (en) | 1990-02-28 | 1992-05-19 | President And Fellows Of Harvard College | End-blocked peptides inhibiting binding capacity of gp120 |
| JPH04211648A (ja) | 1990-07-27 | 1992-08-03 | Nippon Kayaku Co Ltd | ケト酸アミド誘導体 |
| DE4015255A1 (de) | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
| US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| JPH06500561A (ja) | 1990-08-24 | 1994-01-20 | ジ・アップジョン・カンパニー | 遷移状態模擬体としてのアミノポリオール含有ペプチド |
| AU8727491A (en) | 1990-08-29 | 1992-03-30 | Vertex Pharmaceuticals Incorporated | Modified di- and tripeptidyl immunosuppressive compounds |
| GB2247456A (en) | 1990-09-03 | 1992-03-04 | Fujisawa Pharmaceutical Co | Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same |
| JPH04149166A (ja) | 1990-10-12 | 1992-05-22 | Nippon Kayaku Co Ltd | 新規ケト酸アミド誘導体 |
| WO1992016501A1 (en) | 1991-03-20 | 1992-10-01 | Vertex Pharmaceuticals Incorporated | Tetrahydroxyalkane derivatives as inhibitors of hiv aspartyl protease |
| IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| US5147877A (en) | 1991-04-18 | 1992-09-15 | Merck & Co. Inc. | Semi-synthetic immunosuppressive macrolides |
| FI934901A7 (fi) | 1991-05-08 | 1993-11-05 | Vertex Pharma | RFKBP: Uusi prolyyli-isomeraasi ja rapamysiiniä/FK506:tta sitova prote iini |
| EP0584223B1 (en) | 1991-05-09 | 1999-08-11 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
| MX9202466A (es) | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
| JPH05178824A (ja) | 1991-08-05 | 1993-07-20 | Takeda Chem Ind Ltd | アスパラギン誘導体およびその用途 |
| WO1993007269A1 (en) | 1991-10-11 | 1993-04-15 | Vertex Pharmaceuticals Incorporated | ISOLATION OF AN Mr 52,000 FK506 BINDING PROTEIN AND MOLECULAR CLONING OF A CORRESPONDING HUMAN cDNA |
| ZA927782B (en) | 1991-10-11 | 1993-04-28 | Ciba Geigy | Novel herbicides. |
| AU3278293A (en) | 1991-12-20 | 1993-07-28 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
| WO1993023548A2 (en) | 1992-05-20 | 1993-11-25 | Vertex Pharmaceuticals Incorporated | METHOD OF DETECTING TISSUE-SPECIFIC FK506 BINDING PROTEIN MESSENGER RNAs AND USES THEREOF |
| IT1254373B (it) | 1992-05-29 | 1995-09-14 | Eteroprostanoidi, procedimento per la loro preparazione e loro impiegoterapeutico. | |
| US5334719A (en) | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| NZ314207A (en) | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
| JPH06135961A (ja) | 1992-10-23 | 1994-05-17 | Nippon Iyakuhin Kogyo Kk | 新規ジフェニルピロリルフラン誘導体 |
| AU5748194A (en) | 1992-12-11 | 1994-07-04 | Vertex Pharmaceuticals Incorporated | Mannitol derivatives and their use as inhibitors of aspartyl protease |
| DE4302860A1 (de) | 1993-01-22 | 1994-08-04 | Chemie Linz Deutschland | N-Cyclische und N,N'dicyclische Harnstoffe |
| US5385918A (en) | 1993-02-09 | 1995-01-31 | Miles Inc. | Aminomethylene-peptides as immunosuppressants |
| US5252579A (en) | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
| US5319098A (en) | 1993-05-18 | 1994-06-07 | Celgene Corporation | Process for the stereoselective preparation of L-alanyl-L-proline |
| IT1270882B (it) | 1993-10-05 | 1997-05-13 | Isagro Srl | Oligopeptidi ad attivita' fungicida |
| DE69417012T2 (de) | 1993-11-04 | 1999-10-07 | Abbott Laboratories, Abbott Park | Cyclobutan-derivate als inhibitoren der squalen-synthetase und der protein-farnesyltransferase |
| JPH10500938A (ja) | 1994-03-07 | 1998-01-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体 |
| US5744485A (en) | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US6057119A (en) | 1994-06-17 | 2000-05-02 | Vertex Pharmaceuticals, Incorporated | Crystal structure and mutants of interleukin-1β converting enzyme |
| ATE299145T1 (de) | 1994-08-18 | 2005-07-15 | Ariad Gene Therapeutics Inc | Neues multimerisierendes reagenz |
| US5543423A (en) | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
| IL115685A (en) | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
| US5621108A (en) | 1994-12-05 | 1997-04-15 | Trustees Of The University Of Pennsylvania | Processes and intermediates for preparing macrocycles |
| US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US6037370A (en) | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5717092A (en) | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
| US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
| US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
| US5801187A (en) * | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
| ZA98825B (en) * | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
| US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
| US5945441A (en) * | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
| US6274602B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
| AU742040C (en) * | 1997-09-24 | 2003-10-02 | Amgen, Inc. | Method for preventing and treating hearing loss using sensorineurotrophic compounds |
| JP2002516844A (ja) * | 1998-06-03 | 2002-06-11 | ジーピーアイ エヌアイエル ホールディングス， インコーポレイテッド | 複素環チオエステルおよびケトン毛髪成長合成物および用法 |
| AU5555699A (en) * | 1998-08-14 | 2000-03-06 | Gpi Nil Holdings, Inc. | Compositions and uses for vision and memory disorders |
-
1999
- 1999-11-22 US US09/444,200 patent/US6218424B1/en not_active Expired - Fee Related
-
2000
- 2000-08-30 AU AU70869/00A patent/AU784388B2/en not_active Ceased
- 2000-08-30 HK HK02108037.6A patent/HK1046530A1/zh unknown
- 2000-08-30 JP JP2001539860A patent/JP2003514893A/ja active Pending
- 2000-08-30 MX MXPA02005206A patent/MXPA02005206A/es unknown
- 2000-08-30 EP EP00959575A patent/EP1233945A1/en not_active Withdrawn
- 2000-08-30 CA CA002391575A patent/CA2391575A1/en not_active Abandoned
- 2000-08-30 WO PCT/US2000/023742 patent/WO2001038304A1/en not_active Ceased
- 2000-12-11 US US09/733,037 patent/US6417209B2/en not_active Expired - Fee Related
-
2002
- 2002-03-25 US US10/104,242 patent/US20020193420A1/en not_active Abandoned
-
2003
- 2003-07-10 US US10/615,803 patent/US6984639B2/en not_active Expired - Fee Related
-
2005
- 2005-03-03 US US11/070,505 patent/US20050148637A1/en not_active Abandoned
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