JP2019507772A5 - - Google Patents
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- JP2019507772A5 JP2019507772A5 JP2018546842A JP2018546842A JP2019507772A5 JP 2019507772 A5 JP2019507772 A5 JP 2019507772A5 JP 2018546842 A JP2018546842 A JP 2018546842A JP 2018546842 A JP2018546842 A JP 2018546842A JP 2019507772 A5 JP2019507772 A5 JP 2019507772A5
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- 238000000034 method Methods 0.000 claims description 34
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 14
- 102100032912 CD44 antigen Human genes 0.000 claims description 14
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 14
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 8
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 8
- 210000005258 dental pulp stem cell Anatomy 0.000 claims description 7
- 230000008499 blood brain barrier function Effects 0.000 claims description 4
- 210000001218 blood-brain barrier Anatomy 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 3
- 230000002255 enzymatic effect Effects 0.000 claims description 3
- 238000003306 harvesting Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 2
- 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 claims 2
- 101710176164 Broad substrate specificity ATP-binding cassette transporter ABCG2 Proteins 0.000 claims 2
- 102000012749 Dopamine and cAMP-Regulated Phosphoprotein 32 Human genes 0.000 claims 2
- 108010090047 Dopamine and cAMP-Regulated Phosphoprotein 32 Proteins 0.000 claims 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- 229930182816 L-glutamine Natural products 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000012091 fetal bovine serum Substances 0.000 claims 1
- 210000004251 human milk Anatomy 0.000 claims 1
- 235000020256 human milk Nutrition 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 229960005322 streptomycin Drugs 0.000 claims 1
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 description 11
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 description 11
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 4
- 238000012744 immunostaining Methods 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 206010003805 Autism Diseases 0.000 description 2
- 208000020706 Autistic disease Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 208000016285 Movement disease Diseases 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000025966 Neurological disease Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 2
- 210000004489 deciduous teeth Anatomy 0.000 description 2
- 201000002491 encephalomyelitis Diseases 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 201000001119 neuropathy Diseases 0.000 description 2
- 230000007823 neuropathy Effects 0.000 description 2
- 208000033808 peripheral neuropathy Diseases 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/065,259 | 2016-03-09 | ||
| US15/065,259 US11207352B2 (en) | 2013-03-15 | 2016-03-09 | Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease |
| PCT/IB2017/051405 WO2017153957A1 (en) | 2016-03-09 | 2017-03-09 | Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507772A JP2019507772A (ja) | 2019-03-22 |
| JP2019507772A5 true JP2019507772A5 (https=) | 2020-04-16 |
| JP6997716B2 JP6997716B2 (ja) | 2022-02-04 |
Family
ID=58387859
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546842A Active JP6997716B2 (ja) | 2016-03-09 | 2017-03-09 | 間葉系マーカーおよびニューロンマーカーを発現する幹細胞、その組成物、ならびにその調製方法 |
| JP2018546882A Active JP7008031B2 (ja) | 2016-03-09 | 2017-03-09 | 間葉系マーカーおよびニューロンマーカーを発現する歯髄幹細胞の使用、ならびに神経学的疾患を治療するためのその組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546882A Active JP7008031B2 (ja) | 2016-03-09 | 2017-03-09 | 間葉系マーカーおよびニューロンマーカーを発現する歯髄幹細胞の使用、ならびに神経学的疾患を治療するためのその組成物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3426770A1 (https=) |
| JP (2) | JP6997716B2 (https=) |
| KR (2) | KR102497999B1 (https=) |
| CN (2) | CN109219441B (https=) |
| CA (1) | CA3055398A1 (https=) |
| IL (2) | IL261622B2 (https=) |
| RU (2) | RU2742828C2 (https=) |
| WO (2) | WO2017153956A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109152801A (zh) * | 2016-05-16 | 2019-01-04 | 国立大学法人名古屋大学 | 采用多能干细胞的围产期脑损伤的改善及治疗 |
| US11547730B2 (en) | 2017-05-26 | 2023-01-10 | Steminent Biotherapeutics Inc. | Therapy for polyglutamine (polyQ) diseases |
| KR20210041578A (ko) * | 2018-07-31 | 2021-04-15 | 제이씨알 파마 가부시키가이샤 | 치수 유래 세포의 제조 방법 |
| DK3894857T3 (da) * | 2019-04-15 | 2022-11-07 | Nanologica Ab | Tomme porøse partikler til anvendelse ved behandling, forebyggelse og/eller udskydelse af degeneration af neurodegenerative sygdomme, neuroner og glia |
| CN110179827A (zh) * | 2019-06-27 | 2019-08-30 | 北京三有利和泽生物科技有限公司 | 牙源性间充质干细胞的应用 |
| CN110314172A (zh) * | 2019-07-17 | 2019-10-11 | 中国医科大学附属第一医院 | 一种用于治疗脊髓损伤的细胞制剂及其制备方法 |
| JPWO2021200744A1 (https=) * | 2020-03-31 | 2021-10-07 | ||
| CN111973631A (zh) * | 2020-08-21 | 2020-11-24 | 卡替(上海)生物技术有限公司 | 牙髓间充质干细胞在制备阿尔茨海默病治疗药物中的用途 |
| CN115192609A (zh) * | 2022-05-10 | 2022-10-18 | 湖南中南大学湘雅口腔医院 | 间充质干细胞在制备治疗抑郁症的药物中的应用 |
| WO2025084896A1 (ko) * | 2023-10-18 | 2025-04-24 | 연세대학교 산학협력단 | 신경세포 분화 유도용 재조합 벡터 및 이를 포함하는 퇴행성 뇌신경 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2465924A3 (en) | 2005-06-16 | 2013-01-02 | Ramot at Tel-Aviv University Ltd. | Isolated cells and populations comprising same for the treament of cns diseases |
| WO2008080200A1 (en) * | 2006-12-29 | 2008-07-10 | Irina Kerkis | Process for obtaining stem cells |
| CN101668848B (zh) | 2007-04-26 | 2014-10-22 | 雷蒙特亚特特拉维夫大学有限公司 | 来自口腔粘膜的多能自体干细胞和使用方法 |
| RU2347579C1 (ru) * | 2007-07-03 | 2009-02-27 | Общество с ограниченной ответственностью "Медицинские технологии" | Способ получения клеточной культуры для лечения сосудистых и демиелинизирующих заболеваний нервной системы и клеточная культура, полученная этим способом (варианты) |
| JP5408578B2 (ja) * | 2007-12-05 | 2014-02-05 | 国立大学法人名古屋大学 | 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途 |
| EP2263706B1 (en) * | 2008-03-12 | 2017-11-15 | National Center for Geriatrics and Gerontology | Root canal filler and dental tissue regeneration method |
| EP2620493B1 (en) | 2008-05-28 | 2019-03-27 | Ramot at Tel Aviv University Ltd. | Mesenchymal stem cells for the treatment of CNS diseases |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
| CN102725398B (zh) * | 2009-12-21 | 2014-01-08 | 学校法人总持学园鹤见大学 | 用于培养及保存牙髓细胞的离体牙的移送方法 |
| WO2012117373A1 (en) | 2011-03-03 | 2012-09-07 | Ramot At Tel-Aviv University Ltd. | Genetically modified muscle cells which express neurotrophic factors |
| WO2013076726A1 (en) | 2011-11-21 | 2013-05-30 | Ramot At Tel-Aviv University Ltd. | Stem cell-derived neural cells for cell therapy in neurological disorders |
| EP2633870B1 (en) * | 2012-02-29 | 2018-08-01 | Technische Universität Berlin | Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom |
| US9790468B2 (en) * | 2013-03-15 | 2017-10-17 | Avita Iinternational Ltd. | Multifunctional immature dental pulp stem cells and therapeutic applications |
-
2017
- 2017-03-09 RU RU2018134615A patent/RU2742828C2/ru active
- 2017-03-09 RU RU2018134710A patent/RU2741839C2/ru active
- 2017-03-09 IL IL261622A patent/IL261622B2/en unknown
- 2017-03-09 EP EP17714293.2A patent/EP3426770A1/en active Pending
- 2017-03-09 CN CN201780027504.4A patent/CN109219441B/zh active Active
- 2017-03-09 IL IL261623A patent/IL261623B2/en unknown
- 2017-03-09 JP JP2018546842A patent/JP6997716B2/ja active Active
- 2017-03-09 CA CA3055398A patent/CA3055398A1/en active Pending
- 2017-03-09 WO PCT/IB2017/051404 patent/WO2017153956A1/en not_active Ceased
- 2017-03-09 CN CN201780028519.2A patent/CN109312303B/zh active Active
- 2017-03-09 KR KR1020187028974A patent/KR102497999B1/ko active Active
- 2017-03-09 WO PCT/IB2017/051405 patent/WO2017153957A1/en not_active Ceased
- 2017-03-09 KR KR1020187028975A patent/KR102363146B1/ko active Active
- 2017-03-09 EP EP17712549.9A patent/EP3426267B1/en active Active
- 2017-03-09 JP JP2018546882A patent/JP7008031B2/ja active Active
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