IL261622B2 - Use of dental pulp stem cells expressing mesenchymal and neuronal markers and the compounds containing them in the treatment of neurological diseases - Google Patents

Use of dental pulp stem cells expressing mesenchymal and neuronal markers and the compounds containing them in the treatment of neurological diseases

Info

Publication number
IL261622B2
IL261622B2 IL261622A IL26162218A IL261622B2 IL 261622 B2 IL261622 B2 IL 261622B2 IL 261622 A IL261622 A IL 261622A IL 26162218 A IL26162218 A IL 26162218A IL 261622 B2 IL261622 B2 IL 261622B2
Authority
IL
Israel
Prior art keywords
cells
pharmaceutical composition
hidpscs
stem cells
hidpsc
Prior art date
Application number
IL261622A
Other languages
English (en)
Hebrew (he)
Other versions
IL261622A (en
IL261622B1 (en
Inventor
Irina Kerkis
Valverde Wenceslau Cristiane
Original Assignee
Avita Int Ltd
Fund Butantan
Irina Kerkis
Valverde Wenceslau Cristiane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/065,259 external-priority patent/US11207352B2/en
Application filed by Avita Int Ltd, Fund Butantan, Irina Kerkis, Valverde Wenceslau Cristiane filed Critical Avita Int Ltd
Publication of IL261622A publication Critical patent/IL261622A/en
Publication of IL261622B1 publication Critical patent/IL261622B1/en
Publication of IL261622B2 publication Critical patent/IL261622B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0664Dental pulp stem cells, Dental follicle stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
IL261622A 2016-03-09 2017-03-09 Use of dental pulp stem cells expressing mesenchymal and neuronal markers and the compounds containing them in the treatment of neurological diseases IL261622B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/065,259 US11207352B2 (en) 2013-03-15 2016-03-09 Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease
PCT/IB2017/051404 WO2017153956A1 (en) 2016-03-09 2017-03-09 Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease

Publications (3)

Publication Number Publication Date
IL261622A IL261622A (en) 2018-10-31
IL261622B1 IL261622B1 (en) 2023-05-01
IL261622B2 true IL261622B2 (en) 2023-09-01

Family

ID=58387859

Family Applications (2)

Application Number Title Priority Date Filing Date
IL261622A IL261622B2 (en) 2016-03-09 2017-03-09 Use of dental pulp stem cells expressing mesenchymal and neuronal markers and the compounds containing them in the treatment of neurological diseases
IL261623A IL261623B2 (en) 2016-03-09 2017-03-09 Stem cells expressing mesenchymal and neuronal markers, compositions containing them and methods for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL261623A IL261623B2 (en) 2016-03-09 2017-03-09 Stem cells expressing mesenchymal and neuronal markers, compositions containing them and methods for their preparation

Country Status (8)

Country Link
EP (2) EP3426770A1 (https=)
JP (2) JP6997716B2 (https=)
KR (2) KR102497999B1 (https=)
CN (2) CN109219441B (https=)
CA (1) CA3055398A1 (https=)
IL (2) IL261622B2 (https=)
RU (2) RU2742828C2 (https=)
WO (2) WO2017153956A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152801A (zh) * 2016-05-16 2019-01-04 国立大学法人名古屋大学 采用多能干细胞的围产期脑损伤的改善及治疗
US11547730B2 (en) 2017-05-26 2023-01-10 Steminent Biotherapeutics Inc. Therapy for polyglutamine (polyQ) diseases
KR20210041578A (ko) * 2018-07-31 2021-04-15 제이씨알 파마 가부시키가이샤 치수 유래 세포의 제조 방법
DK3894857T3 (da) * 2019-04-15 2022-11-07 Nanologica Ab Tomme porøse partikler til anvendelse ved behandling, forebyggelse og/eller udskydelse af degeneration af neurodegenerative sygdomme, neuroner og glia
CN110179827A (zh) * 2019-06-27 2019-08-30 北京三有利和泽生物科技有限公司 牙源性间充质干细胞的应用
CN110314172A (zh) * 2019-07-17 2019-10-11 中国医科大学附属第一医院 一种用于治疗脊髓损伤的细胞制剂及其制备方法
JPWO2021200744A1 (https=) * 2020-03-31 2021-10-07
CN111973631A (zh) * 2020-08-21 2020-11-24 卡替(上海)生物技术有限公司 牙髓间充质干细胞在制备阿尔茨海默病治疗药物中的用途
CN115192609A (zh) * 2022-05-10 2022-10-18 湖南中南大学湘雅口腔医院 间充质干细胞在制备治疗抑郁症的药物中的应用
WO2025084896A1 (ko) * 2023-10-18 2025-04-24 연세대학교 산학협력단 신경세포 분화 유도용 재조합 벡터 및 이를 포함하는 퇴행성 뇌신경 질환의 예방 또는 치료용 약학적 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110002895A1 (en) * 2007-12-05 2011-01-06 Minoru Ueda Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition
US20110158962A1 (en) * 2008-06-26 2011-06-30 Federico Ferro Dental pulp marrow similar cells (dpmsc) and methods of isolating and using
US20150050248A1 (en) * 2013-03-15 2015-02-19 Avita International Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2465924A3 (en) 2005-06-16 2013-01-02 Ramot at Tel-Aviv University Ltd. Isolated cells and populations comprising same for the treament of cns diseases
WO2008080200A1 (en) * 2006-12-29 2008-07-10 Irina Kerkis Process for obtaining stem cells
CN101668848B (zh) 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 来自口腔粘膜的多能自体干细胞和使用方法
RU2347579C1 (ru) * 2007-07-03 2009-02-27 Общество с ограниченной ответственностью "Медицинские технологии" Способ получения клеточной культуры для лечения сосудистых и демиелинизирующих заболеваний нервной системы и клеточная культура, полученная этим способом (варианты)
EP2263706B1 (en) * 2008-03-12 2017-11-15 National Center for Geriatrics and Gerontology Root canal filler and dental tissue regeneration method
EP2620493B1 (en) 2008-05-28 2019-03-27 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
CN102725398B (zh) * 2009-12-21 2014-01-08 学校法人总持学园鹤见大学 用于培养及保存牙髓细胞的离体牙的移送方法
WO2012117373A1 (en) 2011-03-03 2012-09-07 Ramot At Tel-Aviv University Ltd. Genetically modified muscle cells which express neurotrophic factors
WO2013076726A1 (en) 2011-11-21 2013-05-30 Ramot At Tel-Aviv University Ltd. Stem cell-derived neural cells for cell therapy in neurological disorders
EP2633870B1 (en) * 2012-02-29 2018-08-01 Technische Universität Berlin Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110002895A1 (en) * 2007-12-05 2011-01-06 Minoru Ueda Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition
US20110158962A1 (en) * 2008-06-26 2011-06-30 Federico Ferro Dental pulp marrow similar cells (dpmsc) and methods of isolating and using
US20150050248A1 (en) * 2013-03-15 2015-02-19 Avita International Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RYAN, J.M., BARRY, F.P., MURPHY, J.M. AND MAHON, B.P., MESENCHYMAL STEM CELLS AVOID ALLOGENEIC REJECTION., 31 December 2005 (2005-12-31) *
SAKAI, K., YAMAMOTO, A., MATSUBARA, K., NAKAMURA, S., NARUSE, M., YAMAGATA, M., SAKAMOTO, K., TAUCHI, R., WAKAO, N., IMAGAMA, S. A, HUMAN DENTAL PULP-DERIVED STEM CELLS PROMOTE LOCOMOTOR RECOVERY AFTER COMPLETE TRANSECTION OF THE RAT SPINAL CORD BY MULTIPLE NEURO-REGENERATIVE MECHANISMS., 31 December 2012 (2012-12-31) *

Also Published As

Publication number Publication date
CA3055398A1 (en) 2017-09-14
CN109219441A (zh) 2019-01-15
CA3055399A1 (en) 2017-09-14
RU2018134615A3 (https=) 2020-07-28
RU2018134710A (ru) 2020-04-09
JP2019507772A (ja) 2019-03-22
JP2019510758A (ja) 2019-04-18
IL261623A (en) 2018-10-31
EP3426770A1 (en) 2019-01-16
WO2017153957A9 (en) 2017-11-02
RU2018134710A3 (https=) 2020-06-25
JP6997716B2 (ja) 2022-02-04
BR112018067969A2 (pt) 2019-01-15
CN109312303B (zh) 2024-03-26
WO2017153957A1 (en) 2017-09-14
CN109219441B (zh) 2022-06-10
EP3426267B1 (en) 2023-01-11
RU2741839C2 (ru) 2021-01-29
RU2742828C2 (ru) 2021-02-11
RU2018134615A (ru) 2020-04-10
BR112018067971A2 (pt) 2019-01-15
CN109312303A (zh) 2019-02-05
KR102497999B1 (ko) 2023-02-08
WO2017153956A1 (en) 2017-09-14
IL261623B1 (en) 2023-11-01
EP3426267A1 (en) 2019-01-16
IL261622A (en) 2018-10-31
IL261622B1 (en) 2023-05-01
IL261623B2 (en) 2024-03-01
KR20180137488A (ko) 2018-12-27
KR102363146B1 (ko) 2022-02-14
KR20190003489A (ko) 2019-01-09
JP7008031B2 (ja) 2022-02-10

Similar Documents

Publication Publication Date Title
EP3426267B1 (en) Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
US20250295700A1 (en) Use of stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
AU2023200036B2 (en) Assessing retinal pigment epithelial cell populations
US20210332325A1 (en) Rpe cell populations and methods of generating same
US20240245727A1 (en) Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease
US11306290B2 (en) Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
CA3055399C (en) Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
BR112018067971B1 (pt) Método para produzir células estaminais de polpa dentária imaturas humanas
BR112018067969B1 (pt) Uso de células estaminais de polpa dentária que expressam marcadores neuronais mesenquimais e composições das mesmas para tratar doença neurológica
HK40001515B (zh) 表达间充质和神经元标志物的干细胞、其组合物及其制备方法
HK40001297A (en) Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
HK40001297B (en) Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
HK40001515A (en) Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
US20230220336A1 (en) Fibroblasts as a regenerative cellular source for the treatment of blindness