KR102497999B1 - 신경계 질환을 치료하기 위한 간엽 마커와 뉴런 마커를 발현하는 치수 줄기 세포 및 이의 조성물의 용도 - Google Patents

신경계 질환을 치료하기 위한 간엽 마커와 뉴런 마커를 발현하는 치수 줄기 세포 및 이의 조성물의 용도 Download PDF

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KR102497999B1
KR102497999B1 KR1020187028974A KR20187028974A KR102497999B1 KR 102497999 B1 KR102497999 B1 KR 102497999B1 KR 1020187028974 A KR1020187028974 A KR 1020187028974A KR 20187028974 A KR20187028974 A KR 20187028974A KR 102497999 B1 KR102497999 B1 KR 102497999B1
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이리나 컬키스
벤세슬라우 크리스치아니 발베르데
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아비타 인터내셔널 리미티드
푼다카오 부탄탄
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KR1020187028974A 2016-03-09 2017-03-09 신경계 질환을 치료하기 위한 간엽 마커와 뉴런 마커를 발현하는 치수 줄기 세포 및 이의 조성물의 용도 Active KR102497999B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/065,259 2016-03-09
US15/065,259 US11207352B2 (en) 2013-03-15 2016-03-09 Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease
PCT/IB2017/051404 WO2017153956A1 (en) 2016-03-09 2017-03-09 Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease

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KR20190003489A KR20190003489A (ko) 2019-01-09
KR102497999B1 true KR102497999B1 (ko) 2023-02-08

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KR1020187028975A Active KR102363146B1 (ko) 2016-03-09 2017-03-09 간엽 마커와 뉴런 마커를 발현하는 줄기 세포, 이의 조성물 및 이의 제조 방법

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EP (2) EP3426770A1 (https=)
JP (2) JP6997716B2 (https=)
KR (2) KR102497999B1 (https=)
CN (2) CN109219441B (https=)
CA (1) CA3055398A1 (https=)
IL (2) IL261622B2 (https=)
RU (2) RU2742828C2 (https=)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152801A (zh) * 2016-05-16 2019-01-04 国立大学法人名古屋大学 采用多能干细胞的围产期脑损伤的改善及治疗
US11547730B2 (en) 2017-05-26 2023-01-10 Steminent Biotherapeutics Inc. Therapy for polyglutamine (polyQ) diseases
KR20210041578A (ko) * 2018-07-31 2021-04-15 제이씨알 파마 가부시키가이샤 치수 유래 세포의 제조 방법
DK3894857T3 (da) * 2019-04-15 2022-11-07 Nanologica Ab Tomme porøse partikler til anvendelse ved behandling, forebyggelse og/eller udskydelse af degeneration af neurodegenerative sygdomme, neuroner og glia
CN110179827A (zh) * 2019-06-27 2019-08-30 北京三有利和泽生物科技有限公司 牙源性间充质干细胞的应用
CN110314172A (zh) * 2019-07-17 2019-10-11 中国医科大学附属第一医院 一种用于治疗脊髓损伤的细胞制剂及其制备方法
JPWO2021200744A1 (https=) * 2020-03-31 2021-10-07
CN111973631A (zh) * 2020-08-21 2020-11-24 卡替(上海)生物技术有限公司 牙髓间充质干细胞在制备阿尔茨海默病治疗药物中的用途
CN115192609A (zh) * 2022-05-10 2022-10-18 湖南中南大学湘雅口腔医院 间充质干细胞在制备治疗抑郁症的药物中的应用
WO2025084896A1 (ko) * 2023-10-18 2025-04-24 연세대학교 산학협력단 신경세포 분화 유도용 재조합 벡터 및 이를 포함하는 퇴행성 뇌신경 질환의 예방 또는 치료용 약학적 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110158962A1 (en) * 2008-06-26 2011-06-30 Federico Ferro Dental pulp marrow similar cells (dpmsc) and methods of isolating and using
US20150050248A1 (en) * 2013-03-15 2015-02-19 Avita International Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2465924A3 (en) 2005-06-16 2013-01-02 Ramot at Tel-Aviv University Ltd. Isolated cells and populations comprising same for the treament of cns diseases
WO2008080200A1 (en) * 2006-12-29 2008-07-10 Irina Kerkis Process for obtaining stem cells
CN101668848B (zh) 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 来自口腔粘膜的多能自体干细胞和使用方法
RU2347579C1 (ru) * 2007-07-03 2009-02-27 Общество с ограниченной ответственностью "Медицинские технологии" Способ получения клеточной культуры для лечения сосудистых и демиелинизирующих заболеваний нервной системы и клеточная культура, полученная этим способом (варианты)
JP5408578B2 (ja) * 2007-12-05 2014-02-05 国立大学法人名古屋大学 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途
EP2263706B1 (en) * 2008-03-12 2017-11-15 National Center for Geriatrics and Gerontology Root canal filler and dental tissue regeneration method
EP2620493B1 (en) 2008-05-28 2019-03-27 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
CN102725398B (zh) * 2009-12-21 2014-01-08 学校法人总持学园鹤见大学 用于培养及保存牙髓细胞的离体牙的移送方法
WO2012117373A1 (en) 2011-03-03 2012-09-07 Ramot At Tel-Aviv University Ltd. Genetically modified muscle cells which express neurotrophic factors
WO2013076726A1 (en) 2011-11-21 2013-05-30 Ramot At Tel-Aviv University Ltd. Stem cell-derived neural cells for cell therapy in neurological disorders
EP2633870B1 (en) * 2012-02-29 2018-08-01 Technische Universität Berlin Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110158962A1 (en) * 2008-06-26 2011-06-30 Federico Ferro Dental pulp marrow similar cells (dpmsc) and methods of isolating and using
US20150050248A1 (en) * 2013-03-15 2015-02-19 Avita International Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications

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CA3055398A1 (en) 2017-09-14
CN109219441A (zh) 2019-01-15
CA3055399A1 (en) 2017-09-14
RU2018134615A3 (https=) 2020-07-28
RU2018134710A (ru) 2020-04-09
JP2019507772A (ja) 2019-03-22
JP2019510758A (ja) 2019-04-18
IL261623A (en) 2018-10-31
EP3426770A1 (en) 2019-01-16
WO2017153957A9 (en) 2017-11-02
RU2018134710A3 (https=) 2020-06-25
JP6997716B2 (ja) 2022-02-04
BR112018067969A2 (pt) 2019-01-15
CN109312303B (zh) 2024-03-26
WO2017153957A1 (en) 2017-09-14
CN109219441B (zh) 2022-06-10
EP3426267B1 (en) 2023-01-11
RU2741839C2 (ru) 2021-01-29
RU2742828C2 (ru) 2021-02-11
RU2018134615A (ru) 2020-04-10
BR112018067971A2 (pt) 2019-01-15
CN109312303A (zh) 2019-02-05
IL261622B2 (en) 2023-09-01
WO2017153956A1 (en) 2017-09-14
IL261623B1 (en) 2023-11-01
EP3426267A1 (en) 2019-01-16
IL261622A (en) 2018-10-31
IL261622B1 (en) 2023-05-01
IL261623B2 (en) 2024-03-01
KR20180137488A (ko) 2018-12-27
KR102363146B1 (ko) 2022-02-14
KR20190003489A (ko) 2019-01-09
JP7008031B2 (ja) 2022-02-10

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