JPWO2021200744A1 - - Google Patents
Info
- Publication number
- JPWO2021200744A1 JPWO2021200744A1 JP2022512159A JP2022512159A JPWO2021200744A1 JP WO2021200744 A1 JPWO2021200744 A1 JP WO2021200744A1 JP 2022512159 A JP2022512159 A JP 2022512159A JP 2022512159 A JP2022512159 A JP 2022512159A JP WO2021200744 A1 JPWO2021200744 A1 JP WO2021200744A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/231—Interleukin-10 (IL-10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022160399A JP2022181218A (ja) | 2020-03-31 | 2022-10-04 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
| JP2023206347A JP2024015245A (ja) | 2020-03-31 | 2023-12-06 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020063408 | 2020-03-31 | ||
| PCT/JP2021/013099 WO2021200744A1 (ja) | 2020-03-31 | 2021-03-26 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022160399A Division JP2022181218A (ja) | 2020-03-31 | 2022-10-04 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
| JP2023206347A Division JP2024015245A (ja) | 2020-03-31 | 2023-12-06 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021200744A1 true JPWO2021200744A1 (https=) | 2021-10-07 |
| JPWO2021200744A5 JPWO2021200744A5 (https=) | 2022-12-07 |
Family
ID=77930052
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022512159A Pending JPWO2021200744A1 (https=) | 2020-03-31 | 2021-03-26 | |
| JP2022160399A Pending JP2022181218A (ja) | 2020-03-31 | 2022-10-04 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
| JP2023206347A Withdrawn JP2024015245A (ja) | 2020-03-31 | 2023-12-06 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022160399A Pending JP2022181218A (ja) | 2020-03-31 | 2022-10-04 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
| JP2023206347A Withdrawn JP2024015245A (ja) | 2020-03-31 | 2023-12-06 | 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230172992A1 (https=) |
| EP (2) | EP4130240A4 (https=) |
| JP (3) | JPWO2021200744A1 (https=) |
| CN (2) | CN115362252A (https=) |
| AU (2) | AU2021247879B2 (https=) |
| CA (2) | CA3177567A1 (https=) |
| TW (2) | TW202204605A (https=) |
| WO (1) | WO2021200744A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2021200744A1 (https=) * | 2020-03-31 | 2021-10-07 | ||
| EP4324914B1 (en) * | 2021-06-11 | 2026-03-18 | Fullstem Co., Ltd. | Exosome production promoting agent and exosome production promoting method |
| JP7763475B2 (ja) * | 2021-12-24 | 2025-11-04 | 株式会社日本バイオセラピー研究所 | 培養上清を生産する方法 |
| WO2024019080A1 (ja) * | 2022-07-19 | 2024-01-25 | 国立大学法人 長崎大学 | 血管内皮増殖因子を高発現する臍帯由来間葉系細胞の製造方法、および肺疾患治療用医薬組成物 |
| JP7851648B2 (ja) * | 2022-12-23 | 2026-04-27 | Ｃｅｌｌ Ｅｘｏｓｏｍｅ Ｔｈｅｒａｐｅｕｔｉｃｓ株式会社 | 間葉系幹細胞又はその培養上清の利用 |
| WO2025151805A1 (en) * | 2024-01-10 | 2025-07-17 | Biotech Therapeutics, LLC | Mesenchymal stromal cell-derived extracellular vesicle-exosomes |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007023875A1 (ja) * | 2005-08-23 | 2007-03-01 | Oriental Yeast Co., Ltd. | ラミニン５を利用した間葉系幹細胞の培養技術 |
| WO2014199754A1 (ja) * | 2013-06-12 | 2014-12-18 | 国立大学法人大阪大学 | ラミニンフラグメントが乾燥状態でコーティングされている細胞培養器具 |
| WO2016010082A1 (ja) * | 2014-07-16 | 2016-01-21 | 国立大学法人大阪大学 | ラミニンフラグメントの細胞培養基質活性増強方法 |
| WO2017082220A1 (ja) * | 2015-11-10 | 2017-05-18 | 国立大学法人京都大学 | ラミニンフラグメント含有培地を用いる細胞培養方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378612A (en) * | 1990-05-11 | 1995-01-03 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Culture medium for production of recombinant protein |
| JPH05207875A (ja) * | 1992-01-28 | 1993-08-20 | Mitsui Toatsu Chem Inc | 無血清培地 |
| AU680909B2 (en) * | 1994-04-06 | 1997-08-14 | Immunex Corporation | Interleukin-15 |
| JPH10179147A (ja) * | 1996-12-27 | 1998-07-07 | Ishikawajima Harima Heavy Ind Co Ltd | 植物細胞培養方法および二次代謝物高生産性植物細胞 |
| AU2007294731B2 (en) * | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| WO2010040262A1 (zh) * | 2008-10-10 | 2010-04-15 | 深圳市嘉天源生物科技有限公司 | 分离动物胚胎间质性干细胞并提取其分泌物的方法 |
| WO2012137970A1 (ja) | 2011-04-08 | 2012-10-11 | 国立大学法人大阪大学 | 改変ラミニンおよびその利用 |
| WO2012145682A1 (en) * | 2011-04-21 | 2012-10-26 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
| CN104884468B (zh) | 2012-12-28 | 2018-08-31 | 国立大学法人大阪大学 | 附加有胶原结合性分子的改造层粘连蛋白及其利用 |
| CN104651305A (zh) * | 2015-02-13 | 2015-05-27 | 沈阳澔源生物科技有限公司 | 一种利用脐带间充质干细胞获取生物活性蛋白的方法 |
| RU2742828C2 (ru) * | 2016-03-09 | 2021-02-11 | Авита Интернэшнл Лтд. | Применение стволовых клеток, экспрессирующих мезенхимальные и нейрональные маркеры, и их композиций для лечения неврологических заболеваний (варианты) |
| AU2018228352B2 (en) * | 2017-02-28 | 2024-08-01 | Centre Hospitalier Régional Universitaire De Nancy | Mesenchymal stem cells obtained from Wharton's jelly for the treatment of sepsis |
| JP6469287B1 (ja) * | 2018-06-22 | 2019-02-13 | 株式会社 バイオミメティクスシンパシーズ | 中空糸細胞培養装置，細胞培養方法，培養上清の製造方法 |
| JPWO2021200744A1 (https=) * | 2020-03-31 | 2021-10-07 |
-
2021
- 2021-03-26 JP JP2022512159A patent/JPWO2021200744A1/ja active Pending
- 2021-03-26 EP EP21779739.8A patent/EP4130240A4/en active Pending
- 2021-03-26 CN CN202180024893.1A patent/CN115362252A/zh active Pending
- 2021-03-26 EP EP22207135.9A patent/EP4155389A3/en active Pending
- 2021-03-26 US US17/995,095 patent/US20230172992A1/en active Pending
- 2021-03-26 AU AU2021247879A patent/AU2021247879B2/en active Active
- 2021-03-26 WO PCT/JP2021/013099 patent/WO2021200744A1/ja not_active Ceased
- 2021-03-26 CN CN202310081275.1A patent/CN116179480A/zh not_active Withdrawn
- 2021-03-26 CA CA3177567A patent/CA3177567A1/en active Pending
- 2021-03-26 CA CA3173721A patent/CA3173721A1/en active Pending
- 2021-03-30 TW TW110111636A patent/TW202204605A/zh unknown
- 2021-03-30 TW TW111147409A patent/TW202311526A/zh unknown
-
2022
- 2022-10-04 JP JP2022160399A patent/JP2022181218A/ja active Pending
- 2022-10-25 AU AU2022259729A patent/AU2022259729B2/en active Active
-
2023
- 2023-12-06 JP JP2023206347A patent/JP2024015245A/ja not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007023875A1 (ja) * | 2005-08-23 | 2007-03-01 | Oriental Yeast Co., Ltd. | ラミニン５を利用した間葉系幹細胞の培養技術 |
| WO2014199754A1 (ja) * | 2013-06-12 | 2014-12-18 | 国立大学法人大阪大学 | ラミニンフラグメントが乾燥状態でコーティングされている細胞培養器具 |
| WO2016010082A1 (ja) * | 2014-07-16 | 2016-01-21 | 国立大学法人大阪大学 | ラミニンフラグメントの細胞培養基質活性増強方法 |
| WO2017082220A1 (ja) * | 2015-11-10 | 2017-05-18 | 国立大学法人京都大学 | ラミニンフラグメント含有培地を用いる細胞培養方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021247879A1 (en) | 2022-11-03 |
| EP4155389A3 (en) | 2023-07-12 |
| EP4130240A1 (en) | 2023-02-08 |
| CA3177567A1 (en) | 2021-10-07 |
| EP4130240A4 (en) | 2024-05-08 |
| EP4155389A2 (en) | 2023-03-29 |
| CN116179480A (zh) | 2023-05-30 |
| TW202311526A (zh) | 2023-03-16 |
| AU2022259729B2 (en) | 2025-05-01 |
| AU2022259729A1 (en) | 2022-12-01 |
| AU2021247879B2 (en) | 2025-04-24 |
| JP2024015245A (ja) | 2024-02-01 |
| US20230172992A1 (en) | 2023-06-08 |
| JP2022181218A (ja) | 2022-12-07 |
| WO2021200744A1 (ja) | 2021-10-07 |
| TW202204605A (zh) | 2022-02-01 |
| CN115362252A (zh) | 2022-11-18 |
| CA3173721A1 (en) | 2021-10-07 |
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