JP2011517563A5 - - Google Patents
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- Publication number
- JP2011517563A5 JP2011517563A5 JP2011502014A JP2011502014A JP2011517563A5 JP 2011517563 A5 JP2011517563 A5 JP 2011517563A5 JP 2011502014 A JP2011502014 A JP 2011502014A JP 2011502014 A JP2011502014 A JP 2011502014A JP 2011517563 A5 JP2011517563 A5 JP 2011517563A5
- Authority
- JP
- Japan
- Prior art keywords
- progenitor cells
- human
- cardiovascular progenitor
- population
- human cardiovascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 35
- 210000000130 stem cell Anatomy 0.000 claims 24
- 230000002526 effect on cardiovascular system Effects 0.000 claims 23
- 102000013814 Wnt Human genes 0.000 claims 9
- 108050003627 Wnt Proteins 0.000 claims 9
- 238000012258 culturing Methods 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 9
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 101000864646 Homo sapiens Dickkopf-related protein 1 Proteins 0.000 claims 7
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 6
- 210000004413 cardiac myocyte Anatomy 0.000 claims 6
- 239000012679 serum free medium Substances 0.000 claims 6
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 5
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 5
- 108010023082 activin A Proteins 0.000 claims 5
- 108010059616 Activins Proteins 0.000 claims 4
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 4
- 239000000488 activin Substances 0.000 claims 4
- 210000002242 embryoid body Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 210000004509 vascular smooth muscle cell Anatomy 0.000 claims 2
- 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims 1
- 102100030091 Dickkopf-related protein 2 Human genes 0.000 claims 1
- 101000864647 Homo sapiens Dickkopf-related protein 2 Proteins 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4004908P | 2008-03-27 | 2008-03-27 | |
| US61/040,049 | 2008-03-27 | ||
| PCT/US2009/038220 WO2009120762A2 (en) | 2008-03-27 | 2009-03-25 | Human cardiovascular progenitor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517563A JP2011517563A (ja) | 2011-06-16 |
| JP2011517563A5 true JP2011517563A5 (https=) | 2012-05-24 |
| JP5801187B2 JP5801187B2 (ja) | 2015-10-28 |
Family
ID=41114664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502014A Active JP5801187B2 (ja) | 2008-03-27 | 2009-03-25 | ヒト心血管前駆細胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10077428B2 (https=) |
| EP (1) | EP2273996B8 (https=) |
| JP (1) | JP5801187B2 (https=) |
| AU (1) | AU2009228354B2 (https=) |
| CA (1) | CA2717962C (https=) |
| DK (1) | DK2273996T3 (https=) |
| IL (2) | IL208334A (https=) |
| WO (1) | WO2009120762A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103627671A (zh) * | 2007-01-30 | 2014-03-12 | 佐治亚大学研究基金会 | 产生中内胚层细胞及多能游走细胞的方法与细胞群及用途 |
| EP2490701B9 (en) * | 2009-10-19 | 2017-11-15 | Cellular Dynamics International, Inc. | Cardiomyocyte production |
| WO2011090684A2 (en) * | 2009-12-29 | 2011-07-28 | Cornell University | Methods for developing endothelial cells from pluripotent cells and endothelial cells derived |
| US20120301445A1 (en) * | 2010-01-26 | 2012-11-29 | Universite Libre De Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| US9273286B2 (en) | 2010-06-13 | 2016-03-01 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
| US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
| WO2012112776A2 (en) * | 2011-02-16 | 2012-08-23 | Salk Institute For Biological Studies | Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors |
| JP6185907B2 (ja) | 2011-03-30 | 2017-08-23 | セルラー ダイナミクス インターナショナル， インコーポレイテッド | 神経分化のための多能性幹細胞の予備刺激 |
| GB201109882D0 (en) | 2011-06-13 | 2011-07-27 | Cambridge Entpr Ltd | Population of smooth muscle cells of specific embryonic lineages |
| GB201121101D0 (en) * | 2011-12-08 | 2012-01-18 | Nhs Blood & Transplant | A method of preparing isolated cells and uses |
| US9764063B2 (en) * | 2012-03-15 | 2017-09-19 | Iheart Japan Corporation | Method for producing mixed cell population of cardiomyocytes and vascular cells from induced pluripotent stem cell |
| CN104508121B (zh) * | 2012-07-23 | 2018-01-19 | 中国科学院生物物理研究所 | 体外诱导多能干细胞分化为心室肌细胞的方法 |
| WO2014192925A1 (ja) * | 2013-05-31 | 2014-12-04 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | 効率的な内皮細胞の誘導方法 |
| WO2014197421A1 (en) | 2013-06-05 | 2014-12-11 | Biotime, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
| NZ716860A (en) * | 2013-09-13 | 2022-07-01 | Univ Health Network | Methods and compositions for generating epicardium cells |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
| GB201412554D0 (en) * | 2014-07-15 | 2014-08-27 | Cambridge Entpr Ltd | In vitro mesodermal differentiation |
| CA2976283C (en) | 2015-02-17 | 2022-04-26 | University Health Network | Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes |
| CA3202332A1 (en) | 2015-12-07 | 2017-06-15 | Agex Therapeutics, Inc. | Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells |
| US10612002B2 (en) | 2016-02-19 | 2020-04-07 | University Of Washington | Human pluripotent stem cell derived endocardial endothelium |
| WO2017147381A1 (en) * | 2016-02-25 | 2017-08-31 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Generation of expandable cardiovascular progenitor cells |
| CN116096388A (zh) * | 2020-05-08 | 2023-05-09 | 大学健康网络 | 用于制备和使用心内膜细胞的方法和组合物 |
| EP4508645A1 (en) | 2022-04-15 | 2025-02-19 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5919449A (en) | 1995-05-30 | 1999-07-06 | Diacrin, Inc. | Porcine cardiomyocytes and their use in treatment of insufficient cardiac function |
| US20050021439A1 (en) | 1999-04-09 | 2005-01-27 | Pinga Louis J. | Arcade casino and home investment system |
| WO2003006950A2 (en) | 2001-07-12 | 2003-01-23 | Geron Corporation | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| US20030082153A1 (en) | 2001-10-22 | 2003-05-01 | The Government Of The United States Of America | Stem cells that transform to beating cardiomyocytes |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2004094610A2 (en) | 2003-04-21 | 2004-11-04 | Baylor College Of Medicine | Wnt as a factor for cardiac myogenesis |
| US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| US20050214938A1 (en) * | 2004-03-26 | 2005-09-29 | Gold Joseph D | Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function |
| CA2611809C (en) | 2005-06-22 | 2018-06-19 | Geron Corporation | Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells |
| CA2620567A1 (en) | 2005-06-23 | 2007-01-04 | Mount Sinai School Of Medicine Of New York University | Cardiomyocyte cell populations |
-
2009
- 2009-03-25 AU AU2009228354A patent/AU2009228354B2/en active Active
- 2009-03-25 JP JP2011502014A patent/JP5801187B2/ja active Active
- 2009-03-25 US US12/410,782 patent/US10077428B2/en active Active
- 2009-03-25 WO PCT/US2009/038220 patent/WO2009120762A2/en not_active Ceased
- 2009-03-25 CA CA2717962A patent/CA2717962C/en active Active
- 2009-03-25 EP EP09726362.8A patent/EP2273996B8/en active Active
- 2009-03-25 DK DK09726362.8T patent/DK2273996T3/en active
-
2010
- 2010-09-21 IL IL208334A patent/IL208334A/en active IP Right Grant
-
2015
- 2015-08-27 IL IL240870A patent/IL240870B/en active IP Right Grant
-
2018
- 2018-08-09 US US16/059,647 patent/US10947506B2/en active Active
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