JP2012070731A5 - - Google Patents
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- Publication number
- JP2012070731A5 JP2012070731A5 JP2011189582A JP2011189582A JP2012070731A5 JP 2012070731 A5 JP2012070731 A5 JP 2012070731A5 JP 2011189582 A JP2011189582 A JP 2011189582A JP 2011189582 A JP2011189582 A JP 2011189582A JP 2012070731 A5 JP2012070731 A5 JP 2012070731A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- pluripotent stem
- hematopoietic
- cells
- tgf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 56
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 40
- 230000004069 differentiation Effects 0.000 claims 28
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 24
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 24
- 239000003112 inhibitor Substances 0.000 claims 24
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 14
- 230000001939 inductive effect Effects 0.000 claims 13
- 238000000034 method Methods 0.000 claims 13
- 230000001737 promoting effect Effects 0.000 claims 11
- 230000006698 induction Effects 0.000 claims 9
- 108091005735 TGF-beta receptors Proteins 0.000 claims 8
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 8
- 238000012258 culturing Methods 0.000 claims 8
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 8
- 238000000338 in vitro Methods 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000003394 haemopoietic effect Effects 0.000 claims 4
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 3
- 102000046148 human BMP4 Human genes 0.000 claims 3
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 102000058223 human VEGFA Human genes 0.000 claims 2
- 102000008137 Bone Morphogenetic Protein 4 Human genes 0.000 claims 1
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 claims 1
- 101000799461 Homo sapiens Thrombopoietin Proteins 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- IBCXZJCWDGCXQT-UHFFFAOYSA-N c([nH]nc1-c2ccccn2)c1-c1ccnc2c1cccc2 Chemical compound c([nH]nc1-c2ccccn2)c1-c1ccnc2c1cccc2 IBCXZJCWDGCXQT-UHFFFAOYSA-N 0.000 description 2
- DKPQHFZUICCZHF-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ccc3nccnc3c2)c(-c2cccc(C)n2)[nH]1 Chemical compound CC(C)(C)c1nc(-c2ccc3nccnc3c2)c(-c2cccc(C)n2)[nH]1 DKPQHFZUICCZHF-UHFFFAOYSA-N 0.000 description 1
- FHYUGAJXYORMHI-UHFFFAOYSA-N NC(c(cc1)ccc1-c1nc(-c(cc2)cc3c2OCO3)c(-c2ncccc2)[nH]1)=O Chemical compound NC(c(cc1)ccc1-c1nc(-c(cc2)cc3c2OCO3)c(-c2ncccc2)[nH]1)=O FHYUGAJXYORMHI-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011189582A JP5928681B2 (ja) | 2010-08-31 | 2011-08-31 | ヒト多能性幹細胞からの造血幹細胞の効率的な誘導方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010193827 | 2010-08-31 | ||
| JP2010193827 | 2010-08-31 | ||
| JP2011189582A JP5928681B2 (ja) | 2010-08-31 | 2011-08-31 | ヒト多能性幹細胞からの造血幹細胞の効率的な誘導方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012070731A JP2012070731A (ja) | 2012-04-12 |
| JP2012070731A5 true JP2012070731A5 (https=) | 2014-10-16 |
| JP5928681B2 JP5928681B2 (ja) | 2016-06-01 |
Family
ID=46167285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011189582A Expired - Fee Related JP5928681B2 (ja) | 2010-08-31 | 2011-08-31 | ヒト多能性幹細胞からの造血幹細胞の効率的な誘導方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5928681B2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160146788A1 (en) * | 2013-05-23 | 2016-05-26 | Kyoto University | Method for screening drugs for treating/preventing myelodysplastic syndrome, etc. |
| EP3211071B1 (en) | 2014-10-24 | 2021-05-05 | Sumitomo Dainippon Pharma Co., Ltd. | Production method for retinal tissue |
| TWI810142B (zh) * | 2014-10-24 | 2023-08-01 | 日商住友製藥股份有限公司 | 神經組織的製造方法 |
| SG11201809201UA (en) | 2016-04-22 | 2018-11-29 | Sumitomo Dainippon Pharma Co Ltd | Method for producing retinal tissue |
| CN110551688B (zh) * | 2019-09-26 | 2023-03-21 | 上海交通大学医学院附属瑞金医院 | 一种诱导体细胞重编程为造血干/祖细胞且促进造血干/祖细胞体外扩增的组合物及其应用 |
| JP7654259B2 (ja) * | 2019-10-29 | 2025-04-01 | 国立大学法人京都大学 | 多能性幹細胞から造血性内皮細胞および／または造血前駆細胞を製造する方法 |
| JP7744155B2 (ja) * | 2021-04-19 | 2025-09-25 | キヤノンメディカルシステムズ株式会社 | 多能性幹細胞製造システム |
| CN113215086A (zh) * | 2021-05-26 | 2021-08-06 | 杭州原生生物科技有限公司 | 一种多能干细胞诱导分化成造血干细胞的培养基及方法 |
| CN113373115A (zh) * | 2021-06-11 | 2021-09-10 | 杭州原生生物科技有限公司 | 一种低成本多能干细胞分化造血干细胞的培养基及培养方法 |
| CN115786259B (zh) * | 2022-12-02 | 2025-12-23 | 华南理工大学 | 一种诱导干细胞分化为巨核细胞和/或血小板的试剂盒及其应用 |
| CN117402818B (zh) * | 2023-12-15 | 2024-02-23 | 成都艾名迈德医学检验实验室有限公司 | 一种拟胚体封装材料、封装装置及封装装置的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009311232B2 (en) * | 2008-11-07 | 2014-10-30 | Sunnybrook Health Sciences Centre | Human progenitor T-cells |
-
2011
- 2011-08-31 JP JP2011189582A patent/JP5928681B2/ja not_active Expired - Fee Related
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