JP2018527007A5 - - Google Patents

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Publication number
JP2018527007A5
JP2018527007A5 JP2018514450A JP2018514450A JP2018527007A5 JP 2018527007 A5 JP2018527007 A5 JP 2018527007A5 JP 2018514450 A JP2018514450 A JP 2018514450A JP 2018514450 A JP2018514450 A JP 2018514450A JP 2018527007 A5 JP2018527007 A5 JP 2018527007A5
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JP
Japan
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cells
expresses
npc
pluripotent stem
metanephric
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JP2018514450A
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English (en)
Japanese (ja)
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JP2018527007A (ja
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Priority claimed from PCT/US2016/052350 external-priority patent/WO2017049243A1/en
Publication of JP2018527007A publication Critical patent/JP2018527007A/ja
Publication of JP2018527007A5 publication Critical patent/JP2018527007A5/ja
Pending legal-status Critical Current

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JP2018514450A 2015-09-17 2016-09-16 ヒト多能性幹細胞からネフロンを生成する方法 Pending JP2018527007A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219704P 2015-09-17 2015-09-17
US62/219,704 2015-09-17
PCT/US2016/052350 WO2017049243A1 (en) 2015-09-17 2016-09-16 Methods of generating nephrons from human pluripotent stem cells

Publications (2)

Publication Number Publication Date
JP2018527007A JP2018527007A (ja) 2018-09-20
JP2018527007A5 true JP2018527007A5 (https=) 2019-10-17

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ID=58289693

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Application Number Title Priority Date Filing Date
JP2018514450A Pending JP2018527007A (ja) 2015-09-17 2016-09-16 ヒト多能性幹細胞からネフロンを生成する方法

Country Status (3)

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US (1) US20180258404A1 (https=)
JP (1) JP2018527007A (https=)
WO (1) WO2017049243A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
US11268950B2 (en) * 2016-09-28 2022-03-08 Organovo, Inc. Use of engineered renal tissues in assays
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3633026A4 (en) * 2017-05-25 2021-03-10 Kyoto University METHOD FOR INDUCING THE DIFFERENTIATION OF A MESODERMAL INTERMEDIATE CELL TO A KIDNEY PRECURSOR CELL AND METHOD FOR INDUCING THE DIFFERENTIATION OF A PLURIPOTENT STEM CELL FROM A KIDNEY PRECURSOR CELL
CN110997024A (zh) 2017-06-09 2020-04-10 哈佛大学的校长及成员们 增强肾脏类器官发育的方法及其使用方法
EP3681998A1 (en) 2017-09-11 2020-07-22 IMBA-Institut für Molekulare Biotechnologie GmbH Tumor organoid model
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
SG11202003790PA (en) * 2017-10-31 2020-05-28 Murdoch Childrens Res Inst Composition and method
EP3719116A4 (en) * 2017-11-30 2021-08-11 Public University Corporation Yokohama City University PRODUCTION OF A THREE-DIMENSIONAL ORGAN FROM PLURIPOTENT STEM CELLS
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US20220135940A1 (en) * 2018-11-08 2022-05-05 National University Corporation Kumamoto University Method for producing kidney structure having dendritically branched collecting duct from pluripotent stem cells
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020170240A1 (en) * 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reduction drug-induced nephrotoxicity
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
JP7671987B2 (ja) * 2019-07-23 2025-05-07 国立大学法人京都大学 繊毛関連疾患モデルおよびその利用
CN110468095A (zh) * 2019-09-05 2019-11-19 安徽中盛溯源生物科技有限公司 一种肾上皮细胞及其制备方法和应用
US12371669B2 (en) * 2021-11-09 2025-07-29 POSTECH Research and Business Development Foundation Kidney organoids and method for producing the same
WO2023235828A1 (en) * 2022-06-03 2023-12-07 The Trustees Of The University Of Pennsylvania Manipulating nephron differentiation rate in induced human pluripotent stem cell organoids and tissues by engineering mechanics of the microenvironment
GB202308793D0 (en) * 2023-06-13 2023-07-26 Astrazeneca Ab Tissue regeneration
WO2025114599A1 (en) * 2023-12-01 2025-06-05 Academisch Ziekenhuis Maastricht Improved kidney organoid culture method by modulating pka
WO2025192746A1 (ja) * 2024-03-15 2025-09-18 株式会社Racthera 腎臓オルガノイド及びその製造方法
CN120988975A (zh) * 2025-08-26 2025-11-21 复旦大学附属中山医院 一种多能干细胞衍生肾脏类器官的诱导分化方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2334804B1 (en) * 2008-10-07 2013-12-04 True North Therapeutics, Inc. Co-culture compositions and methods
KR102145967B1 (ko) * 2013-06-11 2020-08-19 고쿠리츠 다이가쿠 호진 교토 다이가쿠 신장 전구세포의 제조 방법 및 신장 전구세포를 포함하는 의약
RU2016100232A (ru) * 2013-06-14 2017-07-17 Дзе Юниверсити Оф Квинсленд Почечные клетки-предшественники
MX2015017330A (es) * 2013-07-29 2016-04-06 Hoffmann La Roche Metodo para la diferenciacion de celulas madre pluripotenciales en precursores renales multi-competentes.
JP6455729B2 (ja) * 2013-10-18 2019-01-23 国立大学法人 熊本大学 多能性幹細胞からの腎臓誘導法
WO2015130935A1 (en) * 2014-02-26 2015-09-03 Maine Medical Center Research Institute Culture conditions for expansion of nephron progenitor cells

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