JP2018527007A - ヒト多能性幹細胞からネフロンを生成する方法 - Google Patents

ヒト多能性幹細胞からネフロンを生成する方法 Download PDF

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JP2018527007A
JP2018527007A JP2018514450A JP2018514450A JP2018527007A JP 2018527007 A JP2018527007 A JP 2018527007A JP 2018514450 A JP2018514450 A JP 2018514450A JP 2018514450 A JP2018514450 A JP 2018514450A JP 2018527007 A JP2018527007 A JP 2018527007A
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ジョセフ ブイ． ボンベンター
ジョセフ ブイ． ボンベンター
リュウジ モリザネ
リュウジ モリザネ
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Brigham and Womens Hospital Inc
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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JP2018514450A 2015-09-17 2016-09-16 ヒト多能性幹細胞からネフロンを生成する方法 Pending JP2018527007A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219704P 2015-09-17 2015-09-17
US62/219,704 2015-09-17
PCT/US2016/052350 WO2017049243A1 (en) 2015-09-17 2016-09-16 Methods of generating nephrons from human pluripotent stem cells

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JP2018527007A true JP2018527007A (ja) 2018-09-20
JP2018527007A5 JP2018527007A5 (https=) 2019-10-17

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Cited By (4)

* Cited by examiner, † Cited by third party
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WO2020095423A1 (ja) * 2018-11-08 2020-05-14 国立大学法人熊本大学 多能性幹細胞から樹状分岐した集合管を伴う腎臓構造を作製する方法
JPWO2021015245A1 (https=) * 2019-07-23 2021-01-28
JP2023070667A (ja) * 2021-11-09 2023-05-19 ポステック・リサーチ・アンド・ビジネス・ディベロップメント・ファウンデーション 腎臓オルガノイド及びその製造方法
WO2025192746A1 (ja) * 2024-03-15 2025-09-18 株式会社Racthera 腎臓オルガノイド及びその製造方法

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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
US11268950B2 (en) * 2016-09-28 2022-03-08 Organovo, Inc. Use of engineered renal tissues in assays
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3633026A4 (en) * 2017-05-25 2021-03-10 Kyoto University METHOD FOR INDUCING THE DIFFERENTIATION OF A MESODERMAL INTERMEDIATE CELL TO A KIDNEY PRECURSOR CELL AND METHOD FOR INDUCING THE DIFFERENTIATION OF A PLURIPOTENT STEM CELL FROM A KIDNEY PRECURSOR CELL
CN110997024A (zh) 2017-06-09 2020-04-10 哈佛大学的校长及成员们 增强肾脏类器官发育的方法及其使用方法
EP3681998A1 (en) 2017-09-11 2020-07-22 IMBA-Institut für Molekulare Biotechnologie GmbH Tumor organoid model
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
SG11202003790PA (en) * 2017-10-31 2020-05-28 Murdoch Childrens Res Inst Composition and method
EP3719116A4 (en) * 2017-11-30 2021-08-11 Public University Corporation Yokohama City University PRODUCTION OF A THREE-DIMENSIONAL ORGAN FROM PLURIPOTENT STEM CELLS
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020170240A1 (en) * 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reduction drug-induced nephrotoxicity
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN110468095A (zh) * 2019-09-05 2019-11-19 安徽中盛溯源生物科技有限公司 一种肾上皮细胞及其制备方法和应用
WO2023235828A1 (en) * 2022-06-03 2023-12-07 The Trustees Of The University Of Pennsylvania Manipulating nephron differentiation rate in induced human pluripotent stem cell organoids and tissues by engineering mechanics of the microenvironment
GB202308793D0 (en) * 2023-06-13 2023-07-26 Astrazeneca Ab Tissue regeneration
WO2025114599A1 (en) * 2023-12-01 2025-06-05 Academisch Ziekenhuis Maastricht Improved kidney organoid culture method by modulating pka
CN120988975A (zh) * 2025-08-26 2025-11-21 复旦大学附属中山医院 一种多能干细胞衍生肾脏类器官的诱导分化方法

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020095423A1 (ja) * 2018-11-08 2020-05-14 国立大学法人熊本大学 多能性幹細胞から樹状分岐した集合管を伴う腎臓構造を作製する方法
JPWO2021015245A1 (https=) * 2019-07-23 2021-01-28
WO2021015245A1 (ja) * 2019-07-23 2021-01-28 国立大学法人京都大学 繊毛関連疾患モデルおよびその利用
JP7671987B2 (ja) 2019-07-23 2025-05-07 国立大学法人京都大学 繊毛関連疾患モデルおよびその利用
JP2023070667A (ja) * 2021-11-09 2023-05-19 ポステック・リサーチ・アンド・ビジネス・ディベロップメント・ファウンデーション 腎臓オルガノイド及びその製造方法
US12371669B2 (en) 2021-11-09 2025-07-29 POSTECH Research and Business Development Foundation Kidney organoids and method for producing the same
WO2025192746A1 (ja) * 2024-03-15 2025-09-18 株式会社Racthera 腎臓オルガノイド及びその製造方法

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