JP2019506394A5 - - Google Patents
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- JP2019506394A5 JP2019506394A5 JP2018538085A JP2018538085A JP2019506394A5 JP 2019506394 A5 JP2019506394 A5 JP 2019506394A5 JP 2018538085 A JP2018538085 A JP 2018538085A JP 2018538085 A JP2018538085 A JP 2018538085A JP 2019506394 A5 JP2019506394 A5 JP 2019506394A5
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- JP
- Japan
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- acid sequence
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 81
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 24
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 23
- 210000004899 c-terminal region Anatomy 0.000 claims 17
- 210000002865 immune cell Anatomy 0.000 claims 17
- 230000004068 intracellular signaling Effects 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 206010073128 Anaplastic oligodendroglioma Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 206010014967 Ependymoma Diseases 0.000 claims 2
- 208000000172 Medulloblastoma Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 208000007641 Pinealoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 206010014968 Ependymoma malignant Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010050487 Pinealoblastoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 1
- 206010073334 Rhabdoid tumour Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010043276 Teratoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010002224 anaplastic astrocytoma Diseases 0.000 claims 1
- 208000014534 anaplastic ependymoma Diseases 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000010932 epithelial neoplasm Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 208000026436 grade III glioma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 108020001756 ligand binding domains Proteins 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 201000004058 mixed glioma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000003113 pineoblastoma Diseases 0.000 claims 1
- 206010035059 pineocytoma Diseases 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662281533P | 2016-01-21 | 2016-01-21 | |
| US62/281,533 | 2016-01-21 | ||
| US201662431758P | 2016-12-08 | 2016-12-08 | |
| US62/431,758 | 2016-12-08 | ||
| PCT/IB2017/050108 WO2017125830A1 (en) | 2016-01-21 | 2017-01-10 | Chimeric antigen receptors targeting epidermal growth factor receptor variant iii |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177399A Division JP7198797B2 (ja) | 2016-01-21 | 2020-10-22 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506394A JP2019506394A (ja) | 2019-03-07 |
| JP2019506394A5 true JP2019506394A5 (enExample) | 2020-02-20 |
| JP6823659B2 JP6823659B2 (ja) | 2021-02-03 |
Family
ID=57868301
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538085A Active JP6823659B2 (ja) | 2016-01-21 | 2017-01-10 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
| JP2020177399A Active JP7198797B2 (ja) | 2016-01-21 | 2020-10-22 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177399A Active JP7198797B2 (ja) | 2016-01-21 | 2020-10-22 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10259876B2 (enExample) |
| EP (1) | EP3405481B1 (enExample) |
| JP (2) | JP6823659B2 (enExample) |
| KR (1) | KR102479606B1 (enExample) |
| CN (1) | CN108699124A (enExample) |
| AU (1) | AU2017208834B2 (enExample) |
| BR (1) | BR112018014585A2 (enExample) |
| CA (1) | CA2954014A1 (enExample) |
| DK (1) | DK3405481T5 (enExample) |
| EA (1) | EA201891641A1 (enExample) |
| ES (1) | ES2942362T3 (enExample) |
| IL (1) | IL260666B2 (enExample) |
| MX (1) | MX2018008978A (enExample) |
| MY (1) | MY192474A (enExample) |
| NZ (1) | NZ744821A (enExample) |
| PH (1) | PH12018501473B1 (enExample) |
| RU (1) | RU2751662C2 (enExample) |
| SA (1) | SA518392058B1 (enExample) |
| SG (2) | SG10202111458RA (enExample) |
| TW (2) | TWI634125B (enExample) |
| UA (1) | UA125252C2 (enExample) |
| WO (1) | WO2017125830A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA43134A (fr) | 2015-10-30 | 2018-09-05 | Aleta Biotherapeutics Inc | Compositions et méthodes de transduction tumorale |
| WO2017075537A1 (en) | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| ES2904593T3 (es) | 2016-01-21 | 2022-04-05 | Pfizer | Anticuerpos monoespecíficos y biespecíficos para la variante III del receptor del factor de crecimiento epidérmico y CD3 y sus usos |
| BR112018014585A2 (pt) | 2016-01-21 | 2018-12-11 | Pfizer | receptores de antígeno quiméricos que direcionam o receptor do fator de crescimento epidérmico variante iii |
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| IL327498A (en) | 2017-06-02 | 2026-05-01 | Juno Therapeutics Inc | Articles of manufacture and methods for treatment using adoptive cell therapy |
| CA3096202A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| EP3773633A4 (en) | 2018-04-06 | 2022-01-26 | The Regents of The University of California | METHODS OF TREATMENT OF GLIOBLASTOMA |
| TW202020146A (zh) * | 2018-07-26 | 2020-06-01 | 大陸商南京傳奇生物科技有限公司 | 含nef之t細胞及其產生方法 |
| CN109265561B (zh) * | 2018-09-25 | 2021-05-25 | 山东兴瑞生物科技有限公司 | 抗EGFRvⅢ安全型嵌合抗原受体、其制备方法、利用其修饰的NK细胞及应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20220033848A1 (en) * | 2018-11-19 | 2022-02-03 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| PE20211915A1 (es) * | 2018-12-01 | 2021-09-28 | Allogene Therapeutics Inc | Receptores de antigenos quimericos dirigidos al antigeno de maduracion de celulas b y sus metodos de uso |
| SG11202102859TA (en) * | 2018-12-21 | 2021-04-29 | Hoffmann La Roche | Antibodies binding to cd3 |
| LT4279082T (lt) * | 2019-01-17 | 2026-05-11 | Immunocore Limited | Farmacinės kompozicijos |
| CN111454358A (zh) * | 2019-01-18 | 2020-07-28 | 四川科伦博泰生物医药股份有限公司 | 一种嵌合抗原受体及其应用 |
| CN113710697A (zh) * | 2019-03-15 | 2021-11-26 | 美国政府(由卫生和人类服务部的部长所代表) | 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途 |
| MX2022000174A (es) | 2019-07-02 | 2022-05-20 | Us Health | Anticuerpos monoclonales que se enlazan a egfrviii y sus usos. |
| US20220288118A1 (en) * | 2019-07-31 | 2022-09-15 | Forty Seven, Inc. | Depletion regimes for engineered t-cell or nk-cell therapy |
| US20220401537A1 (en) * | 2019-09-16 | 2022-12-22 | Fred Hutchinson Cancer Research Center | Chimeric receptor proteins and uses thereof |
| AU2020358898B2 (en) * | 2019-10-01 | 2025-10-16 | Epsilogen Ltd | Hybrid antibody |
| EP4081537A1 (en) * | 2019-12-23 | 2022-11-02 | Cellectis | New mesothelin specific chimeric antigen receptors (car) for solid tumors cancer immunotherapy |
| WO2021130535A2 (en) * | 2019-12-28 | 2021-07-01 | Shanghai Cell Therapy Group Company Co., Ltd. | Cell expressing immune modulatory molecules and system for expressing immune modulatory molecules |
| CN111019959B (zh) * | 2019-12-30 | 2022-09-13 | 北京立康生命科技有限公司 | 一种体外转录mRNA的核苷酸分子、呈递细胞及应用 |
| WO2021150936A1 (en) * | 2020-01-22 | 2021-07-29 | City Of Hope | Oncolytic virus compositions including il-15 complex and methods for the treatment of cancer |
| WO2021159035A1 (en) | 2020-02-07 | 2021-08-12 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
| JP2023541253A (ja) * | 2020-09-10 | 2023-09-29 | ムスタング バイオ，インコーポレイテッド | 癌標的のｃａｒ－ｔ細胞を含む併用療法と、それを癌治療に使用する方法 |
| JP2024500189A (ja) | 2020-12-21 | 2024-01-04 | アロジーン セラピューティクス，インコーポレイテッド | プロテアーゼ活性化ｃｄ４５ゲートｃａｒ |
| MX2023008809A (es) | 2021-01-29 | 2023-08-04 | Allogene Therapeutics Inc | ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. |
| JPWO2023286840A1 (enExample) * | 2021-07-16 | 2023-01-19 | ||
| AU2021467228A1 (en) * | 2021-09-29 | 2024-04-04 | National Research Council Of Canada | Humanized anti-egfrviii antibodies and antigen-binding fragments thereof |
| US20240042030A1 (en) | 2022-07-29 | 2024-02-08 | Allogene Therapeutics, Inc. | Engineered cells with reduced gene expression to mitigate immune cell recognition |
| EP4567046A1 (en) * | 2022-08-05 | 2025-06-11 | Beijing DCTY Biotech Co., Ltd. | Antibody targeting egfrviii and use thereof in cell immunotherapy |
| CN116284435A (zh) * | 2022-09-19 | 2023-06-23 | 卡瑞济(北京)生命科技有限公司 | EGFRvIII嵌合抗原受体及其用途 |
| CN120936371A (zh) * | 2023-03-30 | 2025-11-11 | 诺沃库勒有限责任公司 | 用于使用肿瘤治疗电场和嵌合抗原受体(car)免疫细胞治疗癌症的组合物、系统和方法 |
| KR20260105764A (ko) | 2023-10-30 | 2026-07-07 | 알로젠 테라퓨틱스 인코포레이티드 | 조작된 세포 |
| CN117659196B (zh) * | 2023-12-12 | 2024-08-23 | 成都优赛诺生物科技有限公司 | 一种靶向cd7的单域抗体、嵌合抗原受体及其应用 |
| CN119912588B (zh) * | 2025-04-01 | 2025-08-12 | 浙江大学 | 嵌合抗原受体、人诱导多能干细胞、髓系前体细胞样巨噬细胞及其制备方法 |
| CN120248142B (zh) * | 2025-06-06 | 2025-09-12 | 上海兴瑞一达生物科技有限公司 | 一种共表达cd47和il-15的双靶点嵌合抗原受体、car-t细胞及其应用 |
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| SI2997141T1 (sl) | 2013-05-13 | 2023-04-28 | Cellectis | CD19 specifični himerni antigenski receptor in njegova uporaba |
| JP6608807B2 (ja) | 2013-05-29 | 2019-11-20 | セレクティス | Ｒｎａガイドｃａｓヌクレアーゼ系を用いることによって免疫療法のためにｔ細胞を操作するための方法 |
| CA2917919C (en) | 2013-07-09 | 2019-07-02 | Duke University | Certain improved human bispecific egfrviii antibody engaging molecules |
| CN105555804B (zh) | 2013-08-07 | 2020-12-25 | 阿菲姆德股份有限公司 | 对EGFRvIII有特异性的抗体结合位点 |
| WO2015092024A2 (en) | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| RU2017102769A (ru) * | 2014-07-29 | 2018-08-28 | Пфайзер Инк. | EGFRvIII СПЕЦИФИЧЕСКИЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРЫ ДЛЯ ИММУНОТЕРАПИИ РАКА |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| BR112018014585A2 (pt) | 2016-01-21 | 2018-12-11 | Pfizer | receptores de antígeno quiméricos que direcionam o receptor do fator de crescimento epidérmico variante iii |
| ES2904593T3 (es) | 2016-01-21 | 2022-04-05 | Pfizer | Anticuerpos monoespecíficos y biespecíficos para la variante III del receptor del factor de crecimiento epidérmico y CD3 y sus usos |
-
2017
- 2017-01-10 BR BR112018014585A patent/BR112018014585A2/pt not_active Application Discontinuation
- 2017-01-10 AU AU2017208834A patent/AU2017208834B2/en not_active Ceased
- 2017-01-10 MX MX2018008978A patent/MX2018008978A/es unknown
- 2017-01-10 DK DK17701190.5T patent/DK3405481T5/da active
- 2017-01-10 CN CN201780012883.XA patent/CN108699124A/zh active Pending
- 2017-01-10 ES ES17701190T patent/ES2942362T3/es active Active
- 2017-01-10 UA UAA201808794A patent/UA125252C2/uk unknown
- 2017-01-10 TW TW106100738A patent/TWI634125B/zh not_active IP Right Cessation
- 2017-01-10 MY MYPI2018702481A patent/MY192474A/en unknown
- 2017-01-10 SG SG10202111458RA patent/SG10202111458RA/en unknown
- 2017-01-10 TW TW107120550A patent/TWI755547B/zh active
- 2017-01-10 JP JP2018538085A patent/JP6823659B2/ja active Active
- 2017-01-10 WO PCT/IB2017/050108 patent/WO2017125830A1/en not_active Ceased
- 2017-01-10 US US15/402,760 patent/US10259876B2/en active Active
- 2017-01-10 EA EA201891641A patent/EA201891641A1/ru unknown
- 2017-01-10 NZ NZ744821A patent/NZ744821A/en unknown
- 2017-01-10 EP EP17701190.5A patent/EP3405481B1/en active Active
- 2017-01-10 KR KR1020187023865A patent/KR102479606B1/ko active Active
- 2017-01-10 SG SG11201805872SA patent/SG11201805872SA/en unknown
- 2017-01-10 CA CA2954014A patent/CA2954014A1/en active Pending
- 2017-01-10 RU RU2018130088A patent/RU2751662C2/ru active
- 2017-01-10 PH PH1/2018/501473A patent/PH12018501473B1/en unknown
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2018
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- 2018-07-19 IL IL260666A patent/IL260666B2/en unknown
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2019
- 2019-01-23 US US16/255,348 patent/US11267892B2/en not_active Expired - Fee Related
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2020
- 2020-10-22 JP JP2020177399A patent/JP7198797B2/ja active Active
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2022
- 2022-01-27 US US17/586,321 patent/US20220227874A1/en not_active Abandoned
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