CN108699124A - 靶向表皮生长因子受体变体iii的嵌合抗原受体 - Google Patents

靶向表皮生长因子受体变体iii的嵌合抗原受体 Download PDF

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Publication number
CN108699124A
CN108699124A CN201780012883.XA CN201780012883A CN108699124A CN 108699124 A CN108699124 A CN 108699124A CN 201780012883 A CN201780012883 A CN 201780012883A CN 108699124 A CN108699124 A CN 108699124A
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gly
thr
leu
egfrviii
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O·J·黄
J·C·周
M·B·迪索
J·史密斯
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Pfizer Inc
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Pfizer Inc
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2319/00—Fusion polypeptide
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CN201780012883.XA 2016-01-21 2017-01-10 靶向表皮生长因子受体变体iii的嵌合抗原受体 Pending CN108699124A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662281533P 2016-01-21 2016-01-21
US62/281,533 2016-01-21
US201662431758P 2016-12-08 2016-12-08
US62/431,758 2016-12-08
PCT/IB2017/050108 WO2017125830A1 (en) 2016-01-21 2017-01-10 Chimeric antigen receptors targeting epidermal growth factor receptor variant iii

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CN108699124A true CN108699124A (zh) 2018-10-23

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EP (1) EP3405481B1 (enExample)
JP (2) JP6823659B2 (enExample)
KR (1) KR102479606B1 (enExample)
CN (1) CN108699124A (enExample)
AU (1) AU2017208834B2 (enExample)
BR (1) BR112018014585A2 (enExample)
CA (1) CA2954014A1 (enExample)
DK (1) DK3405481T5 (enExample)
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CN111454358A (zh) * 2019-01-18 2020-07-28 四川科伦博泰生物医药股份有限公司 一种嵌合抗原受体及其应用
CN113286813A (zh) * 2018-11-19 2021-08-20 得克萨斯大学体系董事会 用于car和tcr转导的模块化多顺反子载体
CN113621062A (zh) * 2018-12-21 2021-11-09 豪夫迈·罗氏有限公司 与cd3结合的抗体
CN113710697A (zh) * 2019-03-15 2021-11-26 美国政府(由卫生和人类服务部的部长所代表) 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途
CN114269783A (zh) * 2019-07-02 2022-04-01 美国政府(由卫生和人类服务部的部长所代表) 结合egfrviii的单克隆抗体及其应用
CN115103857A (zh) * 2019-12-28 2022-09-23 上海细胞治疗集团有限公司 表达免疫调节分子的细胞和表达免疫调节分子的系统
CN115175736A (zh) * 2019-10-01 2022-10-11 艾普西洛根有限公司 杂交抗体
CN116284435A (zh) * 2022-09-19 2023-06-23 卡瑞济(北京)生命科技有限公司 EGFRvIII嵌合抗原受体及其用途
CN116963759A (zh) * 2020-09-10 2023-10-27 野马生物股份有限公司 包含靶向癌症的car-t细胞的组合疗法及使用其治疗癌症的方法
WO2024027835A1 (zh) * 2022-08-05 2024-02-08 北京鼎成肽源生物技术有限公司 靶向EGFRvIII的抗体及其在细胞免疫治疗的应用
CN119912588A (zh) * 2025-04-01 2025-05-02 浙江大学 嵌合抗原受体、人诱导多能干细胞、髓系前体细胞样巨噬细胞及其制备方法
CN120248142A (zh) * 2025-06-06 2025-07-04 上海兴瑞一达生物科技有限公司 一种共表达cd47和il-15的双靶点嵌合抗原受体、car-t细胞及其应用

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CN109265561B (zh) * 2018-09-25 2021-05-25 山东兴瑞生物科技有限公司 抗EGFRvⅢ安全型嵌合抗原受体、其制备方法、利用其修饰的NK细胞及应用
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CN111019959B (zh) * 2019-12-30 2022-09-13 北京立康生命科技有限公司 一种体外转录mRNA的核苷酸分子、呈递细胞及应用
WO2021150936A1 (en) * 2020-01-22 2021-07-29 City Of Hope Oncolytic virus compositions including il-15 complex and methods for the treatment of cancer
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JP2024500189A (ja) 2020-12-21 2024-01-04 アロジーン セラピューティクス，インコーポレイテッド プロテアーゼ活性化ｃｄ４５ゲートｃａｒ
MX2023008809A (es) 2021-01-29 2023-08-04 Allogene Therapeutics Inc ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS.
JPWO2023286840A1 (enExample) * 2021-07-16 2023-01-19
AU2021467228A1 (en) * 2021-09-29 2024-04-04 National Research Council Of Canada Humanized anti-egfrviii antibodies and antigen-binding fragments thereof
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CN120936371A (zh) * 2023-03-30 2025-11-11 诺沃库勒有限责任公司 用于使用肿瘤治疗电场和嵌合抗原受体(car)免疫细胞治疗癌症的组合物、系统和方法
KR20260105764A (ko) 2023-10-30 2026-07-07 알로젠 테라퓨틱스 인코포레이티드 조작된 세포
CN117659196B (zh) * 2023-12-12 2024-08-23 成都优赛诺生物科技有限公司 一种靶向cd7的单域抗体、嵌合抗原受体及其应用

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