JP2017140051A5 - - Google Patents
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- JP2017140051A5 JP2017140051A5 JP2017102733A JP2017102733A JP2017140051A5 JP 2017140051 A5 JP2017140051 A5 JP 2017140051A5 JP 2017102733 A JP2017102733 A JP 2017102733A JP 2017102733 A JP2017102733 A JP 2017102733A JP 2017140051 A5 JP2017140051 A5 JP 2017140051A5
- Authority
- JP
- Japan
- Prior art keywords
- targeting construct
- cell
- cancer
- cell targeting
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 35
- 230000008685 targeting Effects 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 238000006467 substitution reaction Methods 0.000 claims 16
- 238000012217 deletion Methods 0.000 claims 14
- 230000037430 deletion Effects 0.000 claims 14
- 102000001398 Granzyme Human genes 0.000 claims 5
- 108060005986 Granzyme Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 101100046559 Mus musculus Tnfrsf12a gene Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims 1
- -1 Ala amino acid Chemical class 0.000 claims 1
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 241000223782 Ciliophora Species 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 1
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 claims 1
- 102220467434 Hypoxia-inducible lipid droplet-associated protein_K27E_mutation Human genes 0.000 claims 1
- 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006994 Precancerous Conditions Diseases 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 1
- 208000000277 Splenic Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 102100033579 Trophoblast glycoprotein Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 102220470249 Voltage-dependent L-type calcium channel subunit beta-2_R28A_mutation Human genes 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000002471 spleen cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261709763P | 2012-10-04 | 2012-10-04 | |
| US61/709,763 | 2012-10-04 | ||
| US201361762216P | 2013-02-07 | 2013-02-07 | |
| US201361762173P | 2013-02-07 | 2013-02-07 | |
| US61/762,173 | 2013-02-07 | ||
| US61/762,216 | 2013-02-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535813A Division JP6306596B2 (ja) | 2012-10-04 | 2013-10-04 | セリンプロテアーゼ分子および療法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017165526A Division JP2017205128A (ja) | 2012-10-04 | 2017-08-30 | セリンプロテアーゼ分子および療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017140051A JP2017140051A (ja) | 2017-08-17 |
| JP2017140051A5 true JP2017140051A5 (enExample) | 2017-10-12 |
| JP6722134B2 JP6722134B2 (ja) | 2020-07-15 |
Family
ID=49447827
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535813A Active JP6306596B2 (ja) | 2012-10-04 | 2013-10-04 | セリンプロテアーゼ分子および療法 |
| JP2017102733A Active JP6722134B2 (ja) | 2012-10-04 | 2017-05-24 | セリンプロテアーゼ分子および療法 |
| JP2017165526A Withdrawn JP2017205128A (ja) | 2012-10-04 | 2017-08-30 | セリンプロテアーゼ分子および療法 |
| JP2019177328A Withdrawn JP2019214628A (ja) | 2012-10-04 | 2019-09-27 | セリンプロテアーゼ分子および療法 |
| JP2021215386A Active JP7403521B2 (ja) | 2012-10-04 | 2021-12-29 | セリンプロテアーゼ分子および療法 |
| JP2023013891A Pending JP2023041829A (ja) | 2012-10-04 | 2023-02-01 | セリンプロテアーゼ分子および療法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535813A Active JP6306596B2 (ja) | 2012-10-04 | 2013-10-04 | セリンプロテアーゼ分子および療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017165526A Withdrawn JP2017205128A (ja) | 2012-10-04 | 2017-08-30 | セリンプロテアーゼ分子および療法 |
| JP2019177328A Withdrawn JP2019214628A (ja) | 2012-10-04 | 2019-09-27 | セリンプロテアーゼ分子および療法 |
| JP2021215386A Active JP7403521B2 (ja) | 2012-10-04 | 2021-12-29 | セリンプロテアーゼ分子および療法 |
| JP2023013891A Pending JP2023041829A (ja) | 2012-10-04 | 2023-02-01 | セリンプロテアーゼ分子および療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US9096840B2 (enExample) |
| EP (3) | EP3456734B1 (enExample) |
| JP (6) | JP6306596B2 (enExample) |
| AU (2) | AU2013326933B2 (enExample) |
| CA (2) | CA2885376C (enExample) |
| DK (1) | DK3456734T3 (enExample) |
| WO (1) | WO2014055836A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3456734B1 (en) | 2012-10-04 | 2022-01-05 | Research Development Foundation | Serine protease molecules and therapies |
| KR102488961B1 (ko) * | 2014-05-19 | 2023-01-16 | 삼성전자주식회사 | 그랜자임 b를 포함하는 융합 단백질 및 이의 용도 |
| GB2530479A (en) * | 2014-08-06 | 2016-03-30 | Hilmar Meek Warenius | Peptides useful for treating cancer |
| EP3234120B1 (en) | 2014-12-15 | 2025-09-03 | The Regents of the University of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| WO2016100232A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| JP6775515B2 (ja) | 2015-03-11 | 2020-10-28 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | トランスポザーゼポリペプチド及びその使用 |
| EP3368571B1 (en) | 2015-10-30 | 2022-12-07 | The Regents of The University of California | Transforming growth factor-beta-responsive polypeptides and their methods for use |
| ES2909973T3 (es) * | 2015-11-04 | 2022-05-10 | Hope City | Receptores quiméricos para el antígeno que se dirigen a HER2 |
| GB201602409D0 (en) * | 2016-02-10 | 2016-03-23 | Warenius Hilmar M | Compositions and uses thereof |
| DK3417058T3 (da) | 2016-02-16 | 2021-11-15 | Res Found Dev | Sortase-modificerede molekyler og anvendelser deraf |
| WO2017209274A1 (ja) * | 2016-06-02 | 2017-12-07 | 国立研究開発法人理化学研究所 | アジュバント組成物とその利用 |
| TW201809013A (zh) | 2016-06-06 | 2018-03-16 | 艾斯克立必恩股份有限公司 | 用於藥物遞送之抗體融合蛋白 |
| CA3039136A1 (en) | 2016-09-02 | 2018-03-08 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| CN106554422A (zh) * | 2016-10-26 | 2017-04-05 | 天津科技大学 | 高透皮吸收皮下靶向释放型因子及构建方法和应用 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CN119264274A (zh) | 2017-10-12 | 2025-01-07 | 免疫苏醒公司 | Vegfr-抗体轻链融合蛋白 |
| WO2019126960A1 (zh) * | 2017-12-25 | 2019-07-04 | 清华大学 | 一种具有蛋白酶活性的多肽及其应用 |
| KR102194644B1 (ko) * | 2018-04-26 | 2020-12-24 | 주식회사 굳티셀 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| KR102875649B1 (ko) * | 2018-11-26 | 2025-10-23 | 삼성디스플레이 주식회사 | 유기금속 화합물 및 이를 포함한 유기 발광 소자 |
| KR20210124308A (ko) | 2019-01-30 | 2021-10-14 | 트루바인딩 아이엔씨. | 항-gal3 항체 및 이의 용도 |
| MX2022014786A (es) | 2020-05-26 | 2023-01-16 | Truebinding Inc | Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3. |
| US20230203108A1 (en) * | 2020-05-28 | 2023-06-29 | Chugai Seiyaku Kabushiki Kaisha | Improved granzyme b variant |
| AU2022361048B2 (en) * | 2021-10-07 | 2026-04-02 | Omeros Corporation | Targeted catalytic complement-activating molecules and methods of use thereof |
| TW202605146A (zh) * | 2024-05-01 | 2026-02-01 | 美商震撼治療有限公司 | ＩｇＥ蛋白酶及其用途 |
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| EP3456734B1 (en) | 2012-10-04 | 2022-01-05 | Research Development Foundation | Serine protease molecules and therapies |
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2013
- 2013-10-04 EP EP18202465.3A patent/EP3456734B1/en active Active
- 2013-10-04 JP JP2015535813A patent/JP6306596B2/ja active Active
- 2013-10-04 DK DK18202465.3T patent/DK3456734T3/da active
- 2013-10-04 CA CA2885376A patent/CA2885376C/en active Active
- 2013-10-04 US US14/046,211 patent/US9096840B2/en active Active
- 2013-10-04 EP EP13779684.3A patent/EP2904004B1/en active Active
- 2013-10-04 EP EP22150046.5A patent/EP4029937A1/en active Pending
- 2013-10-04 WO PCT/US2013/063402 patent/WO2014055836A2/en not_active Ceased
- 2013-10-04 AU AU2013326933A patent/AU2013326933B2/en active Active
- 2013-10-04 CA CA3247166A patent/CA3247166A1/en active Pending
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2014
- 2014-07-02 US US14/322,083 patent/US9499807B2/en active Active
- 2014-07-02 US US14/322,485 patent/US9951325B2/en active Active
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2017
- 2017-05-24 JP JP2017102733A patent/JP6722134B2/ja active Active
- 2017-08-30 JP JP2017165526A patent/JP2017205128A/ja not_active Withdrawn
- 2017-09-12 AU AU2017228534A patent/AU2017228534B2/en active Active
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2018
- 2018-03-09 US US15/916,743 patent/US10323239B2/en active Active
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2019
- 2019-04-30 US US16/399,339 patent/US10738295B2/en active Active
- 2019-09-19 US US16/575,715 patent/US10920211B2/en active Active
- 2019-09-27 JP JP2019177328A patent/JP2019214628A/ja not_active Withdrawn
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2020
- 2020-06-15 US US16/901,460 patent/US11535838B2/en active Active
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2021
- 2021-12-29 JP JP2021215386A patent/JP7403521B2/ja active Active
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2022
- 2022-11-03 US US18/052,476 patent/US20230203467A1/en active Pending
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2023
- 2023-02-01 JP JP2023013891A patent/JP2023041829A/ja active Pending