JP2019506160A5 - - Google Patents
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- Publication number
- JP2019506160A5 JP2019506160A5 JP2018538560A JP2018538560A JP2019506160A5 JP 2019506160 A5 JP2019506160 A5 JP 2019506160A5 JP 2018538560 A JP2018538560 A JP 2018538560A JP 2018538560 A JP2018538560 A JP 2018538560A JP 2019506160 A5 JP2019506160 A5 JP 2019506160A5
- Authority
- JP
- Japan
- Prior art keywords
- wnt polypeptide
- polypeptide
- hours
- frizzled
- wnt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000013814 Wnt Human genes 0.000 claims 17
- 108050003627 Wnt Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 108010006519 Molecular Chaperones Proteins 0.000 claims 9
- 102100028466 Frizzled-8 Human genes 0.000 claims 8
- 101710140933 Frizzled-8 Proteins 0.000 claims 8
- 102000005431 Molecular Chaperones Human genes 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 238000011534 incubation Methods 0.000 claims 3
- 239000002502 liposome Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 1
- 241000699800 Cricetinae Species 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 102000044880 Wnt3A Human genes 0.000 claims 1
- 108700013515 Wnt3A Proteins 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022030120A JP2022068372A (ja) | 2016-01-28 | 2022-02-28 | 無血清合成のためのｗｎｔ組成物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662288365P | 2016-01-28 | 2016-01-28 | |
| US62/288,365 | 2016-01-28 | ||
| PCT/US2017/015312 WO2017132494A1 (en) | 2016-01-28 | 2017-01-27 | Wnt compositions and methods for serum-free synthesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022030120A Division JP2022068372A (ja) | 2016-01-28 | 2022-02-28 | 無血清合成のためのｗｎｔ組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506160A JP2019506160A (ja) | 2019-03-07 |
| JP2019506160A5 true JP2019506160A5 (enExample) | 2020-03-05 |
| JP7150604B2 JP7150604B2 (ja) | 2022-10-11 |
Family
ID=59398758
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538560A Active JP7150604B2 (ja) | 2016-01-28 | 2017-01-27 | 無血清合成のためのｗｎｔ組成物及び方法 |
| JP2022030120A Pending JP2022068372A (ja) | 2016-01-28 | 2022-02-28 | 無血清合成のためのｗｎｔ組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022030120A Pending JP2022068372A (ja) | 2016-01-28 | 2022-02-28 | 無血清合成のためのｗｎｔ組成物及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20200270570A1 (enExample) |
| EP (1) | EP3407907A4 (enExample) |
| JP (2) | JP7150604B2 (enExample) |
| CN (1) | CN108601818A (enExample) |
| AU (1) | AU2017212629A1 (enExample) |
| CA (1) | CA3009999A1 (enExample) |
| WO (1) | WO2017132494A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2610090B (en) * | 2017-08-01 | 2023-05-17 | Ankasa Regenerative Therapeutics Inc | WNT compositions and methods of process from serum-free culturing conditions |
| JP6860915B2 (ja) * | 2017-10-31 | 2021-04-21 | 株式会社日本バイオセラピー研究所 | 培養上清を生産する方法 |
| CN114404573A (zh) * | 2021-12-24 | 2022-04-29 | 华南农业大学 | Wnt3a蛋白质在促进动物生长中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2262469C (en) * | 1996-08-16 | 2005-11-22 | Genentech, Inc. | Uses for wnt polypeptides |
| US20040014209A1 (en) * | 2002-01-23 | 2004-01-22 | Lassar Andrew B. | Compositions and methods for modulating cell differentiation |
| US8124087B2 (en) * | 2002-12-05 | 2012-02-28 | Board Of Trustees Of The University Of Arkansas | Methods of controlling bone loss by inhibiting DKK1 |
| US7374760B2 (en) * | 2003-05-15 | 2008-05-20 | The University Of Chicago | Methods and compositions for nerve regeneration |
| US20050158311A1 (en) * | 2003-10-24 | 2005-07-21 | California Institute Of Technology | Methods and compositions for inhibiting cell growth and proliferation |
| WO2006130076A1 (en) * | 2005-05-30 | 2006-12-07 | Astrazeneca Ab | Methods for identifying fzd8 modulators and the use of such modulators for treating osteoarthritis |
| PT2500360E (pt) * | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
| US7723477B2 (en) * | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CN101479376A (zh) * | 2006-06-27 | 2009-07-08 | 株式会社资生堂 | 含有源自身体的多个细胞种类的、能形成原始的器官样的细胞块 |
| WO2008070112A1 (en) * | 2006-12-06 | 2008-06-12 | The Board Of Trustees Of The University Of Arkansas | Overexpression of wnt ligands and treatment of lytic bone diseases |
| JP2010517578A (ja) * | 2007-02-09 | 2010-05-27 | ザ ジェネラル ホスピタル コーポレイション | Ｉｓｌｅｔ１＋系統に入るように細胞を誘導する方法およびそれを拡大する方法 |
| WO2008109119A2 (en) * | 2007-03-05 | 2008-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods of use thereof |
| MX2011003183A (es) * | 2008-09-26 | 2011-04-21 | Oncomed Pharm Inc | Agentes que se unen a receptor encrespado y usos de los mismos. |
| EP2343080B1 (en) * | 2008-09-30 | 2017-11-08 | Kyowa Hakko Kirin Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES PROTEIN COMPRISING Frizzled1, Frizzled2 OR Frizzled7 EXTRACELLULAR CYSTEINE-RICH DOMAIN AND Fc PROTEIN |
| TWI535445B (zh) * | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| KR20130043102A (ko) * | 2010-04-01 | 2013-04-29 | 온코메드 파마슈티칼스, 인크. | 프리즐드-결합 작용제 및 그의 용도 |
| SG192182A1 (en) * | 2011-01-28 | 2013-08-30 | Univ Leland Stanford Junior | Wnt compositions and methods of use thereof |
| US9873722B2 (en) * | 2011-09-16 | 2018-01-23 | Fate Therapeutics, Inc. | Wnt compositions and therapeutic uses of such compositions |
| WO2013155447A1 (en) * | 2012-04-13 | 2013-10-17 | Children's Medical Center Corporation | Tiki inhibitors |
| HK1212216A1 (en) * | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| HK1211887A1 (en) * | 2013-02-04 | 2016-06-03 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
| NL2011170C2 (en) * | 2013-07-15 | 2015-01-21 | Univ Erasmus Medical Ct | Method and culture medium for in vitro culturing of stem cells. |
| AU2014329547B2 (en) * | 2013-10-02 | 2019-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods for purification |
| US20160304968A1 (en) * | 2013-12-02 | 2016-10-20 | Oncomed Pharmaceuticals, Inc. | Identification of Predictive Biomarkers Associated With WNT Pathway Inhibitors |
| US10213479B2 (en) * | 2014-01-23 | 2019-02-26 | The University Of Kansas | Compounds and methods for increasing hair growth |
| JP6399563B2 (ja) * | 2014-12-24 | 2018-10-03 | 国立大学法人大阪大学 | Ｗｎｔ蛋白質の製造方法および保存方法 |
-
2017
- 2017-01-27 JP JP2018538560A patent/JP7150604B2/ja active Active
- 2017-01-27 AU AU2017212629A patent/AU2017212629A1/en not_active Abandoned
- 2017-01-27 WO PCT/US2017/015312 patent/WO2017132494A1/en not_active Ceased
- 2017-01-27 US US16/067,944 patent/US20200270570A1/en not_active Abandoned
- 2017-01-27 CN CN201780007954.7A patent/CN108601818A/zh active Pending
- 2017-01-27 CA CA3009999A patent/CA3009999A1/en active Pending
- 2017-01-27 EP EP17744960.0A patent/EP3407907A4/en not_active Withdrawn
-
2022
- 2022-02-28 JP JP2022030120A patent/JP2022068372A/ja active Pending
- 2022-03-18 US US17/698,636 patent/US20220325238A1/en active Pending
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