AU2017212629A1 - Wnt compositions and methods for serum-free synthesis - Google Patents
Wnt compositions and methods for serum-free synthesis Download PDFInfo
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- AU2017212629A1 AU2017212629A1 AU2017212629A AU2017212629A AU2017212629A1 AU 2017212629 A1 AU2017212629 A1 AU 2017212629A1 AU 2017212629 A AU2017212629 A AU 2017212629A AU 2017212629 A AU2017212629 A AU 2017212629A AU 2017212629 A1 AU2017212629 A1 AU 2017212629A1
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- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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-
- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
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- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| JP6860915B2 (ja) * | 2017-10-31 | 2021-04-21 | 株式会社日本バイオセラピー研究所 | 培養上清を生産する方法 |
| CN114404573A (zh) * | 2021-12-24 | 2022-04-29 | 华南农业大学 | Wnt3a蛋白质在促进动物生长中的应用 |
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| US20040014209A1 (en) * | 2002-01-23 | 2004-01-22 | Lassar Andrew B. | Compositions and methods for modulating cell differentiation |
| US8124087B2 (en) * | 2002-12-05 | 2012-02-28 | Board Of Trustees Of The University Of Arkansas | Methods of controlling bone loss by inhibiting DKK1 |
| US7374760B2 (en) * | 2003-05-15 | 2008-05-20 | The University Of Chicago | Methods and compositions for nerve regeneration |
| US20050158311A1 (en) * | 2003-10-24 | 2005-07-21 | California Institute Of Technology | Methods and compositions for inhibiting cell growth and proliferation |
| WO2006130076A1 (en) * | 2005-05-30 | 2006-12-07 | Astrazeneca Ab | Methods for identifying fzd8 modulators and the use of such modulators for treating osteoarthritis |
| PT2500360E (pt) * | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
| US7723477B2 (en) * | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CN101479376A (zh) * | 2006-06-27 | 2009-07-08 | 株式会社资生堂 | 含有源自身体的多个细胞种类的、能形成原始的器官样的细胞块 |
| WO2008070112A1 (en) * | 2006-12-06 | 2008-06-12 | The Board Of Trustees Of The University Of Arkansas | Overexpression of wnt ligands and treatment of lytic bone diseases |
| JP2010517578A (ja) * | 2007-02-09 | 2010-05-27 | ザ ジェネラル ホスピタル コーポレイション | Ｉｓｌｅｔ１＋系統に入るように細胞を誘導する方法およびそれを拡大する方法 |
| WO2008109119A2 (en) * | 2007-03-05 | 2008-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods of use thereof |
| MX2011003183A (es) * | 2008-09-26 | 2011-04-21 | Oncomed Pharm Inc | Agentes que se unen a receptor encrespado y usos de los mismos. |
| EP2343080B1 (en) * | 2008-09-30 | 2017-11-08 | Kyowa Hakko Kirin Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES PROTEIN COMPRISING Frizzled1, Frizzled2 OR Frizzled7 EXTRACELLULAR CYSTEINE-RICH DOMAIN AND Fc PROTEIN |
| TWI535445B (zh) * | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| KR20130043102A (ko) * | 2010-04-01 | 2013-04-29 | 온코메드 파마슈티칼스, 인크. | 프리즐드-결합 작용제 및 그의 용도 |
| SG192182A1 (en) * | 2011-01-28 | 2013-08-30 | Univ Leland Stanford Junior | Wnt compositions and methods of use thereof |
| US9873722B2 (en) * | 2011-09-16 | 2018-01-23 | Fate Therapeutics, Inc. | Wnt compositions and therapeutic uses of such compositions |
| WO2013155447A1 (en) * | 2012-04-13 | 2013-10-17 | Children's Medical Center Corporation | Tiki inhibitors |
| HK1212216A1 (en) * | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| HK1211887A1 (en) * | 2013-02-04 | 2016-06-03 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
| NL2011170C2 (en) * | 2013-07-15 | 2015-01-21 | Univ Erasmus Medical Ct | Method and culture medium for in vitro culturing of stem cells. |
| AU2014329547B2 (en) * | 2013-10-02 | 2019-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods for purification |
| US20160304968A1 (en) * | 2013-12-02 | 2016-10-20 | Oncomed Pharmaceuticals, Inc. | Identification of Predictive Biomarkers Associated With WNT Pathway Inhibitors |
| US10213479B2 (en) * | 2014-01-23 | 2019-02-26 | The University Of Kansas | Compounds and methods for increasing hair growth |
| JP6399563B2 (ja) * | 2014-12-24 | 2018-10-03 | 国立大学法人大阪大学 | Ｗｎｔ蛋白質の製造方法および保存方法 |
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| EP3407907A1 (en) | 2018-12-05 |
| JP2019506160A (ja) | 2019-03-07 |
| WO2017132494A1 (en) | 2017-08-03 |
| CN108601818A (zh) | 2018-09-28 |
| CA3009999A1 (en) | 2017-08-03 |
| JP7150604B2 (ja) | 2022-10-11 |
| US20220325238A1 (en) | 2022-10-13 |
| US20200270570A1 (en) | 2020-08-27 |
| JP2022068372A (ja) | 2022-05-09 |
| EP3407907A4 (en) | 2019-09-04 |
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