JP2020512284A5 - - Google Patents

Info

Publication number

JP2020512284A5

JP2020512284A5 JP2019530043A JP2019530043A JP2020512284A5 JP 2020512284 A5 JP2020512284 A5 JP 2020512284A5 JP 2019530043 A JP2019530043 A JP 2019530043A JP 2019530043 A JP2019530043 A JP 2019530043A JP 2020512284 A5 JP2020512284 A5 JP 2020512284A5

Authority

JP

Japan

Prior art keywords

intracellular signaling

domain

signaling domain

intracellular

protein

Prior art date

2017-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 230000004068 intracellular signaling Effects 0.000 claims 37
• 102000004169 proteins and genes Human genes 0.000 claims 21
• 108090000623 proteins and genes Proteins 0.000 claims 21
• 210000004027 cell Anatomy 0.000 claims 15
• 102100027207 CD27 antigen Human genes 0.000 claims 11
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 11
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 11
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 11
• 230000003834 intracellular effect Effects 0.000 claims 8
• 238000000034 method Methods 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• 241001465754 Metazoa Species 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 206010021143 Hypoxia Diseases 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 208000035269 cancer or benign tumor Diseases 0.000 claims 5
• 230000001146 hypoxic effect Effects 0.000 claims 5
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
• 206010025323 Lymphomas Diseases 0.000 claims 2
• 208000034578 Multiple myelomas Diseases 0.000 claims 2
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
• 229910001882 dioxygen Inorganic materials 0.000 claims 2
• 208000032839 leukemia Diseases 0.000 claims 2
• 210000004698 lymphocyte Anatomy 0.000 claims 2
• 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 239000011324 bead Substances 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000011534 incubation Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1