JP2019504848A5 - - Google Patents
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- Publication number
- JP2019504848A5 JP2019504848A5 JP2018541196A JP2018541196A JP2019504848A5 JP 2019504848 A5 JP2019504848 A5 JP 2019504848A5 JP 2018541196 A JP2018541196 A JP 2018541196A JP 2018541196 A JP2018541196 A JP 2018541196A JP 2019504848 A5 JP2019504848 A5 JP 2019504848A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- salt
- composition according
- cytisine
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- ANJTVLIZGCUXLD-BDAKNGLRSA-N (-)-Cytisine Natural products C1NC[C@@H]2CN3C(=O)C=CC=C3[C@H]1C2 ANJTVLIZGCUXLD-BDAKNGLRSA-N 0.000 claims 2
- ANJTVLIZGCUXLD-DTWKUNHWSA-N cytisine Chemical compound C1NC[C@H]2CN3C(=O)C=CC=C3[C@@H]1C2 ANJTVLIZGCUXLD-DTWKUNHWSA-N 0.000 claims 2
- 229940027564 cytisine Drugs 0.000 claims 2
- 229930017327 cytisine Natural products 0.000 claims 2
- ANJTVLIZGCUXLD-UHFFFAOYSA-N ent-cytisine Natural products C1NCC2CN3C(=O)C=CC=C3C1C2 ANJTVLIZGCUXLD-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920002261 Corn starch Polymers 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-M succinate(1-) Chemical compound OC(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-M 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940100445 wheat starch Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1602145.3 | 2016-02-05 | ||
| GBGB1602145.3A GB201602145D0 (en) | 2016-02-05 | 2016-02-05 | Salt |
| PCT/GB2017/050294 WO2017134468A1 (en) | 2016-02-05 | 2017-02-06 | Succinate salt of cytisine and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000114A Division JP7292316B2 (ja) | 2016-02-05 | 2021-01-04 | シチシンのコハク酸塩およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504848A JP2019504848A (ja) | 2019-02-21 |
| JP2019504848A5 true JP2019504848A5 (enExample) | 2019-08-29 |
| JP6820344B2 JP6820344B2 (ja) | 2021-01-27 |
Family
ID=55641904
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541196A Active JP6820344B2 (ja) | 2016-02-05 | 2017-02-06 | シチシンのコハク酸塩およびその使用 |
| JP2021000114A Active JP7292316B2 (ja) | 2016-02-05 | 2021-01-04 | シチシンのコハク酸塩およびその使用 |
| JP2023092903A Withdrawn JP2023113803A (ja) | 2016-02-05 | 2023-06-06 | シチシンのコハク酸塩およびその使用 |
| JP2024219787A Pending JP2025038099A (ja) | 2016-02-05 | 2024-12-16 | シチシンのコハク酸塩およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000114A Active JP7292316B2 (ja) | 2016-02-05 | 2021-01-04 | シチシンのコハク酸塩およびその使用 |
| JP2023092903A Withdrawn JP2023113803A (ja) | 2016-02-05 | 2023-06-06 | シチシンのコハク酸塩およびその使用 |
| JP2024219787A Pending JP2025038099A (ja) | 2016-02-05 | 2024-12-16 | シチシンのコハク酸塩およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10300050B2 (enExample) |
| EP (2) | EP3411029B1 (enExample) |
| JP (4) | JP6820344B2 (enExample) |
| KR (4) | KR20250004182A (enExample) |
| CN (1) | CN108883101A (enExample) |
| AU (2) | AU2017215300B2 (enExample) |
| CA (1) | CA3013454C (enExample) |
| DK (1) | DK3411029T3 (enExample) |
| ES (1) | ES2963451T3 (enExample) |
| GB (2) | GB201602145D0 (enExample) |
| MX (1) | MX372607B (enExample) |
| PL (1) | PL3411029T3 (enExample) |
| PT (1) | PT3411029T (enExample) |
| SI (1) | SI3411029T1 (enExample) |
| SM (1) | SMT202300416T1 (enExample) |
| WO (1) | WO2017134468A1 (enExample) |
| ZA (1) | ZA201805296B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201602145D0 (en) | 2016-02-05 | 2016-03-23 | Achieve Pharma Uk Ltd | Salt |
| NZ761596A (en) | 2017-07-24 | 2025-08-29 | Achieve Pharma Uk Ltd | Cytisine salts |
| EP3598968A1 (en) * | 2018-07-23 | 2020-01-29 | Adamed Pharma S.A. | Solid pharmaceutical cytisine composition |
| CN114727647A (zh) * | 2019-09-12 | 2022-07-08 | 阿奇维生命科学公司 | 治疗和/或预防有需要的受试者的成瘾的包括野靛碱的组合物 |
| CN116509857A (zh) * | 2023-04-11 | 2023-08-01 | 广州医科大学 | 金雀花碱的新应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698224A (en) | 1994-06-27 | 1997-12-16 | Alza Corporation | Tacrine therapy |
| WO1996027303A1 (en) | 1995-03-06 | 1996-09-12 | Lectec Corporation | Nicotine-free smoking material |
| ATE326468T1 (de) | 1996-10-30 | 2006-06-15 | Pfizer | Pyridon-kondensierte azabicyclische- oder cytisin-derivate, ihre herstellung und verwendung in der suchttherapie |
| RU2228179C2 (ru) | 2002-07-22 | 2004-05-10 | Институт органической химии Уфимского научного центра РАН | Гидрохлорид n-(бета-гидроксиэтил)цитизина, проявляющий антиаритмическую активность |
| JP2006528695A (ja) | 2003-05-14 | 2006-12-21 | ファルマシア・コーポレーション | 血流量の減少又は中枢神経系の外傷を治療するためのベンゼンスルホンアミド又はメチルスルホニルベンゼン系シクロオキシゲナーゼ−２選択的阻害剤及びコリン作動性作用物質の組成物 |
| BG65536B1 (bg) | 2004-04-16 | 2008-11-28 | "Софарма" Ад | Лекарствена форма, съдържаща цитизин |
| WO2007115092A2 (en) * | 2006-03-29 | 2007-10-11 | Georgetown University | 10-substituted cytisine derivatives and methods of use thereof |
| CN101428021B (zh) * | 2007-11-09 | 2012-07-18 | 江苏中康药物科技有限公司 | 一种用于戒除烟瘾酒瘾的外用药物制剂 |
| US9233109B2 (en) | 2010-04-23 | 2016-01-12 | University Of Florida Research Foundation, Inc. | Compositions, methods of use, and methods of treatment |
| CN102167680B (zh) | 2011-03-23 | 2014-07-02 | 合亚医药科技（上海）有限公司 | 八氢环戊基并[c]吡咯羧酸衍生物的制备方法 |
| ES2560404T3 (es) * | 2011-06-17 | 2016-02-18 | Astrazeneca Ab | Procesos para preparar compuestos heterocíclicos, incluida trans-7-oxo-6-(sulfooxi)-1,6-diazabiciclo[3,2,1]octano-2-carboxamida y sales de la misma |
| CN103044423B (zh) | 2012-01-11 | 2013-10-23 | 上海合全药物研发有限公司 | 取代的吡啶-2-酮类化合物及其制备方法 |
| CN103509021B (zh) | 2012-06-21 | 2016-08-17 | 天津药明康德新药开发有限公司 | 金雀花碱衍生物及其制备方法和抗癌作用研究 |
| FR2992315B1 (fr) | 2012-06-25 | 2014-08-08 | Pf Medicament | Derives utiles dans le traitement de maladies du systeme nerveux central |
| US20170209415A1 (en) | 2012-08-13 | 2017-07-27 | Anthony Alexander McKINNEY | Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive disorders including nicotine addiction |
| PL220354B1 (pl) | 2012-11-19 | 2015-10-30 | Aflofarm Fabryka Leków Spółka Z Ograniczoną Odpowiedzialnością | Stała postać dawkowania zawierająca zmikronizowaną cytyzynę oraz sposób jej otrzymywania |
| CN102952134B (zh) | 2012-12-05 | 2015-01-07 | 苏州药明康德检测检验有限责任公司 | 含二氟甲基的金雀花碱衍生物及制备方法和抗癌作用研究 |
| CN103284319A (zh) | 2013-06-20 | 2013-09-11 | 昌宁德康生物科技有限公司 | 一种金雀花碱替代尼古丁口腔雾化液及其制备方法 |
| GB201315030D0 (en) * | 2013-08-22 | 2013-10-02 | Knight Martin | Magazine |
| JP6324964B2 (ja) * | 2013-08-23 | 2018-05-16 | 久光製薬株式会社 | 貼付剤 |
| CN103588773B (zh) | 2013-11-07 | 2016-01-06 | 东南大学 | 一种金雀花碱的提取分离方法 |
| CN104710422A (zh) * | 2013-12-13 | 2015-06-17 | 上海壹志医药科技有限公司 | 金雀花碱衍生物 |
| PL408608A1 (pl) * | 2014-06-18 | 2015-12-21 | Pharmacia Polonica Spółka Z Ograniczoną Odpowiedzialnością | Trwała stała kompozycja farmaceutyczna cytyzyny oraz sposób jej wytwarzania |
| PL409830A1 (pl) | 2014-10-18 | 2016-04-25 | Łukasz Zalewski | Papieros z cytyzyną |
| GB201602145D0 (en) * | 2016-02-05 | 2016-03-23 | Achieve Pharma Uk Ltd | Salt |
| CN106188057A (zh) | 2016-07-21 | 2016-12-07 | 西安岳达生物科技股份有限公司 | 一种金雀花碱的分离提取方法 |
| LT3500572T (lt) | 2016-08-19 | 2023-02-10 | The University Of Bristol | Citizino dariniai, skirti priklausomybių gydymui |
-
2016
- 2016-02-05 GB GBGB1602145.3A patent/GB201602145D0/en not_active Ceased
-
2017
- 2017-02-06 ES ES17704814T patent/ES2963451T3/es active Active
- 2017-02-06 EP EP17704814.7A patent/EP3411029B1/en active Active
- 2017-02-06 PT PT177048147T patent/PT3411029T/pt unknown
- 2017-02-06 KR KR1020247042937A patent/KR20250004182A/ko active Pending
- 2017-02-06 SM SM20230416T patent/SMT202300416T1/it unknown
- 2017-02-06 KR KR1020257017169A patent/KR20250078632A/ko active Pending
- 2017-02-06 WO PCT/GB2017/050294 patent/WO2017134468A1/en not_active Ceased
- 2017-02-06 US US16/075,902 patent/US10300050B2/en active Active
- 2017-02-06 PL PL17704814.7T patent/PL3411029T3/pl unknown
- 2017-02-06 DK DK17704814.7T patent/DK3411029T3/da active
- 2017-02-06 JP JP2018541196A patent/JP6820344B2/ja active Active
- 2017-02-06 AU AU2017215300A patent/AU2017215300B2/en active Active
- 2017-02-06 CN CN201780009979.0A patent/CN108883101A/zh active Pending
- 2017-02-06 GB GB1701939.9A patent/GB2550241B/en active Active
- 2017-02-06 MX MX2018009364A patent/MX372607B/es active IP Right Grant
- 2017-02-06 KR KR1020187025475A patent/KR20180121900A/ko not_active Ceased
- 2017-02-06 CA CA3013454A patent/CA3013454C/en active Active
- 2017-02-06 SI SI201731450T patent/SI3411029T1/sl unknown
- 2017-02-06 KR KR1020247009722A patent/KR20240042257A/ko not_active Ceased
- 2017-02-06 EP EP23197173.0A patent/EP4265298A3/en active Pending
-
2018
- 2018-08-10 ZA ZA2018/05296A patent/ZA201805296B/en unknown
-
2021
- 2021-01-04 JP JP2021000114A patent/JP7292316B2/ja active Active
-
2022
- 2022-06-02 AU AU2022203808A patent/AU2022203808B2/en active Active
-
2023
- 2023-06-06 JP JP2023092903A patent/JP2023113803A/ja not_active Withdrawn
-
2024
- 2024-12-16 JP JP2024219787A patent/JP2025038099A/ja active Pending
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