JP2019502677A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019502677A5 JP2019502677A5 JP2018530023A JP2018530023A JP2019502677A5 JP 2019502677 A5 JP2019502677 A5 JP 2019502677A5 JP 2018530023 A JP2018530023 A JP 2018530023A JP 2018530023 A JP2018530023 A JP 2018530023A JP 2019502677 A5 JP2019502677 A5 JP 2019502677A5
- Authority
- JP
- Japan
- Prior art keywords
- agents
- replaced
- group formed
- substituted
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims description 94
- 150000001875 compounds Chemical class 0.000 claims description 36
- 230000015572 biosynthetic process Effects 0.000 claims description 28
- 238000003786 synthesis reaction Methods 0.000 claims description 28
- 210000003491 skin Anatomy 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 235000001014 amino acid Nutrition 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 14
- 239000002537 cosmetic Substances 0.000 claims description 9
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 8
- 210000002510 keratinocyte Anatomy 0.000 claims description 8
- 230000035755 proliferation Effects 0.000 claims description 8
- -1 myrispheres Substances 0.000 claims description 7
- 125000002015 acyclic group Chemical group 0.000 claims description 6
- 210000001789 adipocyte Anatomy 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 239000000693 micelle Substances 0.000 claims description 6
- 210000004400 mucous membrane Anatomy 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 102000010637 Aquaporins Human genes 0.000 claims description 4
- 108010063290 Aquaporins Proteins 0.000 claims description 4
- 102000016942 Elastin Human genes 0.000 claims description 4
- 108010014258 Elastin Proteins 0.000 claims description 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 4
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 4
- 244000137850 Marrubium vulgare Species 0.000 claims description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 102000011990 Sirtuin Human genes 0.000 claims description 4
- 108050002485 Sirtuin Proteins 0.000 claims description 4
- 239000002269 analeptic agent Substances 0.000 claims description 4
- 239000003429 antifungal agent Substances 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 238000006731 degradation reaction Methods 0.000 claims description 4
- 230000001934 delay Effects 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 4
- 229920002549 elastin Polymers 0.000 claims description 4
- 239000003974 emollient agent Substances 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 4
- 230000003779 hair growth Effects 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
- 150000002632 lipids Chemical class 0.000 claims description 4
- 239000002502 liposome Substances 0.000 claims description 4
- 239000011707 mineral Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 239000003223 protective agent Substances 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000002516 radical scavenger Substances 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- NTQVODZUQIATFS-WAUHAFJUSA-N (2s)-2-[[(2s)-6-amino-2-[[2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-methylbutanoic acid Chemical compound OC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O NTQVODZUQIATFS-WAUHAFJUSA-N 0.000 claims description 2
- 102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 claims description 2
- 108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 claims description 2
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 claims description 2
- 239000002677 5-alpha reductase inhibitor Substances 0.000 claims description 2
- 235000007173 Abies balsamea Nutrition 0.000 claims description 2
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims description 2
- 229910017935 Ag-OH Inorganic materials 0.000 claims description 2
- 201000004384 Alopecia Diseases 0.000 claims description 2
- 108090000991 Aquaporin 3 Proteins 0.000 claims description 2
- 102100037332 Aquaporin-3 Human genes 0.000 claims description 2
- 239000004857 Balsam Substances 0.000 claims description 2
- 208000035985 Body Odor Diseases 0.000 claims description 2
- 241000195940 Bryophyta Species 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- 108010009685 Cholinergic Receptors Proteins 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 230000033616 DNA repair Effects 0.000 claims description 2
- 102000004237 Decorin Human genes 0.000 claims description 2
- 108090000738 Decorin Proteins 0.000 claims description 2
- 102000000541 Defensins Human genes 0.000 claims description 2
- 108010002069 Defensins Proteins 0.000 claims description 2
- 102000016359 Fibronectins Human genes 0.000 claims description 2
- 108010067306 Fibronectins Proteins 0.000 claims description 2
- 229940123457 Free radical scavenger Drugs 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 2
- 101001123331 Homo sapiens Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Proteins 0.000 claims description 2
- 102000004157 Hydrolases Human genes 0.000 claims description 2
- 108090000604 Hydrolases Proteins 0.000 claims description 2
- 206010020649 Hyperkeratosis Diseases 0.000 claims description 2
- 244000018716 Impatiens biflora Species 0.000 claims description 2
- 229920002774 Maltodextrin Polymers 0.000 claims description 2
- 239000005913 Maltodextrin Substances 0.000 claims description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 2
- 108010006519 Molecular Chaperones Proteins 0.000 claims description 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims description 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims description 2
- 102000000536 PPAR gamma Human genes 0.000 claims description 2
- 108010016731 PPAR gamma Proteins 0.000 claims description 2
- 102100028960 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Human genes 0.000 claims description 2
- 206010051246 Photodermatosis Diseases 0.000 claims description 2
- 229940078467 Prolyl hydroxylase inhibitor Drugs 0.000 claims description 2
- 229940123575 Protein synthesis stimulant Drugs 0.000 claims description 2
- 102100037132 Proteinase-activated receptor 2 Human genes 0.000 claims description 2
- 101710121435 Proteinase-activated receptor 2 Proteins 0.000 claims description 2
- 102000012479 Serine Proteases Human genes 0.000 claims description 2
- 108010022999 Serine Proteases Proteins 0.000 claims description 2
- 206010040904 Skin odour abnormal Diseases 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 208000031439 Striae Distensae Diseases 0.000 claims description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- 102000034337 acetylcholine receptors Human genes 0.000 claims description 2
- 239000012190 activator Substances 0.000 claims description 2
- 210000000577 adipose tissue Anatomy 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 230000002776 aggregation Effects 0.000 claims description 2
- 238000004220 aggregation Methods 0.000 claims description 2
- 230000032683 aging Effects 0.000 claims description 2
- 238000003915 air pollution Methods 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 2
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims description 2
- 235000008206 alpha-amino acids Nutrition 0.000 claims description 2
- 230000003444 anaesthetic effect Effects 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000003712 anti-aging effect Effects 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 230000001387 anti-histamine Effects 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 230000002141 anti-parasite Effects 0.000 claims description 2
- 230000001166 anti-perspirative effect Effects 0.000 claims description 2
- 230000001139 anti-pruritic effect Effects 0.000 claims description 2
- 230000002682 anti-psoriatic effect Effects 0.000 claims description 2
- 230000000840 anti-viral effect Effects 0.000 claims description 2
- 230000001153 anti-wrinkle effect Effects 0.000 claims description 2
- 239000000729 antidote Substances 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 239000000739 antihistaminic agent Substances 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 239000003213 antiperspirant Substances 0.000 claims description 2
- 239000003908 antipruritic agent Substances 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims description 2
- 239000000022 bacteriostatic agent Substances 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 150000001277 beta hydroxy acids Chemical class 0.000 claims description 2
- 229920001222 biopolymer Polymers 0.000 claims description 2
- 238000011138 biotechnological process Methods 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 230000019522 cellular metabolic process Effects 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 239000000812 cholinergic antagonist Substances 0.000 claims description 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims description 2
- 230000004087 circulation Effects 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 230000011382 collagen catabolic process Effects 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 230000002995 comedolytic effect Effects 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 229940097362 cyclodextrins Drugs 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- 239000007854 depigmenting agent Substances 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000008298 dragée Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 230000002500 effect on skin Effects 0.000 claims description 2
- 210000002514 epidermal stem cell Anatomy 0.000 claims description 2
- 230000028023 exocytosis Effects 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 208000024963 hair loss Diseases 0.000 claims description 2
- 230000003676 hair loss Effects 0.000 claims description 2
- 239000007902 hard capsule Substances 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims description 2
- 239000013003 healing agent Substances 0.000 claims description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims description 2
- 230000001969 hypertrophic effect Effects 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 229940040145 liniment Drugs 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 230000006372 lipid accumulation Effects 0.000 claims description 2
- 230000003520 lipogenic effect Effects 0.000 claims description 2
- 230000004130 lipolysis Effects 0.000 claims description 2
- 230000002366 lipolytic effect Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 125000001288 lysyl group Chemical group 0.000 claims description 2
- 229920002521 macromolecule Polymers 0.000 claims description 2
- 229940035034 maltodextrin Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000000873 masking effect Effects 0.000 claims description 2
- 210000002752 melanocyte Anatomy 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 230000004089 microcirculation Effects 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 239000004005 microsphere Substances 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000011929 mousse Nutrition 0.000 claims description 2
- 230000004118 muscle contraction Effects 0.000 claims description 2
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000002088 nanocapsule Substances 0.000 claims description 2
- 239000007908 nanoemulsion Substances 0.000 claims description 2
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 239000002077 nanosphere Substances 0.000 claims description 2
- 230000001537 neural effect Effects 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000002353 niosome Substances 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000019198 oils Nutrition 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 229920000620 organic polymer Polymers 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000008845 photoaging Effects 0.000 claims description 2
- 230000003711 photoprotective effect Effects 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 230000019612 pigmentation Effects 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000004224 protection Effects 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 230000037309 reepithelialization Effects 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000003716 rejuvenation Effects 0.000 claims description 2
- 230000037390 scarring Effects 0.000 claims description 2
- 210000002374 sebum Anatomy 0.000 claims description 2
- 239000000932 sedative agent Substances 0.000 claims description 2
- 230000001624 sedative effect Effects 0.000 claims description 2
- 230000037307 sensitive skin Effects 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000000344 soap Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000002047 solid lipid nanoparticle Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 210000000434 stratum corneum Anatomy 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 230000000475 sunscreen effect Effects 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims description 2
- 239000012730 sustained-release form Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 235000015961 tonic Nutrition 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- 229960000716 tonics Drugs 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- 230000008728 vascular permeability Effects 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 239000000341 volatile oil Substances 0.000 claims description 2
- 230000002087 whitening effect Effects 0.000 claims description 2
- 230000037303 wrinkles Effects 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims 1
- 230000037393 skin firmness Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382614.4 | 2015-12-10 | ||
| EP15382614 | 2015-12-10 | ||
| PCT/US2016/065568 WO2017100421A1 (en) | 2015-12-10 | 2016-12-08 | Compounds useful in the treatment and/or care of the skin, hair, nails, and/or mucous membranes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502677A JP2019502677A (ja) | 2019-01-31 |
| JP2019502677A5 true JP2019502677A5 (enExample) | 2020-01-23 |
| JP7010823B2 JP7010823B2 (ja) | 2022-01-26 |
Family
ID=55085519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530023A Active JP7010823B2 (ja) | 2015-12-10 | 2016-12-08 | 皮膚、毛髪、爪および/または粘膜の処置および/またはケアにおいて有用な化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10799442B2 (enExample) |
| EP (1) | EP3386528A1 (enExample) |
| JP (1) | JP7010823B2 (enExample) |
| KR (1) | KR20180094008A (enExample) |
| CN (1) | CN108495646B (enExample) |
| AU (1) | AU2016366220B2 (enExample) |
| WO (1) | WO2017100421A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10945778B2 (en) | 2017-05-22 | 2021-03-16 | Ethicon Llc | Combination ultrasonic and electrosurgical instrument having slip ring electrical contact assembly |
| BR112020000123A2 (pt) * | 2017-07-04 | 2020-07-07 | Lubrizol Advanced Materials, Inc. | composto, uso de um composto, composição cosmética, e, método para cuidado e/ou tratamento cosmético não terapêutico da pele, cabelos, unhas e/ou membranas mucosas |
| US20230190616A1 (en) * | 2018-08-10 | 2023-06-22 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
| CN109671138B (zh) * | 2018-11-26 | 2021-06-25 | 声望(上海)文化传播有限公司 | 自拍视频头像背景双重叠方法及相关产品 |
| JP7686563B2 (ja) | 2019-02-08 | 2025-06-02 | ルブリゾル アドバンスド マテリアルズ, インコーポレイテッド | 皮膚、毛髪、爪および/または粘膜の処置および/またはケアに有用な化合物 |
| CN109988304B (zh) * | 2019-04-22 | 2021-06-08 | 苏州美瑞姿生物科技有限公司 | 甘氨酰组氨酰赖氨酸接枝的聚天冬氨酸衍生物的合成方法 |
| CN110420140B (zh) * | 2019-07-16 | 2022-09-27 | 广州艾蓓生物科技有限公司 | 一种具有长效祛眼袋效果的祛眼袋霜及其制备方法 |
| CN110403896A (zh) * | 2019-08-30 | 2019-11-05 | 广州艾蓓生物科技有限公司 | 一种益生菌面膜 |
| CN111053031A (zh) * | 2019-11-28 | 2020-04-24 | 云南程盈森林资源开发控股集团有限公司 | 一种适用于沙漠种植的杂交构树的组织培养工艺 |
| PL3831358T3 (pl) * | 2019-12-04 | 2025-08-04 | Lipotrue, S.L. | Peptydy i kompozycje do stosowania w kosmetyce i medycynie |
| CN111053721B (zh) * | 2020-01-03 | 2022-02-15 | 深圳市仙迪化妆品股份有限公司 | 一种丝滑焕彩眼霜及其制备方法 |
| WO2021201310A1 (ko) * | 2020-03-30 | 2021-10-07 | 현대바이오사이언스 주식회사 | 비타민과 덱스판테놀이 봉입된 에토좀 조성물 및 이의 제조방법 |
| US20220110852A1 (en) * | 2020-10-14 | 2022-04-14 | Chanda Zaveri | Pigment Stabilizers |
| KR102487742B1 (ko) * | 2020-11-24 | 2023-01-12 | 주식회사 에이엠메딕스 | 피부미백용 조성물 |
| EP4274663A4 (en) * | 2021-01-07 | 2024-10-16 | Ramot at Tel-Aviv University Ltd. | METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MELANIN |
| WO2023275811A1 (en) * | 2021-07-02 | 2023-01-05 | Lubrizol Advanced Materials, Inc. | Cosmetic, non-therapeutic uses of peptides |
| IT202100019727A1 (it) * | 2021-07-23 | 2023-01-23 | Giuliani Spa | Composizione per prevenire e trattare alterazioni e malattie delle unghie |
| CN113520955B (zh) * | 2021-08-26 | 2022-02-22 | 广东丸美生物技术股份有限公司 | 一种美白保湿组合物及其应用 |
| EP4144337B1 (en) | 2021-09-02 | 2024-08-07 | Guangzhou Jiyan Cosmetics Technology Co. Ltd. | Vitis vinifera cosmetic composition |
| CN115252649B (zh) * | 2022-09-28 | 2023-02-17 | 广州集妍化妆品科技有限公司 | 嗜热菌发酵产物在防脱发和/或生发中的用途、组合物及其制剂 |
| CN117257670B (zh) * | 2023-05-10 | 2025-07-25 | 麦吉丽生物科技有限公司 | 具有去皱抗衰功效的活性分子马达、面霜组合物及制法和应用 |
| CN117720619B (zh) * | 2023-05-16 | 2024-10-29 | 杭州禾泰健宇生物科技有限公司 | 一种多肽、抗光老化多肽及其应用 |
| CN117338628B (zh) * | 2023-12-05 | 2024-04-09 | 杭州湃肽生化科技有限公司 | 一种紧肤抗皱组合物及其应用 |
| WO2025137392A1 (en) * | 2023-12-19 | 2025-06-26 | K18, Inc. | Conditioner compositions, cleanser compositions and methods of using the same |
| EP4606437A1 (en) * | 2024-02-23 | 2025-08-27 | Laboratoire Native | Cosmetic compositions to inhibit the activity of klf4, to reduce skin, hair, mucous membranes aging |
| CN119606786B (zh) * | 2024-08-31 | 2025-09-19 | 珠海金肽生物科技有限公司 | 促进多型胶原结构蛋白再生的细胞活性肽组合物及其制备方法与在医学和美容中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030007976A1 (en) * | 1997-12-23 | 2003-01-09 | Watson James D. | Methods and compounds for the treatment of immunologically-mediated skin disorders |
| DK2538222T3 (da) * | 2007-11-05 | 2021-11-15 | Nordic Bioscience As | Biokemiske markører til cvd-risikovurdering |
| US20110318380A1 (en) | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
| ES2349972B1 (es) * | 2009-02-16 | 2011-11-24 | Lipotec, S.A. | Péptidos útiles en el tratamiento y/o cuidado de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosméticas o farmacéuticas. |
| ES2397890B1 (es) | 2011-03-25 | 2014-02-07 | Lipotec, S.A. | Péptidos útiles en el tratamiento y/o cuidado de la piel y/o mucosas y su uso en composiciones cosméticas o farmacéuticas. |
| ES2625847T3 (es) * | 2011-11-04 | 2017-07-20 | Lipotec, S.A. | Péptidos que inhiben la actividad de receptores activados y su uso en composiciones cosméticas o farmacéuticas |
| WO2013156493A1 (en) * | 2012-04-16 | 2013-10-24 | Lipotec S.A. | Compounds for the treatment and/or care of the skin and/or mucous membranes and their use in cosmetic or pharmaceutical compositions |
-
2016
- 2016-12-08 CN CN201680078720.7A patent/CN108495646B/zh active Active
- 2016-12-08 WO PCT/US2016/065568 patent/WO2017100421A1/en not_active Ceased
- 2016-12-08 KR KR1020187019616A patent/KR20180094008A/ko active Pending
- 2016-12-08 AU AU2016366220A patent/AU2016366220B2/en active Active
- 2016-12-08 EP EP16815694.1A patent/EP3386528A1/en active Pending
- 2016-12-08 JP JP2018530023A patent/JP7010823B2/ja active Active
- 2016-12-08 US US16/060,476 patent/US10799442B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019502677A5 (enExample) | ||
| JP2016502550A5 (enExample) | ||
| JP2016519105A5 (enExample) | ||
| CA2749750C (en) | Skin care compositions and methods of use thereof | |
| JP2015514721A5 (enExample) | ||
| JP2015514124A5 (enExample) | ||
| ES2421262T3 (es) | Composición para el cuidado personal y cosmética que contiene tetrapéptidos con las unidades CX1X2G, PX1X2P o PX1X2K | |
| RU2012118581A (ru) | Пептиды, используемые в лечении и/или наблюдении за кожей, слизистыми оболочками и/или волосами, и их применение в косметических или фармацевтических композициях | |
| JP2018500279A5 (enExample) | ||
| JP2016535035A5 (enExample) | ||
| JP2013544309A5 (enExample) | ||
| JP2015514722A5 (enExample) | ||
| JP2015514125A5 (enExample) | ||
| US9918916B2 (en) | Active ingredient comprising a mixture of unsaturated dicarboxylic fatty acids, compositions comprising said ingredient and cosmetic or dermatological uses | |
| KR20060014047A (ko) | 피부 노화 징후를 감소시키는 화장제 또는 피부약제 조성물 | |
| US20100189675A1 (en) | Cosmetic use of an imidopercarboxylic acid derivative as desquamating agent | |
| JP2013503871A (ja) | 細胞老化を遅延させるための組成物 | |
| ES2578636T3 (es) | Péptidos novedosos antienvejecimiento y composición cosmética y/o farmacéutica que los contiene | |
| JP2013533226A5 (enExample) | ||
| ES2612237T3 (es) | Exopolisacárido para el tratamiento y/o cuidado de la piel, membranas de mucosas y/o uñas | |
| JP2008143903A (ja) | 落屑を促進するためのアニス酸の美容的使用 | |
| BRPI0814709B1 (pt) | Compostos, seus usos em aplicações cosméticas e cosmecêuticas e composições contendo os mesmos | |
| CN105496938B (zh) | α-红没药醇护肤液 | |
| BR112012017716B1 (pt) | Composto, e, composição | |
| US9387235B2 (en) | Cosmetic preparations containing PTH fragments |