JP2019501927A5 - - Google Patents
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- Publication number
- JP2019501927A5 JP2019501927A5 JP2018536252A JP2018536252A JP2019501927A5 JP 2019501927 A5 JP2019501927 A5 JP 2019501927A5 JP 2018536252 A JP2018536252 A JP 2018536252A JP 2018536252 A JP2018536252 A JP 2018536252A JP 2019501927 A5 JP2019501927 A5 JP 2019501927A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrate
- pharmaceutically acceptable
- acceptable salt
- cycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 4
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 4
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 4
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 4
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 206010012434 Dermatitis allergic Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662278085P | 2016-01-13 | 2016-01-13 | |
| US62/278,085 | 2016-01-13 | ||
| PCT/US2017/013100 WO2017123695A1 (en) | 2016-01-13 | 2017-01-12 | Isoquinolones as btk inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501927A JP2019501927A (ja) | 2019-01-24 |
| JP2019501927A5 true JP2019501927A5 (enExample) | 2020-02-13 |
| JP6916185B2 JP6916185B2 (ja) | 2021-08-11 |
Family
ID=57907002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536252A Active JP6916185B2 (ja) | 2016-01-13 | 2017-01-12 | Ｂｔｋ阻害剤としてのイソキノロン類 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10570118B2 (enExample) |
| EP (1) | EP3402789B1 (enExample) |
| JP (1) | JP6916185B2 (enExample) |
| WO (1) | WO2017123695A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3433246B1 (en) * | 2016-03-24 | 2022-05-04 | Mission Therapeutics Limited | 1-cyano-pyrrolidine derivatives as dbu inhibitors |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| US20220227729A1 (en) * | 2019-05-21 | 2022-07-21 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| IL287745B1 (en) * | 2019-05-23 | 2025-10-01 | Novartis Ag | Methods for treating Sjögren's syndrome using a Bruton's tyrosine kinase inhibitor |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| CN115650851A (zh) * | 2022-11-10 | 2023-01-31 | 无锡双启科技有限公司 | 一种2-氟-4-溴-6-甲基苯甲酸甲酯的制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| HUP0401160A3 (en) | 2001-08-13 | 2008-01-28 | Janssen Pharmaceutica Nv | 2,4,5-trisubstituted thiazolyl derivatives having antiinflammatory activity, process for their preparation and pharmaceutical compositions containing them |
| EP1436265A4 (en) | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | CHEMICALS |
| FR2881426B1 (fr) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| CN101460466B (zh) | 2006-04-11 | 2012-06-13 | 沃泰克斯药物股份有限公司 | 适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 |
| SI2529622T1 (en) | 2006-09-22 | 2018-06-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| SG10201508035TA (en) | 2007-03-28 | 2015-10-29 | Pharmacyclics Inc | Inhibitors of bruton's tyrosine kinase |
| EP2242749B1 (en) * | 2008-02-05 | 2013-04-10 | F. Hoffmann-La Roche AG | Novel pyridinones and pyridazinones |
| CN103408533B (zh) * | 2008-06-24 | 2015-08-26 | 霍夫曼-拉罗奇有限公司 | 新型取代的吡啶-2-酮和哒嗪-3-酮 |
| PL2310528T3 (pl) | 2008-07-29 | 2014-04-30 | Univ Liege | Marker genetyczny do testowania brachyspiny i płodności u bydła |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| CA2750935A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| EP2513066A1 (de) | 2009-12-17 | 2012-10-24 | Merck Patent GmbH | Inhibitoren der sphingosinkinase |
| EP3112368B1 (en) | 2010-05-31 | 2020-02-12 | Ono Pharmaceutical Co., Ltd. | Purinone derivative as btk kinase inhibitor |
| EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| WO2012156334A1 (en) * | 2011-05-17 | 2012-11-22 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2013113097A1 (en) | 2012-01-31 | 2013-08-08 | Beta Pharma Canada Inc. | Cyclic molecules as bruton's tyrosine kinase inhibitors |
| AU2013250726B2 (en) | 2012-04-20 | 2017-01-05 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
| EP2882741B1 (en) | 2012-08-10 | 2018-10-24 | Boehringer Ingelheim International GmbH | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| CA2881761A1 (en) * | 2012-09-13 | 2014-03-20 | Christine E. Brotherton-Pleiss | Inhibitors of bruton's tyrosine kinase |
| JP6178861B2 (ja) | 2012-11-02 | 2017-08-09 | ファイザー・インク | ブルトン型チロシンキナーゼ阻害剤 |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| WO2015033888A1 (ja) * | 2013-09-03 | 2015-03-12 | カルナバイオサイエンス株式会社 | 新規２，６－ジアミノピリミジン誘導体 |
| JP2016535764A (ja) * | 2013-10-04 | 2016-11-17 | ビヨンド オンコロジー ファーマシューティカル エルエルシー | ブルトンのチロシンキナーゼの阻害剤 |
| JP6486954B2 (ja) | 2014-01-29 | 2019-03-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としてのピラゾール化合物 |
| TWI726017B (zh) | 2015-12-16 | 2021-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 做為布魯頓式酪胺酸激酶（ｂｔｋ）抑制劑之雜芳族化合物 |
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2017
- 2017-01-12 US US16/069,046 patent/US10570118B2/en active Active
- 2017-01-12 WO PCT/US2017/013100 patent/WO2017123695A1/en not_active Ceased
- 2017-01-12 EP EP17701778.7A patent/EP3402789B1/en active Active
- 2017-01-12 JP JP2018536252A patent/JP6916185B2/ja active Active