JP2019196365A5 - - Google Patents
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- JP2019196365A5 JP2019196365A5 JP2019117073A JP2019117073A JP2019196365A5 JP 2019196365 A5 JP2019196365 A5 JP 2019196365A5 JP 2019117073 A JP2019117073 A JP 2019117073A JP 2019117073 A JP2019117073 A JP 2019117073A JP 2019196365 A5 JP2019196365 A5 JP 2019196365A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- bispecific fusion
- tissue
- protein according
- bispecific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037240 fusion proteins Human genes 0.000 claims 15
- 108020001507 fusion proteins Proteins 0.000 claims 15
- 210000001519 tissues Anatomy 0.000 claims 6
- 230000036499 Half live Effects 0.000 claims 5
- 230000000051 modifying Effects 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 210000004027 cells Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000000451 tissue damage Effects 0.000 claims 2
- 231100000827 tissue damage Toxicity 0.000 claims 2
- 102100008450 AFP Human genes 0.000 claims 1
- 102100001249 ALB Human genes 0.000 claims 1
- 101710027066 ALB Proteins 0.000 claims 1
- 102000004121 Annexin A5 Human genes 0.000 claims 1
- 108090000672 Annexin A5 Proteins 0.000 claims 1
- 206010059512 Apoptosis Diseases 0.000 claims 1
- 210000000601 Blood Cells Anatomy 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 claims 1
- 210000000845 Cartilage Anatomy 0.000 claims 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006822 Human Serum Albumin Proteins 0.000 claims 1
- 102000038595 IGF Type 1 Receptor Human genes 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 102000004218 Insulin-like growth factor I Human genes 0.000 claims 1
- 108090000723 Insulin-like growth factor I Proteins 0.000 claims 1
- 210000001503 Joints Anatomy 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- UNJJBGNPUUVVFQ-ZJUUUORDSA-N Phosphatidylserine Chemical compound CCCC(=O)O[C@H](COC(=O)CC)COP(O)(=O)OC[C@H](N)C(O)=O UNJJBGNPUUVVFQ-ZJUUUORDSA-N 0.000 claims 1
- 102000007584 Prealbumin Human genes 0.000 claims 1
- 108010071690 Prealbumin Proteins 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 229940050528 albumin Drugs 0.000 claims 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000004923 pancreatic tissues Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001116 prolino group Chemical group [H]OC(=O)C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000268 renotropic Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 102000028599 vitamin D binding proteins Human genes 0.000 claims 1
- 108091022026 vitamin D binding proteins Proteins 0.000 claims 1
Claims (12)
- （ａ）ホスファチジルセリンに結合特異性を有する、アネキシンＶまたはその変異体またはその断片；および
（ｂ）ＩＧＦ−１受容体に結合特異性を有する、ＩＧＦ−１またはその変異体またはその断片：
を含む二重特異的融合タンパク質。 - さらに、二重特異的融合タンパク質の半減期を調節するペプチド半減期モジュレータを含む、請求項１に記載の二重特異的融合タンパク質。
- 半減期モジュレータが、非免疫原性のタンパク質である、請求項２に記載の二重特異的融合タンパク質。
- 半減期モジュレータがヒト血清アルブミン、アルファ−フェトプロテイン、ビタミンＤ結合タンパク質、トランスサイレチン、抗体Ｆｃドメイン、単一鎖の抗体Ｆｃドメイン、プロリン−、アラニン−、および／または、セリン−豊富な配列、アルブミン結合ドメイン抗体、それらの変異体、それらの断片、およびそれらの組合せのうちの一からの配列を含む、請求項２または３に記載の二重特異的融合タンパク質。
- ｉｎ ｖｉｖｏで２時間から２４時間の間、２４時間より長い時間、または１週間より長い期間の半減期を示す、請求項２〜４のいずれか１項に記載の二重特異的融合タンパク質。
- 二重特異的融合タンパク質が、組織の細胞動員、アポトーシスの抑制、および／または、細胞増殖の誘導を促進する、請求項１〜５のいずれか１項に記載の二重特異的融合タンパク質。
- 二重特異的融合タンパク質が、組織の細胞の損傷を防ぐ、細胞の成長を促進する、幹細胞の運動性を促進する、および／または幹細胞の分化を促進する、請求項１〜５のいずれか１項に記載の二重特異的融合タンパク質。
- 必要とする対象の組織損傷を治療するための、請求項１〜７のいずれか１項に記載の二重特異的融合タンパク質。
- 心臓組織、腎組織、骨、軟骨、間接、皮膚、肝組織、膵臓組織、血球、肺組織、または神経系の組織のための、請求項１〜８のいずれか１項に記載の二重特異的融合タンパク質。
- 必要とする対象の腎組織の損傷を治療するための、請求項１〜９のいずれか１項に記載の二重特異的融合タンパク質。
- 請求項１〜１０のいずれか１項に記載の二重特異的融合タンパク質をコードする核酸分子。
- 医薬上好適な担体および治療上有効量の請求項１〜１０のいずれか１項に記載の二重特異的融合タンパク質を含む、医薬組成物。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34704010P | 2010-05-21 | 2010-05-21 | |
| US61/347,040 | 2010-05-21 | ||
| US13/112,907 | 2011-05-20 | ||
| US13/112,907 US8691771B2 (en) | 2010-05-21 | 2011-05-20 | Bi-specific fusion proteins for tissue repair |
| US13/068,808 US9238080B2 (en) | 2010-05-21 | 2011-05-20 | Bi-specific fusion proteins |
| US13/068,808 | 2011-05-20 | ||
| JP2017132859A JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017132859A Division JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019196365A JP2019196365A (ja) | 2019-11-14 |
| JP2019196365A5 true JP2019196365A5 (ja) | 2020-02-13 |
| JP6965311B2 JP6965311B2 (ja) | 2021-11-10 |
Family
ID=44972647
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511403A Active JP6200806B2 (ja) | 2010-05-21 | 2011-05-20 | 二重特異的融合タンパク質 |
| JP2016130526A Active JP6174763B2 (ja) | 2010-05-21 | 2016-06-30 | 二重特異的融合タンパク質 |
| JP2017132859A Active JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
| JP2019117073A Active JP6965311B2 (ja) | 2010-05-21 | 2019-06-25 | 二重特異的融合タンパク質 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511403A Active JP6200806B2 (ja) | 2010-05-21 | 2011-05-20 | 二重特異的融合タンパク質 |
| JP2016130526A Active JP6174763B2 (ja) | 2010-05-21 | 2016-06-30 | 二重特異的融合タンパク質 |
| JP2017132859A Active JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (11) | US9238080B2 (ja) |
| EP (1) | EP2571992B1 (ja) |
| JP (4) | JP6200806B2 (ja) |
| CN (1) | CN103124788B (ja) |
| AU (1) | AU2011255238B2 (ja) |
| BR (1) | BR112012029611A2 (ja) |
| CA (1) | CA2800173C (ja) |
| ES (1) | ES2674567T3 (ja) |
| WO (1) | WO2011146902A1 (ja) |
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