JP2019094345A5 - - Google Patents
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- JP2019094345A5 JP2019094345A5 JP2019023478A JP2019023478A JP2019094345A5 JP 2019094345 A5 JP2019094345 A5 JP 2019094345A5 JP 2019023478 A JP2019023478 A JP 2019023478A JP 2019023478 A JP2019023478 A JP 2019023478A JP 2019094345 A5 JP2019094345 A5 JP 2019094345A5
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- Prior art keywords
- substituted
- alkyl
- compound
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- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 4
- 125000006706 (C3-C6) carbocyclyl group Chemical group 0.000 claims 2
- -1 CN Inorganic materials 0.000 claims 2
- 206010007554 Cardiac failure Diseases 0.000 claims 2
- 206010019280 Heart failure Diseases 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000005755 formation reaction Methods 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- DUJCVVIZCWSVIV-UHFFFAOYSA-N CCCCc1c(-c(c(Cl)ccc2)c2Cl)c(O)c(-c2nnc(Cc3n[o]c4c3cccc4)[o]2)c(O)n1 Chemical compound CCCCc1c(-c(c(Cl)ccc2)c2Cl)c(O)c(-c2nnc(Cc3n[o]c4c3cccc4)[o]2)c(O)n1 DUJCVVIZCWSVIV-UHFFFAOYSA-N 0.000 description 1
- RMUPKTGAGNBLFQ-UHFFFAOYSA-N CCCCc1c(-c(c(OC)ccc2)c2OC)c(O)c(-c2nnc(CN(C(CN3C)=O)C3=O)[o]2)c(O)n1 Chemical compound CCCCc1c(-c(c(OC)ccc2)c2OC)c(O)c(-c2nnc(CN(C(CN3C)=O)C3=O)[o]2)c(O)n1 RMUPKTGAGNBLFQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562170215P | 2015-06-03 | 2015-06-03 | |
| US62/170,215 | 2015-06-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562603A Division JP6483288B2 (ja) | 2015-06-03 | 2016-06-02 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019094345A JP2019094345A (ja) | 2019-06-20 |
| JP2019094345A5 true JP2019094345A5 (tr) | 2019-10-10 |
Family
ID=56131647
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562603A Active JP6483288B2 (ja) | 2015-06-03 | 2016-06-02 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
| JP2019023478A Pending JP2019094345A (ja) | 2015-06-03 | 2019-02-13 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562603A Active JP6483288B2 (ja) | 2015-06-03 | 2016-06-02 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US10011594B2 (tr) |
| EP (2) | EP3530660A1 (tr) |
| JP (2) | JP6483288B2 (tr) |
| KR (1) | KR102066336B1 (tr) |
| CN (1) | CN107922401B (tr) |
| AR (1) | AR104884A1 (tr) |
| AU (1) | AU2016270903B2 (tr) |
| CA (1) | CA2988147C (tr) |
| CL (1) | CL2017003055A1 (tr) |
| CO (1) | CO2017013229A2 (tr) |
| CY (1) | CY1121938T1 (tr) |
| DK (1) | DK3303330T3 (tr) |
| EA (1) | EA034912B1 (tr) |
| ES (1) | ES2739526T3 (tr) |
| HK (1) | HK1247915B (tr) |
| HR (1) | HRP20191327T1 (tr) |
| HU (1) | HUE045546T2 (tr) |
| IL (1) | IL255951B (tr) |
| LT (1) | LT3303330T (tr) |
| MA (1) | MA41562B1 (tr) |
| ME (1) | ME03474B (tr) |
| MX (1) | MX2017014956A (tr) |
| MY (1) | MY189453A (tr) |
| NZ (1) | NZ738563A (tr) |
| PE (1) | PE20180506A1 (tr) |
| PH (1) | PH12017502158A1 (tr) |
| PL (1) | PL3303330T3 (tr) |
| PT (1) | PT3303330T (tr) |
| RS (1) | RS59220B1 (tr) |
| SI (1) | SI3303330T1 (tr) |
| TN (1) | TN2017000503A1 (tr) |
| TW (1) | TWI672299B (tr) |
| UY (1) | UY36705A (tr) |
| WO (1) | WO2016196771A1 (tr) |
| ZA (1) | ZA201708191B (tr) |
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| AU2016340264B2 (en) | 2015-10-14 | 2021-01-07 | Bristol-Myers Squibb Company | 2,4-dihydroxy-nicotinamides as APJ agonists |
| JP6817305B2 (ja) | 2015-12-04 | 2021-01-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | アペリン受容体アゴニストおよびその使用方法 |
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| EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
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| CN109734616B (zh) * | 2019-02-16 | 2022-05-13 | 安徽诺全药业有限公司 | 两步法合成(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的方法 |
| CN109704981B (zh) * | 2019-02-16 | 2022-01-28 | 安徽诺全药业有限公司 | 取代合成(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的方法 |
| CN109704980B (zh) * | 2019-02-16 | 2022-05-13 | 安徽大学 | 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法 |
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| TWI744301B (zh) | 2016-03-24 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 做為apj促效劑之6-羥基-4-側氧-1,4-二氫嘧啶-5-甲醯胺 |
| KR102521955B1 (ko) | 2016-06-14 | 2023-04-13 | 브리스톨-마이어스 스큅 컴퍼니 | Apj 수용체 효능제로서의 4-히드록시-3-술포닐피리딘-2(1h)-온 |
| JP6993357B2 (ja) | 2016-06-14 | 2022-01-13 | ブリストル－マイヤーズ スクイブ カンパニー | Ａｐｊアゴニストとしての６－ヒドロキシ－５－（フェニル／ヘテロアリールスルホニル）ピリミジン－４（１ｈ）－オン |
| EP3526198B1 (en) | 2016-10-14 | 2020-08-12 | Bristol-Myers Squibb Company | 3-sulfonyl-5-aminopyridine-2,4-diol apj agonists |
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2017
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2018
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2019
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