JP2019088900A5 - - Google Patents
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- Publication number
- JP2019088900A5 JP2019088900A5 JP2019027933A JP2019027933A JP2019088900A5 JP 2019088900 A5 JP2019088900 A5 JP 2019088900A5 JP 2019027933 A JP2019027933 A JP 2019027933A JP 2019027933 A JP2019027933 A JP 2019027933A JP 2019088900 A5 JP2019088900 A5 JP 2019088900A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- metal salt
- alginic acid
- low endotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 20
- 239000002158 endotoxin Substances 0.000 claims description 12
- 235000010443 alginic acid Nutrition 0.000 claims description 8
- 229920000615 alginic acid Polymers 0.000 claims description 8
- 229960001126 alginic acid Drugs 0.000 claims description 7
- 239000000783 alginic acid Substances 0.000 claims description 7
- 150000004781 alginic acids Chemical class 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims description 2
- 230000009969 flowable effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 208000034628 Celiac artery compression syndrome Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000000569 multi-angle light scattering Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 9
- 239000000661 sodium alginate Substances 0.000 description 9
- 235000010413 sodium alginate Nutrition 0.000 description 9
- 229940005550 sodium alginate Drugs 0.000 description 9
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021107910A JP7314207B2 (ja) | 2016-03-23 | 2021-06-29 | 椎間板治療用組成物 |
| JP2023113813A JP2023134610A (ja) | 2016-03-23 | 2023-07-11 | 椎間板治療用組成物 |
| JP2025126019A JP2025160358A (ja) | 2016-03-23 | 2025-07-29 | 椎間板治療用組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016058396 | 2016-03-23 | ||
| JP2016058396 | 2016-03-23 | ||
| JP2018507084A JP6487110B2 (ja) | 2016-03-23 | 2017-01-27 | 椎間板治療用組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507084A Division JP6487110B2 (ja) | 2016-03-23 | 2017-01-27 | 椎間板治療用組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021107910A Division JP7314207B2 (ja) | 2016-03-23 | 2021-06-29 | 椎間板治療用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019088900A JP2019088900A (ja) | 2019-06-13 |
| JP2019088900A5 true JP2019088900A5 (cg-RX-API-DMAC7.html) | 2020-03-05 |
| JP6907254B2 JP6907254B2 (ja) | 2021-07-21 |
Family
ID=59901106
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507084A Active JP6487110B2 (ja) | 2016-03-23 | 2017-01-27 | 椎間板治療用組成物 |
| JP2019027933A Active JP6907254B2 (ja) | 2016-03-23 | 2019-02-20 | 椎間板治療用組成物 |
| JP2021107910A Active JP7314207B2 (ja) | 2016-03-23 | 2021-06-29 | 椎間板治療用組成物 |
| JP2023113813A Pending JP2023134610A (ja) | 2016-03-23 | 2023-07-11 | 椎間板治療用組成物 |
| JP2025126019A Pending JP2025160358A (ja) | 2016-03-23 | 2025-07-29 | 椎間板治療用組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507084A Active JP6487110B2 (ja) | 2016-03-23 | 2017-01-27 | 椎間板治療用組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021107910A Active JP7314207B2 (ja) | 2016-03-23 | 2021-06-29 | 椎間板治療用組成物 |
| JP2023113813A Pending JP2023134610A (ja) | 2016-03-23 | 2023-07-11 | 椎間板治療用組成物 |
| JP2025126019A Pending JP2025160358A (ja) | 2016-03-23 | 2025-07-29 | 椎間板治療用組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12478636B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3434291B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP6487110B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109069692A (cg-RX-API-DMAC7.html) |
| BR (2) | BR112018069060A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3018152A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2972523T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017163603A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110545824A (zh) | 2017-03-07 | 2019-12-06 | 持田制药株式会社 | 海藻酸液体制剂 |
| US11951231B2 (en) | 2018-01-31 | 2024-04-09 | Kinki University | Therapeutic agent for intervertebral disc degeneration and material for culturing inter vertebral disc cells |
| CN116891540A (zh) | 2018-03-22 | 2023-10-17 | 持田制药株式会社 | 连接有非甾体抗炎化合物的海藻酸衍生物 |
| CN113195083B (zh) * | 2018-12-26 | 2022-12-27 | 东丽株式会社 | 多孔膜、复合膜和多孔膜的制造方法 |
| BR112022011557A2 (pt) | 2019-12-12 | 2022-08-30 | Ineb Inst De Engenharia Biomedica | Material fetal descelularizado do núcleo pulposo e métodos para a obtenção de composições farmacêuticas a serem utilizadas no tratamento da degeneração do disco intervertebral e dor nas costas |
| WO2021145325A1 (ja) * | 2020-01-14 | 2021-07-22 | 持田製薬株式会社 | アルギン酸塩を使用した対象の処置のための組合せ及び方法 |
| WO2021145404A1 (ja) * | 2020-01-17 | 2021-07-22 | 持田製薬株式会社 | 骨髄液を用いた軟骨損傷治療材 |
| JP7761941B2 (ja) * | 2020-11-01 | 2025-10-29 | 日本全薬工業株式会社 | 脊髄損傷の治療剤 |
| WO2022102093A1 (ja) * | 2020-11-13 | 2022-05-19 | 国立大学法人北海道大学 | 椎間板性疼痛抑制用組成物 |
| BR112023014896A2 (pt) * | 2021-01-29 | 2023-10-31 | Mochida Pharm Co Ltd | Composição para regeneração do disco intervertebral |
| CN116115824B (zh) * | 2022-10-04 | 2025-08-26 | 奥美医疗用品股份有限公司 | 一种注射型髓核修复产品及其制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5589591A (en) | 1986-07-03 | 1996-12-31 | Advanced Magnetics, Inc. | Endotoxin-free polysaccharides |
| WO1993013136A1 (en) | 1991-12-20 | 1993-07-08 | Howmedica Inc. | Ultra-pure polysaccharide materials for medical use |
| US6187048B1 (en) | 1994-05-24 | 2001-02-13 | Surgical Dynamics, Inc. | Intervertebral disc implant |
| JPH08269102A (ja) | 1995-03-30 | 1996-10-15 | Shiseido Co Ltd | エンドトキシンフリーのβ１，３−グルカン及びその製造法並びに医療用ゲル素材 |
| JPH09324001A (ja) | 1996-04-02 | 1997-12-16 | Kyowa Hakko Kogyo Co Ltd | ヒアルロン酸ナトリウムの精製法 |
| JPH11253547A (ja) | 1998-03-11 | 1999-09-21 | Kunio Ishikawa | 細胞遮断膜 |
| US6451772B1 (en) | 1998-11-13 | 2002-09-17 | Monsanto Company | Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same |
| US20030069639A1 (en) | 2001-04-14 | 2003-04-10 | Tom Sander | Methods and compositions for repair or replacement of joints and soft tissues |
| JP3993855B2 (ja) | 2001-11-01 | 2007-10-17 | スパイン・ウェイブ・インコーポレーテッド | 脊椎椎間板の回復のための装置 |
| JP2005036036A (ja) | 2003-07-16 | 2005-02-10 | Tanabe Seiyaku Co Ltd | エンドトキシン除去方法 |
| WO2006119455A1 (en) | 2005-05-03 | 2006-11-09 | Yeung Jeffrey E | Injection device for the intervertebral disc |
| AU2006261357A1 (en) | 2005-06-17 | 2006-12-28 | Zimmer Spine Austin, Inc. | Improved method of treating degenerative spinal disorders |
| ITPI20050071A1 (it) * | 2005-06-20 | 2006-12-21 | Giuseppe Calvosa | Composizione biocompatibile per la sostituzione/rigenerazione di tessuti |
| US8506633B2 (en) | 2005-12-27 | 2013-08-13 | Warsaw Orthopedic, Inc. | Rehydration and restoration of intervertebral discs with polyelectrolytes |
| ES2637163T3 (es) | 2007-02-21 | 2017-10-11 | Mochida Pharmaceutical Co., Ltd. | Composición de tratamiento de condropatías |
| EP2082755A1 (de) | 2008-01-16 | 2009-07-29 | CellMed AG | Monolithische in-situ vernetzte Alginatimplantate |
| EP2749299B1 (en) | 2011-08-23 | 2018-04-25 | Mochida Pharmaceutical Co., Ltd. | Composition for regeneration of cartilage |
| EP3348271B1 (en) * | 2015-09-07 | 2024-09-04 | Mochida Pharmaceutical Co., Ltd. | Freeze-dried alginic acid preparation |
| JP6196283B2 (ja) | 2015-12-10 | 2017-09-13 | トヨタ自動車株式会社 | 燃料電池用電極、燃料電池用電極の製造方法、固体高分子形燃料電池、および触媒インクの製造方法 |
| US11426425B2 (en) | 2017-03-02 | 2022-08-30 | Mochida Pharmaceutical Co., Ltd. | Composition for treating fibrocartilage tissue damage |
-
2017
- 2017-01-27 EP EP17769650.7A patent/EP3434291B1/en active Active
- 2017-01-27 EP EP23212370.3A patent/EP4374886A1/en active Pending
- 2017-01-27 JP JP2018507084A patent/JP6487110B2/ja active Active
- 2017-01-27 CN CN201780018143.7A patent/CN109069692A/zh active Pending
- 2017-01-27 CA CA3018152A patent/CA3018152A1/en active Pending
- 2017-01-27 US US16/086,081 patent/US12478636B2/en active Active
- 2017-01-27 ES ES17769650T patent/ES2972523T3/es active Active
- 2017-01-27 WO PCT/JP2017/002925 patent/WO2017163603A1/ja not_active Ceased
- 2017-01-27 BR BR112018069060A patent/BR112018069060A2/pt not_active Application Discontinuation
- 2017-01-27 BR BR122021024709-9A patent/BR122021024709B1/pt active IP Right Grant
-
2019
- 2019-02-20 JP JP2019027933A patent/JP6907254B2/ja active Active
-
2021
- 2021-06-29 JP JP2021107910A patent/JP7314207B2/ja active Active
-
2023
- 2023-07-11 JP JP2023113813A patent/JP2023134610A/ja active Pending
-
2025
- 2025-07-29 JP JP2025126019A patent/JP2025160358A/ja active Pending
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