CA3018152A1 - Composition comprising a salt of alginic acid for treating intervertebral disc - Google Patents

Composition comprising a salt of alginic acid for treating intervertebral disc Download PDF

Info

Publication number
CA3018152A1
CA3018152A1 CA3018152A CA3018152A CA3018152A1 CA 3018152 A1 CA3018152 A1 CA 3018152A1 CA 3018152 A CA3018152 A CA 3018152A CA 3018152 A CA3018152 A CA 3018152A CA 3018152 A1 CA3018152 A1 CA 3018152A1
Authority
CA
Canada
Prior art keywords
composition
nucleus pulposus
intervertebral disc
present
alginic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3018152A
Other languages
English (en)
French (fr)
Inventor
Hideki Sudo
Takeru Tsujimoto
Norimasa Iwasaki
Satoshi Shimizu
Mitsuko Isaji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Mochida Pharmaceutical Co Ltd
Original Assignee
Hokkaido University NUC
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Mochida Pharmaceutical Co Ltd filed Critical Hokkaido University NUC
Publication of CA3018152A1 publication Critical patent/CA3018152A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Prostheses (AREA)
CA3018152A 2016-03-23 2017-01-27 Composition comprising a salt of alginic acid for treating intervertebral disc Pending CA3018152A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-058396 2016-03-23
JP2016058396 2016-03-23
PCT/JP2017/002925 WO2017163603A1 (ja) 2016-03-23 2017-01-27 椎間板治療用組成物

Publications (1)

Publication Number Publication Date
CA3018152A1 true CA3018152A1 (en) 2017-09-28

Family

ID=59901106

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3018152A Pending CA3018152A1 (en) 2016-03-23 2017-01-27 Composition comprising a salt of alginic acid for treating intervertebral disc

Country Status (8)

Country Link
US (1) US12478636B2 (cg-RX-API-DMAC7.html)
EP (2) EP3434291B1 (cg-RX-API-DMAC7.html)
JP (5) JP6487110B2 (cg-RX-API-DMAC7.html)
CN (1) CN109069692A (cg-RX-API-DMAC7.html)
BR (2) BR112018069060A2 (cg-RX-API-DMAC7.html)
CA (1) CA3018152A1 (cg-RX-API-DMAC7.html)
ES (1) ES2972523T3 (cg-RX-API-DMAC7.html)
WO (1) WO2017163603A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230045844A1 (en) * 2020-01-14 2023-02-16 Mochida Pharmaceutical Co., Ltd. Combination and method for treating subject using alginate

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110545824A (zh) 2017-03-07 2019-12-06 持田制药株式会社 海藻酸液体制剂
US11951231B2 (en) 2018-01-31 2024-04-09 Kinki University Therapeutic agent for intervertebral disc degeneration and material for culturing inter vertebral disc cells
CN116891540A (zh) 2018-03-22 2023-10-17 持田制药株式会社 连接有非甾体抗炎化合物的海藻酸衍生物
CN113195083B (zh) * 2018-12-26 2022-12-27 东丽株式会社 多孔膜、复合膜和多孔膜的制造方法
BR112022011557A2 (pt) 2019-12-12 2022-08-30 Ineb Inst De Engenharia Biomedica Material fetal descelularizado do núcleo pulposo e métodos para a obtenção de composições farmacêuticas a serem utilizadas no tratamento da degeneração do disco intervertebral e dor nas costas
WO2021145404A1 (ja) * 2020-01-17 2021-07-22 持田製薬株式会社 骨髄液を用いた軟骨損傷治療材
JP7761941B2 (ja) * 2020-11-01 2025-10-29 日本全薬工業株式会社 脊髄損傷の治療剤
WO2022102093A1 (ja) * 2020-11-13 2022-05-19 国立大学法人北海道大学 椎間板性疼痛抑制用組成物
BR112023014896A2 (pt) * 2021-01-29 2023-10-31 Mochida Pharm Co Ltd Composição para regeneração do disco intervertebral
CN116115824B (zh) * 2022-10-04 2025-08-26 奥美医疗用品股份有限公司 一种注射型髓核修复产品及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589591A (en) 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
WO1993013136A1 (en) 1991-12-20 1993-07-08 Howmedica Inc. Ultra-pure polysaccharide materials for medical use
US6187048B1 (en) 1994-05-24 2001-02-13 Surgical Dynamics, Inc. Intervertebral disc implant
JPH08269102A (ja) 1995-03-30 1996-10-15 Shiseido Co Ltd エンドトキシンフリーのβ１，３−グルカン及びその製造法並びに医療用ゲル素材
JPH09324001A (ja) 1996-04-02 1997-12-16 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸ナトリウムの精製法
JPH11253547A (ja) 1998-03-11 1999-09-21 Kunio Ishikawa 細胞遮断膜
US6451772B1 (en) 1998-11-13 2002-09-17 Monsanto Company Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same
US20030069639A1 (en) 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
JP3993855B2 (ja) 2001-11-01 2007-10-17 スパイン・ウェイブ・インコーポレーテッド 脊椎椎間板の回復のための装置
JP2005036036A (ja) 2003-07-16 2005-02-10 Tanabe Seiyaku Co Ltd エンドトキシン除去方法
WO2006119455A1 (en) 2005-05-03 2006-11-09 Yeung Jeffrey E Injection device for the intervertebral disc
AU2006261357A1 (en) 2005-06-17 2006-12-28 Zimmer Spine Austin, Inc. Improved method of treating degenerative spinal disorders
ITPI20050071A1 (it) * 2005-06-20 2006-12-21 Giuseppe Calvosa Composizione biocompatibile per la sostituzione/rigenerazione di tessuti
US8506633B2 (en) 2005-12-27 2013-08-13 Warsaw Orthopedic, Inc. Rehydration and restoration of intervertebral discs with polyelectrolytes
ES2637163T3 (es) 2007-02-21 2017-10-11 Mochida Pharmaceutical Co., Ltd. Composición de tratamiento de condropatías
EP2082755A1 (de) 2008-01-16 2009-07-29 CellMed AG Monolithische in-situ vernetzte Alginatimplantate
EP2749299B1 (en) 2011-08-23 2018-04-25 Mochida Pharmaceutical Co., Ltd. Composition for regeneration of cartilage
EP3348271B1 (en) * 2015-09-07 2024-09-04 Mochida Pharmaceutical Co., Ltd. Freeze-dried alginic acid preparation
JP6196283B2 (ja) 2015-12-10 2017-09-13 トヨタ自動車株式会社 燃料電池用電極、燃料電池用電極の製造方法、固体高分子形燃料電池、および触媒インクの製造方法
US11426425B2 (en) 2017-03-02 2022-08-30 Mochida Pharmaceutical Co., Ltd. Composition for treating fibrocartilage tissue damage

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230045844A1 (en) * 2020-01-14 2023-02-16 Mochida Pharmaceutical Co., Ltd. Combination and method for treating subject using alginate

Also Published As

Publication number Publication date
EP3434291A4 (en) 2019-10-23
JP6487110B2 (ja) 2019-03-20
EP3434291A1 (en) 2019-01-30
BR122021024709B1 (pt) 2023-01-03
JP6907254B2 (ja) 2021-07-21
CN109069692A (zh) 2018-12-21
EP3434291B1 (en) 2023-11-29
ES2972523T3 (es) 2024-06-13
US12478636B2 (en) 2025-11-25
JP2023134610A (ja) 2023-09-27
JP7314207B2 (ja) 2023-07-25
WO2017163603A1 (ja) 2017-09-28
US20200289547A1 (en) 2020-09-17
BR112018069060A2 (pt) 2019-01-29
EP4374886A1 (en) 2024-05-29
JP2025160358A (ja) 2025-10-22
JP2019088900A (ja) 2019-06-13
JP2021154163A (ja) 2021-10-07
JPWO2017163603A1 (ja) 2019-01-31

Similar Documents

Publication Publication Date Title
US12478636B2 (en) Composition for treating intervertebral disc
JP5425134B2 (ja) 軟骨疾患治療用組成物
JP5491866B2 (ja) 関節疾患治療用組成物
EP2749299B1 (en) Composition for regeneration of cartilage
US11426425B2 (en) Composition for treating fibrocartilage tissue damage
AU2022214480A1 (en) Composition for regeneration of intervertebral disc
JP7607595B2 (ja) 骨髄液を用いた軟骨損傷治療材
US12478637B2 (en) Method for suppressing intervertebral disc pain

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308

EEER Examination request

Effective date: 20210308