JP2019077643A - Wnt発現抑制剤 - Google Patents
Wnt発現抑制剤 Download PDFInfo
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- JP2019077643A JP2019077643A JP2017206279A JP2017206279A JP2019077643A JP 2019077643 A JP2019077643 A JP 2019077643A JP 2017206279 A JP2017206279 A JP 2017206279A JP 2017206279 A JP2017206279 A JP 2017206279A JP 2019077643 A JP2019077643 A JP 2019077643A
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Abstract
Description
(1)サンショウの抽出物を有効成分として含有するWnt発現抑制剤。
(2)Wntが、Wnt/β−カテニンシグナルに関与するWntである、(1)に記載のWnt発現抑制剤。
(3)サンショウの抽出物を有効成分として含有するWnt発現抑制用化粧品、医薬品、または医薬部外品。
(4)サンショウの抽出物を有効成分として含有するWnt発現抑制用飲食品。
サンショウの抽出物を以下のとおり製造した。
ブドウザンショウ果皮の乾燥物10gを200mLの50%(v/v)エタノール水溶液に室温で4日間浸漬した。得られた抽出液を濾過した後エバポレーターで濃縮乾固してブドウザンショウ果皮の50%エタノール抽出物を1.0g得た。
ブドウザンショウ果皮の乾燥物10gに200mLの水を加え、95〜100℃で2時間抽出した。得られた抽出液を濾過し、そのろ液を濃縮し、凍結乾燥してブドウザンショウ果皮の熱水抽出物を2.3g得た。
ブドウザンショウ果皮の乾燥物10gを200mLのエタノール水溶液に室温で4日間浸漬した。得られた抽出液を濾過した後エバポレーターで濃縮乾固してブドウザンショウ果皮のエタノール抽出物を0.5g得た。
ブドウザンショウ種子の乾燥物10gを200mLの50%(v/v)エタノール水溶液に室温で4日間浸漬した。得られた抽出液を濾過した後エバポレーターで濃縮乾固してブドウザンショウ種子の50%エタノール抽出物を1.0g得た。
アサクラザンショウ果皮の乾燥物10gを200mLの50%(v/v)エタノール水溶液に室温で4日間浸漬した。得られた抽出液を濾過した後エバポレーターで濃縮乾固してアサクラザンショウ果皮の50%エタノール抽出物を1.0g得た。
アサクラザンショウ果皮の乾燥物10gに200mLの水を加え、95〜100℃で2時間抽出した。得られた抽出液を濾過し、そのろ液を濃縮し、凍結乾燥してアサクラザンショウ果皮の熱水抽出物を2.3g得た。
サンショウ果皮の乾燥物10gを200mLのエタノール水溶液に室温で4日間浸漬した。得られた抽出液を濾過した後エバポレーターで濃縮乾固してアサクラザンショウ果皮のエタノール抽出物を0.5g得た。
アサクラザンショウ種子の乾燥物10gを200mLの50%(v/v)エタノール水溶液に室温で4日間浸漬した。得られた抽出液を濾過した後エバポレーターで濃縮乾固してアサクラザンショウ種子の50%エタノール抽出物を1.0g得た。
サンショウの抽出物のWnt1発現抑制効果の評価実験を次のとおり行った。
20%(v/v)ウシ胎児血清(FBS、ニチレイバイオ社製)を含有するDulbecco's Modified Eagle's Medium(DMEM、Sigma-Aldrich社製)を用いて培養したヒト扁平上皮がん細胞HSC-1(Wnt1発現細胞、JCRB細胞バンク製)を、2%(v/v)FBS含有DMEMに懸濁し、8ウェルカルチャースライドに1x103個ずつ播種した。24時間培養後、サンショウ抽出物(製造例1〜8)を最終濃度が0.01%(w/v)になるように添加した2%(v/v)FBS含有DMEMに交換し、さらに72時間培養した。細胞をPBS(-)にて2回洗浄し、4%(w/v)パラホルムアルデヒドを加え、室温で10分間インキュベーションして細胞を固定した。
Claims (4)
- サンショウの抽出物を有効成分として含有するWnt発現抑制剤。
- Wntが、Wnt/β−カテニンシグナルに関与するWntである、請求項1に記載のWnt発現抑制剤。
- サンショウの抽出物を有効成分として含有するWnt発現抑制用化粧品、医薬品、または医薬部外品。
- サンショウの抽出物を有効成分として含有するWnt発現抑制用飲食品。
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