JP2019058671A5 - - Google Patents

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Publication number
JP2019058671A5
JP2019058671A5 JP2018194292A JP2018194292A JP2019058671A5 JP 2019058671 A5 JP2019058671 A5 JP 2019058671A5 JP 2018194292 A JP2018194292 A JP 2018194292A JP 2018194292 A JP2018194292 A JP 2018194292A JP 2019058671 A5 JP2019058671 A5 JP 2019058671A5
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Japan
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electrode
electroporation
pulse
microcontroller
electrode array
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JP2018194292A
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English (en)
Japanese (ja)
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JP6626176B2 (ja
JP2019058671A (ja
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Publication of JP2019058671A5 publication Critical patent/JP2019058671A5/ja
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JP2018194292A 2011-06-28 2018-10-15 低侵襲表皮電気穿孔装置 Active JP6626176B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
US61/502,198 2011-06-28

Related Parent Applications (1)

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JP2017094200A Division JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置

Related Child Applications (1)

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JP2019214718A Division JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置

Publications (3)

Publication Number Publication Date
JP2019058671A JP2019058671A (ja) 2019-04-18
JP2019058671A5 true JP2019058671A5 (enExample) 2019-05-30
JP6626176B2 JP6626176B2 (ja) 2019-12-25

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ID=48192559

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2014518993A Withdrawn JP2014524796A (ja) 2011-06-28 2012-06-28 低侵襲表皮電気穿孔装置
JP2017094200A Active JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置
JP2018194292A Active JP6626176B2 (ja) 2011-06-28 2018-10-15 低侵襲表皮電気穿孔装置
JP2019214718A Active JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置
JP2020190104A Active JP6955076B2 (ja) 2011-06-28 2020-11-16 低侵襲表皮電気穿孔装置
JP2021161141A Active JP7519339B2 (ja) 2011-06-28 2021-09-30 低侵襲表皮電気穿孔装置
JP2024076760A Pending JP2024096416A (ja) 2011-06-28 2024-05-09 低侵襲表皮電気穿孔装置

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2014518993A Withdrawn JP2014524796A (ja) 2011-06-28 2012-06-28 低侵襲表皮電気穿孔装置
JP2017094200A Active JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019214718A Active JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置
JP2020190104A Active JP6955076B2 (ja) 2011-06-28 2020-11-16 低侵襲表皮電気穿孔装置
JP2021161141A Active JP7519339B2 (ja) 2011-06-28 2021-09-30 低侵襲表皮電気穿孔装置
JP2024076760A Pending JP2024096416A (ja) 2011-06-28 2024-05-09 低侵襲表皮電気穿孔装置

Country Status (10)

Country Link
US (4) US9913978B2 (enExample)
EP (4) EP3473296B1 (enExample)
JP (7) JP2014524796A (enExample)
KR (6) KR102171142B1 (enExample)
CN (1) CN103687644B (enExample)
AU (1) AU2012333211A1 (enExample)
CA (1) CA2837214C (enExample)
DK (2) DK3473296T3 (enExample)
ES (1) ES2992120T3 (enExample)
WO (1) WO2013066427A1 (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
EP3473296B1 (en) 2011-06-28 2020-08-05 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
CA2892529C (en) 2012-11-26 2023-04-25 Moderna Therapeutics, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
US10384051B2 (en) 2014-05-02 2019-08-20 Koninklijke Philips N.V. Device for inactivating bacteria on the surface of the stratum corneum layer of skin
KR20160038566A (ko) * 2014-09-30 2016-04-07 엘지전자 주식회사 피부침투장치 및 피부침투방법
KR102350517B1 (ko) * 2014-09-30 2022-01-14 주식회사 엘지생활건강 피부침투장치 및 피부침투방법
KR101507493B1 (ko) * 2014-10-22 2015-03-30 (주)와이브레인 전기 자극 장치
CN104403943B (zh) * 2014-12-02 2016-06-15 陈剑 一种电击管和具有电击管的细胞电转仪
PL3277368T3 (pl) * 2015-03-31 2021-01-25 Oncosec Medical Incorporated Układy do ulepszonej elektroporacji opartej na wykrywaniu tkanek
US20180126183A1 (en) * 2015-05-29 2018-05-10 Koninklijke Philips N.V. A device for treating skin using non-thermal plasma
JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
AU2016343077A1 (en) * 2015-10-19 2018-05-10 Bex Co.,Ltd. Bubble ejection chip, local ablation device, local ablation method, injection device, and injection method
CN108601940B (zh) * 2015-12-22 2023-05-23 因诺维奥制药公司 具有带电源开关的电池组的电穿孔装置
EP3397144B1 (en) 2015-12-28 2024-10-30 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
SG10202110370PA (en) * 2015-12-30 2021-11-29 Inovio Pharmaceuticals Inc Electroporation device with detachable needle array with lock-out system
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
AU2017347725B2 (en) 2016-10-17 2024-01-04 Janssen Pharmaceuticals, Inc. Recombinant virus replicon systems and uses thereof
EP3548625B1 (en) 2016-12-05 2024-06-26 Janssen Pharmaceuticals, Inc. Compositions and methods for enhancing gene expression
WO2018204249A1 (en) * 2017-05-03 2018-11-08 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
EA202091517A1 (ru) * 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
JP7494117B2 (ja) 2018-01-19 2024-06-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えレプリコン系を使用する免疫応答の誘導および増強
AU2019359204B2 (en) 2018-10-08 2024-12-05 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
KR102279603B1 (ko) * 2019-06-11 2021-07-20 (주)비올 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법
WO2021173105A1 (ru) * 2020-02-28 2021-09-02 Ирына Мыхайливна УДОВИЧЕНКО Устройство для электростимуляции
WO2021189012A1 (en) * 2020-03-20 2021-09-23 Inovio Pharmaceuticals, Inc. Vacuum-assisted electroporation devices, and related systems and methods
KR20220086094A (ko) 2020-12-16 2022-06-23 주식회사 은성글로벌 일렉트로포레이션 장치용 니들 주입 구성체
WO2023278795A1 (en) * 2021-06-30 2023-01-05 Inovio Pharmaceuticals, Inc. Electrode arrays for electroporation, and related systems and methods
KR102832435B1 (ko) * 2022-04-11 2025-07-09 전우금 전극 교체형 전기 자극기
KR102812336B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 밀폐할 수 있는 전기천공장치
KR102812334B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 제거할 수 있는 올가미 형태의 와이어를 갖는 전기천공장치
KR102753355B1 (ko) * 2023-04-14 2025-01-13 (주)이지템 분할전극구조를 포함하는 에너지 기반 디바이스
US12485280B1 (en) 2024-07-15 2025-12-02 Tav-Tech Ltd Unitary enhanced jet spray dermal treatment handpiece

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US7456012B2 (en) 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
JP2003505114A (ja) * 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療
WO2000044438A1 (en) 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
AU2938100A (en) * 1999-03-08 2000-09-28 Yoram Palti Transdermal drug delivery system and method
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
AU4996300A (en) * 1999-05-10 2000-11-21 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US6493402B1 (en) 1999-05-27 2002-12-10 Zenith Electronics Corporation Mode control for trellis decoder
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
CA2531493A1 (en) * 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
US20050123565A1 (en) 2003-10-31 2005-06-09 Janardhanan Subramony System and method for transdermal vaccine delivery
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7657317B2 (en) 2005-04-26 2010-02-02 Boston Scientific Neuromodulation Corporation Evaluating stimulation therapies and patient satisfaction
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
EP1981581B1 (en) * 2006-02-11 2016-04-13 Genetronics, Inc. Device for single-needle in vivo electroporation
AU2007295932A1 (en) 2006-09-15 2008-03-20 Shoo Sticks Pty Limited Substrate to releasably adhere to a region of apparel
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
ES2993941T3 (en) * 2006-10-17 2025-01-14 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080312580A1 (en) 2007-06-15 2008-12-18 Transport Pharmaceuticals, Inc. Current concentration system and method for electrokinetic delivery of medicaments
JP2011509743A (ja) * 2008-01-17 2011-03-31 ジェネトロニクス，インコーポレイティド 可変電流密度単一針電気穿孔システムおよび方法
US9066738B2 (en) * 2008-07-14 2015-06-30 Syneron Medical Ltd. Devices and methods for percutaneous energy delivery
US10232173B2 (en) * 2009-04-16 2019-03-19 Vgx Pharmaceuticals, Llc Contactless electropermeabilization electrode and method
WO2010133578A2 (en) * 2009-05-20 2010-11-25 Sonion A/S Electroporation device with improved tip and electrode support
WO2011016019A1 (en) * 2009-08-04 2011-02-10 Pollogen Ltd. Cosmetic skin rejuvination
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
WO2011109399A1 (en) 2010-03-01 2011-09-09 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
BR112012021805A2 (pt) 2010-03-01 2016-05-17 Inovio Pharmaceuticals Inc dispositivo de eletroporação de pele tolerável e minimamente invasivo
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
EP3473296B1 (en) 2011-06-28 2020-08-05 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device

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