DK2726145T3 - Minimalt invasivt, dermalt elektroporationsapparat - Google Patents

Minimalt invasivt, dermalt elektroporationsapparat Download PDF

Info

Publication number
DK2726145T3
DK2726145T3 DK12846201.7T DK12846201T DK2726145T3 DK 2726145 T3 DK2726145 T3 DK 2726145T3 DK 12846201 T DK12846201 T DK 12846201T DK 2726145 T3 DK2726145 T3 DK 2726145T3
Authority
DK
Denmark
Prior art keywords
minimally invasive
electroporation apparatus
dermal electroporation
dermal
minimally
Prior art date
Application number
DK12846201.7T
Other languages
English (en)
Inventor
Kate Broderick
Stephen Kemmerrer
Jay Mccoy
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2726145T3 publication Critical patent/DK2726145T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Electromagnetism (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Finger-Pressure Massage (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
DK12846201.7T 2011-06-28 2012-06-28 Minimalt invasivt, dermalt elektroporationsapparat DK2726145T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
PCT/US2012/044539 WO2013066427A1 (en) 2011-06-28 2012-06-28 A miniminally invasive dermal electroporation device

Publications (1)

Publication Number Publication Date
DK2726145T3 true DK2726145T3 (da) 2019-01-02

Family

ID=48192559

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18190065.5T DK3473296T3 (da) 2011-06-28 2012-06-28 Minimalt invasiv dermal elektroporeringsenhed
DK12846201.7T DK2726145T3 (da) 2011-06-28 2012-06-28 Minimalt invasivt, dermalt elektroporationsapparat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK18190065.5T DK3473296T3 (da) 2011-06-28 2012-06-28 Minimalt invasiv dermal elektroporeringsenhed

Country Status (9)

Country Link
US (4) US9913978B2 (da)
EP (3) EP3797824B1 (da)
JP (7) JP2014524796A (da)
KR (6) KR102081868B1 (da)
CN (1) CN103687644B (da)
AU (1) AU2012333211A1 (da)
CA (1) CA2837214C (da)
DK (2) DK3473296T3 (da)
WO (1) WO2013066427A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN103429606A (zh) 2010-10-01 2013-12-04 现代治疗公司 设计核酸及其使用方法
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
EP3797824B1 (en) * 2011-06-28 2024-06-12 Inovio Pharmaceuticals, Inc. A miniminally invasive dermal electroporation device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RS62993B1 (sr) 2011-10-03 2022-03-31 Modernatx Inc Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe
SG10201604896TA (en) 2011-12-16 2016-08-30 Moderna Therapeutics Inc Modified nucleoside, nucleotide, and nucleic acid compositions
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
JP2015513913A (ja) 2012-04-02 2015-05-18 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ポリヌクレオチド
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
CA2926218A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
CN106255525B (zh) * 2014-05-02 2020-02-11 皇家飞利浦有限公司 用于使细菌失活的设备
KR102350517B1 (ko) * 2014-09-30 2022-01-14 주식회사 엘지생활건강 피부침투장치 및 피부침투방법
KR20160038566A (ko) * 2014-09-30 2016-04-07 엘지전자 주식회사 피부침투장치 및 피부침투방법
KR101507493B1 (ko) * 2014-10-22 2015-03-30 (주)와이브레인 전기 자극 장치
CN104403943B (zh) * 2014-12-02 2016-06-15 陈剑 一种电击管和具有电击管的细胞电转仪
EP3277368B1 (en) * 2015-03-31 2020-05-20 OncoSec Medical Incorporated Systems for improved tissue-sensing based electroporation
BR112017025426A2 (pt) * 2015-05-29 2018-08-07 Koninklijke Philips Nv dispositivo para tratamento da pele e conjunto de cabeça de eletrodo
WO2016205895A1 (en) * 2015-06-25 2016-12-29 Newsouth Innovations Pty Limited Electroporation system for controlled localized therapeutics delivery
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
AU2016343077A1 (en) * 2015-10-19 2018-05-10 Bex Co.,Ltd. Bubble ejection chip, local ablation device, local ablation method, injection device, and injection method
RU2765328C2 (ru) * 2015-12-22 2022-01-28 Иновио Фармасьютикалз, Инк. Электропорационное устройство, имеющее батарейный блок с переключателем питания
EP3397144A4 (en) * 2015-12-28 2019-02-13 Inovio Pharmaceuticals, Inc. DEVICE FOR ELECTROPORATION AND INJECTION BY INTRADERMIC JET
PL3397337T3 (pl) 2015-12-30 2021-01-25 Inovio Pharmaceuticals, Inc. Urządzenie do elektroporacji z odłączalnym układem igieł z systemem blokady
AU2017347725B2 (en) 2016-10-17 2024-01-04 Janssen Pharmaceuticals, Inc. Recombinant virus replicon systems and uses thereof
MX2019006467A (es) 2016-12-05 2019-12-09 Janssen Pharmaceuticals Inc Star Composiciones y métodos para mejorar la expresión génica.
US20200147361A1 (en) * 2017-05-03 2020-05-14 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
US11389531B2 (en) * 2017-12-19 2022-07-19 Janssen Sciences Ireland Unlimited Company Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
KR20200111729A (ko) 2018-01-19 2020-09-29 얀센 파마슈티칼즈, 인코포레이티드 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
KR102279603B1 (ko) * 2019-06-11 2021-07-20 (주)비올 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법
WO2021173105A1 (ru) * 2020-02-28 2021-09-02 Ирына Мыхайливна УДОВИЧЕНКО Устройство для электростимуляции
KR20220086094A (ko) 2020-12-16 2022-06-23 주식회사 은성글로벌 일렉트로포레이션 장치용 니들 주입 구성체
US20230001169A1 (en) * 2021-06-30 2023-01-05 Inovio Pharmaceuticals, Inc. Electrode Arrays For Electroporation, and Related Systems and Methods

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
DE69722414T2 (de) * 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US7456012B2 (en) 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
WO2000002621A1 (en) * 1998-07-13 2000-01-20 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
WO2000044438A1 (en) * 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
AU2938100A (en) * 1999-03-08 2000-09-28 Yoram Palti Transdermal drug delivery system and method
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
EP1183068A4 (en) * 1999-05-10 2008-12-17 Gentronics Inc ENHANCED ACTIVE AGENT DELIVERY METHOD BY ELECTROPORATION
US6493402B1 (en) 1999-05-27 2002-12-10 Zenith Electronics Corporation Mode control for trellis decoder
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
WO2005010161A2 (en) * 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
AU2004287411A1 (en) 2003-10-31 2005-05-19 Alza Corporation System and method for transdermal vaccine delivery
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7657317B2 (en) * 2005-04-26 2010-02-02 Boston Scientific Neuromodulation Corporation Evaluating stimulation therapies and patient satisfaction
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
WO2007095140A2 (en) * 2006-02-11 2007-08-23 Genetronics, Inc. Device and method for single-needle in vivo electroporation
AU2007295932A1 (en) 2006-09-15 2008-03-20 Shoo Sticks Pty Limited Substrate to releasably adhere to a region of apparel
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
US9452285B2 (en) 2006-10-17 2016-09-27 Vgx Pharmaceuticals, Inc. Electroporation devices and methods of using same for electroporation of cells in mammals
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080312580A1 (en) 2007-06-15 2008-12-18 Transport Pharmaceuticals, Inc. Current concentration system and method for electrokinetic delivery of medicaments
EP3593855B1 (en) * 2008-01-17 2023-10-04 Inovio Pharmaceuticals, Inc. Variable current density single needle electroporation system
US8882753B2 (en) * 2008-07-14 2014-11-11 Syneron Medical Ltd Devices and methods for percutaneous energy delivery
KR102560518B1 (ko) * 2009-04-16 2023-07-28 이노비오 파마수티컬즈, 인크. 비접촉식 전기천공 전극을 포함하는 디바이스
WO2010133578A2 (en) * 2009-05-20 2010-11-25 Sonion A/S Electroporation device with improved tip and electrode support
US9596920B2 (en) * 2009-08-04 2017-03-21 Pollogen Ltd. Cosmetic skin rejuvination
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
EA025705B1 (ru) * 2010-03-01 2017-01-30 Иновио Фармасьютикалз, Инк. Терпимое и минимально инвазивное устройство электропорации кожи
CA2789733A1 (en) * 2010-03-01 2011-09-09 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
EP3797824B1 (en) 2011-06-28 2024-06-12 Inovio Pharmaceuticals, Inc. A miniminally invasive dermal electroporation device

Also Published As

Publication number Publication date
EP3797824B1 (en) 2024-06-12
AU2012333211A1 (en) 2013-12-19
CN103687644A (zh) 2014-03-26
US20140222105A1 (en) 2014-08-07
JP7519339B2 (ja) 2024-07-19
JP6626176B2 (ja) 2019-12-25
KR20230156804A (ko) 2023-11-14
CN103687644B (zh) 2016-11-09
CA2837214C (en) 2021-06-01
KR20200123864A (ko) 2020-10-30
CA2837214A1 (en) 2013-05-10
JP6799128B2 (ja) 2020-12-09
US9913978B2 (en) 2018-03-13
KR102171142B1 (ko) 2020-10-28
KR20200023494A (ko) 2020-03-04
KR20210135370A (ko) 2021-11-12
WO2013066427A1 (en) 2013-05-10
JP2014524796A (ja) 2014-09-25
US20200246613A1 (en) 2020-08-06
EP3473296B1 (en) 2020-08-05
JP2021037322A (ja) 2021-03-11
KR102599318B1 (ko) 2023-11-07
JP2019058671A (ja) 2019-04-18
JP2017170161A (ja) 2017-09-28
KR20220121912A (ko) 2022-09-01
US11291836B2 (en) 2022-04-05
KR102325369B1 (ko) 2021-11-11
JP2022002731A (ja) 2022-01-11
EP3797824A1 (en) 2021-03-31
JP2024096416A (ja) 2024-07-12
EP2726145A4 (en) 2015-02-25
US20220212002A1 (en) 2022-07-07
EP2726145A1 (en) 2014-05-07
KR20140048213A (ko) 2014-04-23
JP6423042B2 (ja) 2018-11-14
EP2726145B1 (en) 2018-08-22
US10668279B2 (en) 2020-06-02
US20180236225A1 (en) 2018-08-23
EP3473296A1 (en) 2019-04-24
JP2020028759A (ja) 2020-02-27
DK3473296T3 (da) 2020-11-09
KR102081868B1 (ko) 2020-02-26
KR102436439B1 (ko) 2022-08-25
JP6955076B2 (ja) 2021-10-27

Similar Documents

Publication Publication Date Title
DK2726145T3 (da) Minimalt invasivt, dermalt elektroporationsapparat
HK1212879A1 (zh) 電外科設備
EP2819589A4 (en) MINIMALLY INVASIVE SURGICAL PROCEDURES
PT2663250T (pt) Instrumento eletrocirúrgico
GB2496735B (en) Electrosurgical instrument
EP2937066A4 (en) FACE PLASTER
GB2489925B (en) Electrosurgical generator
PT2865378T (pt) Adesivo para a pele
HK1198129A1 (zh) 含水貼劑
GB2492325B (en) Electrosurgical electrode
BR112013023142A2 (pt) método de tratamento de cabelos
GB201319096D0 (en) Electrosurgical generator
EP2787906A4 (en) SURGICAL TROCART
EP2907515A4 (en) SKIN PATCH
GB2497886B (en) Hair treatment methods
EP2699245A4 (en) TREATMENT AGAINST HAIR LOSS
GB201205911D0 (en) Hair treatment method
BR112012030404A2 (pt) método de tratamento do cabelo
HK1201132A1 (en) Rib-protecting devices for thoracoscopic surgery, and related methods
GB2492064B (en) Electrosurgical instrument
GB2500999B (en) Hair treatment methods
PL395785A1 (pl) Zastosowanie medyczne N-etylo-3-amino-4-fenylo-5-okso-2,5-dihydro-1H-pirazolo-1-karbotioamidu
GB201113723D0 (en) Electrosurgical system
IL222594A0 (en) Combined treatment utilizing vb-201
AU341051S (en) Forceps