JP2014524796A - 低侵襲表皮電気穿孔装置 - Google Patents

低侵襲表皮電気穿孔装置 Download PDF

Info

Publication number
JP2014524796A
JP2014524796A JP2014518993A JP2014518993A JP2014524796A JP 2014524796 A JP2014524796 A JP 2014524796A JP 2014518993 A JP2014518993 A JP 2014518993A JP 2014518993 A JP2014518993 A JP 2014518993A JP 2014524796 A JP2014524796 A JP 2014524796A
Authority
JP
Japan
Prior art keywords
electrode
electroporation
pulse
array
electroporation pulse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2014518993A
Other languages
English (en)
Japanese (ja)
Inventor
ブロデリック ケイト
ケンマーラー スティーブン
マッコイ ジェイ
Original Assignee
イノビオ ファーマシューティカルズ，インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イノビオ ファーマシューティカルズ，インコーポレイティド filed Critical イノビオ ファーマシューティカルズ，インコーポレイティド
Publication of JP2014524796A publication Critical patent/JP2014524796A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Electromagnetism (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Finger-Pressure Massage (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
JP2014518993A 2011-06-28 2012-06-28 低侵襲表皮電気穿孔装置 Withdrawn JP2014524796A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
US61/502,198 2011-06-28
PCT/US2012/044539 WO2013066427A1 (en) 2011-06-28 2012-06-28 A miniminally invasive dermal electroporation device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017094200A Division JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置

Publications (1)

Publication Number Publication Date
JP2014524796A true JP2014524796A (ja) 2014-09-25

Family

ID=48192559

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2014518993A Withdrawn JP2014524796A (ja) 2011-06-28 2012-06-28 低侵襲表皮電気穿孔装置
JP2017094200A Active JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置
JP2018194292A Active JP6626176B2 (ja) 2011-06-28 2018-10-15 低侵襲表皮電気穿孔装置
JP2019214718A Active JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置
JP2020190104A Active JP6955076B2 (ja) 2011-06-28 2020-11-16 低侵襲表皮電気穿孔装置
JP2021161141A Active JP7519339B2 (ja) 2011-06-28 2021-09-30 低侵襲表皮電気穿孔装置
JP2024076760A Pending JP2024096416A (ja) 2011-06-28 2024-05-09 低侵襲表皮電気穿孔装置

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2017094200A Active JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置
JP2018194292A Active JP6626176B2 (ja) 2011-06-28 2018-10-15 低侵襲表皮電気穿孔装置
JP2019214718A Active JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置
JP2020190104A Active JP6955076B2 (ja) 2011-06-28 2020-11-16 低侵襲表皮電気穿孔装置
JP2021161141A Active JP7519339B2 (ja) 2011-06-28 2021-09-30 低侵襲表皮電気穿孔装置
JP2024076760A Pending JP2024096416A (ja) 2011-06-28 2024-05-09 低侵襲表皮電気穿孔装置

Country Status (10)

Country Link
US (4) US9913978B2 (enExample)
EP (4) EP3473296B1 (enExample)
JP (7) JP2014524796A (enExample)
KR (6) KR102171142B1 (enExample)
CN (1) CN103687644B (enExample)
AU (1) AU2012333211A1 (enExample)
CA (1) CA2837214C (enExample)
DK (2) DK3473296T3 (enExample)
ES (1) ES2992120T3 (enExample)
WO (1) WO2013066427A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019506921A (ja) * 2015-12-22 2019-03-14 イノビオ ファーマシューティカルズ，インコーポレイティド 電源スイッチを備えたバッテリーパックを有するエレクトロポレーション装置
JP2022002731A (ja) * 2011-06-28 2022-01-11 イノビオ ファーマシューティカルズ，インコーポレイティド 低侵襲表皮電気穿孔装置
JP2022535026A (ja) * 2019-06-11 2022-08-04 ヴィオル カンパニー リミテッド 針組立体、これを含む皮膚刺激器およびその製造方法

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
CA2892529C (en) 2012-11-26 2023-04-25 Moderna Therapeutics, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
US10384051B2 (en) 2014-05-02 2019-08-20 Koninklijke Philips N.V. Device for inactivating bacteria on the surface of the stratum corneum layer of skin
KR20160038566A (ko) * 2014-09-30 2016-04-07 엘지전자 주식회사 피부침투장치 및 피부침투방법
KR102350517B1 (ko) * 2014-09-30 2022-01-14 주식회사 엘지생활건강 피부침투장치 및 피부침투방법
KR101507493B1 (ko) * 2014-10-22 2015-03-30 (주)와이브레인 전기 자극 장치
CN104403943B (zh) * 2014-12-02 2016-06-15 陈剑 一种电击管和具有电击管的细胞电转仪
PL3277368T3 (pl) * 2015-03-31 2021-01-25 Oncosec Medical Incorporated Układy do ulepszonej elektroporacji opartej na wykrywaniu tkanek
US20180126183A1 (en) * 2015-05-29 2018-05-10 Koninklijke Philips N.V. A device for treating skin using non-thermal plasma
JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
AU2016343077A1 (en) * 2015-10-19 2018-05-10 Bex Co.,Ltd. Bubble ejection chip, local ablation device, local ablation method, injection device, and injection method
EP3397144B1 (en) 2015-12-28 2024-10-30 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
SG10202110370PA (en) * 2015-12-30 2021-11-29 Inovio Pharmaceuticals Inc Electroporation device with detachable needle array with lock-out system
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
AU2017347725B2 (en) 2016-10-17 2024-01-04 Janssen Pharmaceuticals, Inc. Recombinant virus replicon systems and uses thereof
EP3548625B1 (en) 2016-12-05 2024-06-26 Janssen Pharmaceuticals, Inc. Compositions and methods for enhancing gene expression
WO2018204249A1 (en) * 2017-05-03 2018-11-08 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
EA202091517A1 (ru) * 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
JP7494117B2 (ja) 2018-01-19 2024-06-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えレプリコン系を使用する免疫応答の誘導および増強
AU2019359204B2 (en) 2018-10-08 2024-12-05 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
WO2021173105A1 (ru) * 2020-02-28 2021-09-02 Ирына Мыхайливна УДОВИЧЕНКО Устройство для электростимуляции
WO2021189012A1 (en) * 2020-03-20 2021-09-23 Inovio Pharmaceuticals, Inc. Vacuum-assisted electroporation devices, and related systems and methods
KR20220086094A (ko) 2020-12-16 2022-06-23 주식회사 은성글로벌 일렉트로포레이션 장치용 니들 주입 구성체
WO2023278795A1 (en) * 2021-06-30 2023-01-05 Inovio Pharmaceuticals, Inc. Electrode arrays for electroporation, and related systems and methods
KR102832435B1 (ko) * 2022-04-11 2025-07-09 전우금 전극 교체형 전기 자극기
KR102812336B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 밀폐할 수 있는 전기천공장치
KR102812334B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 제거할 수 있는 올가미 형태의 와이어를 갖는 전기천공장치
KR102753355B1 (ko) * 2023-04-14 2025-01-13 (주)이지템 분할전극구조를 포함하는 에너지 기반 디바이스
US12485280B1 (en) 2024-07-15 2025-12-02 Tav-Tech Ltd Unitary enhanced jet spray dermal treatment handpiece

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010161A2 (en) * 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
JP2010506660A (ja) * 2006-10-17 2010-03-04 ヴィージーエックス ファーマシューティカルズ，インコーポレイテッド 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US7456012B2 (en) 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
JP2003505114A (ja) * 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療
WO2000044438A1 (en) 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
AU2938100A (en) * 1999-03-08 2000-09-28 Yoram Palti Transdermal drug delivery system and method
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
AU4996300A (en) * 1999-05-10 2000-11-21 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US6493402B1 (en) 1999-05-27 2002-12-10 Zenith Electronics Corporation Mode control for trellis decoder
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US20050123565A1 (en) 2003-10-31 2005-06-09 Janardhanan Subramony System and method for transdermal vaccine delivery
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7657317B2 (en) 2005-04-26 2010-02-02 Boston Scientific Neuromodulation Corporation Evaluating stimulation therapies and patient satisfaction
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
EP1981581B1 (en) * 2006-02-11 2016-04-13 Genetronics, Inc. Device for single-needle in vivo electroporation
AU2007295932A1 (en) 2006-09-15 2008-03-20 Shoo Sticks Pty Limited Substrate to releasably adhere to a region of apparel
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080312580A1 (en) 2007-06-15 2008-12-18 Transport Pharmaceuticals, Inc. Current concentration system and method for electrokinetic delivery of medicaments
JP2011509743A (ja) * 2008-01-17 2011-03-31 ジェネトロニクス，インコーポレイティド 可変電流密度単一針電気穿孔システムおよび方法
US9066738B2 (en) * 2008-07-14 2015-06-30 Syneron Medical Ltd. Devices and methods for percutaneous energy delivery
US10232173B2 (en) * 2009-04-16 2019-03-19 Vgx Pharmaceuticals, Llc Contactless electropermeabilization electrode and method
WO2010133578A2 (en) * 2009-05-20 2010-11-25 Sonion A/S Electroporation device with improved tip and electrode support
WO2011016019A1 (en) * 2009-08-04 2011-02-10 Pollogen Ltd. Cosmetic skin rejuvination
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
WO2011109399A1 (en) 2010-03-01 2011-09-09 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
BR112012021805A2 (pt) 2010-03-01 2016-05-17 Inovio Pharmaceuticals Inc dispositivo de eletroporação de pele tolerável e minimamente invasivo
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
EP3473296B1 (en) 2011-06-28 2020-08-05 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010161A2 (en) * 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
JP2010506660A (ja) * 2006-10-17 2010-03-04 ヴィージーエックス ファーマシューティカルズ，インコーポレイテッド 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022002731A (ja) * 2011-06-28 2022-01-11 イノビオ ファーマシューティカルズ，インコーポレイティド 低侵襲表皮電気穿孔装置
JP7519339B2 (ja) 2011-06-28 2024-07-19 イノビオ ファーマシューティカルズ，インコーポレイティド 低侵襲表皮電気穿孔装置
US12251561B2 (en) 2011-06-28 2025-03-18 Inovio Pharmaceuticals, Inc. Minimally invasive dermal electroporation device
JP2019506921A (ja) * 2015-12-22 2019-03-14 イノビオ ファーマシューティカルズ，インコーポレイティド 電源スイッチを備えたバッテリーパックを有するエレクトロポレーション装置
US11291827B2 (en) 2015-12-22 2022-04-05 Inovio Pharmaceuticals. Inc. Electroporation device having a battery pack with power switch
JP7163182B2 (ja) 2015-12-22 2022-10-31 イノビオ ファーマシューティカルズ，インコーポレイティド 電源スイッチを備えたバッテリーパックを有するエレクトロポレーション装置
AU2023226689B2 (en) * 2015-12-22 2025-03-13 Inovio Pharmaceuticals, Inc. Electroporation device having a battery pack with power switch
JP2022535026A (ja) * 2019-06-11 2022-08-04 ヴィオル カンパニー リミテッド 針組立体、これを含む皮膚刺激器およびその製造方法
JP7278427B2 (ja) 2019-06-11 2023-05-19 ヴィオル カンパニー リミテッド 針組立体、これを含む皮膚刺激器およびその製造方法

Also Published As

Publication number Publication date
JP7519339B2 (ja) 2024-07-19
AU2012333211A1 (en) 2013-12-19
EP3473296B1 (en) 2020-08-05
EP3797824A1 (en) 2021-03-31
JP2024096416A (ja) 2024-07-12
WO2013066427A1 (en) 2013-05-10
CN103687644A (zh) 2014-03-26
JP6626176B2 (ja) 2019-12-25
DK3473296T3 (da) 2020-11-09
US11291836B2 (en) 2022-04-05
EP3797824B1 (en) 2024-06-12
EP2726145A4 (en) 2015-02-25
KR20200023494A (ko) 2020-03-04
JP2017170161A (ja) 2017-09-28
KR102436439B1 (ko) 2022-08-25
KR20200123864A (ko) 2020-10-30
JP6423042B2 (ja) 2018-11-14
KR102325369B1 (ko) 2021-11-11
EP4438058A2 (en) 2024-10-02
US20200246613A1 (en) 2020-08-06
CA2837214C (en) 2021-06-01
KR20230156804A (ko) 2023-11-14
JP6799128B2 (ja) 2020-12-09
KR20140048213A (ko) 2014-04-23
US20140222105A1 (en) 2014-08-07
US10668279B2 (en) 2020-06-02
US12251561B2 (en) 2025-03-18
US20220212002A1 (en) 2022-07-07
JP2019058671A (ja) 2019-04-18
JP2020028759A (ja) 2020-02-27
EP2726145B1 (en) 2018-08-22
DK2726145T3 (da) 2019-01-02
ES2992120T3 (es) 2024-12-09
CA2837214A1 (en) 2013-05-10
KR102171142B1 (ko) 2020-10-28
EP2726145A1 (en) 2014-05-07
JP2022002731A (ja) 2022-01-11
KR102599318B1 (ko) 2023-11-07
US20180236225A1 (en) 2018-08-23
KR20220121912A (ko) 2022-09-01
JP6955076B2 (ja) 2021-10-27
KR20210135370A (ko) 2021-11-12
CN103687644B (zh) 2016-11-09
KR102081868B1 (ko) 2020-02-26
US9913978B2 (en) 2018-03-13
JP2021037322A (ja) 2021-03-11
EP3473296A1 (en) 2019-04-24

Similar Documents

Publication Publication Date Title
JP6423042B2 (ja) 低侵襲表皮電気穿孔装置
AU2017204802B2 (en) A minimally invasive dermal electroporation device

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150407

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160311

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160315

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160614

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160915

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170510

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170511

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20170630

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20170719