DK3473296T3 - Minimalt invasiv dermal elektroporeringsenhed - Google Patents

Minimalt invasiv dermal elektroporeringsenhed Download PDF

Info

Publication number
DK3473296T3
DK3473296T3 DK18190065.5T DK18190065T DK3473296T3 DK 3473296 T3 DK3473296 T3 DK 3473296T3 DK 18190065 T DK18190065 T DK 18190065T DK 3473296 T3 DK3473296 T3 DK 3473296T3
Authority
DK
Denmark
Prior art keywords
minimally invasive
electroporation unit
invasive dermal
dermal electroporation
unit
Prior art date
Application number
DK18190065.5T
Other languages
Danish (da)
English (en)
Inventor
Kate Broderick
Stephen Kemmerrer
Jay Mccoy
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3473296T3 publication Critical patent/DK3473296T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Electromagnetism (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Finger-Pressure Massage (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK18190065.5T 2011-06-28 2012-06-28 Minimalt invasiv dermal elektroporeringsenhed DK3473296T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
EP12846201.7A EP2726145B1 (en) 2011-06-28 2012-06-28 A miniminally invasive dermal electroporation device

Publications (1)

Publication Number Publication Date
DK3473296T3 true DK3473296T3 (da) 2020-11-09

Family

ID=48192559

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18190065.5T DK3473296T3 (da) 2011-06-28 2012-06-28 Minimalt invasiv dermal elektroporeringsenhed
DK12846201.7T DK2726145T3 (da) 2011-06-28 2012-06-28 Minimalt invasivt, dermalt elektroporationsapparat

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK12846201.7T DK2726145T3 (da) 2011-06-28 2012-06-28 Minimalt invasivt, dermalt elektroporationsapparat

Country Status (10)

Country Link
US (4) US9913978B2 (enExample)
EP (4) EP3473296B1 (enExample)
JP (7) JP2014524796A (enExample)
KR (6) KR102436439B1 (enExample)
CN (1) CN103687644B (enExample)
AU (1) AU2012333211A1 (enExample)
CA (1) CA2837214C (enExample)
DK (2) DK3473296T3 (enExample)
ES (1) ES2992120T3 (enExample)
WO (1) WO2013066427A1 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857499A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
DK3473296T3 (da) * 2011-06-28 2020-11-09 Inovio Pharmaceuticals Inc Minimalt invasiv dermal elektroporeringsenhed
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT3682905T (pt) 2011-10-03 2022-04-07 Modernatx Inc Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
US12559741B2 (en) 2013-06-08 2026-02-24 Suzhou Etta Biotech Co., Ltd. High density distributed three-dimensional electrode device
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
EP3137160B1 (en) * 2014-05-02 2023-04-19 Koninklijke Philips N.V. A device for inactivating bacteria
KR20160038566A (ko) * 2014-09-30 2016-04-07 엘지전자 주식회사 피부침투장치 및 피부침투방법
KR102350517B1 (ko) * 2014-09-30 2022-01-14 주식회사 엘지생활건강 피부침투장치 및 피부침투방법
KR101507493B1 (ko) * 2014-10-22 2015-03-30 (주)와이브레인 전기 자극 장치
CN104403943B (zh) * 2014-12-02 2016-06-15 陈剑 一种电击管和具有电击管的细胞电转仪
DK3277368T3 (da) * 2015-03-31 2020-07-27 Oncosec Medical Inc Systemer til forbedret vævsregistreringsbaseret elektroporering
US20230329777A1 (en) * 2015-04-10 2023-10-19 Angiodynamics, Inc. Techniques for controlling an irreversible electroporation system
US20180126183A1 (en) * 2015-05-29 2018-05-10 Koninklijke Philips N.V. A device for treating skin using non-thermal plasma
NZ737871A (en) * 2015-06-25 2023-02-24 Newsouth Innovations Pty Ltd Electroporation system for controlled localized therapeutics delivery
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
EP3366757A4 (en) * 2015-10-19 2019-06-26 Bex Co., Ltd. BUBBLE EXTRACTION, LOCAL ABLATION DEVICE, LOCAL ABLATION METHOD, INJECTION DEVICE AND INJECTION METHOD
PE20181500A1 (es) * 2015-12-22 2018-09-18 Inovio Pharmaceuticals Inc Dispositivo electroporacion que tiene un paquete de bateria con conmutador de alimentacion
US11027071B2 (en) 2015-12-28 2021-06-08 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
PT3397337T (pt) 2015-12-30 2020-11-24 Inovio Pharmaceuticals Inc Dispositivo de eletroporação com conjunto de agulhas destacável com sistema de bloqueio
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
ES2993107T3 (en) 2016-10-17 2024-12-23 Janssen Pharmaceuticals Inc Recombinant virus replicon systems and uses thereof
JP7788787B2 (ja) 2016-12-05 2025-12-19 ヤンセン ファーマシューティカルズ，インコーポレーテッド 遺伝子発現増強のための組成物および方法
US20200147361A1 (en) * 2017-05-03 2020-05-14 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
EA202091517A1 (ru) * 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
KR20200111729A (ko) 2018-01-19 2020-09-29 얀센 파마슈티칼즈, 인코포레이티드 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진
EP3864027A1 (en) 2018-10-08 2021-08-18 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
CN113613711B (zh) 2019-02-04 2024-09-17 新泽西州立罗格斯大学 使用微电极进行组织电转移的装置
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
KR102279603B1 (ko) * 2019-06-11 2021-07-20 (주)비올 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법
WO2021173105A1 (ru) * 2020-02-28 2021-09-02 Ирына Мыхайливна УДОВИЧЕНКО Устройство для электростимуляции
EP4121161A4 (en) 2020-03-20 2024-10-16 Inovio Pharmaceuticals, Inc. VACUUM-ASSISTED ELECTROPORATION DEVICES AND CORRESPONDING SYSTEMS AND METHODS
KR20220086094A (ko) 2020-12-16 2022-06-23 주식회사 은성글로벌 일렉트로포레이션 장치용 니들 주입 구성체
JP7842134B2 (ja) * 2021-06-30 2026-04-07 イノビオ ファーマシューティカルズ，インコーポレイティド 電気穿孔のための電極アレイ、並びに関連するシステム及び方法
KR102832435B1 (ko) * 2022-04-11 2025-07-09 전우금 전극 교체형 전기 자극기
KR102812334B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 제거할 수 있는 올가미 형태의 와이어를 갖는 전기천공장치
KR102812336B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 밀폐할 수 있는 전기천공장치
KR102753355B1 (ko) * 2023-04-14 2025-01-13 (주)이지템 분할전극구조를 포함하는 에너지 기반 디바이스
US12485280B1 (en) 2024-07-15 2025-12-02 Tav-Tech Ltd Unitary enhanced jet spray dermal treatment handpiece

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US7456012B2 (en) 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
EP2428250A1 (en) * 1998-07-13 2012-03-14 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
WO2000044438A1 (en) 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
AU2938100A (en) * 1999-03-08 2000-09-28 Yoram Palti Transdermal drug delivery system and method
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
EP1183068A4 (en) * 1999-05-10 2008-12-17 Gentronics Inc ENHANCED ACTIVE AGENT DELIVERY METHOD BY ELECTROPORATION
US6493402B1 (en) 1999-05-27 2002-12-10 Zenith Electronics Corporation Mode control for trellis decoder
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
WO2005010161A2 (en) 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
EP1680178A4 (en) * 2003-10-31 2008-01-02 Alza Corp SYSTEM AND METHOD FOR THE TRANSDERMAL DISTRIBUTION OF A VACCINE
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7657317B2 (en) * 2005-04-26 2010-02-02 Boston Scientific Neuromodulation Corporation Evaluating stimulation therapies and patient satisfaction
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
CA3063263C (en) * 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
GB2455475B (en) 2006-09-15 2011-04-13 Shoo Sticks Pty Ltd Accessory
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
AU2007313203B2 (en) * 2006-10-17 2012-08-16 Vgx Pharmaceuticals, Llc Electroporation devices and methods of using same for electroporation of cells in mammals
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080312580A1 (en) 2007-06-15 2008-12-18 Transport Pharmaceuticals, Inc. Current concentration system and method for electrokinetic delivery of medicaments
WO2009091578A1 (en) * 2008-01-17 2009-07-23 Genetronics, Inc. Variable current density single needle electroporation system and method
US9066738B2 (en) * 2008-07-14 2015-06-30 Syneron Medical Ltd. Devices and methods for percutaneous energy delivery
KR102309963B1 (ko) * 2009-04-16 2021-10-08 이노비오 파마수티컬즈, 인크. 비접촉식 전기천공 전극 및 방법
WO2010133578A2 (en) * 2009-05-20 2010-11-25 Sonion A/S Electroporation device with improved tip and electrode support
CA2769836A1 (en) * 2009-08-04 2011-02-10 Pollogen Ltd. Cosmetic skin rejuvination
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
ES2549190T3 (es) * 2010-03-01 2015-10-23 Inovio Pharmaceuticals, Inc. Aplicador y dispositivo de electroporación de múltiples capas de tejido
PL2542300T3 (pl) 2010-03-01 2017-06-30 Inovio Pharmaceuticals, Inc. Tolerowane i minimalnie inwazyjne urządzenie do elektroporacji skóry
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
DK3473296T3 (da) * 2011-06-28 2020-11-09 Inovio Pharmaceuticals Inc Minimalt invasiv dermal elektroporeringsenhed

Also Published As

Publication number Publication date
EP4438058A2 (en) 2024-10-02
KR102325369B1 (ko) 2021-11-11
JP7519339B2 (ja) 2024-07-19
JP2021037322A (ja) 2021-03-11
EP3473296A1 (en) 2019-04-24
JP6799128B2 (ja) 2020-12-09
KR102599318B1 (ko) 2023-11-07
AU2012333211A1 (en) 2013-12-19
KR102081868B1 (ko) 2020-02-26
JP2024096416A (ja) 2024-07-12
KR20220121912A (ko) 2022-09-01
KR102171142B1 (ko) 2020-10-28
EP2726145B1 (en) 2018-08-22
JP6626176B2 (ja) 2019-12-25
EP2726145A4 (en) 2015-02-25
WO2013066427A1 (en) 2013-05-10
JP2019058671A (ja) 2019-04-18
KR20230156804A (ko) 2023-11-14
KR102436439B1 (ko) 2022-08-25
EP2726145A1 (en) 2014-05-07
CN103687644A (zh) 2014-03-26
CA2837214C (en) 2021-06-01
US20220212002A1 (en) 2022-07-07
US20140222105A1 (en) 2014-08-07
ES2992120T3 (es) 2024-12-09
KR102908569B1 (ko) 2026-01-07
US20200246613A1 (en) 2020-08-06
EP3797824B1 (en) 2024-06-12
KR20140048213A (ko) 2014-04-23
CN103687644B (zh) 2016-11-09
DK2726145T3 (da) 2019-01-02
JP2022002731A (ja) 2022-01-11
CA2837214A1 (en) 2013-05-10
JP6423042B2 (ja) 2018-11-14
US20180236225A1 (en) 2018-08-23
JP2014524796A (ja) 2014-09-25
EP3473296B1 (en) 2020-08-05
US9913978B2 (en) 2018-03-13
US12251561B2 (en) 2025-03-18
EP3797824A1 (en) 2021-03-31
JP6955076B2 (ja) 2021-10-27
KR20210135370A (ko) 2021-11-12
US10668279B2 (en) 2020-06-02
US11291836B2 (en) 2022-04-05
KR20200123864A (ko) 2020-10-30
JP2017170161A (ja) 2017-09-28
JP2020028759A (ja) 2020-02-27
KR20200023494A (ko) 2020-03-04

Similar Documents

Publication Publication Date Title
DK2726145T3 (da) Minimalt invasivt, dermalt elektroporationsapparat
EP2819589A4 (en) MINIMALLY INVASIVE SURGICAL PROCEDURES
DK3061401T3 (da) Vævsbeholder
DK2539015T3 (da) Nethindeprotese
CO6930321A2 (es) Curación de tejidos
PT2663250T (pt) Instrumento eletrocirúrgico
EP2736612A4 (en) CARD MIXER
DK3501558T3 (da) Flydbare vævsprodukter
EP2744390A4 (en) ENDOSCOPE WITH MULTIVUE ELEMENT
GB2489925B (en) Electrosurgical generator
PT2744519T (pt) Composições de rejuvenescimento dérmico
EP2833964A4 (en) MINIMALLY INVASIVE EPICARDIAL PACEMAKER
DE102011075781A8 (de) Elektrochirurgisches Instrument
EP2790769A4 (en) ANTISEPTIC APPLICATOR
GB2496735B (en) Electrosurgical instrument
EP2612610A4 (en) MEDICAL KNIFE
PL2542300T3 (pl) Tolerowane i minimalnie inwazyjne urządzenie do elektroporacji skóry
ZA201401944B (en) Hydrous adhesive skin patch
EP2714975A4 (en) ELASTIC FABRIC
EP2790770A4 (en) ANTISEPTIC APPLICATOR
IL227732A0 (en) Cosmetic use
EP2851007A4 (en) TROKAR
EP2702954A4 (en) MEDICAL KNIFE
GB2492064B (en) Electrosurgical instrument
EP2657957A4 (en) EVAPORATOR