KR102436439B1 - 최소 침습 피부 전기천공 장치 - Google Patents

최소 침습 피부 전기천공 장치 Download PDF

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Publication number
KR102436439B1
KR102436439B1 KR1020217036357A KR20217036357A KR102436439B1 KR 102436439 B1 KR102436439 B1 KR 102436439B1 KR 1020217036357 A KR1020217036357 A KR 1020217036357A KR 20217036357 A KR20217036357 A KR 20217036357A KR 102436439 B1 KR102436439 B1 KR 102436439B1
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South Korea
Prior art keywords
electroporation
electrode
microcontroller
arrays
pulse
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Expired - Fee Related
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KR1020217036357A
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English (en)
Korean (ko)
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KR20210135370A (ko
Inventor
케이트 브로데릭
스테판 케머러
제이 맥코이
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이노비오 파마수티컬즈, 인크.
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Priority to KR1020227028974A priority Critical patent/KR102599318B1/ko
Publication of KR20210135370A publication Critical patent/KR20210135370A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Electromagnetism (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Finger-Pressure Massage (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217036357A 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치 Expired - Fee Related KR102436439B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227028974A KR102599318B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
US61/502,198 2011-06-28
KR1020207030414A KR102325369B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
PCT/US2012/044539 WO2013066427A1 (en) 2011-06-28 2012-06-28 A miniminally invasive dermal electroporation device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207030414A Division KR102325369B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치

Related Child Applications (1)

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KR1020227028974A Division KR102599318B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치

Publications (2)

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KR20210135370A KR20210135370A (ko) 2021-11-12
KR102436439B1 true KR102436439B1 (ko) 2022-08-25

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KR1020217036357A Expired - Fee Related KR102436439B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020227028974A Active KR102599318B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020237037854A Active KR102908569B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020207005036A Expired - Fee Related KR102171142B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020147001564A Active KR102081868B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020207030414A Active KR102325369B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치

Family Applications After (5)

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KR1020227028974A Active KR102599318B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020237037854A Active KR102908569B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020207005036A Expired - Fee Related KR102171142B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020147001564A Active KR102081868B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치
KR1020207030414A Active KR102325369B1 (ko) 2011-06-28 2012-06-28 최소 침습 피부 전기천공 장치

Country Status (10)

Country Link
US (4) US9913978B2 (enExample)
EP (4) EP3473296B1 (enExample)
JP (7) JP2014524796A (enExample)
KR (6) KR102436439B1 (enExample)
CN (1) CN103687644B (enExample)
AU (1) AU2012333211A1 (enExample)
CA (1) CA2837214C (enExample)
DK (2) DK3473296T3 (enExample)
ES (1) ES2992120T3 (enExample)
WO (1) WO2013066427A1 (enExample)

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