JP2019037837A - 組織製品の酵素処理方法 - Google Patents
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Abstract
【解決手段】組織マトリックスの処理方法において、上皮を含まない皮膚組織マトリックスを選択するステップと、前記皮膚組織マトリックスを第1の溶液で処理して前記皮膚組織マトリックスから実質的にすべての細胞および細胞成分を除去するステップと、前記皮膚組織マトリックスに所望のレベルの可撓性を生じさせるのに十分な条件下で、前記皮膚組織マトリックスをスルフヒドリルプロテアーゼを含む第2の溶液と接触させるステップと、を含むことを特徴とする方法。
【選択図】図1
Description
「無細胞組織マトリックス」という用語は、本明細書で使用する場合、一般に、細胞および/または細胞成分を実質的に含まない任意の組織マトリックスを指す。皮膚、皮膚の一部(例えば、真皮)、および他の組織、例えば、血管、心臓弁、筋膜、軟骨、骨、神経結合組織などを使用して、本開示の範囲に入る無細胞マトリックスを作製することができる。無細胞組織マトリックスが細胞および/または細胞成分を実質的に含まないかどうかを判定するために、多くの方法で無細胞組織マトリックスの試験または評価を行うことができる。例えば、処理された組織を光学顕微鏡検査で検査して、細胞(生細胞もしくは死細胞)および/または細胞成分が残存するかどうかを判定することができる。さらに、特定のアッセイを使用して細胞または細胞成分の有無を確認することができる。例えば、DNAまたは他の核酸のアッセイを使用して、組織マトリックス中に残存する核物質を定量することができる。一般に、残存するDNAまたは他の核酸がない場合、完全に脱細胞化されている(即ち、細胞および/または細胞成分が除去されている)ことが分かる。最後に、細胞特異的成分(例えば、表面抗原)を同定する他のアッセイを使用して、組織マトリックスが無細胞であるかどうかを判定することができる。皮膚、皮膚の一部(例えば、真皮)、および他の組織、例えば、血管、心臓弁、筋膜、軟骨、骨、および神経結合組織などを使用して、本開示の範囲に入る無細胞マトリックスを作製することができる。
Claims (11)
- 組織マトリックスの処理方法において、
上皮を含まない皮膚組織マトリックスを選択するステップと、
前記皮膚組織マトリックスを第1の溶液で処理して前記皮膚組織マトリックスから実質的にすべての細胞および細胞成分を除去するステップと、
前記皮膚組織マトリックスに所望のレベルの可撓性を生じさせるのに十分な条件下で、前記皮膚組織マトリックスをスルフヒドリルプロテアーゼを含む第2の溶液と接触させるステップと、
を含むことを特徴とする方法。 - 請求項1に記載の方法において、前記スルフヒドリルプロテアーゼがブロメラインであることを特徴とする方法。
- 請求項1に記載の方法において、前記スルフヒドリルプロテアーゼがブロメライン、パパイン、フィシン、アクチニジン、またはこれらの組み合わせから選択されることを特徴とする方法。
- 請求項1に記載の方法において、引張強度、引裂強度、縫合強度、耐クリープ性、破裂強度、熱転移温度、またはこれらの組み合わせの少なくとも1つの望ましくない変化を生じさせない条件下で、前記組織マトリックスを前記スルフヒドリルプロテアーゼと接触させることを特徴とする方法。
- 請求項1に記載の方法において、引張強度、引裂強度、縫合強度、耐クリープ性、熱転移温度、またはこれらの組み合わせの統計学的に有意な低下を引き起こさない条件下で、前記組織マトリックスを前記スルフヒドリルプロテアーゼと接触させることを特徴とする方法。
- 請求項1に記載の方法において、前記皮膚組織マトリックスがインタクトな組織を含むことを特徴とする方法。
- 組織マトリックスの処理方法において、
上皮を含まない皮膚無細胞組織マトリックスを選択するステップと、
前記皮膚無細胞組織マトリックスに所望のレベルの可撓性を生じさせるのに十分な条件下で、前記皮膚無細胞組織マトリックスをスルフヒドリルプロテアーゼと接触させるステップと、
を含むことを特徴とする方法。 - 請求項7に記載の方法において、前記スルフヒドリルプロテアーゼがブロメラインであることを特徴とする方法。
- 請求項7に記載の方法において、前記スルフヒドリルプロテアーゼがブロメライン、パパイン、フィシン、アクチニジン、またはこれらの組み合わせから選択されることを特徴とする方法。
- 請求項7に記載の方法において、引張強度、引裂強度、縫合強度、耐クリープ性、破裂強度、熱転移温度、またはこれらの組み合わせの少なくとも1つの望ましくない変化を生じさせない条件下で、前記皮膚無細胞組織マトリックスを前記スルフヒドリルプロテアーゼと接触させることを特徴とする方法。
- 請求項7に記載の方法において、引張強度、引裂強度、縫合強度、耐クリープ性、熱転移温度、またはこれらの組み合わせの統計学的に有意な低下を引き起こさない条件下で、前記皮膚無細胞組織マトリックスを前記スルフヒドリルプロテアーゼと接触させることを特徴とする方法。
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US10207025B2 (en) | 2011-04-28 | 2019-02-19 | Lifecell Corporation | Method for enzymatic treatment of tissue products |
US9238793B2 (en) | 2011-04-28 | 2016-01-19 | Lifecell Corporation | Method for enzymatic treatment of tissue products |
US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
WO2014008181A2 (en) | 2012-07-06 | 2014-01-09 | Lifecell Corporation | Decellularized muscle matrix |
US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
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