JP2018538307A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018538307A5 JP2018538307A5 JP2018532035A JP2018532035A JP2018538307A5 JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5 JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- lymphoma
- fibrosis
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O Chemical compound *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O 0.000 description 13
- ZJBPMQFCMFACQD-UHFFFAOYSA-O CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O Chemical compound CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O ZJBPMQFCMFACQD-UHFFFAOYSA-O 0.000 description 1
- FUZMNSBMAWGICZ-UHFFFAOYSA-N CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F Chemical compound CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F FUZMNSBMAWGICZ-UHFFFAOYSA-N 0.000 description 1
- YXKMZZLFDQINKP-CSKWCJJFSA-N CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O Chemical compound CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O YXKMZZLFDQINKP-CSKWCJJFSA-N 0.000 description 1
- RGSRIRHSVLYJIG-YYOOZPTRSA-N CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O Chemical compound CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O RGSRIRHSVLYJIG-YYOOZPTRSA-N 0.000 description 1
- VPMRBWJJRDQKLC-UHFFFAOYSA-N COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F Chemical compound COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F VPMRBWJJRDQKLC-UHFFFAOYSA-N 0.000 description 1
- BZTXIQSFUSNIMJ-UHFFFAOYSA-N COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O Chemical compound COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O BZTXIQSFUSNIMJ-UHFFFAOYSA-N 0.000 description 1
- COSCVQYQAHCLMI-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O COSCVQYQAHCLMI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522245.8 | 2015-12-16 | ||
| GBGB1522245.8A GB201522245D0 (en) | 2015-12-16 | 2015-12-16 | Compounds useful as kinase inhibitors |
| GB1613945.3 | 2016-08-15 | ||
| GBGB1613945.3A GB201613945D0 (en) | 2016-08-15 | 2016-08-15 | Compounds useful as kinase inhibitors |
| PCT/GB2016/053968 WO2017103611A1 (en) | 2015-12-16 | 2016-12-16 | Compounds useful as kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Division JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538307A JP2018538307A (ja) | 2018-12-27 |
| JP2018538307A5 true JP2018538307A5 (enExample) | 2020-06-18 |
| JP6731483B2 JP6731483B2 (ja) | 2020-07-29 |
Family
ID=57590725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Country Status (38)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| US10611766B2 (en) | 2015-09-16 | 2020-04-07 | Loxo Oncology Inc. | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer |
| CN114605327B (zh) | 2015-12-16 | 2025-03-11 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| KR20210028144A (ko) * | 2018-04-06 | 2021-03-11 | 블랙 벨트 티엑스 리미티드 | Atf6 저해제 및 그의 용도 |
| JP6995195B2 (ja) | 2018-05-18 | 2022-02-04 | 富士フイルム株式会社 | ３－ジフルオロメチルピラゾール化合物の製造方法及び３－ジフルオロメチルピラゾール－４－カルボン酸化合物の製造方法、並びに、ピラゾリジン化合物 |
| CA3108065C (en) * | 2018-07-31 | 2025-10-07 | Loxo Oncology, Inc. | SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021053234A1 (en) * | 2019-09-19 | 2021-03-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Compounds and compositions for treating kidney disease |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| KR20220100992A (ko) | 2019-12-06 | 2022-07-18 | 록쏘 온콜로지, 인코포레이티드 | 브루톤 티로신 키나제 억제제의 투여 |
| MX2022008148A (es) | 2020-01-02 | 2022-07-21 | Dizal Jiangsu Pharmaceutical Co Ltd | Inhibidores de btk. |
| WO2021180107A1 (en) * | 2020-03-12 | 2021-09-16 | Fochon Pharmaceuticals, Ltd. | Compounds useful as kinase inhibitors |
| TW202317099A (zh) * | 2020-09-10 | 2023-05-01 | 美商絡速藥業公司 | 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體 |
| CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2022228302A1 (en) * | 2021-04-25 | 2022-11-03 | Bionova Pharmaceuticals (Shanghai) Limited | Heteroaromatic carboxamide compounds and its use |
| BR112023021235A2 (pt) * | 2021-05-14 | 2023-12-12 | Loxo Oncology Inc | Formas cocristalinas de um inibidor da tirosina quinase de bruton |
| KR20240029070A (ko) * | 2021-07-01 | 2024-03-05 | 항저우 힐젠 테라퓨틱스 컴퍼니 리미티드 | 브루톤 티로신 키나아제, 이의 돌연변이체 분해제, 조성물 및 응용 |
| CN115611810B (zh) * | 2021-07-16 | 2025-03-04 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑类化合物及包含该化合物的组合物及其用途 |
| EP4448523A1 (en) | 2021-12-14 | 2024-10-23 | Crossfire Oncology Holding B.V. | Macrocyclic btk inhibitors |
| WO2023143355A1 (en) * | 2022-01-28 | 2023-08-03 | Hansoh Bio Llc | Azacycle amide derivative, preparation methods and medicinal uses thereof |
| EP4474377A4 (en) * | 2022-03-03 | 2025-07-30 | Shenzhen Targetrx Inc | Cycloalkyl or heterocyclyl substituted heteroaryl compound, and composition and use thereof |
| CN119053592A (zh) * | 2022-03-18 | 2024-11-29 | 英矽智能科技知识产权有限公司 | 吡唑膜相关的酪氨酸和苏氨酸特异性cdc2抑制激酶(pkmyt1)抑制剂及其用途 |
| CN115894376B (zh) * | 2022-12-15 | 2025-05-16 | 南京雷正医药科技有限公司 | 一种芳香族酰胺类化合物、药物组合物及其用途 |
| IL322630A (en) | 2023-02-22 | 2025-10-01 | Assia Chem Ind Ltd | Solid forms of pirobrutinib |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| KR20250046558A (ko) | 2023-09-27 | 2025-04-03 | 임창섭 | 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템 |
| TW202532067A (zh) * | 2023-12-13 | 2025-08-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有吡唑環及雙環雜芳基的化合物 |
| WO2025137329A1 (en) * | 2023-12-22 | 2025-06-26 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| CN119059973A (zh) * | 2024-08-12 | 2024-12-03 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的合成工艺 |
| CN119059974B (zh) * | 2024-08-12 | 2025-10-28 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的制备方法 |
| CN120504661B (zh) * | 2025-07-14 | 2025-11-07 | 复旦大学 | Alkbh8小分子抑制剂及其制备方法和用途 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020088406A (ko) | 1999-09-17 | 2002-11-27 | 애보트 게엠베하 운트 콤파니 카게 | 치료제로서의 피라졸로피리미딘 |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| US6291504B1 (en) * | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| US20030225098A1 (en) | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| EP2529621B1 (en) | 2006-09-22 | 2016-10-05 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| CN101553224A (zh) * | 2006-10-06 | 2009-10-07 | 艾博特公司 | 新型咪唑并噻唑和咪唑并唑 |
| WO2008054827A2 (en) | 2006-11-03 | 2008-05-08 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
| EP2139487B1 (en) | 2007-03-28 | 2015-11-11 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| AU2009262068C1 (en) | 2008-06-27 | 2015-07-02 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| CN102159214A (zh) | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
| EP2324008B1 (en) * | 2008-07-24 | 2012-05-09 | Nerviano Medical Sciences S.R.L. | 3,4-diarylpyrazoles as protein kinase inhibitors |
| US8426428B2 (en) | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
| US7741330B1 (en) | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| MX380504B (es) | 2010-06-03 | 2025-03-12 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| TWI532737B (zh) * | 2010-06-30 | 2016-05-11 | 艾諾屋製藥公司 | 可溶性鳥苷酸環化酶（ｓＧＣ）刺激物 |
| AU2012255860C1 (en) | 2011-05-17 | 2015-12-10 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| DK2710007T3 (da) | 2011-05-17 | 2020-01-27 | Principia Biopharma Inc | Kinasehæmmere |
| KR20140048968A (ko) | 2011-07-13 | 2014-04-24 | 파마시클릭스, 인코포레이티드 | 브루톤형 티로신 키나제의 억제제 |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| CN104487441B (zh) | 2012-06-18 | 2018-06-01 | 普林斯匹亚生物制药公司 | 有用于治疗癌症和自身免疫性疾病的可逆的共价吡咯并嘧啶或吡唑并嘧啶 |
| US9572811B2 (en) | 2012-08-03 | 2017-02-21 | Principia Biopharma Inc. | Treatment of dry eye |
| CN104603124B (zh) * | 2012-08-10 | 2018-04-17 | 勃林格殷格翰国际有限公司 | 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 |
| GB201214750D0 (en) * | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| US20150291554A1 (en) * | 2012-11-02 | 2015-10-15 | Pfizer Inc. | Bruton's Tyrosine Kinase Inhibitors |
| CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| GB201309085D0 (en) | 2013-05-20 | 2013-07-03 | Redx Pharma Ltd | Compounds |
| RU2677884C2 (ru) * | 2013-09-30 | 2019-01-22 | Гуанчжоу Иннокэа Фарма Тек Ко., Лтд. | Замещенные никотинимидные ингибиторы втк, их получение и применение в терапии раковых, воспалительных и аутоиммунных заболеваний |
| WO2015075051A1 (en) * | 2013-11-19 | 2015-05-28 | Universitaet Des Saarlandes | Allosteric inhibitors of atypical protein kinases c |
| US9637486B2 (en) | 2013-12-20 | 2017-05-02 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| CN112353806A (zh) | 2014-02-21 | 2021-02-12 | 普林斯匹亚生物制药公司 | Btk抑制剂的盐和固体形式 |
| GB201404987D0 (en) | 2014-03-20 | 2014-05-07 | Redx Pharma Ltd | Compounds |
| CN105085474B (zh) * | 2014-05-07 | 2018-05-18 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN107406417B (zh) | 2015-01-28 | 2020-06-09 | 拜耳制药股份公司 | 4H-吡咯并[3,2-c]吡啶-4-酮衍生物 |
| GB2548542A (en) * | 2015-06-16 | 2017-09-27 | Redx Pharma Plc | Compounds |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| US10611766B2 (en) | 2015-09-16 | 2020-04-07 | Loxo Oncology Inc. | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PE20181758A1 (es) | 2015-12-16 | 2018-10-30 | Ecolab Usa Inc | Metodos para remover microorganismos o crecimiento microbiano y depositos minerales en un sistema de membrana |
| CN108884018B (zh) | 2015-12-16 | 2021-08-31 | 优星私人有限公司 | 树枝状聚合物和其制剂 |
| HRP20211845T1 (hr) | 2015-12-16 | 2022-03-04 | Boehringer Ingelheim International Gmbh | Derivati bipirazolila korisni za liječenje autoimunih bolesti |
| CN114605327B (zh) | 2015-12-16 | 2025-03-11 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| EP3390400B1 (en) | 2015-12-16 | 2021-01-20 | Bristol-Myers Squibb Company | Heteroarylhydroxypyrimidinones as agonists of the apj receptor |
-
2016
- 2016-12-16 CN CN202210312064.XA patent/CN114605327B/zh active Active
- 2016-12-16 TN TNP/2018/000213A patent/TN2018000213A1/en unknown
- 2016-12-16 EP EP16816363.2A patent/EP3390395B1/en active Active
- 2016-12-16 MX MX2021003478A patent/MX394193B/es unknown
- 2016-12-16 IL IL285976A patent/IL285976B2/en unknown
- 2016-12-16 MA MA055064A patent/MA55064A/fr unknown
- 2016-12-16 US US16/063,542 patent/US10695323B2/en active Active
- 2016-12-16 ES ES16816363T patent/ES2828431T3/es active Active
- 2016-12-16 PE PE2018001143A patent/PE20181449A1/es unknown
- 2016-12-16 EP EP20194724.9A patent/EP3782994B1/en active Active
- 2016-12-16 MA MA49809A patent/MA49809A1/fr unknown
- 2016-12-16 CN CN202111022492.0A patent/CN113636978B/zh active Active
- 2016-12-16 KR KR1020217003683A patent/KR20210018530A/ko not_active Withdrawn
- 2016-12-16 MY MYPI2022003989A patent/MY202026A/en unknown
- 2016-12-16 EA EA201891268A patent/EA035132B1/ru not_active IP Right Cessation
- 2016-12-16 WO PCT/GB2016/053968 patent/WO2017103611A1/en not_active Ceased
- 2016-12-16 SG SG10202012498TA patent/SG10202012498TA/en unknown
- 2016-12-16 SI SI201630920T patent/SI3390395T1/sl unknown
- 2016-12-16 KR KR1020187020225A patent/KR102215792B1/ko active Active
- 2016-12-16 HU HUE16816363A patent/HUE051921T2/hu unknown
- 2016-12-16 CN CN202210312050.8A patent/CN114591242B/zh active Active
- 2016-12-16 UA UAA201807294A patent/UA122258C2/uk unknown
- 2016-12-16 ES ES20194724T patent/ES3041897T3/es active Active
- 2016-12-16 CA CA3008488A patent/CA3008488C/en active Active
- 2016-12-16 UA UAA202003795A patent/UA127863C2/uk unknown
- 2016-12-16 CN CN202210311995.8A patent/CN114634447B/zh active Active
- 2016-12-16 RS RS20201291A patent/RS60982B9/sr unknown
- 2016-12-16 DK DK16816363.2T patent/DK3390395T3/da active
- 2016-12-16 JP JP2018532035A patent/JP6731483B2/ja active Active
- 2016-12-16 MD MDE20181001T patent/MD3390395T2/ro unknown
- 2016-12-16 PE PE2021001581A patent/PE20220507A1/es unknown
- 2016-12-16 MY MYPI2022003990A patent/MY200590A/en unknown
- 2016-12-16 CN CN202111022488.4A patent/CN113603645B/zh active Active
- 2016-12-16 LT LTEP16816363.2T patent/LT3390395T/lt unknown
- 2016-12-16 HR HRP20201835TT patent/HRP20201835T1/hr unknown
- 2016-12-16 CN CN202210312076.2A patent/CN114621146A/zh active Pending
- 2016-12-16 CR CR20180367A patent/CR20180367A/es unknown
- 2016-12-16 CN CN202210311970.8A patent/CN114573510B/zh active Active
- 2016-12-16 AU AU2016373530A patent/AU2016373530B2/en active Active
- 2016-12-16 PT PT168163632T patent/PT3390395T/pt unknown
- 2016-12-16 PE PE2021001592A patent/PE20220502A1/es unknown
- 2016-12-16 NZ NZ743553A patent/NZ743553A/en unknown
- 2016-12-16 SG SG11201805044WA patent/SG11201805044WA/en unknown
- 2016-12-16 CO CONC2018/0006164A patent/CO2018006164A2/es unknown
- 2016-12-16 CN CN202210310724.0A patent/CN114716381B/zh active Active
- 2016-12-16 CN CN201680073031.7A patent/CN108473481B/zh active Active
- 2016-12-16 MX MX2018007267A patent/MX380907B/es unknown
-
2018
- 2018-06-10 IL IL259923A patent/IL259923B/en active IP Right Grant
- 2018-06-13 PH PH12018501268A patent/PH12018501268A1/en unknown
- 2018-06-14 CL CL2018001591A patent/CL2018001591A1/es unknown
- 2018-06-20 ZA ZA2018/04137A patent/ZA201804137B/en unknown
- 2018-08-22 US US16/109,162 patent/US10342780B2/en active Active
- 2018-08-27 US US16/113,661 patent/US10464905B2/en active Active
-
2020
- 2020-05-13 US US15/930,657 patent/US10918622B2/en active Active
- 2020-05-28 ZA ZA2020/03176A patent/ZA202003176B/en unknown
- 2020-07-06 JP JP2020116636A patent/JP7086140B2/ja active Active
- 2020-07-26 IL IL276283A patent/IL276283B/en active IP Right Grant
- 2020-11-16 CY CY20201101090T patent/CY1123561T1/el unknown
- 2020-12-15 US US17/122,103 patent/US11471441B2/en active Active
-
2021
- 2021-01-26 ZA ZA2021/00544A patent/ZA202100544B/en unknown
- 2021-02-24 IL IL281067A patent/IL281067B/en unknown
- 2021-03-23 AU AU2021201811A patent/AU2021201811B2/en active Active
- 2021-08-31 AU AU2021225161A patent/AU2021225161B2/en active Active
- 2021-08-31 AU AU2021225162A patent/AU2021225162B2/en active Active
- 2021-10-05 ZA ZA2021/07472A patent/ZA202107472B/en unknown
- 2021-10-05 ZA ZA2021/07471A patent/ZA202107471B/en unknown
- 2021-11-12 US US17/525,350 patent/US11826351B2/en active Active
-
2022
- 2022-06-07 JP JP2022092275A patent/JP7419437B2/ja active Active
-
2023
- 2023-07-31 US US18/362,249 patent/US12220401B2/en active Active
-
2024
- 2024-02-27 HU HUS2400003C patent/HUS2400003I1/hu unknown
- 2024-02-29 LU LU00330C patent/LUC00330I2/fr unknown
- 2024-02-29 NO NO2024008C patent/NO2024008I1/no unknown
- 2024-03-01 FI FIC20240004C patent/FIC20240004I1/fi unknown
- 2024-03-04 CY CY2024003C patent/CY2024003I1/el unknown
- 2024-03-04 FR FR24C1009C patent/FR24C1009I2/fr active Active
- 2024-03-06 LT LTPA2024506C patent/LTPA2024506I1/lt unknown
- 2024-03-06 NL NL301262C patent/NL301262I2/nl unknown
- 2024-11-21 US US18/955,844 patent/US20250090500A1/en active Pending
-
2026
- 2026-03-19 US US19/571,653 patent/US20260207557A1/en active Pending
- 2026-03-19 US US19/571,633 patent/US20260207556A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20201835T1 (hr) | Spojevi korisni kao inhibitori kinaze | |
| JP2020172535A5 (enExample) | ||
| WO2021249057A1 (zh) | 杂环化合物及其用途 | |
| US10800792B2 (en) | Inhibitors of Bruton's tyrosine kinase and method of their use | |
| JP2022110135A (ja) | Ｓｙｋ阻害剤としての縮合複素芳香族ピロリジノン | |
| EP3013337B1 (en) | Primary carboxamides as btk inhibitors | |
| SI2892900T1 (en) | Pyrazolopyrimidine compounds as kinase inhibitors | |
| TWI922529B (zh) | 化合物、組合物及方法 | |
| WO2010131146A1 (en) | Cyclobutenedione derivatives | |
| JP2016534146A5 (enExample) | ||
| JP2024508794A (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| CN106459045A (zh) | 杂环激酶抑制剂 | |
| CA3045371C (en) | Inhibitors of influenza virus replication and uses thereof | |
| JP2015527401A5 (enExample) | ||
| JP2018534326A5 (enExample) | ||
| JP2018536686A (ja) | ブルトン型チロシンキナーゼの阻害剤としての多環式化合物 | |
| JP2024519088A (ja) | ピペラジン誘導体及びその医薬における使用 | |
| EA028816B1 (ru) | Модуляторы р2х7 | |
| US20150361100A1 (en) | Indolizine derivatives as phoshoinositide 3-kinases inhibitors | |
| JP2023538304A (ja) | 化合物、組成物及び方法 | |
| CN107344940A (zh) | Btk抑制剂及其用途 | |
| WO2015151006A1 (en) | Substituted purine compounds as btk inhibitors | |
| JP2022500466A (ja) | 抗ウイルス剤としての官能化複素環 | |
| SG11202113167QA (en) | Fused heterocyclic derivatives | |
| CN102858769A (zh) | 吡唑并吡啶激酶抑制剂 |