JP2018538307A5 - - Google Patents
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- JP2018538307A5 JP2018538307A5 JP2018532035A JP2018532035A JP2018538307A5 JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5 JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- lymphoma
- fibrosis
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O Chemical compound *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O 0.000 description 13
- ZJBPMQFCMFACQD-UHFFFAOYSA-O CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O Chemical compound CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O ZJBPMQFCMFACQD-UHFFFAOYSA-O 0.000 description 1
- FUZMNSBMAWGICZ-UHFFFAOYSA-N CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F Chemical compound CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F FUZMNSBMAWGICZ-UHFFFAOYSA-N 0.000 description 1
- YXKMZZLFDQINKP-CSKWCJJFSA-N CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O Chemical compound CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O YXKMZZLFDQINKP-CSKWCJJFSA-N 0.000 description 1
- RGSRIRHSVLYJIG-YYOOZPTRSA-N CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O Chemical compound CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O RGSRIRHSVLYJIG-YYOOZPTRSA-N 0.000 description 1
- VPMRBWJJRDQKLC-UHFFFAOYSA-N COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F Chemical compound COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F VPMRBWJJRDQKLC-UHFFFAOYSA-N 0.000 description 1
- BZTXIQSFUSNIMJ-UHFFFAOYSA-N COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O Chemical compound COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O BZTXIQSFUSNIMJ-UHFFFAOYSA-N 0.000 description 1
- COSCVQYQAHCLMI-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O COSCVQYQAHCLMI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1522245.8A GB201522245D0 (en) | 2015-12-16 | 2015-12-16 | Compounds useful as kinase inhibitors |
| GB1522245.8 | 2015-12-16 | ||
| GBGB1613945.3A GB201613945D0 (en) | 2016-08-15 | 2016-08-15 | Compounds useful as kinase inhibitors |
| GB1613945.3 | 2016-08-15 | ||
| PCT/GB2016/053968 WO2017103611A1 (en) | 2015-12-16 | 2016-12-16 | Compounds useful as kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Division JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538307A JP2018538307A (ja) | 2018-12-27 |
| JP2018538307A5 true JP2018538307A5 (enExample) | 2020-06-18 |
| JP6731483B2 JP6731483B2 (ja) | 2020-07-29 |
Family
ID=57590725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Country Status (38)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN114685516A (zh) | 2015-09-16 | 2022-07-01 | 洛克索肿瘤学股份有限公司 | 用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物 |
| UA127863C2 (uk) | 2015-12-16 | 2024-01-31 | Локсо Онколоджі, Інк. | Сполуки, які можна застосовувати як інгібітори кінази |
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| KR20210028144A (ko) * | 2018-04-06 | 2021-03-11 | 블랙 벨트 티엑스 리미티드 | Atf6 저해제 및 그의 용도 |
| WO2019220962A1 (ja) * | 2018-05-18 | 2019-11-21 | 富士フイルム株式会社 | ３－ジフルオロメチルピラゾール化合物の製造方法及び３－ジフルオロメチルピラゾール－４－カルボン酸化合物の製造方法、並びに、ピラゾリジン化合物 |
| JP7286755B2 (ja) | 2018-07-31 | 2023-06-05 | ロクソ オンコロジー， インコーポレイテッド | （ｓ）－５－アミノ－３－（４－（（５－フルオロ－２－メトキシベンズアミド）メチル）フェニル）－１－（１，１，１－トリフルオロプロパン－２－イル）－１ｈ－ピラゾール－４－カルボキサミドの噴霧乾燥分散体および製剤 |
| CN114206852A (zh) | 2019-08-09 | 2022-03-18 | 卡尔维斯塔制药有限公司 | 血浆激肽释放酶抑制剂 |
| US20220273593A1 (en) * | 2019-09-19 | 2022-09-01 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Compounds and compositions for treating kidney disease |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| MX2022006631A (es) * | 2019-12-06 | 2022-09-07 | Loxo Oncology Inc | Dosificacion de un inhibidor de la tirosina cinasa de bruton. |
| US20230122807A1 (en) | 2020-01-02 | 2023-04-20 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Btk inhibitors |
| JP2023518006A (ja) * | 2020-03-12 | 2023-04-27 | フォチョン・バイオサイエンシーズ・リミテッド | キナーゼ阻害剤としての化合物 |
| TWI809489B (zh) | 2020-09-10 | 2023-07-21 | 美商絡速藥業公司 | 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體 |
| CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| CN116348453B (zh) * | 2021-04-25 | 2025-07-04 | 烨辉医药科技(上海)有限公司 | 杂芳族甲酰胺化合物及其用途 |
| BR112023021235A2 (pt) * | 2021-05-14 | 2023-12-12 | Loxo Oncology Inc | Formas cocristalinas de um inibidor da tirosina quinase de bruton |
| IL309427A (en) * | 2021-07-01 | 2024-02-01 | Hangzhou Healzen Therapeutics Co Ltd | TYROSINE KINASE AND MUTANT DEGRADER, Broughton's composition and application |
| CN115611810B (zh) * | 2021-07-16 | 2025-03-04 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑类化合物及包含该化合物的组合物及其用途 |
| US20250074911A1 (en) | 2021-12-14 | 2025-03-06 | Crossfire Oncology Holding B.V. | Macrocyclic btk inhibitors |
| WO2023143355A1 (en) * | 2022-01-28 | 2023-08-03 | Hansoh Bio Llc | Azacycle amide derivative, preparation methods and medicinal uses thereof |
| WO2023165570A1 (zh) * | 2022-03-03 | 2023-09-07 | 深圳市塔吉瑞生物医药有限公司 | 环烷基或杂环基取代的杂芳基化合物及其组合物及用途 |
| EP4493557A4 (en) * | 2022-03-18 | 2026-03-18 | Insilico Medicine Ip Ltd | PYRAZOLE MEMBRANE-ASSOCIATED CDC2-SPECIFIC TYROSINE AND THREONINE KINASE INHIBITORS (PKMYT1) AND THEIR USES |
| CN115894376B (zh) * | 2022-12-15 | 2025-05-16 | 南京雷正医药科技有限公司 | 一种芳香族酰胺类化合物、药物组合物及其用途 |
| IL322630A (en) | 2023-02-22 | 2025-10-01 | Assia Chem Ind Ltd | Solid forms of pirobrutinib |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| KR20250046558A (ko) | 2023-09-27 | 2025-04-03 | 임창섭 | 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템 |
| WO2025124496A1 (zh) * | 2023-12-13 | 2025-06-19 | 正大天晴药业集团股份有限公司 | 含有吡唑环和双环杂芳基的化合物、其药物组合物及用途 |
| WO2025137329A1 (en) * | 2023-12-22 | 2025-06-26 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| CN119059973A (zh) * | 2024-08-12 | 2024-12-03 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的合成工艺 |
| CN119059974B (zh) * | 2024-08-12 | 2025-10-28 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的制备方法 |
| CN120504661B (zh) * | 2025-07-14 | 2025-11-07 | 复旦大学 | Alkbh8小分子抑制剂及其制备方法和用途 |
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| US10981858B2 (en) | 2015-12-16 | 2021-04-20 | Priostar Pty Ltd | Dendrimer and formulations thereof |
| UA127863C2 (uk) * | 2015-12-16 | 2024-01-31 | Локсо Онколоджі, Інк. | Сполуки, які можна застосовувати як інгібітори кінази |
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2016
- 2016-12-16 UA UAA202003795A patent/UA127863C2/uk unknown
- 2016-12-16 KR KR1020217003683A patent/KR20210018530A/ko not_active Withdrawn
- 2016-12-16 CA CA3008488A patent/CA3008488C/en active Active
- 2016-12-16 US US16/063,542 patent/US10695323B2/en active Active
- 2016-12-16 CN CN202111022488.4A patent/CN113603645B/zh active Active
- 2016-12-16 MX MX2021003478A patent/MX394193B/es unknown
- 2016-12-16 PE PE2021001592A patent/PE20220502A1/es unknown
- 2016-12-16 NZ NZ743553A patent/NZ743553A/en unknown
- 2016-12-16 CN CN202210310724.0A patent/CN114716381B/zh active Active
- 2016-12-16 MX MX2018007267A patent/MX380907B/es unknown
- 2016-12-16 JP JP2018532035A patent/JP6731483B2/ja active Active
- 2016-12-16 RS RS20201291A patent/RS60982B9/sr unknown
- 2016-12-16 PT PT168163632T patent/PT3390395T/pt unknown
- 2016-12-16 MA MA49809A patent/MA49809A1/fr unknown
- 2016-12-16 MY MYPI2022003989A patent/MY202026A/en unknown
- 2016-12-16 EP EP16816363.2A patent/EP3390395B1/en active Active
- 2016-12-16 MA MA055064A patent/MA55064A/fr unknown
- 2016-12-16 MY MYPI2022003990A patent/MY200590A/en unknown
- 2016-12-16 CN CN201680073031.7A patent/CN108473481B/zh active Active
- 2016-12-16 ES ES16816363T patent/ES2828431T3/es active Active
- 2016-12-16 CN CN202210312064.XA patent/CN114605327B/zh active Active
- 2016-12-16 SI SI201630920T patent/SI3390395T1/sl unknown
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