JP2018538307A5 - - Google Patents
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- JP2018538307A5 JP2018538307A5 JP2018532035A JP2018532035A JP2018538307A5 JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5 JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5
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- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- lymphoma
- fibrosis
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O Chemical compound *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O 0.000 description 13
- ZJBPMQFCMFACQD-UHFFFAOYSA-O CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O Chemical compound CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O ZJBPMQFCMFACQD-UHFFFAOYSA-O 0.000 description 1
- FUZMNSBMAWGICZ-UHFFFAOYSA-N CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F Chemical compound CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F FUZMNSBMAWGICZ-UHFFFAOYSA-N 0.000 description 1
- YXKMZZLFDQINKP-CSKWCJJFSA-N CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O Chemical compound CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O YXKMZZLFDQINKP-CSKWCJJFSA-N 0.000 description 1
- RGSRIRHSVLYJIG-YYOOZPTRSA-N CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O Chemical compound CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O RGSRIRHSVLYJIG-YYOOZPTRSA-N 0.000 description 1
- VPMRBWJJRDQKLC-UHFFFAOYSA-N COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F Chemical compound COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F VPMRBWJJRDQKLC-UHFFFAOYSA-N 0.000 description 1
- BZTXIQSFUSNIMJ-UHFFFAOYSA-N COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O Chemical compound COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O BZTXIQSFUSNIMJ-UHFFFAOYSA-N 0.000 description 1
- COSCVQYQAHCLMI-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O COSCVQYQAHCLMI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522245.8 | 2015-12-16 | ||
| GBGB1522245.8A GB201522245D0 (en) | 2015-12-16 | 2015-12-16 | Compounds useful as kinase inhibitors |
| GB1613945.3 | 2016-08-15 | ||
| GBGB1613945.3A GB201613945D0 (en) | 2016-08-15 | 2016-08-15 | Compounds useful as kinase inhibitors |
| PCT/GB2016/053968 WO2017103611A1 (en) | 2015-12-16 | 2016-12-16 | Compounds useful as kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Division JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538307A JP2018538307A (ja) | 2018-12-27 |
| JP2018538307A5 true JP2018538307A5 (enExample) | 2020-06-18 |
| JP6731483B2 JP6731483B2 (ja) | 2020-07-29 |
Family
ID=57590725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Country Status (38)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN114685516A (zh) | 2015-09-16 | 2022-07-01 | 洛克索肿瘤学股份有限公司 | 用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物 |
| ES2828431T3 (es) | 2015-12-16 | 2021-05-26 | Loxo Oncology Inc | Compuestos útiles como inhibidores de cinasa |
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| EP3774782A2 (en) * | 2018-04-06 | 2021-02-17 | Black Belt TX Ltd | Atf6 inhibitors and uses thereof |
| WO2019220962A1 (ja) * | 2018-05-18 | 2019-11-21 | 富士フイルム株式会社 | ３－ジフルオロメチルピラゾール化合物の製造方法及び３－ジフルオロメチルピラゾール－４－カルボン酸化合物の製造方法、並びに、ピラゾリジン化合物 |
| CA3224985C (en) * | 2018-07-31 | 2025-11-18 | Loxo Oncology, Inc. | SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021053234A1 (en) * | 2019-09-19 | 2021-03-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Compounds and compositions for treating kidney disease |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| JP7142173B2 (ja) * | 2019-12-06 | 2022-09-26 | ロクソ オンコロジー， インコーポレイテッド | ブルトン型チロシンキナーゼ阻害剤の投薬 |
| MX2022008148A (es) | 2020-01-02 | 2022-07-21 | Dizal Jiangsu Pharmaceutical Co Ltd | Inhibidores de btk. |
| EP4118086A1 (en) * | 2020-03-12 | 2023-01-18 | Fochon Biosciences, Ltd. | Compounds useful as kinase inhibitors |
| TWI809489B (zh) * | 2020-09-10 | 2023-07-21 | 美商絡速藥業公司 | 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體 |
| CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| CN116348453B (zh) * | 2021-04-25 | 2025-07-04 | 烨辉医药科技(上海)有限公司 | 杂芳族甲酰胺化合物及其用途 |
| CN117320712A (zh) | 2021-05-14 | 2023-12-29 | 罗索肿瘤学公司 | 布鲁顿酪氨酸激酶抑制剂的共晶型 |
| CA3223769A1 (en) * | 2021-07-01 | 2023-01-05 | Xinglu ZHOU | Bruton's tyrosine kinase and mutant degrader, composition and application thereof |
| WO2023284765A1 (zh) * | 2021-07-16 | 2023-01-19 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑类化合物及包含该化合物的组合物及其用途 |
| KR20240157639A (ko) | 2021-12-14 | 2024-11-01 | 크로스파이어 온콜로지 홀딩 비.브이. | 거대고리 btk 억제제 |
| WO2023143355A1 (en) * | 2022-01-28 | 2023-08-03 | Hansoh Bio Llc | Azacycle amide derivative, preparation methods and medicinal uses thereof |
| EP4474377A4 (en) * | 2022-03-03 | 2025-07-30 | Shenzhen Targetrx Inc | Cycloalkyl or heterocyclyl substituted heteroaryl compound, and composition and use thereof |
| US20250188094A1 (en) * | 2022-03-18 | 2025-06-12 | Insilico Medicine Ip Limited | Pyrazole membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (pkmyt1) inhibitors and uses thereof |
| CN115894376B (zh) * | 2022-12-15 | 2025-05-16 | 南京雷正医药科技有限公司 | 一种芳香族酰胺类化合物、药物组合物及其用途 |
| WO2024176164A1 (en) | 2023-02-22 | 2024-08-29 | Assia Chemical Industries Ltd. | Solid state form of pirtobrutinib |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| KR20250046558A (ko) | 2023-09-27 | 2025-04-03 | 임창섭 | 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템 |
| TW202532067A (zh) * | 2023-12-13 | 2025-08-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有吡唑環及雙環雜芳基的化合物 |
| WO2025137329A1 (en) * | 2023-12-22 | 2025-06-26 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| CN119059974B (zh) * | 2024-08-12 | 2025-10-28 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的制备方法 |
| CN119059973A (zh) * | 2024-08-12 | 2024-12-03 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的合成工艺 |
| CN120504661B (zh) * | 2025-07-14 | 2025-11-07 | 复旦大学 | Alkbh8小分子抑制剂及其制备方法和用途 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| KR20020088406A (ko) | 1999-09-17 | 2002-11-27 | 애보트 게엠베하 운트 콤파니 카게 | 치료제로서의 피라졸로피리미딘 |
| US6291504B1 (en) * | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| US20030225098A1 (en) | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| PL2526933T3 (pl) | 2006-09-22 | 2015-08-31 | Pharmacyclics Llc | Inhibitory kinazy tyrozynowej Brutona |
| MX2009003650A (es) * | 2006-10-06 | 2009-04-22 | Abbott Lab | Nuevos imidazotiazoles e imidazoxazoles. |
| ES2403546T3 (es) | 2006-11-03 | 2013-05-20 | Pharmacyclics, Inc. | Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización |
| SG10201508035TA (en) | 2007-03-28 | 2015-10-29 | Pharmacyclics Inc | Inhibitors of bruton's tyrosine kinase |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| NZ603525A (en) | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| CA2730930C (en) | 2008-07-16 | 2015-01-13 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| PL2324008T3 (pl) * | 2008-07-24 | 2012-09-28 | Nerviano Medical Sciences Srl | 3,4-diarylopirazole jako inhibitory kinazy białkowej |
| US8426428B2 (en) | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
| US7741330B1 (en) | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| NZ772688A (en) | 2010-06-03 | 2022-09-30 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
| WO2012003405A1 (en) * | 2010-06-30 | 2012-01-05 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EA025496B1 (ru) | 2011-05-17 | 2016-12-30 | Принсипиа Биофарма Инк. | Ингибиторы тирозинкиназы |
| HUE048834T2 (hu) | 2011-05-17 | 2020-08-28 | Univ California | Kináz inhibitorok |
| EA201490265A1 (ru) | 2011-07-13 | 2014-12-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| DK2861599T3 (da) | 2012-06-18 | 2020-03-02 | Principia Biopharma Inc | Reversible kovalente pyrrolo- eller pyrazolopyrimidiner, der er nyttige til behandling af cancer og autoimmunsygdomme |
| WO2014022569A1 (en) | 2012-08-03 | 2014-02-06 | Principia Biopharma Inc. | Treatment of dry eye |
| MA37830B1 (fr) * | 2012-08-10 | 2018-09-28 | Boehringer Ingelheim Int | Composés hétéroromatiques en tant qu'inhibiteurs de la tyrosine kinase de bruton (btk) |
| GB201214750D0 (en) * | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| CN105008344B (zh) * | 2012-11-02 | 2017-07-25 | 辉瑞公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
| CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| GB201309085D0 (en) | 2013-05-20 | 2013-07-03 | Redx Pharma Ltd | Compounds |
| RS60934B1 (sr) * | 2013-09-30 | 2020-11-30 | Guangzhou Innocare Pharma Tech Co Ltd | Supstituisani nikotinimidni inhibitori btk i njihova priprema i upotreba u lečenju karcinoma, inflamatorne i autoimune bolesti |
| WO2015075051A1 (en) * | 2013-11-19 | 2015-05-28 | Universitaet Des Saarlandes | Allosteric inhibitors of atypical protein kinases c |
| EP3082809B1 (en) | 2013-12-20 | 2021-01-20 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| EP4681737A3 (en) | 2014-02-21 | 2026-03-11 | Principia Biopharma Inc. | Salts and solid form of a btk inhibitor |
| GB201404987D0 (en) | 2014-03-20 | 2014-05-07 | Redx Pharma Ltd | Compounds |
| CN105085474B (zh) * | 2014-05-07 | 2018-05-18 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| GB201410430D0 (en) * | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| AU2016212230B2 (en) | 2015-01-28 | 2019-09-19 | Bayer Pharma Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| GB2548542A (en) * | 2015-06-16 | 2017-09-27 | Redx Pharma Plc | Compounds |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN114685516A (zh) | 2015-09-16 | 2022-07-01 | 洛克索肿瘤学股份有限公司 | 用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物 |
| CA3008648C (en) | 2015-12-16 | 2023-01-10 | Priostar Pty Ltd | Dendrimer and formulations thereof |
| US10737302B2 (en) | 2015-12-16 | 2020-08-11 | Ecolab Usa Inc. | Peroxyformic acid compositions for membrane filtration cleaning |
| ES2828431T3 (es) | 2015-12-16 | 2021-05-26 | Loxo Oncology Inc | Compuestos útiles como inhibidores de cinasa |
| ES2854733T3 (es) | 2015-12-16 | 2021-09-22 | Bristol Myers Squibb Co | Heteroarilhidroxipirimidinonas como agonistas del receptor APJ |
| PE20181074A1 (es) | 2015-12-16 | 2018-07-04 | Boehringer Ingelheim Int | Compuestos heteroaromaticos como inhibidores de btk |
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2016
- 2016-12-16 ES ES16816363T patent/ES2828431T3/es active Active
- 2016-12-16 EP EP16816363.2A patent/EP3390395B1/en active Active
- 2016-12-16 IL IL285976A patent/IL285976B2/en unknown
- 2016-12-16 CN CN202210311970.8A patent/CN114573510B/zh active Active
- 2016-12-16 SG SG11201805044WA patent/SG11201805044WA/en unknown
- 2016-12-16 HR HRP20201835TT patent/HRP20201835T1/hr unknown
- 2016-12-16 WO PCT/GB2016/053968 patent/WO2017103611A1/en not_active Ceased
- 2016-12-16 CN CN202210310724.0A patent/CN114716381B/zh active Active
- 2016-12-16 CO CONC2018/0006164A patent/CO2018006164A2/es unknown
- 2016-12-16 PE PE2021001592A patent/PE20220502A1/es unknown
- 2016-12-16 UA UAA201807294A patent/UA122258C2/uk unknown
- 2016-12-16 MX MX2021003478A patent/MX394193B/es unknown
- 2016-12-16 PE PE2018001143A patent/PE20181449A1/es unknown
- 2016-12-16 US US16/063,542 patent/US10695323B2/en active Active
- 2016-12-16 PE PE2021001581A patent/PE20220507A1/es unknown
- 2016-12-16 TN TNP/2018/000213A patent/TN2018000213A1/en unknown
- 2016-12-16 NZ NZ743553A patent/NZ743553A/en unknown
- 2016-12-16 SI SI201630920T patent/SI3390395T1/sl unknown
- 2016-12-16 KR KR1020217003683A patent/KR20210018530A/ko not_active Withdrawn
- 2016-12-16 MY MYPI2022003989A patent/MY202026A/en unknown
- 2016-12-16 CN CN202111022488.4A patent/CN113603645B/zh active Active
- 2016-12-16 ES ES20194724T patent/ES3041897T3/es active Active
- 2016-12-16 CN CN202210311995.8A patent/CN114634447B/zh active Active
- 2016-12-16 UA UAA202003795A patent/UA127863C2/uk unknown
- 2016-12-16 CN CN202210312064.XA patent/CN114605327B/zh active Active
- 2016-12-16 HU HUE16816363A patent/HUE051921T2/hu unknown
- 2016-12-16 MA MA49809A patent/MA49809A1/fr unknown
- 2016-12-16 MD MDE20181001T patent/MD3390395T2/ro unknown
- 2016-12-16 RS RS20201291A patent/RS60982B9/sr unknown
- 2016-12-16 JP JP2018532035A patent/JP6731483B2/ja active Active
- 2016-12-16 EP EP20194724.9A patent/EP3782994B1/en active Active
- 2016-12-16 MA MA055064A patent/MA55064A/fr unknown
- 2016-12-16 SG SG10202012498TA patent/SG10202012498TA/en unknown
- 2016-12-16 CN CN202210312076.2A patent/CN114621146A/zh active Pending
- 2016-12-16 CN CN202210312050.8A patent/CN114591242B/zh active Active
- 2016-12-16 CR CR20180367A patent/CR20180367A/es unknown
- 2016-12-16 AU AU2016373530A patent/AU2016373530B2/en active Active
- 2016-12-16 DK DK16816363.2T patent/DK3390395T3/da active
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