JP2018536684A5

JP2018536684A5 -

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Publication number: JP2018536684A5
Authority: JP; Japan
Prior art keywords: oxo; thia; dihydro; carboxamide; triazaacenaphthylene
Prior art date: 2016-12-09
Legal status : Granted

Application number

JP2018529982A

Other languages

English (en)

Japanese (ja)

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JP7110097B2 (ja

JP2018536684A (ja

Filing date

2016-12-09

Publication date

2020-03-12

2016-12-09 Application filed filed Critical

2016-12-09 Priority claimed from PCT/US2016/065964 external-priority patent/WO2017100668A1/en

2018-12-13 Publication of JP2018536684A publication Critical patent/JP2018536684A/ja

2020-03-12 Publication of JP2018536684A5 publication Critical patent/JP2018536684A5/ja

2022-07-20 Priority to JP2022115945A priority Critical patent/JP7471348B2/ja

2022-08-01 Application granted granted Critical

2022-08-01 Publication of JP7110097B2 publication Critical patent/JP7110097B2/ja

Status Active legal-status Critical Current

2036-12-09 Anticipated expiration legal-status Critical

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-1 dioxino [2 , 3-c] pyrrole -6 (3H) - yl Chemical group 0.000 claims 341
125000000217 alkyl group Chemical group 0.000 claims 55
125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims 42
150000001875 compounds Chemical class 0.000 claims 25
150000003839 salts Chemical class 0.000 claims 22
150000001204 N-oxides Chemical class 0.000 claims 21
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 21
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 10
229910052736 halogen Inorganic materials 0.000 claims 10
150000002367 halogens Chemical class 0.000 claims 10
125000000753 cycloalkyl group Chemical group 0.000 claims 8
125000004076 pyridyl group Chemical group 0.000 claims 7
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 5
DPBWFNDFMCCGGJ-UHFFFAOYSA-N 4-Piperidine carboxamide Chemical compound NC(=O)C1CCNCC1 DPBWFNDFMCCGGJ-UHFFFAOYSA-N 0.000 claims 5
VSYMOLNSFRPNMF-FVDXLRKESA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O VSYMOLNSFRPNMF-FVDXLRKESA-N 0.000 claims 5
101150065749 Churc1 gene Proteins 0.000 claims 5
102100038239 Protein Churchill Human genes 0.000 claims 5
125000001188 haloalkyl group Chemical group 0.000 claims 5
BVOCPVIXARZNQN-UHFFFAOYSA-N nipecotamide Chemical compound NC(=O)C1CCCNC1 BVOCPVIXARZNQN-UHFFFAOYSA-N 0.000 claims 5
125000001424 substituent group Chemical group 0.000 claims 5
ABJZZILCARPEEU-MIOXTJDRSA-N 7-(4-methyl-2-phenoxypyrimidin-5-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=NC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)OC6=CC=CC=C6 ABJZZILCARPEEU-MIOXTJDRSA-N 0.000 claims 4
HUPMANCWIPVQAI-IGCSIZKESA-N 7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)OC6=CC=CC=C6 HUPMANCWIPVQAI-IGCSIZKESA-N 0.000 claims 4
MTLQNRLRIDAODA-UHFFFAOYSA-N C1NC2=C3C(=C(SC3=NC=C2)C(=O)N)N1C4=CC=CC=C4 Chemical compound C1NC2=C3C(=C(SC3=NC=C2)C(=O)N)N1C4=CC=CC=C4 MTLQNRLRIDAODA-UHFFFAOYSA-N 0.000 claims 4
125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims 4
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 3
MVPHLNMXUDUNLZ-KEJOTCJRSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3S)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C(=O)C=C)NC3=O MVPHLNMXUDUNLZ-KEJOTCJRSA-N 0.000 claims 3
OJZXEFYASCMPEK-KAXXRHABSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3S)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCNC6)NC3=O OJZXEFYASCMPEK-KAXXRHABSA-N 0.000 claims 3
ZLJNLITXGGOSBU-KAXXRHABSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3S)-oxan-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCOC6)NC3=O ZLJNLITXGGOSBU-KAXXRHABSA-N 0.000 claims 3
ALEJVIBAMSTPHC-KBZWIDLWSA-N 7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=N2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O ALEJVIBAMSTPHC-KBZWIDLWSA-N 0.000 claims 3
MLGZKPNEYJGSAI-KBZWIDLWSA-N 7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O MLGZKPNEYJGSAI-KBZWIDLWSA-N 0.000 claims 3
IQCQORMDRTVJCU-MIOXTJDRSA-N 7-(2-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O IQCQORMDRTVJCU-MIOXTJDRSA-N 0.000 claims 3
VJUXFFWFBUOTQI-JFLZXDOOSA-N 7-(6-cyclobutyloxy-2-methylpyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2CCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O VJUXFFWFBUOTQI-JFLZXDOOSA-N 0.000 claims 3
FPLUOFGISQZDHL-UQHTVBEOSA-N 7-[2-methyl-4-(oxan-4-yloxy)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCOCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O FPLUOFGISQZDHL-UQHTVBEOSA-N 0.000 claims 3
DFDQUTGHGLZTFA-BHVRQQHWSA-N 7-[2-methyl-4-(trifluoromethoxy)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC(F)(F)F)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O DFDQUTGHGLZTFA-BHVRQQHWSA-N 0.000 claims 3
PIKBBTMRAHAJOT-WOBNGOBWSA-N 7-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)CC(C)C PIKBBTMRAHAJOT-WOBNGOBWSA-N 0.000 claims 3
SUISELPNFYUBIE-WPNUWBHDSA-N N-[(3R)-1-(3-hydroxypropanoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CCO)NC3=O SUISELPNFYUBIE-WPNUWBHDSA-N 0.000 claims 3
YBENJRMEFBXSOI-FSQAKVKISA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O YBENJRMEFBXSOI-FSQAKVKISA-N 0.000 claims 3
VUHSZFVOIZPYHA-OJLSWQFYSA-N N-[(3R)-1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O VUHSZFVOIZPYHA-OJLSWQFYSA-N 0.000 claims 3
XFDKITDAEIHCOE-ADJXXYICSA-N N-[(3R)-1-[(E)-2-cyano-4-methyl-4-morpholin-4-ylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C(C)(C)N7CCOCC7)/C#N)NC3=O XFDKITDAEIHCOE-ADJXXYICSA-N 0.000 claims 3
BYFIMGSWTFIROJ-LOIMDLHYSA-N N-[(3R)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CN(C)C)NC3=O BYFIMGSWTFIROJ-LOIMDLHYSA-N 0.000 claims 3
SZXYGKQOGKRMNI-GPMJBZJGSA-N N-[(3S,4R)-4-hydroxy-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@H]6O)C(=O)C=C)NC3=O SZXYGKQOGKRMNI-GPMJBZJGSA-N 0.000 claims 3
229960002685 biotin Drugs 0.000 claims 3
239000011616 biotin Substances 0.000 claims 3
125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
125000003566 oxetanyl group Chemical group 0.000 claims 3
RCCYSVYHULFYHE-UHFFFAOYSA-N pentanediamide Chemical compound NC(=O)CCCC(N)=O RCCYSVYHULFYHE-UHFFFAOYSA-N 0.000 claims 3
239000008194 pharmaceutical composition Substances 0.000 claims 3
125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 3
125000002098 pyridazinyl group Chemical group 0.000 claims 3
125000000714 pyrimidinyl group Chemical group 0.000 claims 3
125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
125000004486 1-methylpiperidin-3-yl group Chemical group CN1CC(CCC1)* 0.000 claims 2
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
BHRYQIIGHLBZMR-UALGTNEHSA-N 6-oxo-7-(5-phenoxypyrimidin-2-yl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=C(C=N5)OC6=CC=CC=C6 BHRYQIIGHLBZMR-UALGTNEHSA-N 0.000 claims 2
BUBFXKFGJPRTGL-JFLZXDOOSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(4-pyridazin-3-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=NN=CC=C6 BUBFXKFGJPRTGL-JFLZXDOOSA-N 0.000 claims 2
GMZXLNIVIVDDMM-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(1-prop-2-enoylazetidin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(C6)C(=O)C=C)NC3=O GMZXLNIVIVDDMM-UHFFFAOYSA-N 0.000 claims 2
MVPHLNMXUDUNLZ-WPNUWBHDSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O MVPHLNMXUDUNLZ-WPNUWBHDSA-N 0.000 claims 2
XAQYTTUZADGHGV-UQHTVBEOSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O XAQYTTUZADGHGV-UQHTVBEOSA-N 0.000 claims 2
WJFUHNUVPIMVMX-WPNUWBHDSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-ynoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C#C)NC3=O WJFUHNUVPIMVMX-WPNUWBHDSA-N 0.000 claims 2
VJLIQPZUVBVJGC-UTKYEJCASA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-propan-2-ylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(C)C)NC3=O VJLIQPZUVBVJGC-UTKYEJCASA-N 0.000 claims 2
MLDLGHRVVDIKRK-IUKJWVDASA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-propan-2-ylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(C)C)NC3=O MLDLGHRVVDIKRK-IUKJWVDASA-N 0.000 claims 2
KEDMQUPBQSUUMI-UQHTVBEOSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-propanoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C KEDMQUPBQSUUMI-UQHTVBEOSA-N 0.000 claims 2
HHHFSTJNEGZDEX-WKBUCKLXSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3R)-1-methylpyrrolidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C)NC3=O HHHFSTJNEGZDEX-WKBUCKLXSA-N 0.000 claims 2
ZLJNLITXGGOSBU-WKBUCKLXSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3R)-oxan-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCOC6)NC3=O ZLJNLITXGGOSBU-WKBUCKLXSA-N 0.000 claims 2
VSYMOLNSFRPNMF-FKQXYHHHSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C)NC3=O VSYMOLNSFRPNMF-FKQXYHHHSA-N 0.000 claims 2
JCUOXQPCXUGRRD-COBYXZRWSA-N 7-(2-methyl-4-pyridazin-3-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=NN=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O JCUOXQPCXUGRRD-COBYXZRWSA-N 0.000 claims 2
DENDUOQVAGXTRA-MOWZZLTPSA-N 7-(4-cyclobutyloxy-2-methylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O DENDUOQVAGXTRA-MOWZZLTPSA-N 0.000 claims 2
BXCRCFYFWWZZBI-OFRGXYRZSA-N 7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)OC6=CC=CC=C6 BXCRCFYFWWZZBI-OFRGXYRZSA-N 0.000 claims 2
JGTRKKBESXIOGE-LHDJTJFYSA-N 7-(4-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)OC(C)C JGTRKKBESXIOGE-LHDJTJFYSA-N 0.000 claims 2
WJMUVRRDVOVKDV-RQFMUYMZSA-N 7-(4-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)OC(C)C WJMUVRRDVOVKDV-RQFMUYMZSA-N 0.000 claims 2
TUJMUOSZOJCOFB-WIQGMUCESA-N 7-[2-methyl-6-(2-methylpropyl)pyridin-3-yl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)CC(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O TUJMUOSZOJCOFB-WIQGMUCESA-N 0.000 claims 2
PYRBDBLHSYDBEI-VXQQYTINSA-N 7-[4-methyl-6-(2-methylpropoxy)pyridin-3-yl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)OCC(C)C PYRBDBLHSYDBEI-VXQQYTINSA-N 0.000 claims 2
CFMFJLIRRZPODO-MIOXTJDRSA-N 7-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)CC(C)C CFMFJLIRRZPODO-MIOXTJDRSA-N 0.000 claims 2
SILKFHPRXISXIV-WPNUWBHDSA-N N-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)COC)NC3=O SILKFHPRXISXIV-WPNUWBHDSA-N 0.000 claims 2
TYGRCPYIXJZMOT-JUORFJGESA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-5-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=C(C=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O TYGRCPYIXJZMOT-JUORFJGESA-N 0.000 claims 2
AXGQLALUCUCBED-ZWTOEKIXSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(4-methoxy-2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O AXGQLALUCUCBED-ZWTOEKIXSA-N 0.000 claims 2
FJXSWHKYNPWYTN-SHOOHHAZSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O FJXSWHKYNPWYTN-SHOOHHAZSA-N 0.000 claims 2
WQBVXVSLJIZWJW-JCVYNRTPSA-N N-[(3R)-1-[(E)-4-aminobut-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C=C/CN)NC3=O WQBVXVSLJIZWJW-JCVYNRTPSA-N 0.000 claims 2
NQAAFDKFVSZGBQ-COPDTSMESA-N N-[(3R)-1-[(E)-4-aminobut-2-enoyl]pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)/C=C/CN)NC3=O NQAAFDKFVSZGBQ-COPDTSMESA-N 0.000 claims 2
BTYXWSOVGKLEAC-COPDTSMESA-N N-[(3R)-1-[(E)-4-hydroxybut-2-enoyl]pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)/C=C/CO)NC3=O BTYXWSOVGKLEAC-COPDTSMESA-N 0.000 claims 2
FUTYOYQAGVGBPD-PZWLUNLRSA-N N-[(3R)-1-[(E)-but-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C/C=C/C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C FUTYOYQAGVGBPD-PZWLUNLRSA-N 0.000 claims 2
KMGXZSMTORQEJO-YUHYLSLJSA-N N-[(3R,5R)-5-fluoro-1-prop-2-enoylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CN(C6)C(=O)C=C)F)NC3=O KMGXZSMTORQEJO-YUHYLSLJSA-N 0.000 claims 2
DNYZWMUIQOLXHG-YUHYLSLJSA-N N-[(3R,5R)-5-hydroxy-1-prop-2-enoylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CN(C6)C(=O)C=C)O)NC3=O DNYZWMUIQOLXHG-YUHYLSLJSA-N 0.000 claims 2
TZZYGAFLHVSMJE-SHKJMWFZSA-N N-[(3R,5S)-5-methoxy-1-prop-2-enoylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CN(C6)C(=O)C=C)OC)NC3=O TZZYGAFLHVSMJE-SHKJMWFZSA-N 0.000 claims 2
RURPAKNCGYKBTL-KEJOTCJRSA-N N-[(3S)-1-(2-cyanoacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C(=O)CC#N)NC3=O RURPAKNCGYKBTL-KEJOTCJRSA-N 0.000 claims 2
MVOBPFSMWSMGOH-AXXCRCRGSA-N N-[(6R)-1,6-dimethylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C[C@@H]1CCC(CN1C)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C MVOBPFSMWSMGOH-AXXCRCRGSA-N 0.000 claims 2
KQWPHVZRIDCOBL-RRJTYLBCSA-N N-methyl-7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N(C)[C@@H]6CCN(C6)C(=O)C=C)NC3=O KQWPHVZRIDCOBL-RRJTYLBCSA-N 0.000 claims 2
125000003342 alkenyl group Chemical group 0.000 claims 2
125000000304 alkynyl group Chemical group 0.000 claims 2
125000002393 azetidinyl group Chemical group 0.000 claims 2
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 2
125000001624 naphthyl group Chemical group 0.000 claims 2
125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 2
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
239000000546 pharmaceutical excipient Substances 0.000 claims 2
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 2
125000003386 piperidinyl group Chemical group 0.000 claims 2
IQHXABCGSFAKPN-UHFFFAOYSA-N pyrrolidine-3-carboxamide Chemical compound NC(=O)C1CCNC1 IQHXABCGSFAKPN-UHFFFAOYSA-N 0.000 claims 2
125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
125000001544 thienyl group Chemical group 0.000 claims 2
125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
IZDFIEYISHNTFP-PTGBLXJZSA-N 1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]-N-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-en-3-yl]piperidine-4-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)NC(=O)C6CCN(CC6)C(=O)/C(=C/C7CC7)/C#N)NC3=O IZDFIEYISHNTFP-PTGBLXJZSA-N 0.000 claims 1
HNOJNMZAQCTCPO-PTGBLXJZSA-N 1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]-N-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-en-3-yl]piperidine-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)NC(=O)C6CCCN(C6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O HNOJNMZAQCTCPO-PTGBLXJZSA-N 0.000 claims 1
CPHXLFKIUVVIOQ-UHFFFAOYSA-N 2-(trifluoromethoxy)benzaldehyde Chemical group FC(F)(F)OC1=CC=CC=C1C=O CPHXLFKIUVVIOQ-UHFFFAOYSA-N 0.000 claims 1
SALVORIQVUEQKF-UHFFFAOYSA-N 2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,5,8(12),9-pentaene-3-carboxamide Chemical compound S1C(=C2NC=NC3=CC=NC1=C23)C(=O)N SALVORIQVUEQKF-UHFFFAOYSA-N 0.000 claims 1
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
FGSAOLLJLDHZJT-UHFFFAOYSA-N 5-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O(C1=CC=CC=C1)C1=CC=C(C=C1)N1C2=C(SC=3N=CC=C(NC1)C=32)C(=O)N FGSAOLLJLDHZJT-UHFFFAOYSA-N 0.000 claims 1
IONLVYLQGJCJJA-UALGTNEHSA-N 6-oxo-7-(2-phenoxypyrimidin-5-yl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=C(N=C5)OC6=CC=CC=C6 IONLVYLQGJCJJA-UALGTNEHSA-N 0.000 claims 1
YRLXFKKUOJTIJA-QLDSGSDYSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=NC=C5)C6=CC=CC=C6 YRLXFKKUOJTIJA-QLDSGSDYSA-N 0.000 claims 1
XCWQVFKGJQLFOJ-JLGTUDDPSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=NC=C5)C6=CC=CC=C6 XCWQVFKGJQLFOJ-JLGTUDDPSA-N 0.000 claims 1
ATAOWUKBUWDMLL-UQHTVBEOSA-N 6-oxo-7-(3-phenoxyphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC=C5)OC6=CC=CC=C6 ATAOWUKBUWDMLL-UQHTVBEOSA-N 0.000 claims 1
GMHHVXSOAOPDON-AECCHWAESA-N 6-oxo-7-(3-phenoxyphenyl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC=C5)OC6=CC=CC=C6 GMHHVXSOAOPDON-AECCHWAESA-N 0.000 claims 1
HKDFRRJEGLFJKI-HXUWFJFHSA-N 6-oxo-7-(3-phenylphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CCC1)C(C=C)=O)=O)C1=CC=CC=C1 HKDFRRJEGLFJKI-HXUWFJFHSA-N 0.000 claims 1
QXYNUDJMTHUBTH-GOSISDBHSA-N 6-oxo-7-(3-phenylphenyl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CNCCC1)=O)C1=CC=CC=C1 QXYNUDJMTHUBTH-GOSISDBHSA-N 0.000 claims 1
RSYKKRRVNWCATC-QGZVFWFLSA-N 6-oxo-7-(3-phenylphenyl)-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CNCC1)=O)C1=CC=CC=C1 RSYKKRRVNWCATC-QGZVFWFLSA-N 0.000 claims 1
HNBNWBPNFOTYDD-UALGTNEHSA-N 6-oxo-7-(3-propan-2-yloxyphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)OC1=CC=CC(=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O HNBNWBPNFOTYDD-UALGTNEHSA-N 0.000 claims 1
SKJMOWRWVPGHCQ-JHCJGPRDSA-N 6-oxo-7-(3-propan-2-ylphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)C1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O SKJMOWRWVPGHCQ-JHCJGPRDSA-N 0.000 claims 1
UYYFKEHLGWCINW-JAWMWQJPSA-N 6-oxo-7-(3-propan-2-ylphenyl)-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)C1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O UYYFKEHLGWCINW-JAWMWQJPSA-N 0.000 claims 1
YWDXJNOHTHTTPA-UHFFFAOYSA-N 6-oxo-7-(4-phenoxyphenyl)-N-(pyrrolidin-3-ylmethyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNCC1CNC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 YWDXJNOHTHTTPA-UHFFFAOYSA-N 0.000 claims 1
BKCDIVSYWHDQMY-UQHTVBEOSA-N 6-oxo-7-(4-phenoxyphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 BKCDIVSYWHDQMY-UQHTVBEOSA-N 0.000 claims 1
MOXXNGDPSKJZHP-MOWZZLTPSA-N 6-oxo-7-(4-phenoxyphenyl)-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 MOXXNGDPSKJZHP-MOWZZLTPSA-N 0.000 claims 1
PFJUVWWGSZMWBK-AECCHWAESA-N 6-oxo-7-(4-phenoxyphenyl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 PFJUVWWGSZMWBK-AECCHWAESA-N 0.000 claims 1
RPSSTTUTEMQTPD-RAUYMOBSSA-N 6-oxo-7-(4-phenoxyphenyl)-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 RPSSTTUTEMQTPD-RAUYMOBSSA-N 0.000 claims 1
WUCKMTZUSNOPJL-HNNXBMFYSA-N 6-oxo-7-(4-phenoxyphenyl)-N-[(3S)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O=C1NC2=C(SC=3N=CC=C(N1C1=CC=C(C=C1)OC1=CC=CC=C1)C=32)C(=O)N[C@@H]1CNCC1 WUCKMTZUSNOPJL-HNNXBMFYSA-N 0.000 claims 1
QQNRHRVEBCDRDS-UHFFFAOYSA-N 6-oxo-7-(4-phenoxyphenyl)-N-piperidin-4-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNCCC1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 QQNRHRVEBCDRDS-UHFFFAOYSA-N 0.000 claims 1
VFZXPJGFNAHTMD-HXUWFJFHSA-N 6-oxo-7-(4-phenylphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC=C(C=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CCC1)C(C=C)=O)=O)C1=CC=CC=C1 VFZXPJGFNAHTMD-HXUWFJFHSA-N 0.000 claims 1
UTYOTDIAZJNZSY-HVLGOGJMSA-N 6-oxo-7-(4-phenylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=CC(=C5)C6=CC=CC=C6 UTYOTDIAZJNZSY-HVLGOGJMSA-N 0.000 claims 1
YLMAGOKXVCQILQ-UALGTNEHSA-N 6-oxo-7-(4-propan-2-yloxyphenyl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)OC1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O YLMAGOKXVCQILQ-UALGTNEHSA-N 0.000 claims 1
IVQDMELVHVVVDI-UHFFFAOYSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cn4)c(=O)[nH]c1c23 IVQDMELVHVVVDI-UHFFFAOYSA-N 0.000 claims 1
RZYOMYCJGBOGKI-WTBVOWCJSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=C(C=C5)OC6=CC=CC=C6 RZYOMYCJGBOGKI-WTBVOWCJSA-N 0.000 claims 1
ILKNYDBNHGCMTA-WTBVOWCJSA-N 6-oxo-7-(5-phenoxypyrimidin-2-yl)-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=C(C=N5)OC6=CC=CC=C6 ILKNYDBNHGCMTA-WTBVOWCJSA-N 0.000 claims 1
BDUWSPKAKAUFCC-UHFFFAOYSA-N 6-oxo-7-(5-phenoxypyrimidin-2-yl)-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CC(CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=C(C=N5)OC6=CC=CC=C6 BDUWSPKAKAUFCC-UHFFFAOYSA-N 0.000 claims 1
DOAWLOIWFRMARW-OAQFAYNTSA-N 6-oxo-7-(5-phenylpyridazin-3-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NN=CC(=C5)C6=CC=CC=C6 DOAWLOIWFRMARW-OAQFAYNTSA-N 0.000 claims 1
UORMIQDJEWWWSC-MQKVROSBSA-N 6-oxo-7-(5-phenylpyridin-3-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=CC(=C5)C6=CC=CC=C6 UORMIQDJEWWWSC-MQKVROSBSA-N 0.000 claims 1
NXHHOGQYSYDPKC-MXRZHXBVSA-N 6-oxo-7-(6-phenoxypyridazin-3-yl)-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NN=C(C=C5)OC6=CC=CC=C6 NXHHOGQYSYDPKC-MXRZHXBVSA-N 0.000 claims 1
RWVLJYXENWSDRS-WTBVOWCJSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=C(C=C5)OC6=CC=CC=C6 RWVLJYXENWSDRS-WTBVOWCJSA-N 0.000 claims 1
KDTBPTXJYINPJX-BHVRQQHWSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=C(C=C5)OC6=CC=CC=C6 KDTBPTXJYINPJX-BHVRQQHWSA-N 0.000 claims 1
GRYUVQJFLGNJQA-JLGTUDDPSA-N 6-oxo-7-(6-phenylpyridazin-4-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=NN=C5)C6=CC=CC=C6 GRYUVQJFLGNJQA-JLGTUDDPSA-N 0.000 claims 1
XXAFOKOJOZSVAO-JAWMWQJPSA-N 6-oxo-7-(6-phenylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=N5)C6=CC=CC=C6 XXAFOKOJOZSVAO-JAWMWQJPSA-N 0.000 claims 1
ZITQUFGVOGAZSH-UHFFFAOYSA-N 6-oxo-7-(6-phenylpyrimidin-4-yl)-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CC(CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=NC(=C5)C6=CC=CC=C6 ZITQUFGVOGAZSH-UHFFFAOYSA-N 0.000 claims 1
XDOCQDVOPYXBEW-NDPCOACTSA-N 6-oxo-7-[(4-phenoxyphenyl)methyl]-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)CC5=CC=C(C=C5)OC6=CC=CC=C6 XDOCQDVOPYXBEW-NDPCOACTSA-N 0.000 claims 1
VXFPXDQMXJZXGQ-SDUVICNCSA-N 6-oxo-7-[4-phenoxy-2-(trifluoromethyl)phenyl]-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C(F)(F)F VXFPXDQMXJZXGQ-SDUVICNCSA-N 0.000 claims 1
MSUSJTZUEPUKDH-WIDRCTMOSA-N 6-oxo-7-[4-phenoxy-2-(trifluoromethyl)phenyl]-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C(F)(F)F MSUSJTZUEPUKDH-WIDRCTMOSA-N 0.000 claims 1
AVHSRAXVOOQEAP-QOCVKUSBSA-N 6-oxo-7-phenyl-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC=C5 AVHSRAXVOOQEAP-QOCVKUSBSA-N 0.000 claims 1
RXLDTUUACDYCSQ-ULTCOSGZSA-N 6-oxo-7-phenyl-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC=C5 RXLDTUUACDYCSQ-ULTCOSGZSA-N 0.000 claims 1
YRUDQPMVPJSSDJ-CCNPBTCESA-N 6-oxo-7-propan-2-yl-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)N1C2CCNC3C2C(=C(S3)C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)NC1=O YRUDQPMVPJSSDJ-CCNPBTCESA-N 0.000 claims 1
AJSHJVKIWXXAJN-UHFFFAOYSA-N 6-oxo-N-(2-oxopiperidin-3-yl)-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CC(C(=O)NC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 AJSHJVKIWXXAJN-UHFFFAOYSA-N 0.000 claims 1
PSJPHHLFCGTKCI-UHFFFAOYSA-N 6-oxo-N-(2-oxopyrrolidin-3-yl)-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O=C1NC2=C(SC=3N=CC=C(N1C1=CC=C(C=C1)OC1=CC=CC=C1)C=32)C(=O)NC1C(NCC1)=O PSJPHHLFCGTKCI-UHFFFAOYSA-N 0.000 claims 1
PIFQWRQXLIGMRS-UHFFFAOYSA-N 6-oxo-N-(6-oxopiperidin-3-yl)-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CC(=O)NCC1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 PIFQWRQXLIGMRS-UHFFFAOYSA-N 0.000 claims 1
UMUBBNGQWATINQ-JHCJGPRDSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(3-propylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCCC1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O UMUBBNGQWATINQ-JHCJGPRDSA-N 0.000 claims 1
OSSGOJFFQNRBHF-SWAMOUOESA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(3-pyridin-2-ylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)C6=CC=CC=N6 OSSGOJFFQNRBHF-SWAMOUOESA-N 0.000 claims 1
DEEUNELXFZZVPI-WJAIMDLRSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(3-pyridin-3-ylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)C6=CN=CC=C6 DEEUNELXFZZVPI-WJAIMDLRSA-N 0.000 claims 1
VOGHKBVNEHCUQA-WJAIMDLRSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(3-pyridin-4-ylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)C6=CC=NC=C6 VOGHKBVNEHCUQA-WJAIMDLRSA-N 0.000 claims 1
ANPLCZXPBBYITJ-COBYXZRWSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(4-pyridin-2-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=N6 ANPLCZXPBBYITJ-COBYXZRWSA-N 0.000 claims 1
RKCAEFQDZHDOPZ-MOWZZLTPSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-(4-pyridin-3-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CN=CC=C6 RKCAEFQDZHDOPZ-MOWZZLTPSA-N 0.000 claims 1
INLNSNOZWNJYMT-GOSISDBHSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-7-[3-[2-(trifluoromethyl)phenyl]phenyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=C(C=CC=C1)C(F)(F)F INLNSNOZWNJYMT-GOSISDBHSA-N 0.000 claims 1
DDCCWZJJPPGQPB-CGEGXVMMSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-7-(4-pyridazin-3-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=NN=CC=C6 DDCCWZJJPPGQPB-CGEGXVMMSA-N 0.000 claims 1
MQTSHCQNXZFTFL-JFLZXDOOSA-N 6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-7-(4-pyridin-2-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=N6 MQTSHCQNXZFTFL-JFLZXDOOSA-N 0.000 claims 1
UXCQXAOSWHTVTJ-UALGTNEHSA-N 6-oxo-N-[(3R)-1-propanoylpiperidin-3-yl]-7-(4-propan-2-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC(C)C UXCQXAOSWHTVTJ-UALGTNEHSA-N 0.000 claims 1
BBPUOJHHUPXODX-QSVYXZOGSA-N 6-oxo-N-[(3R)-piperidin-3-yl]-7-(2-propan-2-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)C1=NC=CC(=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O BBPUOJHHUPXODX-QSVYXZOGSA-N 0.000 claims 1
PVZNUXKPKCQJDL-DCWGHEPTSA-N 6-oxo-N-[(3R)-piperidin-3-yl]-7-(3-propan-2-ylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)C1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O PVZNUXKPKCQJDL-DCWGHEPTSA-N 0.000 claims 1
XFYWUYVEVLRUBI-RVJVUUFRSA-N 7-(1-benzothiophen-2-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC6=CC=CC=C6S5 XFYWUYVEVLRUBI-RVJVUUFRSA-N 0.000 claims 1
SWCODJWLQYBAGJ-UTSMHQLYSA-N 7-(1-benzothiophen-5-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC6=C(C=C5)SC=C6 SWCODJWLQYBAGJ-UTSMHQLYSA-N 0.000 claims 1
DUFDVFNWWZYEBI-ULTCOSGZSA-N 7-(1-benzothiophen-5-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC6=C(C=C5)SC=C6 DUFDVFNWWZYEBI-ULTCOSGZSA-N 0.000 claims 1
APMVBMPZDMZTIG-PMOLBHAXSA-N 7-(2,2-difluoro-1,3-benzodioxol-5-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC6=C(C=C5)OC(O6)(F)F APMVBMPZDMZTIG-PMOLBHAXSA-N 0.000 claims 1
LCMQDDBWYGVXOC-OMUMBSOFSA-N 7-(2,2-difluoro-1,3-benzodioxol-5-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC6=C(C=C5)OC(O6)(F)F LCMQDDBWYGVXOC-OMUMBSOFSA-N 0.000 claims 1
WUXDJHWFNBBSDO-PNHHPKMASA-N 7-(2,3-dimethyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1C)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O WUXDJHWFNBBSDO-PNHHPKMASA-N 0.000 claims 1
IXEUKAZSGGWTMG-GOSISDBHSA-N 7-(2,3-dimethyl-4-phenoxyphenyl)-N-[(3R)-1-methylpyrrolidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1C)OC2=CC=CC=C2)N3C4=C5C(=C(SC5=NC=C4)C(=O)N[C@@H]6CCN(C6)C)NC3=O IXEUKAZSGGWTMG-GOSISDBHSA-N 0.000 claims 1
XZIFYOBTRBQKKC-JAWMWQJPSA-N 7-(2,4-dimethylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)C XZIFYOBTRBQKKC-JAWMWQJPSA-N 0.000 claims 1
LAHCCTSAXZWURE-AZBLRWBRSA-N 7-(2,4-dimethylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)C LAHCCTSAXZWURE-AZBLRWBRSA-N 0.000 claims 1
IJCDLHDFCDQKTN-JDTIAOCQSA-N 7-(2,6-difluoro-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5F)OC6=CC=CC=C6)F IJCDLHDFCDQKTN-JDTIAOCQSA-N 0.000 claims 1
VBHUSWXYSKIRJE-FLFNDINXSA-N 7-(2,6-difluoro-4-phenoxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5F)OC6=CC=CC=C6)F VBHUSWXYSKIRJE-FLFNDINXSA-N 0.000 claims 1
CGQDIFZFULUKMS-PLZBVOINSA-N 7-(2,6-dimethyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC(=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)C)OC6=CC=CC=C6 CGQDIFZFULUKMS-PLZBVOINSA-N 0.000 claims 1
JXJCXUOCTKULDX-UALGTNEHSA-N 7-(2-cyclobutylpyridin-4-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=NC=C5)C6CCC6 JXJCXUOCTKULDX-UALGTNEHSA-N 0.000 claims 1
PTJMVEYWDQBSGQ-SNIFEWGJSA-N 7-(2-cyclobutylpyridin-4-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=NC=C5)C6CCC6 PTJMVEYWDQBSGQ-SNIFEWGJSA-N 0.000 claims 1
IAAVGXWJKNIYQF-JLGTUDDPSA-N 7-(2-cyclopentylpyridin-4-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CCC(C1)C2=NC=CC(=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCNC6)NC3=O IAAVGXWJKNIYQF-JLGTUDDPSA-N 0.000 claims 1
WQTCLKYSKUKACT-ZHSQGWMNSA-N 7-(2-fluoro-4-phenoxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)F WQTCLKYSKUKACT-ZHSQGWMNSA-N 0.000 claims 1
WCTQYPYOEUBYRE-ZLXONHFJSA-N 7-(2-fluoro-4-phenoxyphenyl)-N-[(3R)-1-(3-methoxypropanoyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound COCCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)F WCTQYPYOEUBYRE-ZLXONHFJSA-N 0.000 claims 1
DVLSCKMAHLXFDW-JILIHXHHSA-N 7-(2-fluoro-6-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC(=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)F)OC6=CC=CC=C6 DVLSCKMAHLXFDW-JILIHXHHSA-N 0.000 claims 1
LCKBAEFPKARYFK-JOKQZACSSA-N 7-(2-fluoro-6-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC(=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)F)OC6=CC=CC=C6 LCKBAEFPKARYFK-JOKQZACSSA-N 0.000 claims 1
OEDCZNSVJYRDOD-BMKPLPIPSA-N 7-(2-fluoro-6-methyl-4-phenoxyphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC(=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C)NC2=O)F)OC6=CC=CC=C6 OEDCZNSVJYRDOD-BMKPLPIPSA-N 0.000 claims 1
DSPHQQCPZNIIOV-JUEPLOHHSA-N 7-(2-fluorophenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC=C5F DSPHQQCPZNIIOV-JUEPLOHHSA-N 0.000 claims 1
XXUKHFARLCVZQN-BPHNOTCESA-N 7-(2-fluorophenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC=C5F XXUKHFARLCVZQN-BPHNOTCESA-N 0.000 claims 1
AAJLQKJGCAYIRC-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-3-(4-methylpiperazin-1-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)N1CCN(CC1)C)=O AAJLQKJGCAYIRC-UHFFFAOYSA-N 0.000 claims 1
IOTLZXIKBOVWSN-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-3-(4-prop-2-enoylpiperazin-1-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound C(C=C)(=O)N1CCN(CC1)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C IOTLZXIKBOVWSN-UHFFFAOYSA-N 0.000 claims 1
VBIHGTWYPXPWDA-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-3-(4-propanoylpiperazin-1-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)N1CCN(CC1)C(CC)=O)=O VBIHGTWYPXPWDA-UHFFFAOYSA-N 0.000 claims 1
AZBVNGLXJJJQGM-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-3-[(1-prop-2-enoylpiperidin-3-yl)amino]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound C(C=C)(=O)N1CC(CCC1)NC=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C AZBVNGLXJJJQGM-UHFFFAOYSA-N 0.000 claims 1
WZSVAROQWMBAFS-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-3-[(1-prop-2-enoylpiperidin-4-yl)amino]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound C(C=C)(=O)N1CCC(CC1)NC=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C WZSVAROQWMBAFS-UHFFFAOYSA-N 0.000 claims 1
BFQRVEMPOACICP-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-3-piperazin-1-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)N1CCNCC1)=O BFQRVEMPOACICP-UHFFFAOYSA-N 0.000 claims 1
OGJHDLPFSHKIHS-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(1-prop-2-enoylpiperidin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C(=O)C=C)NC3=O OGJHDLPFSHKIHS-UHFFFAOYSA-N 0.000 claims 1
CUTLTECASUYRJS-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(1-propan-2-ylazetidin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(C6)C(C)C)NC3=O CUTLTECASUYRJS-UHFFFAOYSA-N 0.000 claims 1
IMEFDMVOJMDBCR-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(1-propanoylpiperidin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCCC(C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C IMEFDMVOJMDBCR-UHFFFAOYSA-N 0.000 claims 1
HVJOSBKIQYBWKZ-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(1-propanoylpiperidin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCC(CC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C HVJOSBKIQYBWKZ-UHFFFAOYSA-N 0.000 claims 1
SAXGBVDAIYWKCC-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(2-oxopiperidin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCNC(=O)C6)NC3=O SAXGBVDAIYWKCC-UHFFFAOYSA-N 0.000 claims 1
YATJOKCOUFWUFX-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-(5-oxopyrrolidin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CC(=O)NC6)NC3=O YATJOKCOUFWUFX-UHFFFAOYSA-N 0.000 claims 1
HNJFFKHGUULXFQ-SKMXHSGUSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-[(3R)-oxolane-3-carbonyl]piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@@H]7CCOC7)NC3=O HNJFFKHGUULXFQ-SKMXHSGUSA-N 0.000 claims 1
HNJFFKHGUULXFQ-YFCJSSSCSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-[(3S)-oxolane-3-carbonyl]piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@H]7CCOC7)NC3=O HNJFFKHGUULXFQ-YFCJSSSCSA-N 0.000 claims 1
IMEFDMVOJMDBCR-WPNUWBHDSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-propanoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C IMEFDMVOJMDBCR-WPNUWBHDSA-N 0.000 claims 1
LZBDCCFXGJGLMF-UTKYEJCASA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-propylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCCN1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C LZBDCCFXGJGLMF-UTKYEJCASA-N 0.000 claims 1
YATJOKCOUFWUFX-GDIICXGYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-5-oxopyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CC(=O)NC6)NC3=O YATJOKCOUFWUFX-GDIICXGYSA-N 0.000 claims 1
YQPUBAMKEQIRFQ-AECCHWAESA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-oxolan-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCOC6)NC3=O YQPUBAMKEQIRFQ-AECCHWAESA-N 0.000 claims 1
JFTJYTXZDGXASY-AECCHWAESA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCNC6)NC3=O JFTJYTXZDGXASY-AECCHWAESA-N 0.000 claims 1
XAQYTTUZADGHGV-RKLPUXCDSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3S)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCN(C6)C(=O)C=C)NC3=O XAQYTTUZADGHGV-RKLPUXCDSA-N 0.000 claims 1
YATJOKCOUFWUFX-HHMLWMOOSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3S)-5-oxopyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CC(=O)NC6)NC3=O YATJOKCOUFWUFX-HHMLWMOOSA-N 0.000 claims 1
YQPUBAMKEQIRFQ-ZIGWWCSZSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3S)-oxolan-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCOC6)NC3=O YQPUBAMKEQIRFQ-ZIGWWCSZSA-N 0.000 claims 1
CNRYOJIRRLQJKZ-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[2-(2-oxoimidazolidin-1-yl)ethyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NCCN6CCNC6=O)NC3=O CNRYOJIRRLQJKZ-UHFFFAOYSA-N 0.000 claims 1
AJKYAKBBIYRRAN-WKBUCKLXSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[[(2R)-pyrrolidin-2-yl]methyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC[C@H]6CCCN6)NC3=O AJKYAKBBIYRRAN-WKBUCKLXSA-N 0.000 claims 1
YLSOMYARMFODFJ-FKQXYHHHSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[[(2S)-piperidin-2-yl]methyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC[C@@H]6CCCCN6)NC3=O YLSOMYARMFODFJ-FKQXYHHHSA-N 0.000 claims 1
AJKYAKBBIYRRAN-KAXXRHABSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[[(2S)-pyrrolidin-2-yl]methyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC[C@@H]6CCCN6)NC3=O AJKYAKBBIYRRAN-KAXXRHABSA-N 0.000 claims 1
OJZXEFYASCMPEK-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCNC6)NC3=O OJZXEFYASCMPEK-UHFFFAOYSA-N 0.000 claims 1
WYMFAGPGEWADNP-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-piperidin-4-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCNCC6)NC3=O WYMFAGPGEWADNP-UHFFFAOYSA-N 0.000 claims 1
VSYMOLNSFRPNMF-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-(1-methylpiperidin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C)NC3=O VSYMOLNSFRPNMF-UHFFFAOYSA-N 0.000 claims 1
KYMFGMYRSKEZEO-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-(1-methylpiperidin-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C)NC3=O KYMFGMYRSKEZEO-UHFFFAOYSA-N 0.000 claims 1
IWMLCAQJWSBULO-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-(2-methylpiperidin-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1CC(CCN1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C IWMLCAQJWSBULO-UHFFFAOYSA-N 0.000 claims 1
PPJZPONMVUNQQO-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-(3-methylpiperidin-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1CNCCC1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C PPJZPONMVUNQQO-UHFFFAOYSA-N 0.000 claims 1
JPYXFLDAMLMKHX-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-(oxan-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCOCC6)NC3=O JPYXFLDAMLMKHX-UHFFFAOYSA-N 0.000 claims 1
ZVLHEFDVZBTDDT-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(1-methylpyrrolidin-3-yl)methyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NCC6CCN(C6)C)NC3=O ZVLHEFDVZBTDDT-UHFFFAOYSA-N 0.000 claims 1
DZCRAZZKBLINBK-LMHRIGTHSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3R)-1-(2-morpholin-4-ylacetyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CN7CCOCC7)NC3=O DZCRAZZKBLINBK-LMHRIGTHSA-N 0.000 claims 1
HUYFJNRGJNQLBV-UTKYEJCASA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3R)-1-(oxetane-3-carbonyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C7COC7)NC3=O HUYFJNRGJNQLBV-UTKYEJCASA-N 0.000 claims 1
JQRFZYPXHQFYPC-CMGCTQEWSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(3R)-1-[(E)-4-morpholin-4-ylbut-2-enoyl]piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C=C/CN7CCOCC7)NC3=O JQRFZYPXHQFYPC-CMGCTQEWSA-N 0.000 claims 1
IWMLCAQJWSBULO-QUZMXJGPSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[(4S)-2-methylpiperidin-4-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1C[C@H](CCN1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C IWMLCAQJWSBULO-QUZMXJGPSA-N 0.000 claims 1
LFNYSIJRFUGQSQ-UHFFFAOYSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NCCC6CCCN6C)NC3=O LFNYSIJRFUGQSQ-UHFFFAOYSA-N 0.000 claims 1
QBZUTMGQSBTPPQ-GOSISDBHSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[[(3R)-1-methylpyrrolidin-3-yl]methyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4=C5C(=C(SC5=NC=C4)C(=O)NC[C@H]6CCN(C6)C)NC3=O QBZUTMGQSBTPPQ-GOSISDBHSA-N 0.000 claims 1
QBZUTMGQSBTPPQ-SFHVURJKSA-N 7-(2-methyl-4-phenoxyphenyl)-N-[[(3S)-1-methylpyrrolidin-3-yl]methyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4=C5C(=C(SC5=NC=C4)C(=O)NC[C@@H]6CCN(C6)C)NC3=O QBZUTMGQSBTPPQ-SFHVURJKSA-N 0.000 claims 1
FRSMPMAHADWRAI-QGZVFWFLSA-N 7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C FRSMPMAHADWRAI-QGZVFWFLSA-N 0.000 claims 1
IRRNVGWSFWRNSS-UALGTNEHSA-N 7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O IRRNVGWSFWRNSS-UALGTNEHSA-N 0.000 claims 1
VXAWEEYUIHUPII-LHUOQCBISA-N 7-(2-methyl-4-propan-2-ylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)C(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O VXAWEEYUIHUPII-LHUOQCBISA-N 0.000 claims 1
WNHUEPCIZHTWMQ-JFLZXDOOSA-N 7-(2-methyl-4-pyridazin-3-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=NN=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O WNHUEPCIZHTWMQ-JFLZXDOOSA-N 0.000 claims 1
KNHKLPAOADXUJH-COBYXZRWSA-N 7-(2-methyl-4-pyridazin-3-yloxyphenyl)-6-oxo-N-[(3R)-1-propanoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=NN=CC=C6)C KNHKLPAOADXUJH-COBYXZRWSA-N 0.000 claims 1
KPJWERSHGNLONP-COBYXZRWSA-N 7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=N2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O KPJWERSHGNLONP-COBYXZRWSA-N 0.000 claims 1
XPDGBMGGIVFNAL-KBZWIDLWSA-N 7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-N-[(3R)-1-propanoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=N6)C XPDGBMGGIVFNAL-KBZWIDLWSA-N 0.000 claims 1
ZCCHBMQUVVYWPZ-OAQYLSRUSA-N 7-(2-methyl-5-phenylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1C)C1=CC=CC=C1 ZCCHBMQUVVYWPZ-OAQYLSRUSA-N 0.000 claims 1
GIIWADZNRAXXEO-LJQANCHMSA-N 7-(2-methyl-5-phenylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=C(C=C1)C1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CNCCC1)=O GIIWADZNRAXXEO-LJQANCHMSA-N 0.000 claims 1
RZQRFSYZDSHHJL-QGZVFWFLSA-N 7-(2-methyl-5-propan-2-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=CC(=C1)OC(C)C)C RZQRFSYZDSHHJL-QGZVFWFLSA-N 0.000 claims 1
VHUKFUVZDVPVJA-COBYXZRWSA-N 7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O VHUKFUVZDVPVJA-COBYXZRWSA-N 0.000 claims 1
FSGDHCZUPJDIRK-WTBVOWCJSA-N 7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-oxolan-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCOC6)NC3=O FSGDHCZUPJDIRK-WTBVOWCJSA-N 0.000 claims 1
VUMJOFQHNJJVKS-UALGTNEHSA-N 7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCNC6)NC3=O VUMJOFQHNJJVKS-UALGTNEHSA-N 0.000 claims 1
NTFOFCJIBYKDKO-WTBVOWCJSA-N 7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCNC6)NC3=O NTFOFCJIBYKDKO-WTBVOWCJSA-N 0.000 claims 1
TZUSLBKUWBJERQ-WGEGCMKZSA-N 7-(2-methyl-6-phenylpyridin-4-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC(=N1)C2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O TZUSLBKUWBJERQ-WGEGCMKZSA-N 0.000 claims 1
DNTNDSQIKFXJEE-UHFFFAOYSA-N 7-(2-methyl-6-phenylpyridin-4-yl)-6-oxo-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC(=N1)C2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCNC6)NC3=O DNTNDSQIKFXJEE-UHFFFAOYSA-N 0.000 claims 1
WZDGFDDUYDDRLW-MXRZHXBVSA-N 7-(2-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=NN=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O WZDGFDDUYDDRLW-MXRZHXBVSA-N 0.000 claims 1
KBNHNJUUIONBFZ-IXVFFECXSA-N 7-(2-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2=NN=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O KBNHNJUUIONBFZ-IXVFFECXSA-N 0.000 claims 1
UFHWPJOISYDNBA-GAPYIYKUSA-N 7-(3,4-dichlorophenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=C(C=C5)Cl)Cl UFHWPJOISYDNBA-GAPYIYKUSA-N 0.000 claims 1
LYRVWNRHCDBYFR-QOCVKUSBSA-N 7-(3,5-dichlorophenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC(=C5)Cl)Cl LYRVWNRHCDBYFR-QOCVKUSBSA-N 0.000 claims 1
WTENQXNMRLAFNZ-JAWMWQJPSA-N 7-(3-acetylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(=O)C1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O WTENQXNMRLAFNZ-JAWMWQJPSA-N 0.000 claims 1
DIDLOOBPBLKNIA-HDNVEZOSSA-N 7-(3-acetylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(=O)C1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O DIDLOOBPBLKNIA-HDNVEZOSSA-N 0.000 claims 1
XDLGCLNXNCDXMV-XGIVMCBUSA-N 7-(3-benzylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)CC6=CC=CC=C6 XDLGCLNXNCDXMV-XGIVMCBUSA-N 0.000 claims 1
BRMXZALFOQAQBU-LBZDYYAASA-N 7-(3-benzylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)CC6=CC=CC=C6 BRMXZALFOQAQBU-LBZDYYAASA-N 0.000 claims 1
AXJFNKGZUOOWRO-GMKOREOWSA-N 7-(3-chloro-4-methylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)Cl AXJFNKGZUOOWRO-GMKOREOWSA-N 0.000 claims 1
MVOBQCDKOAQFMZ-GDIICXGYSA-N 7-(3-chloro-4-phenoxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=C(C=C5)OC6=CC=CC=C6)Cl MVOBQCDKOAQFMZ-GDIICXGYSA-N 0.000 claims 1
ZYDIUFAMVZRLGS-SXKNJTIYSA-N 7-(3-chloro-4-phenoxyphenyl)-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=C(C=C5)OC6=CC=CC=C6)Cl ZYDIUFAMVZRLGS-SXKNJTIYSA-N 0.000 claims 1
CHIPMQYCMOGPQU-PTSAETRTSA-N 7-(3-chloro-4-phenoxyphenyl)-N-[(3R)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN(C)CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=C(C=C5)OC6=CC=CC=C6)Cl CHIPMQYCMOGPQU-PTSAETRTSA-N 0.000 claims 1
ZVOBODHSEVQPNP-IZVLDTAISA-N 7-(3-chlorophenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC=C5)Cl ZVOBODHSEVQPNP-IZVLDTAISA-N 0.000 claims 1
OSFSJLSKPQJROJ-YKJZNPTPSA-N 7-(3-cyclobutyloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC=C5)OC6CCC6 OSFSJLSKPQJROJ-YKJZNPTPSA-N 0.000 claims 1
DJVMJEJUNOJHDO-WIQGMUCESA-N 7-(3-cyclobutylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)C6CCC6 DJVMJEJUNOJHDO-WIQGMUCESA-N 0.000 claims 1
IRUVVQNIWLPQKP-UQHTVBEOSA-N 7-(3-cyclohexyloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC=C5)OC6CCCCC6 IRUVVQNIWLPQKP-UQHTVBEOSA-N 0.000 claims 1
QQXMWOBYTKZCLV-AECCHWAESA-N 7-(3-cyclohexyloxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CCC(CC1)OC2=CC=CC(=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCNC6)NC3=O QQXMWOBYTKZCLV-AECCHWAESA-N 0.000 claims 1
XSYLPRPIFXEUGZ-RGLZCYETSA-N 7-(3-cyclohexylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)C6CCCCC6 XSYLPRPIFXEUGZ-RGLZCYETSA-N 0.000 claims 1
ZHZDEFGLSWKEAW-MOWZZLTPSA-N 7-(3-cyclopentyloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=CC=C5)OC6CCCC6 ZHZDEFGLSWKEAW-MOWZZLTPSA-N 0.000 claims 1
BTPDSBVNUNKXJN-UHFFFAOYSA-N 7-(3-cyclopentyloxyphenyl)-6-oxo-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CCC(C1)OC2=CC=CC(=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCNC6)NC3=O BTPDSBVNUNKXJN-UHFFFAOYSA-N 0.000 claims 1
XRDCLYGUNHAFQS-JHCJGPRDSA-N 7-(3-cyclopropylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=CC(=C5)C6CC6 XRDCLYGUNHAFQS-JHCJGPRDSA-N 0.000 claims 1
OSCJHYSOUUZCAB-ORIIBDJOSA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O OSCJHYSOUUZCAB-ORIIBDJOSA-N 0.000 claims 1
DFAUWMMCGFIQKU-NLQJCJLKSA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-1-(2-hydroxyacetyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CO)NC3=O DFAUWMMCGFIQKU-NLQJCJLKSA-N 0.000 claims 1
OUWAETLQQXYIEJ-ORIIBDJOSA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)COC)NC3=O OUWAETLQQXYIEJ-ORIIBDJOSA-N 0.000 claims 1
DHUKLWQKVJMTIK-ORIIBDJOSA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-1-(3-hydroxypropanoyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CCO)NC3=O DHUKLWQKVJMTIK-ORIIBDJOSA-N 0.000 claims 1
YEMILFRFYFICRT-HOLADMOISA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-1-(3-methoxypropanoyl)piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CCOC)NC3=O YEMILFRFYFICRT-HOLADMOISA-N 0.000 claims 1
RZDLWHQBOVEUSM-RCJBGLKOSA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O RZDLWHQBOVEUSM-RCJBGLKOSA-N 0.000 claims 1
HERJOXXLNBCADR-JSOHRCNXSA-N 7-(3-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3S)-oxan-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1F)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCOC6)NC3=O HERJOXXLNBCADR-JSOHRCNXSA-N 0.000 claims 1
MUNDTNKAVPFDGX-SCIWHTQWSA-N 7-(3-methyl-2-phenylpyridin-4-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CN=C1C2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O MUNDTNKAVPFDGX-SCIWHTQWSA-N 0.000 claims 1
PUBSSKZYSYISDZ-RQILOKFUSA-N 7-(3-methyl-2-phenylpyridin-4-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CN=C1C2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCNC6)NC3=O PUBSSKZYSYISDZ-RQILOKFUSA-N 0.000 claims 1
LYYGPXDYQNHOQW-LLFRVYHXSA-N 7-(3-methyl-4-phenoxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)OC6=CC=CC=C6 LYYGPXDYQNHOQW-LLFRVYHXSA-N 0.000 claims 1
GTUGVYOWVUZHAL-QGZVFWFLSA-N 7-(3-methyl-4-propan-2-yloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=C(C=C1)OC(C)C)C GTUGVYOWVUZHAL-QGZVFWFLSA-N 0.000 claims 1
XRCDMFWDWOMFRI-CUAWPGHGSA-N 7-(3-methyl-5-phenoxypyrazin-2-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=NC(=CN=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)OC6=CC=CC=C6 XRCDMFWDWOMFRI-CUAWPGHGSA-N 0.000 claims 1
AJNPHFQVGYWAJT-MIVSWDHXSA-N 7-(3-methyl-5-phenoxypyrazin-2-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=NC(=CN=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)OC6=CC=CC=C6 AJNPHFQVGYWAJT-MIVSWDHXSA-N 0.000 claims 1
ULYSIFNJIYRCMW-WBTJPIBESA-N 7-(3-methyl-5-phenoxypyridin-2-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CN=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)OC6=CC=CC=C6 ULYSIFNJIYRCMW-WBTJPIBESA-N 0.000 claims 1
PTNJZPBSZYUNNV-HUOQMWRPSA-N 7-(3-methyl-5-phenoxypyridin-2-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CN=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)OC6=CC=CC=C6 PTNJZPBSZYUNNV-HUOQMWRPSA-N 0.000 claims 1
FQFFGBGBFKPFHZ-AYKOGJGSSA-N 7-(3-methylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O FQFFGBGBFKPFHZ-AYKOGJGSSA-N 0.000 claims 1
FZJUIUZHMYPEDB-QOCVKUSBSA-N 7-(4-aminophenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)N FZJUIUZHMYPEDB-QOCVKUSBSA-N 0.000 claims 1
FHXYDDANJORIAC-XGIVMCBUSA-N 7-(4-benzylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)CC6=CC=CC=C6 FHXYDDANJORIAC-XGIVMCBUSA-N 0.000 claims 1
XWEYOVGUHXEKII-LBZDYYAASA-N 7-(4-benzylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)CC6=CC=CC=C6 XWEYOVGUHXEKII-LBZDYYAASA-N 0.000 claims 1
NSNRCXGDCIQHAI-UHFFFAOYSA-N 7-(4-cyclobutyloxy-2-methylphenyl)-6-oxo-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCC2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCNC6)NC3=O NSNRCXGDCIQHAI-UHFFFAOYSA-N 0.000 claims 1
WDGVGCFKFYNHSB-AECCHWAESA-N 7-(4-cyclobutyloxy-2-methylphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O WDGVGCFKFYNHSB-AECCHWAESA-N 0.000 claims 1
BUBZMTHPSQJMNF-YKJZNPTPSA-N 7-(4-cyclobutyloxyphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6CCC6 BUBZMTHPSQJMNF-YKJZNPTPSA-N 0.000 claims 1
CNGYMZQYKDBQFA-LJQANCHMSA-N 7-(4-cyclohexyloxy-2-methylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1CCCCC1)C CNGYMZQYKDBQFA-LJQANCHMSA-N 0.000 claims 1
SAJDMFIXDIFHRR-UQHTVBEOSA-N 7-(4-cyclohexyloxy-2-methylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCCCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O SAJDMFIXDIFHRR-UQHTVBEOSA-N 0.000 claims 1
RTFUFZBILQBQQV-FVDXLRKESA-N 7-(4-cyclohexyloxy-2-methylphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCCCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O RTFUFZBILQBQQV-FVDXLRKESA-N 0.000 claims 1
AASGNVBRWDWXDV-UQHTVBEOSA-N 7-(4-cyclopentyloxy-2-methylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O AASGNVBRWDWXDV-UQHTVBEOSA-N 0.000 claims 1
QAZVXGVBQCWQRG-WKBUCKLXSA-N 7-(4-cyclopentyloxy-2-methylphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O QAZVXGVBQCWQRG-WKBUCKLXSA-N 0.000 claims 1
QTHIOKXIJRBANK-YKJZNPTPSA-N 7-(4-cyclopropyloxy-2-methylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O QTHIOKXIJRBANK-YKJZNPTPSA-N 0.000 claims 1
IAQMADXAKDRNGO-IZVLDTAISA-N 7-(4-fluorophenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)F IAQMADXAKDRNGO-IZVLDTAISA-N 0.000 claims 1
UHKFFTYRIUCZBP-FSUBGKOTSA-N 7-(4-hydroxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)O UHKFFTYRIUCZBP-FSUBGKOTSA-N 0.000 claims 1
VEOGLMIZUOHYCN-WTBVOWCJSA-N 7-(4-methoxy-2-methylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O VEOGLMIZUOHYCN-WTBVOWCJSA-N 0.000 claims 1
ODGQSZVRFFDPQY-GMKOREOWSA-N 7-(4-methoxyphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound COC1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O ODGQSZVRFFDPQY-GMKOREOWSA-N 0.000 claims 1
PSPUXBLSOWGJHZ-WOBNGOBWSA-N 7-(4-methyl-2-phenoxypyrimidin-5-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=NC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)OC6=CC=CC=C6 PSPUXBLSOWGJHZ-WOBNGOBWSA-N 0.000 claims 1
NAZZDXFHLIIGOU-QOCVKUSBSA-N 7-(4-methyl-2-phenoxypyrimidin-5-yl)-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=NC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCNC5)NC2=O)OC6=CC=CC=C6 NAZZDXFHLIIGOU-QOCVKUSBSA-N 0.000 claims 1
KKYDDYRSOSUBCW-UTSMHQLYSA-N 7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCNC5)NC2=O)OC6=CC=CC=C6 KKYDDYRSOSUBCW-UTSMHQLYSA-N 0.000 claims 1
QDSPQYRKIVVEEB-RQBHNKLOSA-N 7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3S,4R)-4-(prop-2-enoylamino)oxolan-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5COC[C@@H]5NC(=O)C=C)NC2=O)OC6=CC=CC=C6 QDSPQYRKIVVEEB-RQBHNKLOSA-N 0.000 claims 1
YZAJSHHNHUONNY-RQBHNKLOSA-N 7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[(3S,4R)-4-prop-2-enoyloxolan-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5COC[C@@H]5C(=O)C=C)NC2=O)OC6=CC=CC=C6 YZAJSHHNHUONNY-RQBHNKLOSA-N 0.000 claims 1
ARXSBWDYFYZZGO-RVJVUUFRSA-N 7-(4-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O)OC(C)C ARXSBWDYFYZZGO-RVJVUUFRSA-N 0.000 claims 1
BKTRAHGMFQXOON-DQIDDCCSSA-N 7-(4-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCNC5)NC2=O)OC(C)C BKTRAHGMFQXOON-DQIDDCCSSA-N 0.000 claims 1
QNFFXFLUGLGQPA-MRXNPFEDSA-N 7-(4-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1N=NC=CC=1 QNFFXFLUGLGQPA-MRXNPFEDSA-N 0.000 claims 1
TXUDGNXITBLVID-OAHLLOKOSA-N 7-(4-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1N=NC=CC=1 TXUDGNXITBLVID-OAHLLOKOSA-N 0.000 claims 1
RCVBGPDYDLGJSV-AYKOGJGSSA-N 7-(4-methylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O RCVBGPDYDLGJSV-AYKOGJGSSA-N 0.000 claims 1
KEZKALMDFXNGCD-DCWGHEPTSA-N 7-(4-tert-butylphenyl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)(C)C1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O KEZKALMDFXNGCD-DCWGHEPTSA-N 0.000 claims 1
PGZNFPCAUOUPNJ-UALGTNEHSA-N 7-(4-tert-butylsulfonylphenyl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)(C)S(=O)(=O)C1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O PGZNFPCAUOUPNJ-UALGTNEHSA-N 0.000 claims 1
IKFXLGIINHWIAA-OCQAFOEYSA-N 7-(5-chloro-1,3-benzodioxol-4-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=CC6=C5OCO6)Cl IKFXLGIINHWIAA-OCQAFOEYSA-N 0.000 claims 1
LBAKHDTYKUQNMG-JJYQMSCCSA-N 7-(5-chloro-1,3-benzodioxol-4-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=CC6=C5OCO6)Cl LBAKHDTYKUQNMG-JJYQMSCCSA-N 0.000 claims 1
KUIVGIWIOBADSA-QQYRIPNCSA-N 7-(5-chloro-1,3-benzodioxol-4-yl)-N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=C(C=CC7=C6OCO7)Cl KUIVGIWIOBADSA-QQYRIPNCSA-N 0.000 claims 1
BENVMAPLCCCYPV-COBYXZRWSA-N 7-(5-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=C(C=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C)NC2=O)F)OC6=CC=CC=C6 BENVMAPLCCCYPV-COBYXZRWSA-N 0.000 claims 1
GZLVEBPQVYYERU-JFLZXDOOSA-N 7-(5-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3R)-oxan-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=C(C=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCOC5)NC2=O)F)OC6=CC=CC=C6 GZLVEBPQVYYERU-JFLZXDOOSA-N 0.000 claims 1
GZLVEBPQVYYERU-NJJNGPRGSA-N 7-(5-fluoro-2-methyl-4-phenoxyphenyl)-N-[(3S)-oxan-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=C(C=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@H]5CCCOC5)NC2=O)F)OC6=CC=CC=C6 GZLVEBPQVYYERU-NJJNGPRGSA-N 0.000 claims 1
IOHDALZLVIIQCR-JHCJGPRDSA-N 7-(5-methyl-2-phenylpyridin-4-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CN=C(C=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)C6=CC=CC=C6 IOHDALZLVIIQCR-JHCJGPRDSA-N 0.000 claims 1
UGODJHWHFUZXGL-CGEGXVMMSA-N 7-(6-cyclobutyloxypyridin-3-yl)-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=C(C=C5)OC6CCC6 UGODJHWHFUZXGL-CGEGXVMMSA-N 0.000 claims 1
AHWHXXZLPOSCHV-JUEPLOHHSA-N 7-(6-cyclobutyloxypyridin-3-yl)-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=C(C=C5)OC6CCC6 AHWHXXZLPOSCHV-JUEPLOHHSA-N 0.000 claims 1
SNRFAALCFFRPHL-IJHRGXPZSA-N 7-[(3R)-2-benzyl-1,3-dihydropyrazol-3-yl]-6-oxo-N-(1-prop-2-enoylpiperidin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C=CC(=O)N1CCCC(C1)NC(=O)C2=C3C4=C(C=CN=C4S2)N(C(=O)N3)[C@H]5C=CNN5CC6=CC=CC=C6 SNRFAALCFFRPHL-IJHRGXPZSA-N 0.000 claims 1
WNPKPBOCUKLWLZ-GDALGIGOSA-N 7-[(6R)-6-cyclobutyloxy-6-methyl-1H-pyridin-3-yl]-6-oxo-N-(1-prop-2-enoylpiperidin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C[C@]1(C=CC(=CN1)N2C3=C4C(=C(SC4=NC=C3)C(=O)NC5CCCN(C5)C(=O)C=C)NC2=O)OC6CCC6 WNPKPBOCUKLWLZ-GDALGIGOSA-N 0.000 claims 1
OZMGCCQHIVDPIH-WGEGCMKZSA-N 7-[2-methyl-4-(2-methylphenoxy)phenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC=CC=C1OC2=CC(=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O)C OZMGCCQHIVDPIH-WGEGCMKZSA-N 0.000 claims 1
PFRNADVBCPJETC-WGEGCMKZSA-N 7-[2-methyl-4-(2-propan-2-yloxyethoxy)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OCCOC(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O PFRNADVBCPJETC-WGEGCMKZSA-N 0.000 claims 1
IOMQSEHRPPGXLT-IUKJWVDASA-N 7-[2-methyl-4-(3-methylphenoxy)phenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=CC=C1)OC2=CC(=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O)C IOMQSEHRPPGXLT-IUKJWVDASA-N 0.000 claims 1
SRIQGRVYDIHOOK-IUKJWVDASA-N 7-[2-methyl-4-(4-methylphenoxy)phenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC=C(C=C1)OC2=CC(=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O)C SRIQGRVYDIHOOK-IUKJWVDASA-N 0.000 claims 1
UXLNUPULPNSTFN-MOWZZLTPSA-N 7-[2-methyl-4-(oxan-4-yloxy)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCOCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O UXLNUPULPNSTFN-MOWZZLTPSA-N 0.000 claims 1
IWZOBVCLFASDGD-WKBUCKLXSA-N 7-[2-methyl-4-(oxan-4-yloxy)phenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCOCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O IWZOBVCLFASDGD-WKBUCKLXSA-N 0.000 claims 1
ZHNBNIMLJHXISH-BHVRQQHWSA-N 7-[2-methyl-4-(pentafluoro-lambda6-sulfanyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)S(F)(F)(F)(F)F)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O ZHNBNIMLJHXISH-BHVRQQHWSA-N 0.000 claims 1
QRPRCXINXHSDPV-JUEPLOHHSA-N 7-[2-methyl-4-(pentafluoro-lambda6-sulfanyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)S(F)(F)(F)(F)F)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCN(C5)C(=O)C=C)NC2=O QRPRCXINXHSDPV-JUEPLOHHSA-N 0.000 claims 1
KWVSXNXLVYSFGM-UHFFFAOYSA-N 7-[2-methyl-4-(trifluoromethoxy)phenyl]-6-oxo-N-piperidin-3-yl-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC(F)(F)F)N2C3CCNC4C3C(=C(S4)C(=O)NC5CCCNC5)NC2=O KWVSXNXLVYSFGM-UHFFFAOYSA-N 0.000 claims 1
ZPFGCOYFGKAKSM-COBYXZRWSA-N 7-[2-methyl-6-(oxan-4-yloxy)pyridin-3-yl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=N1)OC2CCOCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O ZPFGCOYFGKAKSM-COBYXZRWSA-N 0.000 claims 1
MWKZLYISXNLRRF-MRXNPFEDSA-N 7-[3-(2,3-difluorophenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=C(C(=CC=C1)F)F MWKZLYISXNLRRF-MRXNPFEDSA-N 0.000 claims 1
VOIOWDUTKNZEFZ-MRXNPFEDSA-N 7-[3-(2,3-difluorophenyl)phenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound FC1=C(C=CC=C1F)C1=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CCC1)C)=O VOIOWDUTKNZEFZ-MRXNPFEDSA-N 0.000 claims 1
VONJTZLHPFSZRL-GOSISDBHSA-N 7-[3-(2,4-difluorophenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=C(C=C(C=C1)F)F VONJTZLHPFSZRL-GOSISDBHSA-N 0.000 claims 1
VXMQCSAPARGCTB-GOSISDBHSA-N 7-[3-(2-chlorophenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=C(C=CC=C1)Cl VXMQCSAPARGCTB-GOSISDBHSA-N 0.000 claims 1
SIXSDLVUGHNLLK-HXUWFJFHSA-N 7-[3-(2-methylphenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=C(C=CC=C1)C SIXSDLVUGHNLLK-HXUWFJFHSA-N 0.000 claims 1
ZQUCXJWLWFHYJG-GOSISDBHSA-N 7-[3-(2-methylphenyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC=C1)C1=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CNCCC1)=O ZQUCXJWLWFHYJG-GOSISDBHSA-N 0.000 claims 1
YRFWJPJMLHQQLA-WIQGMUCESA-N 7-[3-(2-methylpropyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)CC1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O YRFWJPJMLHQQLA-WIQGMUCESA-N 0.000 claims 1
LJYHXSAXZIMQPK-LHUOQCBISA-N 7-[3-(2-methylpropyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)CC1=CC(=CC=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O LJYHXSAXZIMQPK-LHUOQCBISA-N 0.000 claims 1
CXRCQWFRJKEMCA-HXUWFJFHSA-N 7-[3-(3-chlorophenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=CC(=CC=C1)Cl CXRCQWFRJKEMCA-HXUWFJFHSA-N 0.000 claims 1
DHVWYBJWYAFAGO-HXUWFJFHSA-N 7-[3-(3-fluorophenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=CC(=CC=C1)F DHVWYBJWYAFAGO-HXUWFJFHSA-N 0.000 claims 1
XMHOWEBACOVRRT-OAQYLSRUSA-N 7-[3-(3-methylphenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=CC(=CC=C1)C XMHOWEBACOVRRT-OAQYLSRUSA-N 0.000 claims 1
NCDKASYHRXXKFX-LJQANCHMSA-N 7-[3-(3-methylphenyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC=1C=C(C=CC=1)C1=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CNCCC1)=O NCDKASYHRXXKFX-LJQANCHMSA-N 0.000 claims 1
ZFVBWTUZQQYTFL-OAQYLSRUSA-N 7-[3-(4-methylphenyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1)C1=CC=C(C=C1)C ZFVBWTUZQQYTFL-OAQYLSRUSA-N 0.000 claims 1
IYDNYWVWGUUBSY-LJQANCHMSA-N 7-[3-(4-methylphenyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=CC=C(C=C1)C1=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CNCCC1)=O IYDNYWVWGUUBSY-LJQANCHMSA-N 0.000 claims 1
ZQARFBBDLYYBHN-WTBVOWCJSA-N 7-[3-(dimethylamino)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN(C)C1=CC=CC(=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O ZQARFBBDLYYBHN-WTBVOWCJSA-N 0.000 claims 1
WXAYTVOOKMURJI-PLZBVOINSA-N 7-[4-(1-benzofuran-7-yloxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC3=C2OC=C3)N4C5CCNC6C5C(=C(S6)C(=O)N[C@@H]7CCCN(C7)C)NC4=O WXAYTVOOKMURJI-PLZBVOINSA-N 0.000 claims 1
ARLKSWQKOPQJFS-MOWZZLTPSA-N 7-[4-(2,4-difluorophenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=C(C=C(C=C2)F)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O ARLKSWQKOPQJFS-MOWZZLTPSA-N 0.000 claims 1
BPMYOSPDXZDEHA-FYXCJKFZSA-N 7-[4-(2,6-difluorophenoxy)-2-methylphenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=C(C=CC=C2F)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O BPMYOSPDXZDEHA-FYXCJKFZSA-N 0.000 claims 1
DYPMOCCKXCFWSA-JDTIAOCQSA-N 7-[4-(2,6-difluorophenoxy)-2-methylphenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=C(C=CC=C2F)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)C=C)NC3=O DYPMOCCKXCFWSA-JDTIAOCQSA-N 0.000 claims 1
HZNVUWPSGQBYJR-ZTAHTODWSA-N 7-[4-(2,6-difluorophenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=C(C=CC=C2F)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O HZNVUWPSGQBYJR-ZTAHTODWSA-N 0.000 claims 1
NIXUVHLFZKNGMH-JOKQZACSSA-N 7-[4-(2-carbamoylphenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2C(=O)N)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O NIXUVHLFZKNGMH-JOKQZACSSA-N 0.000 claims 1
ASXLMABEYMOQFJ-LOIMDLHYSA-N 7-[4-(2-cyclopropylphenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2C3CC3)N4C5CCNC6C5C(=C(S6)C(=O)N[C@@H]7CCCN(C7)C)NC4=O ASXLMABEYMOQFJ-LOIMDLHYSA-N 0.000 claims 1
BHJRHAJEXSRVIC-PNHHPKMASA-N 7-[4-(2-ethoxyphenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCOC1=CC=CC=C1OC2=CC(=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O)C BHJRHAJEXSRVIC-PNHHPKMASA-N 0.000 claims 1
OOBBEMFCSKDZTF-NDPCOACTSA-N 7-[4-(2-ethylphenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC1=CC=CC=C1OC2=CC(=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O)C OOBBEMFCSKDZTF-NDPCOACTSA-N 0.000 claims 1
GPVHBHCHLAZRSO-VHHOUOLASA-N 7-[4-(2-fluorophenoxy)-2-methylphenyl]-N-[(3S)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C)NC3=O GPVHBHCHLAZRSO-VHHOUOLASA-N 0.000 claims 1
APXSZNNEOHKEAR-COBYXZRWSA-N 7-[4-(2-hydroxyphenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2O)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O APXSZNNEOHKEAR-COBYXZRWSA-N 0.000 claims 1
YCFZRLFDUZRCCR-UHFFFAOYSA-N 7-[4-(2-methoxyphenoxy)-2-methylphenyl]-N-(1-methylpiperidin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C)NC3=O YCFZRLFDUZRCCR-UHFFFAOYSA-N 0.000 claims 1
VMKHNSQGMIFCAO-UHFFFAOYSA-N 7-[4-(2-methoxyphenoxy)-2-methylphenyl]-N-(1-methylpiperidin-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C)NC3=O VMKHNSQGMIFCAO-UHFFFAOYSA-N 0.000 claims 1
YCFZRLFDUZRCCR-KBZWIDLWSA-N 7-[4-(2-methoxyphenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O YCFZRLFDUZRCCR-KBZWIDLWSA-N 0.000 claims 1
JLGMFLBWFIUQGC-WIQGMUCESA-N 7-[4-(2-methylpropyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)CC1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O JLGMFLBWFIUQGC-WIQGMUCESA-N 0.000 claims 1
WXEADMDSDZEAOK-LHUOQCBISA-N 7-[4-(2-methylpropyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)CC1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O WXEADMDSDZEAOK-LHUOQCBISA-N 0.000 claims 1
FAQSNRRLLMLGLP-KBZWIDLWSA-N 7-[4-(2-methylpyridin-3-yl)oxyphenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC=N1)OC2=CC=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O FAQSNRRLLMLGLP-KBZWIDLWSA-N 0.000 claims 1
SJHGYUXTQBLOBZ-FVDXLRKESA-N 7-[4-(3,5-difluorophenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC(=CC(=C2)F)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O SJHGYUXTQBLOBZ-FVDXLRKESA-N 0.000 claims 1
KXPSEAFHHQXHCF-FVDXLRKESA-N 7-[4-(3-fluorophenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC(=CC=C2)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O KXPSEAFHHQXHCF-FVDXLRKESA-N 0.000 claims 1
GEZQUGARCHXPEF-FVDXLRKESA-N 7-[4-(4-fluorophenoxy)-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=C(C=C2)F)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O GEZQUGARCHXPEF-FVDXLRKESA-N 0.000 claims 1
QCLSFUSXXAEUHK-KBZWIDLWSA-N 7-[4-(5-methylpyridin-2-yl)oxyphenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CN=C(C=C1)OC2=CC=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O QCLSFUSXXAEUHK-KBZWIDLWSA-N 0.000 claims 1
YPTYAIFNJDQRIE-KBZWIDLWSA-N 7-[4-(6-methylpyridin-2-yl)oxyphenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=NC(=CC=C1)OC2=CC=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C)NC3=O YPTYAIFNJDQRIE-KBZWIDLWSA-N 0.000 claims 1
GGKOBIVRQBEFTP-QSVYXZOGSA-N 7-[4-(dimethylamino)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN(C)C1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O GGKOBIVRQBEFTP-QSVYXZOGSA-N 0.000 claims 1
PZKKUIGYRUDQGG-GDIICXGYSA-N 7-[4-(oxetan-3-yloxy)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6COC6 PZKKUIGYRUDQGG-GDIICXGYSA-N 0.000 claims 1
KEWANEIODOJRIV-PXWGLLCJSA-N 7-[4-[2-[fluoro-(2-methylphenyl)methoxy]phenoxy]-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=CC=CC=C1C(OC2=CC=CC=C2OC3=CC(=C(C=C3)N4C5=C6C(=C(SC6=NC=C5)C(=O)N[C@@H]7CCCN(C7)C)NC4=O)C)F KEWANEIODOJRIV-PXWGLLCJSA-N 0.000 claims 1
KOTTXELYGXMBJZ-UTKYEJCASA-N 7-[4-[3-(methoxymethyl)phenoxy]-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC(=C2)COC)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O KOTTXELYGXMBJZ-UTKYEJCASA-N 0.000 claims 1
ZLNGMHBXSICEEA-UHFFFAOYSA-N 7-[4-[3-[(2-cyanophenoxy)methyl]phenoxy]-2-methylphenyl]-N-(1-methylpiperidin-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC(=C2)COC3=CC=CC=C3C#N)N4C5CCNC6C5C(=C(S6)C(=O)NC7CCN(CC7)C)NC4=O ZLNGMHBXSICEEA-UHFFFAOYSA-N 0.000 claims 1
MFAGPUHBAIQHTP-DTFBLTAASA-N 7-[4-[3-[(2-cyanophenoxy)methyl]phenoxy]-2-methylphenyl]-N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC(=C2)COC3=CC=CC=C3C#N)N4C5CCNC6C5C(=C(S6)C(=O)N[C@@H]7CCCN(C7)C)NC4=O MFAGPUHBAIQHTP-DTFBLTAASA-N 0.000 claims 1
FDFUGXCWMXKFEG-DBFGGRIXSA-N 7-[4-chloro-3-(trifluoromethyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CNC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=C(C=C5)Cl)C(F)(F)F FDFUGXCWMXKFEG-DBFGGRIXSA-N 0.000 claims 1
XZKAHQINGIGJAG-BHVRQQHWSA-N 7-[4-methyl-3-(trifluoromethyl)phenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)C=C)NC2=O)C(F)(F)F XZKAHQINGIGJAG-BHVRQQHWSA-N 0.000 claims 1
TWMTVWVCKUENMV-GMKOREOWSA-N 7-[4-methyl-3-(trifluoromethyl)phenyl]-6-oxo-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCNC5)NC2=O)C(F)(F)F TWMTVWVCKUENMV-GMKOREOWSA-N 0.000 claims 1
SGGQLWMFUBUGEY-RQFMUYMZSA-N 7-[4-methyl-6-(2-methylpropoxy)pyridin-3-yl]-6-oxo-N-[(3R)-pyrrolidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC(=NC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCNC5)NC2=O)OCC(C)C SGGQLWMFUBUGEY-RQFMUYMZSA-N 0.000 claims 1
OXSRWBSPDJOENI-GOSISDBHSA-N 7-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-7,11-diazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC(C)CC1=NC=C(N2C(=O)CC3=C(SC4=NC=CC2=C34)C(=O)N[C@@H]2CCCN(C2)C(=O)C=C)C(C)=C1 OXSRWBSPDJOENI-GOSISDBHSA-N 0.000 claims 1
LPPWMHFLFYUTDC-WOBNGOBWSA-N 7-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-6-oxo-N-[(3R)-1-propanoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CN=C(C=C5C)CC(C)C LPPWMHFLFYUTDC-WOBNGOBWSA-N 0.000 claims 1
JZBDJMZCPKNMTH-GOSISDBHSA-N 7-[5-(2,3-difluorophenyl)-2-methylphenyl]-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=C(C=CC=1C)C1=C(C(=CC=C1)F)F JZBDJMZCPKNMTH-GOSISDBHSA-N 0.000 claims 1
RHVPYOIGNLTJAM-WIQGMUCESA-N 7-naphthalen-2-yl-6-oxo-N-[(3R)-1-prop-2-enoylpiperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC6=CC=CC=C6C=C5 RHVPYOIGNLTJAM-WIQGMUCESA-N 0.000 claims 1
IRNUJUQJOXHNKS-CTFWABCASA-N 9-methyl-6-oxo-7-(4-phenoxyphenyl)-N-[(3R)-piperidin-3-yl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)N[C@@H]4CCCNC4)C5=CC=C(C=C5)OC6=CC=CC=C6 IRNUJUQJOXHNKS-CTFWABCASA-N 0.000 claims 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
PHJMPLQBQFICSE-LZBANZJXSA-N CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4=C5C(=C(SC5=NC=C4)C(=O)N[C@@H]6CCCN(C6)C(=O)C(C)C(C)OC)NC3=O Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4=C5C(=C(SC5=NC=C4)C(=O)N[C@@H]6CCCN(C6)C(=O)C(C)C(C)OC)NC3=O PHJMPLQBQFICSE-LZBANZJXSA-N 0.000 claims 1
RAKDMKYFZWGVHR-UHFFFAOYSA-N CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4=C5C(=NC3=O)C(SC5=NC=C4)N6CCN(CC6)C#N Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4=C5C(=NC3=O)C(SC5=NC=C4)N6CCN(CC6)C#N RAKDMKYFZWGVHR-UHFFFAOYSA-N 0.000 claims 1
VKPHFSIDCKGOOU-UHFFFAOYSA-N N-(1,2-dimethylpiperidin-4-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1CC(CCN1C)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C VKPHFSIDCKGOOU-UHFFFAOYSA-N 0.000 claims 1
VLRIKCIWANULLW-UHFFFAOYSA-N N-(1,3-dimethylpiperidin-4-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1CN(CCC1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C)C VLRIKCIWANULLW-UHFFFAOYSA-N 0.000 claims 1
WWKKJBINSIWRMZ-UHFFFAOYSA-N N-(1-azabicyclo[2.2.2]octan-2-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CC7CCN6CC7)NC3=O WWKKJBINSIWRMZ-UHFFFAOYSA-N 0.000 claims 1
KKYNBPBEXUVNDT-UHFFFAOYSA-N N-(1-cyanopiperidin-3-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C#N)NC3=O KKYNBPBEXUVNDT-UHFFFAOYSA-N 0.000 claims 1
WYDQRIHXVBTXNZ-UHFFFAOYSA-N N-(1-cyanopiperidin-3-yl)-7-[4-(2-methoxyphenoxy)-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C#N)NC3=O WYDQRIHXVBTXNZ-UHFFFAOYSA-N 0.000 claims 1
QZOJREWETVITQH-UHFFFAOYSA-N N-(1-cyanopiperidin-4-yl)-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)NC4CCN(CC4)C#N)C5=CC=C(C=C5)OC6=CC=CC=C6 QZOJREWETVITQH-UHFFFAOYSA-N 0.000 claims 1
UOZPMEVWOMKIBF-UHFFFAOYSA-N N-(1-cyanopiperidin-4-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C#N)NC3=O UOZPMEVWOMKIBF-UHFFFAOYSA-N 0.000 claims 1
VHNSGPHYODPGFE-UHFFFAOYSA-N N-(1-cyanopiperidin-4-yl)-7-[4-(2-methoxyphenoxy)-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C#N)NC3=O VHNSGPHYODPGFE-UHFFFAOYSA-N 0.000 claims 1
RZLBXQIXCNAPBM-UHFFFAOYSA-N N-(1-cyclopropylazetidin-3-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(C6)C7CC7)NC3=O RZLBXQIXCNAPBM-UHFFFAOYSA-N 0.000 claims 1
MUWKMMMOBAQRDW-UHFFFAOYSA-N N-(1-ethylazetidin-3-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCN1CC(C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C MUWKMMMOBAQRDW-UHFFFAOYSA-N 0.000 claims 1
VAVCGGOMGBGKOB-UHFFFAOYSA-N N-(1-methyl-5-oxopyrrolidin-3-yl)-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN1CC(CC1=O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 VAVCGGOMGBGKOB-UHFFFAOYSA-N 0.000 claims 1
GFKADIUPEQQCAV-UHFFFAOYSA-N N-(1-methylazetidin-3-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(C6)C)NC3=O GFKADIUPEQQCAV-UHFFFAOYSA-N 0.000 claims 1
OSDPIHYMBHITSM-UHFFFAOYSA-N N-(1-methylpiperidin-4-yl)-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN1CCC(CC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 OSDPIHYMBHITSM-UHFFFAOYSA-N 0.000 claims 1
RSHNEJJEKQGKKL-UHFFFAOYSA-N N-(2-morpholin-4-ylethyl)-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)NCCN4CCOCC4)C5=CC=C(C=C5)OC6=CC=CC=C6 RSHNEJJEKQGKKL-UHFFFAOYSA-N 0.000 claims 1
KMDKYJNKNMBKHZ-UHFFFAOYSA-N N-(3-hydroxy-1-prop-2-enoylpiperidin-4-yl)-6-oxo-7-(4-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CCC(C(C1)O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)C6=CC=CC=C6 KMDKYJNKNMBKHZ-UHFFFAOYSA-N 0.000 claims 1
KHPPSYLVSVRVHG-UHFFFAOYSA-N N-(4-cyano-1,4-oxazepan-6-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(CCOC6)C#N)NC3=O KHPPSYLVSVRVHG-UHFFFAOYSA-N 0.000 claims 1
QSWBDARRFMFGRH-UHFFFAOYSA-N N-(4-methyl-1,4-oxazepan-6-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(CCOC6)C)NC3=O QSWBDARRFMFGRH-UHFFFAOYSA-N 0.000 claims 1
QNMIOTONXDLIQD-UHFFFAOYSA-N N-(azetidin-3-yl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CNC6)NC3=O QNMIOTONXDLIQD-UHFFFAOYSA-N 0.000 claims 1
ZARNNZWCURRELR-UQHTVBEOSA-N N-[(3R)-1-(2-aminoacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CN)NC3=O ZARNNZWCURRELR-UQHTVBEOSA-N 0.000 claims 1
OCSBLDJKOGWESD-MOWZZLTPSA-N N-[(3R)-1-(2-aminoacetyl)pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)CN)NC3=O OCSBLDJKOGWESD-MOWZZLTPSA-N 0.000 claims 1
MNOLRYCRRAGWAS-WXZQSGJUSA-N N-[(3R)-1-(2-chloro-3-methylbut-2-enoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(=C(C)C)Cl)NC3=O MNOLRYCRRAGWAS-WXZQSGJUSA-N 0.000 claims 1
METFFOBOVPMQRY-UQHTVBEOSA-N N-[(3R)-1-(2-chloroacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CCl)NC3=O METFFOBOVPMQRY-UQHTVBEOSA-N 0.000 claims 1
OWWQXKPAVJBLOC-MOWZZLTPSA-N N-[(3R)-1-(2-chloroacetyl)pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)CCl)NC3=O OWWQXKPAVJBLOC-MOWZZLTPSA-N 0.000 claims 1
DBRPCXVPNRKKQD-IUKJWVDASA-N N-[(3R)-1-(2-chloroprop-2-enoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(=C)Cl)NC3=O DBRPCXVPNRKKQD-IUKJWVDASA-N 0.000 claims 1
QLEHTDFRLYDVRN-DBVGPWRDSA-N N-[(3R)-1-(2-cyano-3-methylbut-2-enoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(=C(C)C)C#N)NC3=O QLEHTDFRLYDVRN-DBVGPWRDSA-N 0.000 claims 1
RURPAKNCGYKBTL-WPNUWBHDSA-N N-[(3R)-1-(2-cyanoacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CC#N)NC3=O RURPAKNCGYKBTL-WPNUWBHDSA-N 0.000 claims 1
YAPAYFKZZDDJRV-UQHTVBEOSA-N N-[(3R)-1-(2-cyanoacetyl)pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)CC#N)NC3=O YAPAYFKZZDDJRV-UQHTVBEOSA-N 0.000 claims 1
GTGRPUNAPPEGRU-WXZQSGJUSA-N N-[(3R)-1-(2-fluoro-3-methylbut-2-enoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(=C(C)C)F)NC3=O GTGRPUNAPPEGRU-WXZQSGJUSA-N 0.000 claims 1
XMOPZHLXQGKXDO-IUKJWVDASA-N N-[(3R)-1-(2-fluoroprop-2-enoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(=C)F)NC3=O XMOPZHLXQGKXDO-IUKJWVDASA-N 0.000 claims 1
ZBIZMJBIUVHGDQ-UQHTVBEOSA-N N-[(3R)-1-(2-hydroxyacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CO)NC3=O ZBIZMJBIUVHGDQ-UQHTVBEOSA-N 0.000 claims 1
QOBBPZTVFJORQL-UQHTVBEOSA-N N-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound COCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 QOBBPZTVFJORQL-UQHTVBEOSA-N 0.000 claims 1
BGBMBWWLASKUOC-WPNUWBHDSA-N N-[(3R)-1-(3-aminopropanoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CCN)NC3=O BGBMBWWLASKUOC-WPNUWBHDSA-N 0.000 claims 1
NVZFTKRBQUYPIT-HEDOHFRWSA-N N-[(3R)-1-(3-methoxy-2,2-dimethylpropanoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(C)(C)COC)NC3=O NVZFTKRBQUYPIT-HEDOHFRWSA-N 0.000 claims 1
FJTOUASNOWTAQM-OELAHCOOSA-N N-[(3R)-1-(3-methoxy-2-methylpropanoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C(C)COC)NC3=O FJTOUASNOWTAQM-OELAHCOOSA-N 0.000 claims 1
YMRCDWWHPHBQIB-UCUHLVETSA-N N-[(3R)-1-(3-methoxybutanoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CC(C)OC)NC3=O YMRCDWWHPHBQIB-UCUHLVETSA-N 0.000 claims 1
KMONMRSTPNHZSV-WPNUWBHDSA-N N-[(3R)-1-(3-methoxypropanoyl)piperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound COCCC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 KMONMRSTPNHZSV-WPNUWBHDSA-N 0.000 claims 1
IZPZGTDIAKKZOZ-LOIMDLHYSA-N N-[(3R)-1-(3-methoxypropanoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)CCOC)NC3=O IZPZGTDIAKKZOZ-LOIMDLHYSA-N 0.000 claims 1
MEOBCKDCOINPAQ-WPNUWBHDSA-N N-[(3R)-1-(3-methoxypropanoyl)pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)CCOC)NC3=O MEOBCKDCOINPAQ-WPNUWBHDSA-N 0.000 claims 1
CMGYUHHLUKNVDC-NPBDOVQGSA-N N-[(3R)-1-(3-methylbut-2-enoyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C=C(C)C)NC3=O CMGYUHHLUKNVDC-NPBDOVQGSA-N 0.000 claims 1
OPUKDUJZMUWDST-JIOUQZMASA-N N-[(3R)-1-[(2R)-2-amino-1-hydroxy-3-methoxypropyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C([C@@H](COC)N)O)NC3=O OPUKDUJZMUWDST-JIOUQZMASA-N 0.000 claims 1
ZKTWCIKTNGZFGU-GFOPJIDDSA-N N-[(3R)-1-[(2R)-2-hydroxy-3-methoxypropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@@H](COC)O)NC3=O ZKTWCIKTNGZFGU-GFOPJIDDSA-N 0.000 claims 1
YGRALVOCIRJASJ-XOYYQJEQSA-N N-[(3R)-1-[(2R)-3-hydroxy-2-methylpropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@H](C)CO)NC3=O YGRALVOCIRJASJ-XOYYQJEQSA-N 0.000 claims 1
FJTOUASNOWTAQM-SKMXHSGUSA-N N-[(3R)-1-[(2R)-3-methoxy-2-methylpropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@H](C)COC)NC3=O FJTOUASNOWTAQM-SKMXHSGUSA-N 0.000 claims 1
VATRROUHCGQORJ-DGTUCIMNSA-N N-[(3R)-1-[(2R)-azetidine-2-carbonyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@H]7CCN7)NC3=O VATRROUHCGQORJ-DGTUCIMNSA-N 0.000 claims 1
VXPAWXXUMNPJLP-SRWFVRNUSA-N N-[(3R)-1-[(2S)-2-amino-3-methoxypropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@H](COC)N)NC3=O VXPAWXXUMNPJLP-SRWFVRNUSA-N 0.000 claims 1
ZKTWCIKTNGZFGU-ISOJCLCCSA-N N-[(3R)-1-[(2S)-2-hydroxy-3-methoxypropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@H](COC)O)NC3=O ZKTWCIKTNGZFGU-ISOJCLCCSA-N 0.000 claims 1
YGRALVOCIRJASJ-NOQJQSDCSA-N N-[(3R)-1-[(2S)-3-hydroxy-2-methylpropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@@H](C)CO)NC3=O YGRALVOCIRJASJ-NOQJQSDCSA-N 0.000 claims 1
FJTOUASNOWTAQM-YFCJSSSCSA-N N-[(3R)-1-[(2S)-3-methoxy-2-methylpropanoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@@H](C)COC)NC3=O FJTOUASNOWTAQM-YFCJSSSCSA-N 0.000 claims 1
VATRROUHCGQORJ-SRWFVRNUSA-N N-[(3R)-1-[(2S)-azetidine-2-carbonyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)[C@@H]7CCN7)NC3=O VATRROUHCGQORJ-SRWFVRNUSA-N 0.000 claims 1
FQAFEONWVCAFIL-OEZHIIBRSA-N N-[(3R)-1-[(E)-2-cyano-3-(1-methylcyclobutyl)prop-2-enoyl]piperidin-3-yl]-7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(#N)/C(/C(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC1=CC=CC=C1)C)=C\C1(CCC1)C FQAFEONWVCAFIL-OEZHIIBRSA-N 0.000 claims 1
DRWONQOPVMPXTG-YJZYDXMKSA-N N-[(3R)-1-[(E)-2-cyano-3-(3-methyloxetan-3-yl)prop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7(COC7)C)/C#N)NC3=O DRWONQOPVMPXTG-YJZYDXMKSA-N 0.000 claims 1
QRRCOPFRYNDKEN-BVWZJIGMSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=CC(=NC=C6)C7=CC=CC=C7 QRRCOPFRYNDKEN-BVWZJIGMSA-N 0.000 claims 1
IIVYYKQTTWDTOF-SHOOHHAZSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-7-(3-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=CC(=CC=C6)OC7=CC=CC=C7 IIVYYKQTTWDTOF-SHOOHHAZSA-N 0.000 claims 1
HILORBLXKQHYKP-LMTNUQHTSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=CC=C(C=C6)OC7=CC=CC=C7 HILORBLXKQHYKP-LMTNUQHTSA-N 0.000 claims 1
PIMMUFGGROLZJJ-ULQIABHWSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-7-(4-propan-2-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(C)OC1=CC=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O PIMMUFGGROLZJJ-ULQIABHWSA-N 0.000 claims 1
CKXDJRBZLAPMJJ-PIRZXSEISA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2,6-difluoro-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=C(C=C(C=C6F)OC7=CC=CC=C7)F CKXDJRBZLAPMJJ-PIRZXSEISA-N 0.000 claims 1
XBUGKCJCVREQTN-DEMFRIMRSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-fluoro-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=C(C=C(C=C6)OC7=CC=CC=C7)F XBUGKCJCVREQTN-DEMFRIMRSA-N 0.000 claims 1
DHIXRKAXSKHSMY-KXQRZACPSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-3-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC=C1OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O DHIXRKAXSKHSMY-KXQRZACPSA-N 0.000 claims 1
ZJBQKWDPAUSWRS-QEQIRTOISA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(#N)/C(/C(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC1=CC=CC=C1)C)=C\C1CC1 ZJBQKWDPAUSWRS-QEQIRTOISA-N 0.000 claims 1
PHNFXJRSDDUWGL-HLSKUYFNSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC=CC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O PHNFXJRSDDUWGL-HLSKUYFNSA-N 0.000 claims 1
LZVJHHRWFQXGGP-XATPASBZSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(4-cyclopropyloxy-2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O LZVJHHRWFQXGGP-XATPASBZSA-N 0.000 claims 1
DVGPPKXVZYPGKN-ULQIABHWSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(4-ethoxy-2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCOC1=CC(=C(C=C1)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O)C DVGPPKXVZYPGKN-ULQIABHWSA-N 0.000 claims 1
FTLNQFXCLYSKQZ-SHOOHHAZSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-[2-methyl-4-(oxan-4-yloxy)phenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2CCOCC2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O FTLNQFXCLYSKQZ-SHOOHHAZSA-N 0.000 claims 1
IGUNSCZBUKUBRS-SGZJVPPRSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-[4-(2-ethylphenoxy)-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCC1=CC=CC=C1OC2=CC(=C(C=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O)C IGUNSCZBUKUBRS-SGZJVPPRSA-N 0.000 claims 1
LNTYAZLRALDERF-UUAIZEFVSA-N N-[(3R)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-[4-[3-[(2-cyanophenoxy)methyl]phenoxy]-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC(=C2)COC3=CC=CC=C3C#N)N4C5CCNC6C5C(=C(S6)C(=O)N[C@@H]7CCCN(C7)C(=O)/C(=C/C8CC8)/C#N)NC4=O LNTYAZLRALDERF-UUAIZEFVSA-N 0.000 claims 1
FMNNCEUHHCZVFJ-KGOBVDNUSA-N N-[(3R)-1-[(E)-2-cyano-3-methoxyprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/OC)/C#N)NC3=O FMNNCEUHHCZVFJ-KGOBVDNUSA-N 0.000 claims 1
VMJBQEHDEFBSHX-LMTNUQHTSA-N N-[(3R)-1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O VMJBQEHDEFBSHX-LMTNUQHTSA-N 0.000 claims 1
HBHQBABHXYFDJI-UNUWJKNESA-N N-[(3R)-1-[(E)-2-cyano-4-(cyclopropylamino)-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C(C)(C)NC7CC7)/C#N)NC3=O HBHQBABHXYFDJI-UNUWJKNESA-N 0.000 claims 1
VVNAQRIRJJPEIE-TYJWOLETSA-N N-[(3R)-1-[(E)-2-cyano-4-(ethylamino)-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCNC(C)(C)/C=C(\C#N)/C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C VVNAQRIRJJPEIE-TYJWOLETSA-N 0.000 claims 1
HZJKXAVFKCFHMP-TYJWOLETSA-N N-[(3R)-1-[(E)-2-cyano-4-ethoxy-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCOC(C)(C)/C=C(\C#N)/C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C HZJKXAVFKCFHMP-TYJWOLETSA-N 0.000 claims 1
OWPJGOWCEPBPHC-OEZHIIBRSA-N N-[(3R)-1-[(E)-2-cyano-4-ethoxy-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(#N)/C(/C(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC1=CC=CC=C1)C)=C\C(C)(C)OCC OWPJGOWCEPBPHC-OEZHIIBRSA-N 0.000 claims 1
BAGVBEQIANAXNT-OJLSWQFYSA-N N-[(3R)-1-[(E)-2-cyano-4-methyl-4-(methylamino)pent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C(C)(C)NC)/C#N)NC3=O BAGVBEQIANAXNT-OJLSWQFYSA-N 0.000 claims 1
XXKVCGPOIWHIBV-CGCKYHIGSA-N N-[(3R)-1-[(E)-2-cyano-4-methyl-4-piperidin-1-ylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C(C)(C)N7CCCCC7)/C#N)NC3=O XXKVCGPOIWHIBV-CGCKYHIGSA-N 0.000 claims 1
IFNMLGZXQAKWNN-LMTNUQHTSA-N N-[(3R)-1-[(E)-3-(1-aminocyclopropyl)-2-cyanoprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7(CC7)N)/C#N)NC3=O IFNMLGZXQAKWNN-LMTNUQHTSA-N 0.000 claims 1
YTKJZCILWBTVQW-NYOVIGHBSA-N N-[(3R)-1-[(E)-3-[(2R)-1-acetylpyrrolidin-2-yl]-2-cyanoprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/[C@H]7CCCN7C(=O)C)/C#N)NC3=O YTKJZCILWBTVQW-NYOVIGHBSA-N 0.000 claims 1
YTKJZCILWBTVQW-LLFIUFIOSA-N N-[(3R)-1-[(E)-3-[(2S)-1-acetylpyrrolidin-2-yl]-2-cyanoprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/[C@@H]7CCCN7C(=O)C)/C#N)NC3=O YTKJZCILWBTVQW-LLFIUFIOSA-N 0.000 claims 1
RRWDTLKBVIVRGV-CAWJZQCWSA-N N-[(3R)-1-[(E)-3-cyclopropyl-2-methylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C)NC3=O RRWDTLKBVIVRGV-CAWJZQCWSA-N 0.000 claims 1
VGRRXNZSUXKJEA-ZTHSWVIWSA-N N-[(3R)-1-[(E)-3-ethoxyprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCO/C=C/C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C VGRRXNZSUXKJEA-ZTHSWVIWSA-N 0.000 claims 1
JURXZKBPVLWJNX-BLYZCZELSA-N N-[(3R)-1-[(E)-4,4-dimethylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C=C/C(C)(C)C)NC3=O JURXZKBPVLWJNX-BLYZCZELSA-N 0.000 claims 1
OWEBJBYLXMCDJV-QKIKOGAMSA-N N-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]piperidin-3-yl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CCC1)C(\C=C\CN(C)C)=O)=O)C1=CC=CC=C1 OWEBJBYLXMCDJV-QKIKOGAMSA-N 0.000 claims 1
FOPTWSZKHKAXJO-JNKLARPZSA-N N-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CC1)C(\C=C\CN(C)C)=O)=O)C1=CC=CC=C1 FOPTWSZKHKAXJO-JNKLARPZSA-N 0.000 claims 1
OYGCTOWVFUODJH-KDMWNEELSA-N N-[(3R)-1-[(E)-4-hydroxybut-2-enoyl]piperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C(=O)/C=C/CO)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 OYGCTOWVFUODJH-KDMWNEELSA-N 0.000 claims 1
GIUSMSUYTLKRLK-OINSYYHDSA-N N-[(3R)-1-[(E)-4-hydroxybut-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C=C/CO)NC3=O GIUSMSUYTLKRLK-OINSYYHDSA-N 0.000 claims 1
DAHOAOAVGXBCML-CLOLKSBNSA-N N-[(3R)-1-[(E)-4-hydroxybut-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(OC2=CC=CC=C2)=C1)N1C(=O)NC2=C(SC3=NC=CC1=C23)C(=O)N[C@@H]1CCCN(C1)C(=O)\C=C\CO DAHOAOAVGXBCML-CLOLKSBNSA-N 0.000 claims 1
ROIKWSRCYOLBTD-KYXFWGNKSA-N N-[(3R)-1-[(E)-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C=C/C(C)C)NC3=O ROIKWSRCYOLBTD-KYXFWGNKSA-N 0.000 claims 1
OCPMMYBMFHNBNH-ATNVLAKGSA-N N-[(3R)-1-[(Z)-2-chloro-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/Cl)NC3=O OCPMMYBMFHNBNH-ATNVLAKGSA-N 0.000 claims 1
ACFCCFSPJZJOBT-LRPWHTMSSA-N N-[(3R)-1-[(Z)-2-chlorobut-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C/C=C(/C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C)\Cl ACFCCFSPJZJOBT-LRPWHTMSSA-N 0.000 claims 1
AXGQLALUCUCBED-PBCYPFFNSA-N N-[(3R)-1-[(Z)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(4-methoxy-2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5CCCN(C5)C(=O)/C(=C\C6CC6)/C#N)NC2=O AXGQLALUCUCBED-PBCYPFFNSA-N 0.000 claims 1
ATMZDVFBIQRGSZ-MPMADDBASA-N N-[(3R)-1-[(Z)-2-cyano-4-(dimethylamino)-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(#N)/C(/C(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)=C/C(C)(C)N(C)C ATMZDVFBIQRGSZ-MPMADDBASA-N 0.000 claims 1
VPCXAQKQKMVWIY-OSCCXGCESA-N N-[(3R)-1-[(Z)-2-fluoro-4-(methylamino)but-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/CNC)/F)NC3=O VPCXAQKQKMVWIY-OSCCXGCESA-N 0.000 claims 1
PSWCLFOVYMSFBF-LRPWHTMSSA-N N-[(3R)-1-[(Z)-2-fluorobut-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C/C=C(/C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C)\F PSWCLFOVYMSFBF-LRPWHTMSSA-N 0.000 claims 1
UCEMHZBNBMSJCN-QZHROZNRSA-N N-[(3R)-1-[(Z)-3-acetamidoprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C=C\NC(=O)C)NC3=O UCEMHZBNBMSJCN-QZHROZNRSA-N 0.000 claims 1
XNHCWTDLIHOGDM-ATNVLAKGSA-N N-[(3R)-1-[(Z)-3-cyclopropyl-2-fluoroprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/F)NC3=O XNHCWTDLIHOGDM-ATNVLAKGSA-N 0.000 claims 1
HYKFYDMZONEBPA-LTLCWEMKSA-N N-[(3R)-1-[(Z)-4-amino-2-chlorobut-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C/CN)/Cl)NC3=O HYKFYDMZONEBPA-LTLCWEMKSA-N 0.000 claims 1
FPKRHCJBXUMQBL-UVGKVZOISA-N N-[(3R)-1-[(Z)-4-amino-2-cyano-4-methylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)/C(=C\C(C)(C)N)/C#N)NC3=O FPKRHCJBXUMQBL-UVGKVZOISA-N 0.000 claims 1
FUTYOYQAGVGBPD-IWSXGMKRSA-N N-[(3R)-1-[(Z)-but-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C/C=C\C(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C FUTYOYQAGVGBPD-IWSXGMKRSA-N 0.000 claims 1
OZALDKNJIPHADX-WUZYXKQASA-N N-[(3R)-1-[1-(oxiran-2-yl)ethyl]piperidin-3-yl]-6-oxo-7-(2-phenoxypyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC(C1CO1)N2CCC[C@H](C2)NC(=O)C3=C4C5=C(C=CN=C5S3)N(C(=O)N4)C6=CC(=NC=C6)OC7=CC=CC=C7 OZALDKNJIPHADX-WUZYXKQASA-N 0.000 claims 1
ZMVLPCAASXKBGM-WPNUWBHDSA-N N-[(3R)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN(C)CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 ZMVLPCAASXKBGM-WPNUWBHDSA-N 0.000 claims 1
BPMCLHGBHPGCCY-UQHTVBEOSA-N N-[(3R)-1-[2-(dimethylamino)acetyl]pyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN(C)CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 BPMCLHGBHPGCCY-UQHTVBEOSA-N 0.000 claims 1
PQFCWVRJEKQYNR-WPNUWBHDSA-N N-[(3R)-1-[2-(dimethylamino)acetyl]pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C(=O)CN(C)C)NC3=O PQFCWVRJEKQYNR-WPNUWBHDSA-N 0.000 claims 1
XNHYLJSMXLHIMG-UALGTNEHSA-N N-[(3R)-1-acetylpiperidin-3-yl]-6-oxo-7-(4-pyridazin-3-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=NN=CC=C6 XNHYLJSMXLHIMG-UALGTNEHSA-N 0.000 claims 1
PVUZVQOIRLWIRL-LLFRVYHXSA-N N-[(3R)-1-acetylpiperidin-3-yl]-6-oxo-7-(4-pyridin-2-yloxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(=O)N1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=N6 PVUZVQOIRLWIRL-LLFRVYHXSA-N 0.000 claims 1
KFWMIVVGJMHTEU-QGZVFWFLSA-N N-[(3R)-1-acetylpiperidin-3-yl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C KFWMIVVGJMHTEU-QGZVFWFLSA-N 0.000 claims 1
UFWNJGXVKSQLJX-LLFRVYHXSA-N N-[(3R)-1-acetylpiperidin-3-yl]-7-(2-methyl-4-pyridazin-3-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=NN=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C)NC3=O UFWNJGXVKSQLJX-LLFRVYHXSA-N 0.000 claims 1
HRCGTXCSESSEGG-SWAMOUOESA-N N-[(3R)-1-acetylpiperidin-3-yl]-7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=N2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=O)C)NC3=O HRCGTXCSESSEGG-SWAMOUOESA-N 0.000 claims 1
TUQBBFUEZHGABR-WKBUCKLXSA-N N-[(3R)-1-acetylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(=O)N1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 TUQBBFUEZHGABR-WKBUCKLXSA-N 0.000 claims 1
REBRYHUXQIZNNU-QILYDWKISA-N N-[(3R)-1-benzylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CN(C[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6)CC7=CC=CC=C7 REBRYHUXQIZNNU-QILYDWKISA-N 0.000 claims 1
RUXVETPHAYWZKT-NRTDPDGLSA-N N-[(3R)-1-buta-1,3-dien-2-ylpiperidin-3-yl]-7-(3-methyl-2-phenylpyridin-4-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CN=C1C2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C(=C)C=C)NC3=O RUXVETPHAYWZKT-NRTDPDGLSA-N 0.000 claims 1
QXEZRJVMANCRCZ-WKBUCKLXSA-N N-[(3R)-1-cyanopiperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@H](CN(C1)C#N)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 QXEZRJVMANCRCZ-WKBUCKLXSA-N 0.000 claims 1
KKYNBPBEXUVNDT-FVDXLRKESA-N N-[(3R)-1-cyanopiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C#N)NC3=O KKYNBPBEXUVNDT-FVDXLRKESA-N 0.000 claims 1
FWZZTTWEGZWVMP-QKEPBWLVSA-N N-[(3R)-1-cyclopropylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C7CC7)NC3=O FWZZTTWEGZWVMP-QKEPBWLVSA-N 0.000 claims 1
RPCHXGBQARZSSS-YGGAICHLSA-N N-[(3R)-1-cyclopropylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)C7CC7)NC3=O RPCHXGBQARZSSS-YGGAICHLSA-N 0.000 claims 1
URLITTVWNGYUPK-IUKJWVDASA-N N-[(3R)-1-ethenylsulfonylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)S(=O)(=O)C=C)NC3=O URLITTVWNGYUPK-IUKJWVDASA-N 0.000 claims 1
FPLAEWSJNNMWKE-FVDXLRKESA-N N-[(3R)-1-ethenylsulfonylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCN(C6)S(=O)(=O)C=C)NC3=O FPLAEWSJNNMWKE-FVDXLRKESA-N 0.000 claims 1
CGQGNLBMEQDTQG-NPBDOVQGSA-N N-[(3R)-1-ethylpiperidin-3-yl]-7-[2-methyl-4-(2-propan-2-ylphenoxy)phenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CCN1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6C(C)C)C CGQGNLBMEQDTQG-NPBDOVQGSA-N 0.000 claims 1
NQNJOWRMXUXGPW-MRVPVSSYSA-N N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3NC(NC=1C=23)=O NQNJOWRMXUXGPW-MRVPVSSYSA-N 0.000 claims 1
BERRSZOCCYVAIA-LJQANCHMSA-N N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CCC1)C)=O)C1=CC=CC=C1 BERRSZOCCYVAIA-LJQANCHMSA-N 0.000 claims 1
WGRNPOIGCCSJBD-WKBUCKLXSA-N N-[(3R)-1-methylpiperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN1CCC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 WGRNPOIGCCSJBD-WKBUCKLXSA-N 0.000 claims 1
MXRXZELEQKEPOZ-LLFRVYHXSA-N N-[(3R)-1-methylpiperidin-3-yl]-7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=N2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O MXRXZELEQKEPOZ-LLFRVYHXSA-N 0.000 claims 1
BXPCTOPZCQPHGC-WKBUCKLXSA-N N-[(3R)-1-methylpiperidin-3-yl]-7-(2-methyl-4-pyridin-3-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CN=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O BXPCTOPZCQPHGC-WKBUCKLXSA-N 0.000 claims 1
GLWXZGDSNAESLV-GDXHKRBFSA-N N-[(3R)-1-methylpiperidin-3-yl]-7-[2-methyl-4-(2-propan-2-yloxyphenoxy)phenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC(C)C)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O GLWXZGDSNAESLV-GDXHKRBFSA-N 0.000 claims 1
NLKXMNSYEYSQIH-LOIMDLHYSA-N N-[(3R)-1-methylpiperidin-3-yl]-7-[2-methyl-4-(2-propan-2-ylphenoxy)phenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2C(C)C)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CCCN(C6)C)NC3=O NLKXMNSYEYSQIH-LOIMDLHYSA-N 0.000 claims 1
UIYWMIHSMGIGNZ-GOSISDBHSA-N N-[(3R)-1-methylpyrrolidin-3-yl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1CN(CC1)C)=O)C1=CC=CC=C1 UIYWMIHSMGIGNZ-GOSISDBHSA-N 0.000 claims 1
KPAAIVYNIWKCTG-AECCHWAESA-N N-[(3R)-1-methylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 KPAAIVYNIWKCTG-AECCHWAESA-N 0.000 claims 1
UTQBADXYSHIHGQ-FMWKYMSZSA-N N-[(3R)-1-methylpyrrolidin-3-yl]-6-oxo-7-[(4-phenoxyphenyl)methyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN1CC[C@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)CC5=CC=C(C=C5)OC6=CC=CC=C6 UTQBADXYSHIHGQ-FMWKYMSZSA-N 0.000 claims 1
UTFRJYYYNTXHSC-QFIPXVFZSA-N N-[(3R)-2,3-dihydro-1H-indol-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1[C@@H](C2=CC=CC=C2N1)NC(=O)C3=C4C5=C(C=CN=C5S3)N(C(=O)N4)C6=CC=C(C=C6)OC7=CC=CC=C7 UTFRJYYYNTXHSC-QFIPXVFZSA-N 0.000 claims 1
NGOIHQYRGGFEST-WKBUCKLXSA-N N-[(3R)-5,5-difluoro-1-methylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CC(CN(C6)C)(F)F)NC3=O NGOIHQYRGGFEST-WKBUCKLXSA-N 0.000 claims 1
PHLXUYPURJLXRO-AECCHWAESA-N N-[(3R)-5,5-difluoropiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6CC(CNC6)(F)F)NC3=O PHLXUYPURJLXRO-AECCHWAESA-N 0.000 claims 1
GGJMPEFZAZNYJZ-IFMALSPDSA-N N-[(3R,4R)-3-hydroxy-1-prop-2-enoylpiperidin-4-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@H]([C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC1=CC=CC=C1)O GGJMPEFZAZNYJZ-IFMALSPDSA-N 0.000 claims 1
JPJYKAKFMVHFIV-PSYVXQGXSA-N N-[(3R,4R)-4-hydroxy-1-prop-2-enoylpiperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H]([C@@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6)O JPJYKAKFMVHFIV-PSYVXQGXSA-N 0.000 claims 1
HCBGQYQOICOTFB-DZCOEPGHSA-N N-[(3R,4R)-4-hydroxypiperidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC[C@H]([C@@H]1O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 HCBGQYQOICOTFB-DZCOEPGHSA-N 0.000 claims 1
JYGOKBNSZPQJRX-FTMHIPDTSA-N N-[(3R,5R)-5-fluoro-1-methylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CN(C6)C)F)NC3=O JYGOKBNSZPQJRX-FTMHIPDTSA-N 0.000 claims 1
IVJVTDIUINKNHG-UCBTUMINSA-N N-[(3R,5R)-5-fluoropiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CNC6)F)NC3=O IVJVTDIUINKNHG-UCBTUMINSA-N 0.000 claims 1
PBVOQVUMLQCETG-FTMHIPDTSA-N N-[(3R,5R)-5-hydroxy-1-methylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CN(C6)C)O)NC3=O PBVOQVUMLQCETG-FTMHIPDTSA-N 0.000 claims 1
FLIFGHGFISRFHV-JYBFLCGVSA-N N-[(3R,5R)-5-hydroxy-1-prop-2-enoylpiperidin-3-yl]-6-oxo-7-(4-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1C[C@@H](C[C@H](C1)O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)C6=CC=CC=C6 FLIFGHGFISRFHV-JYBFLCGVSA-N 0.000 claims 1
PEHBKDKPWFHJPB-KMNXPOHVSA-N N-[(3R,5R)-5-hydroxy-1-prop-2-enoylpiperidin-3-yl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@@H]5C[C@H](CN(C5)C(=O)C=C)O)NC2=O PEHBKDKPWFHJPB-KMNXPOHVSA-N 0.000 claims 1
NXDNXWLHESPTAZ-HHZQAKTNSA-N N-[(3R,5R)-5-hydroxypiperidin-3-yl]-6-oxo-7-(4-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)N[C@@H]4C[C@H](CNC4)O)C5=CC=C(C=C5)C6=CC=CC=C6 NXDNXWLHESPTAZ-HHZQAKTNSA-N 0.000 claims 1
OVRLELGZXDUUOL-UCBTUMINSA-N N-[(3R,5R)-5-hydroxypiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CNC6)O)NC3=O OVRLELGZXDUUOL-UCBTUMINSA-N 0.000 claims 1
TZZYGAFLHVSMJE-DFDGSRCZSA-N N-[(3R,5R)-5-methoxy-1-prop-2-enoylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CN(C6)C(=O)C=C)OC)NC3=O TZZYGAFLHVSMJE-DFDGSRCZSA-N 0.000 claims 1
JHGUVOQUGXUCFE-HECVLYIBSA-N N-[(3R,5R)-5-methoxypiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@H](CNC6)OC)NC3=O JHGUVOQUGXUCFE-HECVLYIBSA-N 0.000 claims 1
JYGOKBNSZPQJRX-XUBURNOCSA-N N-[(3R,5S)-5-fluoro-1-methylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CN(C6)C)F)NC3=O JYGOKBNSZPQJRX-XUBURNOCSA-N 0.000 claims 1
IVJVTDIUINKNHG-RKKIWJGFSA-N N-[(3R,5S)-5-fluoropiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CNC6)F)NC3=O IVJVTDIUINKNHG-RKKIWJGFSA-N 0.000 claims 1
PBVOQVUMLQCETG-SVCYRWPYSA-N N-[(3R,5S)-5-hydroxy-1-methylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CN(C6)C)O)NC3=O PBVOQVUMLQCETG-SVCYRWPYSA-N 0.000 claims 1
OVRLELGZXDUUOL-LOGFRAKOSA-N N-[(3R,5S)-5-hydroxypiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CNC6)O)NC3=O OVRLELGZXDUUOL-LOGFRAKOSA-N 0.000 claims 1
DOHXXBHBMHEZKV-FBKSXAHKSA-N N-[(3R,5S)-5-methoxy-1-methylpiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CN(C6)C)OC)NC3=O DOHXXBHBMHEZKV-FBKSXAHKSA-N 0.000 claims 1
JHGUVOQUGXUCFE-NLIBMEPHSA-N N-[(3R,5S)-5-methoxypiperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@@H]6C[C@@H](CNC6)OC)NC3=O JHGUVOQUGXUCFE-NLIBMEPHSA-N 0.000 claims 1
OGMGFFJOERJHHW-RNHHAJMHSA-N N-[(3S)-1-(3-chloropropanoyl)piperidin-3-yl]-6-oxo-7-(5-phenoxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@@H](CN(C1)C(=O)CCCl)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=NC=C(C=C5)OC6=CC=CC=C6 OGMGFFJOERJHHW-RNHHAJMHSA-N 0.000 claims 1
IIVYYKQTTWDTOF-WZEZZSOCSA-N N-[(3S)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-7-(3-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1C[C@@H](CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=CC(=CC=C6)OC7=CC=CC=C7 IIVYYKQTTWDTOF-WZEZZSOCSA-N 0.000 claims 1
YBENJRMEFBXSOI-WISHJUJFSA-N N-[(3S)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O YBENJRMEFBXSOI-WISHJUJFSA-N 0.000 claims 1
TYGRCPYIXJZMOT-JHDFXYHBSA-N N-[(3S)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-5-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=C(C=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O TYGRCPYIXJZMOT-JHDFXYHBSA-N 0.000 claims 1
PHNFXJRSDDUWGL-HWYVFJGKSA-N N-[(3S)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC=CC=C1N2C3CCNC4C3C(=C(S4)C(=O)N[C@H]5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O PHNFXJRSDDUWGL-HWYVFJGKSA-N 0.000 claims 1
AXGQLALUCUCBED-GRFAUZIJSA-N N-[(3S)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(4-methoxy-2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC)N2C3CCNC4C3C(=C(S4)C(=O)N[C@H]5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O AXGQLALUCUCBED-GRFAUZIJSA-N 0.000 claims 1
FJXSWHKYNPWYTN-WZEZZSOCSA-N N-[(3S)-1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O FJXSWHKYNPWYTN-WZEZZSOCSA-N 0.000 claims 1
VUHSZFVOIZPYHA-SKDPOSEVSA-N N-[(3S)-1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCN(C6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O VUHSZFVOIZPYHA-SKDPOSEVSA-N 0.000 claims 1
TUQBBFUEZHGABR-KAXXRHABSA-N N-[(3S)-1-acetylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC(=O)N1CC[C@@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 TUQBBFUEZHGABR-KAXXRHABSA-N 0.000 claims 1
YGPWFECCPMQJIM-RQWPAXSBSA-N N-[(3S)-1-benzyl-2-oxoazepan-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CCCCN(C6=O)CC7=CC=CC=C7)NC3=O YGPWFECCPMQJIM-RQWPAXSBSA-N 0.000 claims 1
REBRYHUXQIZNNU-RLGHEBHOSA-N N-[(3S)-1-benzylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CN(C[C@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6)CC7=CC=CC=C7 REBRYHUXQIZNNU-RLGHEBHOSA-N 0.000 claims 1
KPAAIVYNIWKCTG-ZIGWWCSZSA-N N-[(3S)-1-methylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CN1CC[C@@H](C1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 KPAAIVYNIWKCTG-ZIGWWCSZSA-N 0.000 claims 1
UTFRJYYYNTXHSC-JOCHJYFZSA-N N-[(3S)-2,3-dihydro-1H-indol-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1[C@H](C2=CC=CC=C2N1)NC(=O)C3=C4C5=C(C=CN=C5S3)N(C(=O)N4)C6=CC=C(C=C6)OC7=CC=CC=C7 UTFRJYYYNTXHSC-JOCHJYFZSA-N 0.000 claims 1
KOOCKHFHMNFJHZ-GUJOVLCASA-N N-[(3S,4R)-3-hydroxy-1-prop-2-enoylpiperidin-4-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1CC[C@H]([C@H](C1)O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 KOOCKHFHMNFJHZ-GUJOVLCASA-N 0.000 claims 1
KAYVFMQRFNGLQD-PPJOMVBFSA-N N-[(3S,4R)-3-hydroxypiperidin-4-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC[C@@H]([C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6)O KAYVFMQRFNGLQD-PPJOMVBFSA-N 0.000 claims 1
UORJMTIUXDIRCQ-AELWBYESSA-N N-[(3S,4R)-4-fluoro-1-(3-methoxypropanoyl)pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@H]6F)C(=O)CCOC)NC3=O UORJMTIUXDIRCQ-AELWBYESSA-N 0.000 claims 1
CUSYSGQAFQFODU-VGUGOSFYSA-N N-[(3S,4R)-4-fluoro-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@H]6F)C(=O)C=C)NC3=O CUSYSGQAFQFODU-VGUGOSFYSA-N 0.000 claims 1
YFGAPUUMTFNLAR-DKBSKCMTSA-N N-[(3S,4R)-4-fluoropyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CNC[C@H]6F)NC3=O YFGAPUUMTFNLAR-DKBSKCMTSA-N 0.000 claims 1
PEYYPJXJDDURGR-BEXJPZTJSA-N N-[(3S,4R)-4-hydroxy-1-prop-2-enoylpyrrolidin-3-yl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1C[C@@H]([C@@H](C1)O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC(=NC=C5)C6=CC=CC=C6 PEYYPJXJDDURGR-BEXJPZTJSA-N 0.000 claims 1
YDBCJCZRARCVQV-MEPVZMTNSA-N N-[(3S,4R)-4-hydroxy-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC(C)C)N2C3CCNC4C3C(=C(S4)C(=O)N[C@H]5CN(C[C@H]5O)C(=O)C=C)NC2=O YDBCJCZRARCVQV-MEPVZMTNSA-N 0.000 claims 1
ADRAYRMEBCQZLS-RMAGDJKNSA-N N-[(3S,4R)-4-hydroxypyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CNC[C@H]6O)NC3=O ADRAYRMEBCQZLS-RMAGDJKNSA-N 0.000 claims 1
VXUAYMOXYGCYTR-NZQKXSOJSA-N N-[(3S,4R)-4-methoxy-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H]([C@@H](C1)OC)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C VXUAYMOXYGCYTR-NZQKXSOJSA-N 0.000 claims 1
FBXKABJLGPOAMY-BUEHHDDSSA-N N-[(3S,4R)-4-methoxypyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CNC[C@H]6OC)NC3=O FBXKABJLGPOAMY-BUEHHDDSSA-N 0.000 claims 1
ZEKSTAYAAAHMCE-YOXQFYFMSA-N N-[(3S,4S)-4-fluoro-1-prop-2-enoylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1C[C@@H]([C@H](C1)F)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 ZEKSTAYAAAHMCE-YOXQFYFMSA-N 0.000 claims 1
CUSYSGQAFQFODU-YWDTUCSFSA-N N-[(3S,4S)-4-fluoro-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@@H]6F)C(=O)C=C)NC3=O CUSYSGQAFQFODU-YWDTUCSFSA-N 0.000 claims 1
QTFPLBBYZKQTDA-ZBNBAUEASA-N N-[(3S,4S)-4-fluoropyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)N[C@H]4CNC[C@@H]4F)C5=CC=C(C=C5)OC6=CC=CC=C6 QTFPLBBYZKQTDA-ZBNBAUEASA-N 0.000 claims 1
YFGAPUUMTFNLAR-AIEIOSAZSA-N N-[(3S,4S)-4-fluoropyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CNC[C@@H]6F)NC3=O YFGAPUUMTFNLAR-AIEIOSAZSA-N 0.000 claims 1
SLQHQEYXQHXPKQ-JIYRUIBGSA-N N-[(3S,4S)-4-hydroxy-1-(3-methoxypropanoyl)pyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@@H]6O)C(=O)CCOC)NC3=O SLQHQEYXQHXPKQ-JIYRUIBGSA-N 0.000 claims 1
IAXKIUZWCNWBHG-DCRLZVBBSA-N N-[(3S,4S)-4-hydroxy-1-prop-2-enoylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C=CC(=O)N1C[C@@H]([C@H](C1)O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 IAXKIUZWCNWBHG-DCRLZVBBSA-N 0.000 claims 1
SZXYGKQOGKRMNI-FJYRCJRBSA-N N-[(3S,4S)-4-hydroxy-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@@H]6O)C(=O)C=C)NC3=O SZXYGKQOGKRMNI-FJYRCJRBSA-N 0.000 claims 1
XSYFBQITPGITCI-WJDBMCNVSA-N N-[(3S,4S)-4-hydroxypyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)N[C@H]4CNC[C@@H]4O)C5=CC=C(C=C5)OC6=CC=CC=C6 XSYFBQITPGITCI-WJDBMCNVSA-N 0.000 claims 1
ADRAYRMEBCQZLS-JQCDREMPSA-N N-[(3S,4S)-4-hydroxypyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CNC[C@@H]6O)NC3=O ADRAYRMEBCQZLS-JQCDREMPSA-N 0.000 claims 1
QPRWVADWLMFRFK-POOHFMOFSA-N N-[(3S,4S)-4-methoxy-1-prop-2-enoylpyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CO[C@H]1CN(C[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6)C(=O)C=C QPRWVADWLMFRFK-POOHFMOFSA-N 0.000 claims 1
IPVXPKHKSXEXTP-JIYRUIBGSA-N N-[(3S,4S)-4-methoxy-1-prop-2-enoylpyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CN(C[C@@H]6OC)C(=O)C=C)NC3=O IPVXPKHKSXEXTP-JIYRUIBGSA-N 0.000 claims 1
VFYOWAKYRAVCPR-CIVIGEMWSA-N N-[(3S,4S)-4-methoxypyrrolidin-3-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CO[C@H]1CNC[C@@H]1NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 VFYOWAKYRAVCPR-CIVIGEMWSA-N 0.000 claims 1
FBXKABJLGPOAMY-RDLNDQADSA-N N-[(3S,4S)-4-methoxypyrrolidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)N[C@H]6CNC[C@@H]6OC)NC3=O FBXKABJLGPOAMY-RDLNDQADSA-N 0.000 claims 1
RURPAKNCGYKBTL-UHFFFAOYSA-N N-[1-(2-cyanoacetyl)piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C(=O)CC#N)NC3=O RURPAKNCGYKBTL-UHFFFAOYSA-N 0.000 claims 1
GNEHYAAMRZDUEH-UHFFFAOYSA-N N-[1-(2-cyanoacetyl)piperidin-4-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C(=O)CC#N)NC3=O GNEHYAAMRZDUEH-UHFFFAOYSA-N 0.000 claims 1
PEYCSSZSORBIBK-UHFFFAOYSA-N N-[1-(3-methoxypropanoyl)azetidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(C6)C(=O)CCOC)NC3=O PEYCSSZSORBIBK-UHFFFAOYSA-N 0.000 claims 1
KYMJXMXQWSFFPK-UHFFFAOYSA-N N-[1-(3-methoxypropanoyl)piperidin-4-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound COCCC(=O)N1CCC(CC1)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 KYMJXMXQWSFFPK-UHFFFAOYSA-N 0.000 claims 1
WAYMNYURWVZCPF-XSFVSMFZSA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]azetidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O WAYMNYURWVZCPF-XSFVSMFZSA-N 0.000 claims 1
IIVYYKQTTWDTOF-LTGZKZEYSA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-6-oxo-7-(3-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CC(CN(C1)C(=O)/C(=C/C2CC2)/C#N)NC(=O)C3=C4C5C(CCNC5S3)N(C(=O)N4)C6=CC(=CC=C6)OC7=CC=CC=C7 IIVYYKQTTWDTOF-LTGZKZEYSA-N 0.000 claims 1
YBENJRMEFBXSOI-OQKWZONESA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O YBENJRMEFBXSOI-OQKWZONESA-N 0.000 claims 1
PHNFXJRSDDUWGL-QGOAFFKASA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=CC=CC=C1N2C3CCNC4C3C(=C(S4)C(=O)NC5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O PHNFXJRSDDUWGL-QGOAFFKASA-N 0.000 claims 1
AXGQLALUCUCBED-QGOAFFKASA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-(4-methoxy-2-methylphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC)N2C3CCNC4C3C(=C(S4)C(=O)NC5CCCN(C5)C(=O)/C(=C/C6CC6)/C#N)NC2=O AXGQLALUCUCBED-QGOAFFKASA-N 0.000 claims 1
MYQGELSPGNGVQT-OQKWZONESA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-3-yl]-7-[4-(2-methoxyphenoxy)-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C(=O)/C(=C/C7CC7)/C#N)NC3=O MYQGELSPGNGVQT-OQKWZONESA-N 0.000 claims 1
ZFHABIJLJXNJHR-RELWKKBWSA-N N-[1-[(E)-2-cyano-3-cyclopropylprop-2-enoyl]piperidin-4-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C(=O)/C(=C/C7CC7)/C#N)NC3=O ZFHABIJLJXNJHR-RELWKKBWSA-N 0.000 claims 1
VUHSZFVOIZPYHA-RELWKKBWSA-N N-[1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]piperidin-3-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O VUHSZFVOIZPYHA-RELWKKBWSA-N 0.000 claims 1
QDWFXKLPCSABBB-RELWKKBWSA-N N-[1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]piperidin-3-yl]-7-[4-(2-methoxyphenoxy)-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2OC)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCCN(C6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O QDWFXKLPCSABBB-RELWKKBWSA-N 0.000 claims 1
WZDVRCRMYKYTPR-ZBJSNUHESA-N N-[1-[(E)-2-cyano-4,4-dimethylpent-2-enoyl]piperidin-4-yl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC2=CC=CC=C2)N3C4CCNC5C4C(=C(S5)C(=O)NC6CCN(CC6)C(=O)/C(=C/C(C)(C)C)/C#N)NC3=O WZDVRCRMYKYTPR-ZBJSNUHESA-N 0.000 claims 1
NPHUIXOVDLGAJX-QPJJXVBHSA-N N-[1-[(E)-4-hydroxybut-2-enoyl]piperidin-4-yl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C1CNC2C3C1N(C(=O)NC3=C(S2)C(=O)NC4CCN(CC4)C(=O)/C=C/CO)C5=CC=C(C=C5)OC6=CC=CC=C6 NPHUIXOVDLGAJX-QPJJXVBHSA-N 0.000 claims 1
DCEUIYFDMPTDGK-IUKJWVDASA-N N-[2-[(3R)-3-methylmorpholin-4-yl]ethyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C[C@@H]1COCCN1CCNC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C DCEUIYFDMPTDGK-IUKJWVDASA-N 0.000 claims 1
DCEUIYFDMPTDGK-GJZSYMEPSA-N N-[2-[(3S)-3-methylmorpholin-4-yl]ethyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carboxamide Chemical compound C[C@H]1COCCN1CCNC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=C(C=C(C=C5)OC6=CC=CC=C6)C DCEUIYFDMPTDGK-GJZSYMEPSA-N 0.000 claims 1
FFTXQEJLHXIGNF-UHFFFAOYSA-N N-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-3-yl]-1-propanoylpiperidine-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)NC(=O)C1CN(CCC1)C(CC)=O)=O FFTXQEJLHXIGNF-UHFFFAOYSA-N 0.000 claims 1
IGLBAAICMYQDAO-UHFFFAOYSA-N N-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-3-yl]-1-propanoylpiperidine-4-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)NC(=O)C1CCN(CC1)C(CC)=O)=O IGLBAAICMYQDAO-UHFFFAOYSA-N 0.000 claims 1
MYXVPYKUPPRSEG-UHFFFAOYSA-N N-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-3-yl]piperidine-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)NC(=O)C1CNCCC1)=O MYXVPYKUPPRSEG-UHFFFAOYSA-N 0.000 claims 1
CRIYMKSJUBCFFP-UHFFFAOYSA-N N-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-3-yl]piperidine-4-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)NC(=O)C1CCNCC1)=O CRIYMKSJUBCFFP-UHFFFAOYSA-N 0.000 claims 1
GRYXYDCLWXRVAY-UHFFFAOYSA-N [tert-butyl-(2-sulfanylacetyl)amino] piperidine-1-carboxylate Chemical compound N1(CCCCC1)C(=O)ON(C(CS)=O)C(C)(C)C GRYXYDCLWXRVAY-UHFFFAOYSA-N 0.000 claims 1
125000002877 alkyl aryl group Chemical group 0.000 claims 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
125000003725 azepanyl group Chemical group 0.000 claims 1
YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
235000020958 biotin Nutrition 0.000 claims 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 1
125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
125000005961 oxazepanyl group Chemical group 0.000 claims 1
125000006299 oxetan-3-yl group Chemical group [H]C1([H])OC([H])([H])C1([H])* 0.000 claims 1
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 1
125000003373 pyrazinyl group Chemical group 0.000 claims 1
125000003226 pyrazolyl group Chemical group 0.000 claims 1
125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 1
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 claims 1
JIWVURRNVPBELQ-REORUOTHSA-N tert-butyl (3R,4R)-3-hydroxy-4-[[6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodec-3-ene-3-carbonyl]amino]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@H]([C@@H](C1)O)NC(=O)C2=C3C4C(CCNC4S2)N(C(=O)N3)C5=CC=C(C=C5)OC6=CC=CC=C6 JIWVURRNVPBELQ-REORUOTHSA-N 0.000 claims 1
0 *C(CCCCC1)CCCC1N(c1c(c(N2)c(C(NC3CCCCCCCC3)=O)[s]3)c3ncc1)C2=O Chemical compound *C(CCCCC1)CCCC1N(c1c(c(N2)c(C(NC3CCCCCCCC3)=O)[s]3)c3ncc1)C2=O 0.000 description 12

JP2018529982A 2015-12-10 2016-12-09 ブルトン型チロシンキナーゼの阻害剤及びその使用方法 Active JP7110097B2 (ja)